202 research outputs found

    A Measure of Dysfunctional Eating-Related Cognitions in People with Psychotic Disorders

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    Obesity and binge eating disorder are common in individuals with psychotic disorders. Eating and weight-related cognitions are known to influence eating behaviors. The study was designed to assess the psychometric properties of the Mizes Anorectic Cognitions Questionnaire (MAC-R) in patients with psychotic disorders. Binge eating disorder (BED), body mass index (BMI), the MAC-R and the three factor eating questionnaire (TFEQ) were assessed in 125 patients with a diagnosis of schizophrenia or schizoaffective disorder. Whereas the MAC-R has not acceptable psychometric properties, a brief version of the MAC-R (BMAC) has good psychometrical properties and is correlated with TFEQ and BMI. Binge eating disorder is also correlated to the Rigid Weight Regulation and Fear of Weight Gain subscale. The BMAC is a useful brief measure to assess eating and weight related cognitions in people with psychotic disorder

    Autoroute A16 (Pas-de-Calais)

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    Date de l'opération : 1991 (PR) Inventeur(s) : Dien E. ; Mahin E. ; Martial Emmanuelle ; Cabuy Yves ; Ducrocq Thierry L’autoroute A 16, reliant Paris à Boulogne-sur-Mer, via Amiens, incise le département du Pas-de-Calais sur environ 46 km de long, selon un axe nord-sud entre Boulogne et l’Authie. À l’instar des grands travaux, les interventions archéologiques furent planifiées par une convention avec l’aménageur (SANEF). Pour la section Amiens-Boulogne, les modalités d’exécution des prospecti..

    Changis-sur-Marne – Les Pétreaux

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    La 6e phase de fouille (1998) du site situé dans l’emprise de la Carrière Morillon-Corvol de Changis-sur-Marne (Seine-et-Marne) s’est déroulée sur environ 2,6 ha, et, comme à l’accoutumée, en anticipation des travaux d’extraction de la carrière dont le front de taille se déplace perpendiculairement à la Marne, du nord vers le sud-est (fig. 1). On rappellera que l’occupation humaine de Changis-sur-Marne « les Pétreaux » appartient à la longue durée puisque 15 ha de la nappe alluviale déjà foui..

    Genome sequence of Xanthomonas fuscans subsp. fuscans strain 4834-R reveals that flagellar motility is not a general feature of xanthomonads

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    Abstract\ud \ud \ud \ud Background\ud Xanthomonads are plant-associated bacteria responsible for diseases on economically important crops. Xanthomonas fuscans subsp. fuscans (Xff) is one of the causal agents of common bacterial blight of bean. In this study, the complete genome sequence of strain Xff 4834-R was determined and compared to other Xanthomonas genome sequences.\ud \ud \ud \ud Results\ud Comparative genomics analyses revealed core characteristics shared between Xff 4834-R and other xanthomonads including chemotaxis elements, two-component systems, TonB-dependent transporters, secretion systems (from T1SS to T6SS) and multiple effectors. For instance a repertoire of 29 Type 3 Effectors (T3Es) with two Transcription Activator-Like Effectors was predicted. Mobile elements were associated with major modifications in the genome structure and gene content in comparison to other Xanthomonas genomes. Notably, a deletion of 33 kbp affects flagellum biosynthesis in Xff 4834-R. The presence of a complete flagellar cluster was assessed in a collection of more than 300 strains representing different species and pathovars of Xanthomonas. Five percent of the tested strains presented a deletion in the flagellar cluster and were non-motile. Moreover, half of the Xff strains isolated from the same epidemic than 4834-R was non-motile and this ratio was conserved in the strains colonizing the next bean seed generations.\ud \ud \ud \ud Conclusions\ud This work describes the first genome of a Xanthomonas strain pathogenic on bean and reports the existence of non-motile xanthomonads belonging to different species and pathovars. Isolation of such Xff variants from a natural epidemic may suggest that flagellar motility is not a key function for in planta fitness.AI is funded by a PhD grant from INRA-SPE and region Pays de la Loire, France. EG was funded by a PhD grant from the French Ministry of National Education and Research and French Guyana. SC, EG, MA, EL and LDN are funded by the LABEX TULIP (ANR-10-LABX-41), LSG is funded by ANR-2010-GENM-013 Xanthomix

    Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

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    RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

    Évolution des systèmes techniques à la fin du Néolithique et au début de l’âge du Bronze: Une approche techno-culturelle de l’industrie lithique dans le nord de la France

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    International audienceCette thèse interroge la place, le rôle et l'évolution des industries lithiques taillées du nord de la France, entre le III e millénaire (Néolithique final) et la première moitié du II e millénaire avant notre ère (Âge du Bronze ancien à moyen). Elle est fondée sur les travaux de recherche menés depuis vingt-cinq années dans le cadre de mon activité professionnelle et scientifique (Afan/Inrap). L'ensemble des données mobilisées est analysé et replacé dans le contexte technique et social des différents groupes culturels qui se sont succédés dans le temps, sur une même aire géographique. Cette période, caractérisée par l'essor de la métallurgie, est particulièrement intéressante car cette fin de « l'âge de pierre » est une phase de mutation qui marque un temps fort dans l'évolution des sociétés d'Europe occidentale. Au-delà de la caractérisation techno-fonctionnelle des industries en silex, le propos est aussi de tenter de comprendre par une approche croisée les conditions de changement, de continuité et de rupture observés dans ce sous-système technique. Cadre spatio-temporel, corpus et méthodologie Le cadre géographique considéré correspond aux trois départements les plus septentrionaux de l'Hexagone (Hauts-de-France) : le Nord, le Pas-de-Calais et la Somme. Les connaissances y ont été totalement renouvelées par l'archéologie préventive qui a révélé de nombreux habitats structurés du Néolithique final et nombre de sites funéraires du Bronze ancien à moyen. Le champ chronologique de l'étude couvre treize siècles entre 2900 et 1600 cal BC. Le groupe culturel du Deûle-Escaut (2900-2200 cal BC), entité régionale du Néolithique final, s'inscrit dans le processus de complexification sociale du Chalcolithique et voit l'apparition du Campaniforme au cours de l'étape moyenne de son développement
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