Effects of Coach Turnovers on Intensity for Training and Matches in a Norwegian Football Club

The aim of this study was to examine physical variables between four weeks before and eight weeks after two coach turnovers in a second division Norwegian football club for both training and matches. Individual physical data (n=1174 observations) was derived from the players using GPS-data in combination with the subjects employing wearable instruments from Catapult. The means for variables were divided into four study periods (training 2019, matches 2019, training 2021, and matches 2021) to analyze each variable for each of the four periods. The training period in 2019 revealed four variables having a significant negative effect, including total distance covered, sprint running distance, total player load, and total player load 2D, with all parameters representing a small effect size. Only repeat high-intensity efforts had a statistically significant negative effect for matches in 2019, with the effect size being small. For the training period in 2021, sprint running distance had a small positive effect size but a statistically significant positive outcome. On the other hand, decelerations in band 3 had a statistically significant and small negative influence after the switch. High-speed running distance revealed a statistically significant negative effect, with the effect size being moderate for matches in 2021

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

Peer reviewe

Environmental contaminants in freshwater food webs, 2021

Prosjektledere: Morten Jartun, Asle ØkelsrudThis report presents monitoring data from freshwater food webs and abiotic samples from Lake Mjøsa and Femunden within the Milfersk programme. Studies and monitoring of legacy and emerging contaminants have been carried out through this programme for several years, focusing on the pelagic food web. This is the first report in the monitoring program focusing on a benthic food chain (Chironomids, ruffe, roach and perch) in addition to inputs to Lake Mjøsa by analysis of lake sediments, surface waters, stormwater, effluent and sludge from a wastewater treatment plant (WWTP). The analytical programme includes the determination of a total of ̴ 260 single components.Environmental contaminants in freshwater food webs, 2021MiljødirektoratetpublishedVersio

Gate-dependent Pseudospin Mixing in Graphene/Boron Nitride Moire Superlattices

Electrons in graphene are described by relativistic Dirac-Weyl spinors with a two-component pseudospin1-12. The unique pseudospin structure of Dirac electrons leads to emerging phenomena such as the massless Dirac cone2, anomalous quantum Hall effect2, 3, and Klein tunneling4, 5 in graphene. The capability to manipulate electron pseudospin is highly desirable for novel graphene electronics, and it requires precise control to differentiate the two graphene sub-lattices at atomic level. Graphene/boron nitride (graphene/BN) Moire superlattice, where a fast sub-lattice oscillation due to B-N atoms is superimposed on the slow Moire period, provides an attractive approach to engineer the electron pseudospin in graphene13-18. This unusual Moire superlattice leads to a spinor potential with unusual hybridization of electron pseudospins, which can be probed directly through infrared spectroscopy because optical transitions are very sensitive to excited state wavefunctions. Here, we perform micro-infrared spectroscopy on graphene/BN heterostructure and demonstrate that the Moire superlattice potential is dominated by a pseudospin-mixing component analogous to a spatially varying pseudomagnetic field. In addition, we show that the spinor potential depends sensitively on the gate-induced carrier concentration in graphene, indicating a strong renormalization of the spinor potential from electron-electron interactions. Our study offers deeper understanding of graphene pseudospin structure under spinor Moire potential, as well as exciting opportunities to control pseudospin in two-dimensional heterostructures for novel electronic and photonic nanodevices

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (cHi-C) approach to allow an agnostic characterization of these physical interactions on a genome-wide scale. Single-nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci allows us to identify key long-range chromatin interactions in cis and trans involving these loci

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that can modulate TPO-R signaling are highly desirable for both basic research and clinical utility. We developed a series of surrogate protein ligands for TPO-R, in the form of diabodies (DBs), that homodimerize TPO-R on the cell surface in geometries that are dictated by the DB receptor binding epitope, in effect "tuning" downstream signaling responses. These surrogate ligands exhibit diverse pharmacological properties, inducing graded signaling outputs, from full to partial TPO agonism, thus decoupling the dual functions of TPO/TPO-R. Using single-cell RNA sequencing and HSC self-renewal assays we find that partial agonistic diabodies preserved the stem-like properties of cultured HSCs, but also blocked oncogenic colony formation in essential thrombocythemia (ET) through inverse agonism. Our data suggest that dampening downstream TPO signaling is a powerful approach not only for HSC preservation in culture, but also for inhibiting oncogenic signaling through the TPO-R

UAS Literary & Arts Journal 2017

The 2017 edition of Tidal Echoes presents an annual showcase of writers and artists who share one thing in common: a life surrounded by the rainforests and waterways of Southeast Alaska.Remembering Dr. Teri Rofkar -- Editor's Note -- Acknowledgements -- Esther -- Untitled -- How to Love Your Body -- no mercy -- Winter Sangria -- Morning Poppies -- How Mom Hooked Dad -- Your Ripples and My Ripples -- Making the Kids Clean Up -- Conquering the Wild Skunk Cabbage -- What’s Queer Got To Do With It? -- Mile Ten for Mary Oliver -- Cache -- This Place (The Tongass) -- No More Shoulds -- Nagoon and Caterpillar -- How to age gracefully -- Yellow Legs --Feeding Her Inner Goose at the Boy Scout Camp -- On Guard -- We Are Family -- Grandma Zona -- Mere Minerals -- Life Goes On -- Evergreen Cemetery -- Untitled -- What is the heart but a -- Why I Feel Nostalgic for Hurricanes -- Stardust in Seattle: Motes of Human Activity -- Coyote -- Untitled -- An Affair with Andromeda -- Untitled -- How Night Comes in Winter -- Light Up the Sky -- Courage -- See You In Spring -- Smoking Luckies -- Agape -- Old Days in Douglas, Alaska -- Pink House -- Tableside Conversation/Overheard in a Restaurant -- The Kumquat Cure for Hypomanics -- Pleistocene -- A Taste of Punjab -- Untitled -- Feeding My Family -- Corn -- When Nothing Else Works -- Feedback Loop -- Dancing With Dante -- 451 -- Circle Room -- An Interview with Rico Lanaat’ World -- Check Out Time -- Cabbage Canner Shoes -- Chanterelle (detail) -- Visiting Hour -- That’s Alright It’s a Warm Rain -- Welcome to the Jungle: Jonestown!! -- Green Unfurling -- Four O’ Clock in the Morning -- Pathway -- An Interview with Lynn Schooler -- Glacier Study 2 and Glacier Study 7 -- Storm -- Loitering -- What I Call Home -- Beyond Heritage -- Naming the Sun -- Auke Lake Mirror -- To Be a Superhero -- Keepsies -- Alchemy -- Gleeful Refuge -- Shaatk’ásk’u -- A Smooth Snowfall -- Back Country -- A Good Morning -- Magical Sunset -- A Simple Gesture -- Columbine -- Notorious -- There Are More Dead Veteran Poets Than Live Ones -- Lupine Dreaming -- Untitled -- Peaches -- Squirrel Sampling Sapsucker Holes -- To Alight -- Mattress -- Curveball -- Crossing Chance -- Gyibaw Ukulele -- Ipswiche -- Hummingbird in Formline with Daisy -- The Pigeons of Valparaiso, Chile -- Hold On Come Along -- Man In A Malt Shop -- Untitled -- Downpours -- Untitled -- The Truth -- Swimming in Place -- Matriline -- Writer and Artist Biographies -- Motherhoo

QCD evolution of the gluon density in a nucleus

The Glauber approach to the gluon density in a nucleus, suggested by A. Mueller, is developed and studied in detail. Using the GRV parameterization for the gluon density in a nucleon, the value as well as energy and $Q^2$ dependence of the gluon density in a nucleus is calculated. It is shown that the shadowing corrections are under theoretical control and are essential in the region of small $x$. They change crucially the value of the gluon density as well as the value of the anomalous dimension of the nuclear structure function, unlike of the nucleon one. The systematic theoretical way to treat the correction to the Glauber approach is developed and a new evolution equation is derived and solved. It is shown that the solution of the new evolution equation can provide a selfconsistent matching of ``soft" high energy phenomenology with ``hard" QCD physics.Comment: 63 pages,psfig.sty,25 pictures in eps.file

Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML

<p>Abstract</p> <p>Background</p> <p>WASP family proteins stimulate the actin-nucleating activity of the ARP2/3 complex. They include members of the well-known WASP and WAVE/Scar proteins, and the recently identified WASH and WHAMM proteins. WASP family proteins contain family specific N-terminal domains followed by proline-rich regions and C-terminal VCA domains that harbour the ARP2/3-activating regions.</p> <p>Results</p> <p>To reveal the evolution of ARP2/3 activation by WASP family proteins we performed a "holistic" analysis by manually assembling and annotating all homologs in most of the eukaryotic genomes available. We have identified two new families: the WAML proteins (WASP and MIM like), which combine the membrane-deforming and actin bundling functions of the IMD domains with the ARP2/3-activating VCA regions, and the WAWH protein (WASP without WH1 domain) that have been identified in amoebae, Apusozoa, and the anole lizard. Surprisingly, with one exception we did not identify any alternative splice forms for WASP family proteins, which is in strong contrast to other actin-binding proteins like Ena/VASP, MIM, or NHS proteins that share domains with WASP proteins.</p> <p>Conclusions</p> <p>Our analysis showed that the last common ancestor of the eukaryotes must have contained a homolog of WASP, WAVE, and WASH. Specific families have subsequently been lost in many taxa like the WASPs in plants, algae, Stramenopiles, and Euglenozoa, and the WASH proteins in fungi. The WHAMM proteins are metazoa specific and have most probably been invented by the Eumetazoa. The diversity of WASP family proteins has strongly been increased by many species- and taxon-specific gene duplications and multimerisations. All data is freely accessible via <url>http://www.cymobase.org</url>.</p