344 research outputs found
Perfil da fluência: comparação entre falantes do Português Brasileiro e do Português Europeu
The purpose of the study was to compare the speech fluency of Brazilian Portuguese speakers with that of
European Portuguese speakers. The study participants were 76 individuals of any ethnicity or skin color aged
18–29 years. Of the participants, 38 lived in Brazil and 38 in Portugal. Speech samples from all participants
were obtained and analyzed according to the variables of typology and frequency of speech disruptions and
speech rate. Descriptive and inferential statistical analyses were performed to assess the association between
the fluency profile and linguistic variant variables. We found that the speech rate of European Portuguese
speakers was higher than the speech rate of Brazilian Portuguese speakers in words per minute (p=0.004).
The qualitative distribution of the typology of common dysfluencies (p<0.001) also discriminated between the
linguistic variants. While a speech fluency profile of European Portuguese speakers is not available, speech
therapists in Portugal can use the same speech fluency assessment as has been used in Brazil to establish
a diagnosis of stuttering, especially in regard to typical and stuttering dysfluencies, with care taken when
evaluating the speech rate.O objetivo do estudo foi comparar a fluência de fala de falantes do Português Brasileiro com a de falantes do
Português Europeu. Participaram deste estudo 76 indivíduos, sem distinção de raça e cor, com idades entre
18 e 29 anos, sendo 38 residentes no Brasil e 38 em Portugal. Foram obtidas amostras de fala de todos os
participantes e analisadas segundo as variáveis de tipologia e frequência das disfluências e velocidade de fala.
Foi realizada análise estatística descritiva e inferencial para verificar a associação entre as variáveis do perfil
da fluência e da variante linguística. Foi observado que a velocidade de fala dos falantes do Português Europeu
em palavras por minuto (p=0,004) é maior que a dos falantes do Português Brasileiro. A distribuição qualitativa
das tipologias das disfluências comuns (p<0,001) também diferencia as variantes linguísticas. Enquanto não
há um perfil de fluência de fala dos falantes do Português Europeu, para se estabelecer um diagnóstico de
gagueira, os fonoaudiólogos podem utilizar em Portugal a mesma avaliação de fluência de fala utilizada no
Brasil, principalmente no que se refere às disfluências comuns e gagas, tendo cuidado apenas no que se refere
à velocidade de falaFundação de Amparo à Pesquisa do Estado de Minas Gerais (CDS – APQ – 02141-11)info:eu-repo/semantics/publishedVersio
Chemical injuries of the oesophagus: aetiopathological issues in Nigeria
<p>Abstract</p> <p>Background</p> <p>Chemical injuries of the oesophagus occur worldwide. There is paucity of information on aetiopathological profile of chemical injuries of the oesophagus in Nigeria.</p> <p>Aim</p> <p>The aim of the study was to determine the aetiopathological pattern of chemical injuries of the oesophagus in Nigeria.</p> <p>Materials and methods</p> <p>This is a multi-centre hospital based study in Lagos metropolis spanning a period of 10 years.</p> <p>The patients' bio data, substances ingested, sources of corrosives, reasons for ingesting corrosives and patients' mental state were recorded.</p> <p>Results</p> <p>In all, there were 78 patients (61 Males, 17 Females). The offending agents were acids in 55.1% of cases and it was accidental ingestion in 62 patients. The highest incidence of 57.6% was found in the middle 1/3 of the oesophagus.</p> <p>Conclusion</p> <p>Accidental ingestion of acids is the commonest cause of oesophageal injuries in Nigeria. The incidence of severe strictures necessitating oesophageal substitution could be reduced if early management of corrosive oesophagitis improves in Nigeria.</p
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Racial/ethnic differences in use of alcohol, tobacco, and marijuana: Is there a cross-over from adolescence to adulthood?
Black adolescents in the US are less likely to use alcohol, marijuana, and tobacco compared with non-Hispanic Whites, but little is known about the consistency of these racial/ethnic differences in substance use across the lifecourse. Understanding lifecourse patterning of substance use is critical to inform prevention and intervention efforts. Data were drawn from four waves of the National Longitudinal Study of Adolescent Health (Add Health; Wave 1 (mean age = 16): N = 14,101; Wave 4 (mean age = 29): N = 11,365). Outcomes included alcohol (including at-risk drinking, defined as 5+/4+ drinks per drinking occasion or 14+/7+ drinks per week on average for men and women, respectively), cigarette, and marijuana use in 30-day/past-year. Random effects models stratified by gender tested differences-in-differences for wave by race interactions, controlling for age, parents' highest education/income, public assistance, and urbanicity. Results indicate that for alcohol, Whites were more likely to use alcohol and engage in at-risk alcohol use at all waves. By mean age 29.9, for example, White men were 2.1 times as likely to engage in at-risk alcohol use (95% C.I. 1.48–2.94). For cigarettes, Whites were more likely to use cigarettes and smoked more at Waves 1 through 3; there were no differences by Wave 4 for men and a diminished difference for women, and difference-in-difference models indicated evidence of convergence. For marijuana, there were no racial/ethnic differences in use for men at any wave. For women, by Wave 4 there was convergence in marijuana use and a cross-over in frequency of use among users, with Black women using more than White women. In summary, no convergence or cross-over for racial/ethnic differences through early adulthood in alcohol use; convergence for cigarette as well as marijuana use. Lifecourse patterns of health disparities secondary to heavy substance use by race and ethnicity may be, at least in part, due to age-related variation in cigarette and marijuana use
Proppant immobilization facilitated by carbon nanotube mediated microwave treatment of polymer-proppant structures
The application of multi-walled carbon nanotubes (MWCNTs) to facilitate the aggregation of ceramic particles (proppants) by embedding in the coating through localized microwave heating is reported. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM) along with energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) were used to characterize a series of covalently functionalized proppants with carboxylic acids (lysine and fumaric acid). The bi-functional acids allow for a controlled reaction with a coating (resin and polymer). The addition of carbon nanotubes results in the melting of the coating under exposure to microwave irradiation (20 s @ 100 W) joining the particles. The significant reduction in reaction time (compared to the thermal treatments of 2–24 hours) is due to the presence of the MWCNTs. The microwave heating of the MWCNTs can thus be used to create interaction and adhesion between functionalized particles subject to a specific stimulus
Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
Background: The bone marrow is considered to be an important storage of parasites in Leishmania-infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL).
Methodology/Principal Findings: The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi and presenting different clinical statuses and bone marrow parasite densities. The evolution of CVL from asymptomatic to symptomatic status was accompanied by increasing parasite density in the bone marrow. The impact of bone marrow parasite density on cellularity was similar in dogs at different clinical stages, with animals in the high parasite density group. Erythroid and eosinophilic hypoplasia, proliferation of neutrophilic precursor cells and significant increases in lymphocytes and plasma cell numbers were the major alterations observed. Differential bone marrow cell counts revealed increases in the myeloid:erythroid ratio associated to increased numbers of granulopoietic cells in the different clinical groups compared with non-infected dogs.
Conclusions: Analysis of the data obtained indicated that the assessment of bone marrow constitutes an additional and useful tool by which to elaborate a prognosis for CVL
Evaluation of parameters related to libido and semen quality in Zebu bulls naturally infected with Trypanosoma vivax
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart
International audienceCyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cAMP and cGMP, thereby regulating multiple aspects of cardiac function. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families which are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP controlling specific cell functions in response to various neurohormonal stimuli. In myocardium, the PDE3 and PDE4 families are predominant to degrade cAMP and thereby regulate cardiac excitation-contraction coupling. PDE3 inhibitors are positive inotropes and vasodilators in human, but their use is limited to acute heart failure and intermittent claudication. PDE5 is particularly important to degrade cGMP in vascular smooth muscle, and PDE5 inhibitors are used to treat erectile dysfunction and pulmonary hypertension. However, these drugs do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence that these PDEs as well as other PDE families including PDE1, PDE2 and PDE9 may play important roles in cardiac diseases such as hypertrophy and heart failure. After a brief presentation of the cyclic nucleotide pathways in cardiac cells and the major characteristics of the PDE superfamily, this chapter will present their role in cyclic nucleotide compartmentation and the current use of PDE inhibitors in cardiac diseases together with the recent research progresses that could lead to a better exploitation of the therapeutic potential of these enzymes in the future
Model-independent evidence for contributions to decays
The data sample of decays acquired with the
LHCb detector from 7 and 8~TeV collisions, corresponding to an integrated
luminosity of 3 fb, is inspected for the presence of or
contributions with minimal assumptions about
contributions. It is demonstrated at more than 9 standard deviations that
decays cannot be described with
contributions alone, and that contributions play a dominant role in
this incompatibility. These model-independent results support the previously
obtained model-dependent evidence for charmonium-pentaquark
states in the same data sample.Comment: 21 pages, 12 figures (including the supplemental section added at the
end
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
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