A geomorphological investigation of lateral spreading and translational sliding within the Storegga Slide

Lateral spreading and translational sliding are two of the most prevalent types of slope failures within the Storegga Slide. This has been concluded from a thorough analysis of three acoustic data sets from the Storegga Slide complex – high-resolution multibeam bathymetry, TOBI sidescan sonar imagery and 3D seismic data.We have applied quantitative geomorphometric techniques to the bathymetry data set and analysed the texture of sidescan sonar images using Grey-Level Occurrence Matrices (GLCMs). Both techniques have been shown to improve the geological interpretation of submarine environments (e.g. Micallef et al., 2006), and allowed an objective characterisation of the slide surface to be carried out. These results were then combined with the interpretation of the seismic data set and all the geological information currently available for Storegga in the literature. In this way we were able to define the types and boundaries of the different styles of mass movements, and represent them on a geomorphological map. Further insight is provided into the origin and the mode of failure of lateral spreading and translational sliding. Finally we attempt to describe the characteristic morphology of lateral spreading and demonstrate that it is a very common slope failure process in the Norwegian margin.peer-reviewe

Seismic evidence for shallow gas-escape features associated with a retreating gas hydrate zone offshore west Svalbard

Active gas venting occurs on the uppermost continental slope off west Svalbard, close to and upslope from the present-day intersection of the base of methane hydrate stability (BMHS) with the seabed in about 400 m water depth in the inter-fan region between the Kongsfjorden and Isfjorden cross-shelf troughs. From an integrated analysis of high-resolution, two-dimensional, pre-stack migrated seismic reflection profiles and multibeam bathymetric data, we map out a bottom simulating reflector (BSR) in the inter-fan region and analyze the subsurface gas migration and accumulation. Gas seeps mostly occur in the zone from which the BMHS at the seabed has retreated over the recent past (1975–2008) as a consequence of a bottom water temperature rise of 1°C. The overall margin-parallel alignment of the gas seeps is not related to fault-controlled gas migration, as seismic evidence of faults is absent. There is no evidence for a BSR close to the gas flare region in the upper slope but numerous gas pockets exist directly below the predicted BMHS. While the contour following trend of the gas seeps could be a consequence of retreat of the landward limit of the BMHS and gas hydrate dissociation, the scattered distribution of seeps within the probable hydrate dissociation corridor and the occurrence of a cluster of seeps outside the predicted BMHS limit and near the shelf break indicate the role of lithological heterogeneity in focusing gas migration

How typhoons trigger turbidity currents in submarine canyons

Intense turbidity currents occur in the Malaylay Submarine Canyon off the northern coast of Mindoro Island in the Philippines. They start in very shallow waters at the shelf break and reach deeper waters where a gas pipeline is located. The pipeline was displaced by a turbidity current in 2006 and its rock berm damaged by another 10 years later. Here we propose that they are triggered near the mouth of the Malaylay and Baco rivers by direct sediment resuspension in the shallow shelf and transport to the canyon heads by typhoon-induced waves and currents. We show these rivers are unlikely to generate hyperpycnal flows and trigger turbidity currents by themselves. Characteristic signatures of turbidity currents, in the form of bed shear stress obtained by numerical simulations, match observed erosion/deposition and rock berm damage patterns recorded by repeat bathymetric surveys before and after typhoon Nock-ten in December 2016. Our analysis predicts a larger turbidity current triggered by typhoon Durian in 2006; and reveals the reason for the lack of any significant turbidity current associated with typhoon Melor in December 2015. Key factors to assess turbidity current initiation are typhoon proximity, strength, and synchronicity of typhoon induced waves and currents. Using data from a 66-year hindcast we estimate a ~8-year return period of typhoons with capacity to trigger large turbidity currents

Different frequencies and triggers of canyon filling and flushing events in Nazaré Canyon, offshore Portugal

Submarine canyons are one of the most important pathways for sediment transport into ocean basins. For this reason, understanding canyon architecture and sedimentary processes has importance for sediment budgets, carbon cycling, and geohazard assessment. Despite increasing knowledge of turbidity current triggers, the down-canyon variability in turbidity current frequency within most canyon systems is not well constrained. New AMS radiocarbon chronologies from canyon sediment cores illustrate significant variability in turbidity current frequency within Nazaré Canyon through time. Generalised linear models and Cox proportional hazards models indicate a strong influence of global sea level on the frequency of turbidity currents that fill the canyon. Radiocarbon ages from basin sediment cores indicate that larger, canyon-flushing turbidity currents reaching the Iberian Abyssal Plain have a significantly longer average recurrence interval than turbidity currents that fill the canyon. The recurrence intervals of these canyon-flushing turbidity currents also appear to be unaffected by long-term changes in global sea level. Furthermore, canyon-flushing and canyon-filling have very different statistical distributions of recurrence intervals. This indicates that the factors triggering, and thus controlling the frequency of canyon-flushing and canyon-filling events are very different. Canyon-filling appears to be predominantly triggered by sediment instability during sea level lowstand, and by storm and nepheloid transport during the present day highstand. Canyon-flushing exhibits time-independent behaviour. This indicates that a temporally random process, signal shredding, or summation of non-random processes that cannot be discerned from a random signal, are triggering canyon flushing events

Hysteretic Behavior of Proprotein Convertase 1/3 (PC1/3)

The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a lag phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis. This is an unprecedented observation in peptidases, but is frequent in regulatory enzymes with physiological relevance. The lag phase of mPC1/3 is dependent on substrate, calcium concentration and pH. This hysteretic behavior may have implications in the physiological processes in which PC1/3 participates and could be considered an additional control step in the peptide hormone maturation processes as for instance in the transformation of proinsulin to insulin

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN