Ents, Elves, and Eriador: The Environmental Vision of J.R.R. Tolkien

Many readers drawn into the heroic tales of J. R. R. Tolkien’s imaginary world of Middle-earth have given little conscious thought to the importance of the land itself in his stories or to the vital roles played by the flora and fauna of that land. As a result, The Hobbit, The Lord of the Rings, and The Silmarillion are rarely considered to be works of environmental literature or mentioned together with such authors as John Muir, Rachel Carson, or Aldo Leopold. Tolkien’s works do not express an activist agenda; instead, his environmentalism is expressed in the form of literary fiction. Nonetheless, Tolkien’s vision of nature is as passionate and has had as profound an influence on his readers as that of many contemporary environmental writers. The burgeoning field of agrarianism provides new insights into Tolkien’s view of the natural world and environmental responsibility. In Ents, Elves, and Eriador, Matthew Dickerson and Jonathan Evans show how Tolkien anticipated some of the tenets of modern environmentalism in the imagined world of Middle-earth and the races with which it is peopled. The philosophical foundations that define Tolkien’s environmentalism, as well as the practical outworking of these philosophies, are found throughout his work. Agrarianism is evident in the pastoral lifestyle and sustainable agriculture of the Hobbits, as they harmoniously cultivate the land for food and goods. The Elves practice aesthetic, sustainable horticulture as they shape their forest environs into an elaborate garden. To complete Tolkien’s vision, the Ents of Fangorn Forest represent what Dickerson and Evans label feraculture, which seeks to preserve wilderness in its natural form. Unlike the Entwives, who are described as cultivating food in tame gardens, the Ents risk eventual extinction for their beliefs. These ecological philosophies reflect an aspect of Christian stewardship rooted in Tolkien’s Catholic faith. Dickerson and Evans define it as “stewardship of the kind modeled by Gandalf,” a stewardship that nurtures the land rather than exploiting its life-sustaining capacities to the point of exhaustion. Gandalfian stewardship is at odds with the forces of greed exemplified by Sauron and Saruman, who, with their lust for power, ruin the land they inhabit, serving as a dire warning of what comes to pass when stewardly care is corrupted or ignored. Dickerson and Evans examine Tolkien’s major works as well as his lesser-known stories and essays, comparing his writing to that of the most important naturalists of the past century. A vital contribution to environmental literature and an essential addition to Tolkien scholarship, Ents, Elves, and Eriador offers both Tolkien fans and environmentalists an understanding of Middle-earth that has profound implications for environmental stewardship in the present and the future of our own world. Matthew Dickerson, professor and member of the environmental studies program at Middlebury College, is the author or coauthor of several books, including Following Gandalf: Epic Battles and Moral Victory in The Lord of the Rings and From Homer to Harry Potter: A Handbook on Myth and Fantasy. Jonathan Evans, associate professor of English and director of the medieval studies program at the University of Georgia, is a member of the Environmental Ethics Certificate Program faculty. His essays on J. R. R. Tolkien have been published in J. R. R. Tolkien and His Literary Resonances, Tolkien the Medievalist, and The J. R. R. Tolkien Encyclopedia. Anyone who ever thrilled to Tolkien\u27s fighting trees, or to the earthy Tom Bombadil, or to the novel charm of the Shire will want to read this important and lovely book. --Bill McKibben, Scholar in Residence in Environmental Studies, Middlebury College The writing style is engaging, and the book presents the first fully developed study of Tolkien and the environment at the same time that it offers insights into a range of Tolkien\u27s major and minor works. --Choice A fascinating ecocritical evaluation of the writings of J.R.R. Tolkien. Valuable for both Tolkien fans and those interested in ecocriticism and environmental literature. Especially useful given the popularity of the subject matter. --Northeastern Naturalist This book is a major new contribution to the subject of Tolkien\u27s work in relation to the natural world and environmentalism. . . . The authors have devised an ingenious and useful distinction between agriculture for food (the domain of the Hobbits), horticulture for aesthetic beauty (that of Elves), and feraculture . . . for wilderness preservation (Ents). --Tolkien Studies Dickerson and Evans\u27s ecological thesis has one outstanding merit, which is that Tolkien himself would have recognized and thoroughly approved of what they have to say. --Tom Shippey, from the Afterword Reading a non-fiction book about Tolkien\u27s environmental vision may seem like a way to spoil the sheer fun of reading The Lord of the Rings and his other books. What I found as I read this book was that I wanted to reread every word of Tolkien to see for myself what the authors have given a glimpse of. This book is for everyone who loves the work of J.R..R. Tolkien, and who loves the world around them. --Armchair Interviews “The two authors are unabashed in their effort to use the lure of Tolkien to draw readers to the Green movement. The book constitutes an unorthodox yet largely successful combination of scholarly reading and political manifesto. Dickerson and Evans seek to rouse Tolkien fans to scour their own Shires before it is too late and Mordor triumphs.”--Seven “A well-researched, readable, and relevant study of Tolkien’s ecological principles and concerns. And, as Tom Shippey comments in the afterword, Tolkien, no doubt, would approve.”—Journal of the Fantastic in the Arts This volume is a thorough and welcome explication of Tolkien’s vision of the natural world, and of the ways in which that vision is applicable to our own lives today. --Interdisciplinary Studies in Literature & the Environment Ents, Elves, and Eriador should...be praised for drawing attention to the multifaceted portrayal of the natural world in Tolkien’s work. --Folklore It is an enjoyable and intellectually valuable read for its detailed examination of the landscape cultures of Middle-earth and their liminal overlapping of one another. --Studies in Medieval & Renaissnace Teaching “Does much to show why Tolkein should be recognized as one of those who laid the foundations for and formed the environmental movement as we know it today.”--Mallorn Dickerson and Evans provide a valuable discussion of concepts of stewardship as figured by Gandalf, Treebeard, Sam, Galadriel, and various kings and leaders, and how such examples bridge our inner world of fantasy and what we think of as the outer world of reality. --Studies in Medieval and Renaissance Teaching A fine introduction to Tolkein\u27s environmental achievement. --Flourish Book Reviewhttps://uknowledge.uky.edu/upk_environmental_sciences/1005/thumbnail.jp

Global Health and Disability: A Review and Call to Action for All Rehabilitation Professions

The World Health Organization estimates 15% of the world’s population is living with disability and anticipates an increase as the population ages. Disability is a growing healthcare concern and presents a tremendous burden to all nations. The world will soon need to provide health and rehabilitative care for an enormous number of persons with disability. The purpose of this article is to provide a brief narrative review pertaining to global health and rehabilitation, and to motivate the rehabilitation professions in taking immediate action through further investment in global health initiatives to manage both the current and projected burden of disability. A deficient level of research exists in global health by the rehabilitation professions and there is significant lag in their efforts when compared to other healthcare professions. The World Health Organization’s World Report on Disability (2011), Global Disability Action Plan 2014-2021, and the Global Burden of Disease study are pivotal bodies of work in this field. They serve as both a model and a challenge to affect large-scale global change among the rehabilitation professions. Collectively, an immediate effort is needed to bolster disability and rehabilitation research in developing nations, global rehabilitative outreach programs, and improve access to rehabilitative healthcare to persons with disability in order to fully address the magnitude of this matter

Random Geometric Graphs

We analyse graphs in which each vertex is assigned random coordinates in a geometric space of arbitrary dimensionality and only edges between adjacent points are present. The critical connectivity is found numerically by examining the size of the largest cluster. We derive an analytical expression for the cluster coefficient which shows that the graphs are distinctly different from standard random graphs, even for infinite dimensionality. Insights relevant for graph bi-partitioning are included.Comment: 16 pages, 10 figures. Minor changes. Added reference

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe