Addressing power and scale in resilience programming: a call to engage across funding, delivery and evaluation

Resilience has recently emerged as a conceptual and operational buzzword spanning every facet of the international development agenda. The rise of resilience provides renewed opportunities for geographers to critically engage with the policy sphere and shape ongoing discourse over the nature of resilience programming. Yet, while aspects of the political economy of resilience have long been acknowledged in both academic and practitioner literatures, scholarly inputs have had limited influence in addressing issues of power and scale as applied directly to resilience programming. In this commentary, we argue that enhanced uptake of geographic enquiry is contingent on geographers being more proactive in engaging with resilience practitioners. One way of doing so is to tailor scholarly inputs to three critical elements of the programmatic cycle, namely how resilience-building activities are funded, delivered, and evaluated. Using these three facets, we highlight key practical and ethical considerations worthy of further geographic enquiry – focusing on issues of power and scale as concepts at the heart of geography

Health literacy in schools: prioritising health and well-being issues through the curriculum

Health literacy (HL) is a relatively new concept in health promotion and is concerned with empowering people through enhancing their knowledge of health issues and improving their ability to make choices about their health and well-being. Schools are seen increasingly as key settings for the dissemination of health messages through curricula and other on-site provision. However, such opportunities are amongst many demands being placed on educational providers and finding space in the school day to support the health agenda is a challenge. This practice-based, qualitative study examines the current practices in three schools in the UK. In total 34 pupils (n=16 from Year 9 and n = 18 from Year 11) were interviewed in six focus groups (3 in each school), with up to 6 pupils in each focus group. School staff (n = 8) were also interviewed individually. Findings suggest that pupils and staff have an understanding of health and a capacity for HL, though health education (via taught subjects) is not statutory across the four Key Stages of the National Curriculum. In order to engender health literate young people, with a view to reducing health inequalities, it is recommended that key health messages are delivered through an agenda that integrates current provision for health via the curriculum and other school-based practices, such as the Healthy Schools Programme

Closing the brief case: A Fatal Case of Necrotizing Fasciitis Due to Multidrug-Resistant Acinetobacter baumannii

ANSWERS TO SELF-ASSESSMENT QUESTIONS 1. What is the most common etiology of monomicrobial (type 2) necrotizing fasciitis? a. Acinetobacter baumannii b. Staphylococcus aureus c. Streptococcus pyogenes d. Vibrio vulnificus Answer: c. Although all of the organisms listed cause type 2 necrotizing fasciitis, the most common cause is still S. pyogenes, with an incidence of 0.4 per 100,000 in the United States. Due to variations in reporting practices, the exact incidences of other etiologies are not known, but they are less common than S. pyogenes

Kestrel Aeronautics: KA-Ranger

As combat environments continue to evolve, there is a growing need for dedicated aircraft to provide close air support to ground forces. In response to the 2021 AIAA Undergraduate Team Aircraft Design Competition RFP, Kestrel Aeronautics developed the KA-Ranger, an affordable, light attack aircraft to operate from austere fields and replace current helicopters in close air support missions. The design must accomplish an attack mission with full weapons payload, cruise for 200 nmi at an altitude ≥10,000 ft, and loiter 4 hours. It must also complete a long-range ferry mission of at least 900 nmi range at 60% payload, cruising at an altitude ≥18,000 ft. Both missions require reserves for an additional 3,000 ft climb and 45 minute loiter. A survey of current attack aircraft yielded the initial design including a turboprop engine, low mounted rectangular wings, conventional tail, and retractable tricycle landing gear. The aircraft weighs approximately 12,000 lbf with two crew members, an integrated gun, and 3,000 lbf of externally mounted armament. Current design activities include material selection, detailed structural design, weapon and fuel placement with stability analysis, drag assessment, and power analysis to confirm the KA Ranger’s flight performance

openWAR: An Open Source System for Evaluating Overall Player Performance in Major League Baseball

Within baseball analytics, there is substantial interest in comprehensive statistics intended to capture overall player performance. One such measure is Wins Above Replacement (WAR), which aggregates the contributions of a player in each facet of the game: hitting, pitching, baserunning, and fielding. However, current versions of WAR depend upon proprietary data, ad hoc methodology, and opaque calculations. We propose a competitive aggregate measure, openWAR, that is based upon public data and methodology with greater rigor and transparency. We discuss a principled standard for the nebulous concept of a "replacement" player. Finally, we use simulation-based techniques to provide interval estimates for our openWAR measure.Comment: 27 pages including supplemen

Holocene alluvial fan evolution, Schmidt-hammer exposure-age dating and paraglacial debris floods in the SE Jostedalsbreen region, southern Norway

The evolution of several sub‐alpine alluvial fans SE of the Jostedalsbreen ice cap was investigated based on their geomorphology and Schmidt‐hammer exposure‐age dating (SHD ) applied to 47 boulder deposits on the fan surfaces. A debris‐flood rather than debrisflow or water‐flow origin for the deposits was inferred from their morphology, consisting of low ridges with terminal splays up to 100 m wide without lateral levees. This was supported by fan, catchment, and boulder characteristics. SHD ages ranged from 9480±765 to 1955±810 years. The greatest number of boulder deposits, peak debris‐flood activity and maximum fan aggradation occurred between ̃9.0 and 8.0 ka, following regional deglaciation at ̃9.7 ka. The high debris concentrations necessary for debris floods were attributed to paraglacial processes enhanced by unstable till deposits on steep slopes within the catchments. From ̃8.0 ka, fan aggradation became progressively less as the catchment sediment sources tended towards exhaustion, precipitation decreased during the Holocene Thermal Maximum, and tree cover increased. After ̃4.0 ka, some areas of fan surfaces stabilized, while Late‐Holocene climatic deterioration led to renewed fan aggradation in response to the neoglacial growth of glaciers, culminating in the Little Ice Age. These changes are generalized within a conceptual model of alluvial fan evolution in this recently‐deglaciated mountain region and in glacierized catchments. This study highlights the potential importance of debris floods, of which relatively little is known, especially in the context of alluvial fan evolution

Assessing the Effects of Weather Conditions on Physical Activity Participation Using Objective Measures

Habitual physical activity is an important determinant of health, yet many people are considered to be inactive. Identification of the obstacles to greater participation is necessary for the development of strategies to overcome those obstacles. The weather has been identified as a perceived barrier to participation in physical activity, but exactly which adverse weather conditions are most important, and the extent to which they contribute to decreases in physical activity have rarely been quantified in populations. In the past decade, a small number of studies have used publicly available databases to examine the quantitative effects of weather (e.g., temperature, precipitation, wind) on physical activity in children, adolescents and adults. This review examines our historical, qualitative versus emerging, quantitative understanding of how specific weather conditions affect a population’s activity

A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

ABSTRACT Several biosafety level 3 and/or 4 (BSL-3/4) pathogens are high-consequence, single-stranded RNA viruses, and their genomes, when introduced into permissive cells, are infectious. Moreover, many of these viruses are select agents (SAs), and their genomes are also considered SAs. For this reason, cDNAs and/or their derivatives must be tested to ensure the absence of infectious virus and/or viral RNA before transfer out of the BSL-3/4 and/or SA laboratory. This tremendously limits the capacity to conduct viral genomic research, particularly the application of next-generation sequencing (NGS). Here, we present a sequence-independent method to rapidly amplify viral genomic RNA while simultaneously abolishing both viral and genomic RNA infectivity across multiple single-stranded positive-sense RNA (ssRNA+) virus families. The process generates barcoded DNA amplicons that range in length from 300 to 1,000 bp, which cannot be used to rescue a virus and are stable to transport at room temperature. Our barcoding approach allows for up to 288 barcoded samples to be pooled into a single library and run across various NGS platforms without potential reconstitution of the viral genome. Our data demonstrate that this approach provides full-length genomic sequence information not only from high-titer virion preparations but it can also recover specific viral sequence from samples with limited starting material in the background of cellular RNA, and it can be used to identify pathogens from unknown samples. In summary, we describe a rapid, universal standard operating procedure that generates high-quality NGS libraries free of infectious virus and infectious viral RNA. IMPORTANCE This report establishes and validates a standard operating procedure (SOP) for select agents (SAs) and other biosafety level 3 and/or 4 (BSL-3/4) RNA viruses to rapidly generate noninfectious, barcoded cDNA amenable for next-generation sequencing (NGS). This eliminates the burden of testing all processed samples derived from high-consequence pathogens prior to transfer from high-containment laboratories to lower-containment facilities for sequencing. Our established protocol can be scaled up for high-throughput sequencing of hundreds of samples simultaneously, which can dramatically reduce the cost and effort required for NGS library construction. NGS data from this SOP can provide complete genome coverage from viral stocks and can also detect virus-specific reads from limited starting material. Our data suggest that the procedure can be implemented and easily validated by institutional biosafety committees across research laboratories

Blood Viscosity and Hematocrit as Risk Factors for Type 2 Diabetes Mellitus: The Atherosclerosis Risk in Communities (ARIC) Study

Several lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues. To test this hypothesis, the authors analyzed longitudinal data on 12,881 initially nondiabetic adults, aged 45–64 years, who were participants in the Atherosclerosis Risk in Communities (ARIC) Study (1987–1998). Whole blood viscosity was estimated by using a validated formula based on hematocrit and total plasma proteins at baseline. At baseline, estimated blood viscosity was independently associated with several features of the metabolic syndrome. In models adjusted simultaneously for known predictors of diabetes, estimated whole blood viscosity and hematocrit predicted incident type 2 diabetes mellitus in a graded fashion (Ptrend (linear) < 0.001): Compared with their counterparts in the lowest quartiles, adults in the highest quartile of blood viscosity (hazard ratio = 1.68, 95% confidence interval: 1.53, 1.84) and hematocrit (hazard ratio = 1.63, 95% confidence interval: 1.49, 1.79) were over 60% more likely to develop diabetes. Therefore, elevated blood viscosity and hematocrit deserve attention as emerging risk factors for insulin resistance and type 2 diabetes mellitus

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy