Integrated Assessment of Climate Change Impacts and Urban Resilience: From Climate and Hydrological Hazards to Risk Analysis and Measures

This Special Issue brings together recent research findings related to urban resilience, in particular taking into account climate change impacts and hydrological hazards. Taking advantage of the work done in the H2020 RESCCUE project, 12 different papers dealing with several issues related to the resilience of urban areas have been published. Due to the complexity of cities, urban resilience management is one of the key challenges that our societies have to deal with in the near future. In addition, urban resilience is a transversal and multi-sectorial issue, affecting different urban services, several hazards, and all the steps of the risk management cycle. This is precisely why the papers contained in this Special Issue focus on varied subjects, such as impact assessments, urban resilience assessments, adaptation strategies, flood risk and urban services, always focusing on at least two of these topics

Retinal-binding proteins mirror prokaryotic dynamics in multipond solar salterns

Microbial opsin (i.e. retinal-binding protein) dynamics has been studied along a salinity gradient in Santa Pola solar salterns (Alicante, Spain) by using culture-independent approaches and statistical analyses. Five ponds of salinities ranging from 18% to above 40% were sampled nine times along a year. Forty-three opsin-like sequences were retrieved by denaturing gradient gel electrophoresis and clustered into 18 different phylogroups, indicating that their diversity was higher than expected according to previous data. Moreover, the statistical correlation between environmental factors controlling microbial community structure and dynamics of environmental rhodopsin proteins indicated almost identical temporal fluctuations between the opsin-related sequences and their corresponding putative ‘producers’ in nature. Although most sequences were related to others previously detected in hypersaline environments, some pond-specific opsins putatively belonged to previously uncharacterized hosts. Furthermore, we propose that subtle changes in the bacteriorhodopsin ‘retinal proton binding pocket’, which is key in the photocycle function, could be the molecular basis behind a fine ‘photocycle-tuning’ mechanism to avoid inter/intraspecies light-competition in hypersaline environments.This work was supported by project CGL2012-39627-C03-01 of the Spanish Ministry of Economy and Competitiveness, which was also co-funded with FEDER support from the European Union

Valoración desde la perspectiva de los orientadores de Educación Secundaria de la Región de Murcia del portal de Atención a la Diversidad ORIENTAMUR.

The present project aims to show the opinions of Secondary School counselors about the adequacy and usefulness of the resources offered by the Ministry of Education, Culture and Universities of the Region of Murcia, in providing the necessary care and attention to diversity in the Secondary Schools in this region, through the portal of Attention to Diversity: ORIENTAMUR.It is a descriptive study, conducted mainly through a survey of Secondary School counselors who have agreed to collaborate on this project.The results show that there is general level of satisfaction with this website, especially in the web layout, management and how easy it is to use. However, some aspects of the available resources could be improved, in this way this webpage would become and remain a useful and essential reference for all school counselors in this Region.En el presente trabajo se pretende dar a conocer las opiniones que albergan los orientadores de Educación Secundaria sobre la adecuación y utilidad de los recursos ofertados por la Consejería de Educación y Universidades de la Comunidad Autónoma de la Región de Murcia, en materia de atención a la diversidad, a los centros educativos de Educación Secundaria de esta región, desde el portal de Atención a la Diversidad: ORIENTAMUR.Es un estudio principalmente de carácter descriptivo realizado a través de una encuesta a orientadores de secundaria que han querido colaborar en este proyecto.Los resultados nos muestran que existe una satisfacción general en torno a este portal, especialmente en cuanto a su disposición web, manejo y funcionamiento. Sin embargo, algunos aspectos relacionados con los recursos disponibles podrían perfeccionarse haciendo que esta página web sea y continúe siendo un referente para todos los orientadores de esta región

Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by the presence of inflammatory synovitis accompanied by destruction of joint cartilage and bone. Treatment with vasoactive intestinal peptide (VIP) prevents experimental arthritis in animal models by downregulation of both autoimmune and inflammatory components of the disease. The aim of this study was to characterize the protective effect of VIP on bone erosion in collagen-induced arthritis (CIA) in mice. We have studied the expression of different mediators implicated in bone homeostasis, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), receptor activator of nuclear factor-κB (RANK), receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), IL-1, IL-4, IL-6, IL-10, IL-11 and IL-17. Circulating cytokine levels were assessed by ELISA and the local expression of mediators were determined by RT-PCR in mRNA extracts from joints. VIP treatment resulted in decreased levels of circulating IL-6, IL-1β and TNFα, and increased levels of IL-4 and IL-10. CIA-mice treated with VIP presented a decrease in mRNA expression of IL-17, IL-11 in the joints. The ratio of RANKL to OPG decreased drastically in the joint after VIP treatment, which correlated with an increase in levels of circulating OPG in CIA mice treated with VIP. In addition, VIP treatment decreased the expression of mRNA for RANK, iNOS and COX-2. To investigate the molecular mechanisms involved, we tested the activity of NFκB and AP-1, two transcriptional factors closely related to joint erosion, by EMSA in synovial cells from CIA mice. VIP treatment in vivo was able to affect the transcriptional activity of both factors. Our data indicate that VIP is a viable candidate for the development of treatments for RA

The Efficacy of Short-Term Supplemental Nutrition Education on Nutrition Knowledge and Dietary Behaviors of Urban Middle School Children

Background: Children and adolescents are not meeting the dietary guidelines and overweight and obesity related diseases are on the rise among youth in the United States. However, research is inconsistent with regard to the most effective method of educating urban youth. Purpose: To determine the effect of a supplemental nutrition education on the knowledge and behaviors of urban school students. Methods: Six nutrition lessons were provided to students attending the Boys and Girls Club of Metro Atlanta (BGCMA) in Atlanta, GA. A pre- and posttest was administered to assess differences in students’ nutrition knowledge and behaviors. Chi-square analysis compared the number of correct answers for the entire intervention population and after stratification by gender and number of classes missed. The Wilcoxon signed rank test compared the median number of correct answers in pre- vs. posttest responses for all participants and by the number of classes missed. Results: 15 students enrolled in the study. 2 students did not complete the study. A significant but negative change in knowledge was found in 1 of 15 nutrition questions. A significant negative change in the median number of total answers correct on the pre- vs. posttest was also observed (p=0.049). Approximately 60% of the participants reported that they were more likely to make positive, nutrition-related behavior changes after the intervention. Conclusion: We found a negative association between the nutrition education intervention and knowledge gain. This study suggests that nutrition education alone does not have a significant effect on nutrition knowledge of urban youth

On becoming a Collaborative Professional: From Paradigm Shifting to Transformative Learning through Critical Reflection and Dialogue

In Part II, I provide a brief overview of CL and its underlying assumptions. A description of CL training and learning objectives follows in Parts III and IV. In Parts V and VI, I review the paradigm shifting and transformative learning literature. I provide an overview of the study in Part VII, followed by my analysis of the data in Parts VIII and IX. In Part X, I conclude with a discussion of critical reflection and dialogue in a CL training context

Myths, Miscues, and Misconceptions: No-Aid Separationism and the Establishment Clause

In neutrality theory the recipients of vouchers, grants, and purchase-of-service contracts are eligible to participate as providers in government social service programs without regard to their religious character. Indeed, religious beliefs and practices are prohibited bases for screening out those who want to be welfare program providers. Notable examples of congressional social service legislation conforming to the rule of religious neutrality are the ‘charitable choice‘ feature imbedded in the Welfare Reform Act of 1996 and the Community Services Block Grant Act of 1998, as well as the provision allowing issuance of child care vouchers to indigent parents in the Child Care and Development Block Grant Program of 1990. Likewise, federal grants-in-aid programs, for example the Church Arson Prevention Act of 1996, the Telecommunication Act of 1996, and the President\u27s Values-Based Violence Prevention Initiative to reduce youth violence and gang activity, adhere to the principle of religious neutrality

Machine learning for predicting lifespan-extending chemical compounds

Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age‐related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machine learning method random forests to predict whether or not a chemical compound will increase Caenorhabditis elegans’ lifespan, using as features Gene Ontology (GO) terms annotated for proteins targeted by the compounds and chemical descriptors calculated from each compound’s chemical structure. The model with the best predictive accuracy used both biological and chemical features, achieving a prediction accuracy of 80%. The top 20 most important GO terms include those related to mitochondrial processes, to enzymatic and immunological processes, and terms related to metabolic and transport processes. We applied our best model to predict compounds which are more likely to increase C. elegans’ lifespan in the DGIdb database, where the effect of the compounds on an organism’s lifespan is unknown. The top hit compounds can be broadly divided into four groups: compounds affecting mitochondria, compounds for cancer treatment, anti‐inflammatories, and compounds for gonadotropin‐ releasing hormone therapies