Effect of Methylphenidate on State Anxiety in Children With ADHD-A Single Dose, Placebo Controlled, Crossover Study

Introduction: Non-adherence to efficacious pharmacotherapy is a major obstacle in the treatment of children suffering from attention deficit hyperactive disorder (ADHD). Some hold the position that pharmacotherapy induces anxiety, and that this is one of the reasons for this non-adherence. Previous studies have pointed to the opposite, a moderating effect of methylphenidate (MPH) on state anxiety in patients with ADHD. This has been shown in continuous treatment in children, but not on a single dose. We hypothesized that a single dose might have a different effect.Method: Twenty children with ADHD were given single doses of MPH in a randomized, controlled, crossover, double blind study. State anxiety using The Spielberger State-Trait Anxiety Inventory (STAI) and a continuous performance test were assessed.Results: As a group, no change was detected in state anxiety with MPH or placebo. However, children who were given MPH during the first session as opposed to those who received placebo first, demonstrated deterioration in baseline state anxiety in the second session [t(2.485), p < 0.05].Conclusion: Our findings show a possible delayed anxiety-provoking effect of a single dose of MPH. This may be relevant to the understanding of difficulties in adherence with MPH treatment in children with ADHD.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT0179845

Asylum Seekers and the Labour Market: Spaces of Discomfort and Hostility

This article examines the relationship in the UK between asylum-seeking and the labour market. Since 2002, asylum-seekers have not been allowed to work unless they have waited over twelve months for an initial decision on their asylum claim. This policy change occurred as employment was considered a ‘pull factor’ encouraging unfounded asylum claims. Despite not having the right to work, asylum-seekers – and especially those whose applications for refugee status have been refused by the UK government – interact with the labour market in manifold ways. Drawing on an ESRC-funded study in the UK's Yorkshire and Humber region and related studies, this article argues that both asylum-seekers and refused asylum-seekers form a hyper-exploitable pool of ‘illegalised’ and unprotected workers. As a vital part of their survival terrain, work is largely experienced as for-cash labouring in low-paid labour market sectors where the spectre of exploitation and even ‘modern slavery’ are perpetual threats. Recent policy shifts are deepening such threats through creating increasingly ‘uncomfortable’ and ‘hostile’ environments for certain categories of migrants

An Eisenstein ideal for imaginary quadratic fields and the Bloch-Kato conjecture for Hecke characters

For certain algebraic Hecke characters chi of an imaginary quadratic field F we define an Eisenstein ideal in a p-adic Hecke algebra acting on cuspidal automorphic forms of GL_2/F. By finding congruences between Eisenstein cohomology classes (in the sense of G. Harder) and cuspidal classes we prove a lower bound for the index of the Eisenstein ideal in the Hecke algebra in terms of the special L-value L(0,chi). We further prove that its index is bounded from above by the order of the Selmer group of the p-adic Galois character associated to chi^{-1}. This uses the work of R. Taylor et al. on attaching Galois representations to cuspforms of GL_2/F. Together these results imply a lower bound for the size of the Selmer group in terms of L(0,chi), coinciding with the value given by the Bloch-Kato conjecture.Comment: 26 page

The smooth Whitehead spectrum of a point at odd regular primes

Let p be an odd regular prime, and assume that the Lichtenbaum-Quillen conjecture holds for K(Z[1/p]) at p. Then the p-primary homotopy type of the smooth Whitehead spectrum Wh(*) is described. A suspended copy of the cokernel-of-J spectrum splits off, and the torsion homotopy of the remainder equals the torsion homotopy of the fiber of the restricted S^1-transfer map t: SigmaCP^infty--> S. The homotopy groups of Wh(*) are determined in a range of degrees, and the cohomology of Wh(*) is expressed as an A-module in all degrees, up to an extension. These results have geometric topological interpretations, in terms of spaces of concordances or diffeomorphisms of highly connected, high dimensional compact smooth manifolds.Comment: Published by Geometry and Topology at http://www.maths.warwick.ac.uk/gt/GTVol7/paper4.abs.htm

Radial orbit instability: review and perspectives

This paper presents elements about the radial orbit instability, which occurs in spherical self-gravitating systems with a strong anisotropy in the radial velocity direction. It contains an overview on the history of radial orbit instability. We also present the symplectic method we use to explore stability of equilibrium states, directly related to the dissipation induced instability mechanism well known in theoretical mechanics and plasma physics.Comment: 10 pages, submitted to Transport Theory and Statistical Physics, proceedings of Vlasovia 2009 International Conference. Corrected for typos, redaction, and references adde

Overnight Immune Regulation and Subjective Measures of Sleep: A Three Night Observational Study in Adolescent Track and Field Athletes

To ensure health maintenance of young athletes, immunological stress due to physical exercise has to be balanced for performance development and health maintenance. Sleep is an important influencing factor for immune regulation because of its regenerating effect. In an attempt to assess overnight immune regulation, this observational study aimed to examine associations between changes in capillary immunological blood markers and measures of sleep in adolescent athletes. Over a period of three nights, 12 male ( n = 6) and female ( n = 6) adolescent track and field athletes aged 16.4 ± 1.1 years were monitored for their sleep behavior (e.g., sleep duration, sleep depth) and immune regulation by using subjective (e.g., sleep) and objective (capillary blood markers) measurement tools. Over the 4 day (three nights), athletes followed their daily routines (school, homework, free time activities, and training). Training was performed for different disciplines (sprint, hurdles, and long-jump) following their daily training routines. Training included dynamic core stability training, coordination training, speed training, resistance training, and endurance training. Capillary blood samples were taken 30–45 min after the last training session (10:00–12:00 a.m. or 5:00–6:00 p.m.) and every morning between 7:00 and 10:00 a.m. Changes in capillary blood markers from post-training to the next morning and morning-to-morning fluctuations in capillary blood markers were analyzed over a three-night period using a generalized estimating equations (GEE) statistical approach. Associations of overnight changes with measures of sleep were analyzed using GEE. We found significant decreases in white blood cell count (WBC), granulocytes (GRAN), granulocytes% (GRAN%), monocytes (MID), and granulocyte-lymphocyte-ratio. In contrast, lymphocytes% (LYM%) increased significantly and systemic inflammation index showed no difference from post-training to the next morning. Furthermore, there was a significant decrease in WBC and GRAN between morning 1 and morning 3. At morning 4, values returned to baseline (morning 1), irrespective if athletes performed a training session or rested on day 3. Furthermore, sleep duration was significantly and negatively associated with changes in WBC (β z = −0.491) and lymphocytes (β z = −0.451). Our results indicate that overnight sleep duration is an important parameter of immunological overnight regulation for adolescent athletes

The antinucleon-nucleon interaction at low energy : annihilation dynamics

The general properties of antiproton-proton annihilation at rest are presented, with special focus on the two-meson final states. The data exhibit remarkable dynamical selection rules : some allowed annihilation modes are suppressed by one order of magnitude with respect to modes of comparable phase-space. Various phenomenological analyses are reviewed, based on microscopic quark dynamics or symmetry considerations. The role of initial- and final-state interaction is also examined.Comment: 128 pages, 49 tables, 27 figure

Making sense of violence: a study of narrative meaning

Dramatized violence has been a feature of entertainment in western civilization throughout history. The function of film violence is explored and compared to violence encountered in real life. The role of narrative in individuals' meaning-making processes is also investigated. Six adults were individually interviewed using a semi-structured schedule and narrative analysis was implemented. The findings revealed that real life violence is experientially distinct from film violence but narrative was found to be central to participants' quest for the meaning of violence in both contexts. The narrative framework of violence and whether it is justifiable were fundamental to participants' understanding. The function of violent film was found to be multifaceted: it can teach viewers about the consequences of violence; it allows them to speculate about their own and others' reactions to violence; and it provides an opportunity to experience something which is ordinarily outside of our experience in order to satisfy our human existential needs