Cost-Effective eHealth System Based on a Multi-Sensor System-on-Chip Platform and Data Fusion in Cloud for Sport Activity Monitoring

eHealth systems provide medical support to users and contribute to the development of mobile and quality health care. They also provide results on the prevention and follow-up of diseases by monitoring health-status indicators and methodical data gathering in patients. Telematic management of health services by means of the Internet of Things provides immediate support and it is cheaper than conventional physical presence methods. Currently, wireless communications and sensor networks allow a person or group to be monitored remotely. The aim of this paper is to develop and assess a system for monitoring physiological parameters to be applied in different scenarios, such as health or sports. This system is based on a distributed architecture, where physiological data of a person are collected by several sensors; next, a Raspberry Pi joins the information and makes a standardization process; then, these data are sent to the Cloud to be processed. Our Cloud system stores the received data and makes a data fusion process in order to indicate the athlete's fatigue status at every moment. This system has been tested in collaboration with a small group of voluntary tri-athletes. A network simulation has been performed to plan a monitoring network for a bigger group of athletes. Finally, we have found that this system is useful for medium-term monitoring of the sports activitie

The impact of COVID–19 pandemic and restriction measures on sexual behaviour, couple relationship and psychological well-being in Latvia

Purpose: Since the beginning of COVID-19 restrictions, almost all domains of people’s lives have been affected, including couple and family relationships and sexual life. There are various factors that are likely to influence the partner availability, intimacy, emotional well-being, contraception access and interpersonal tension. Materials and methods: Behavioural cross-sectional online survey (I-SHARE) combined with structured interviews with the aim to determine the impact of COVID-19 social restriction measures on sexual health and psychological well-being and behaviour was conducted. Results and conclusions: Results showed increase of tension and its negative impact on frequency and satisfaction with sex life. Frequency of sexual intercourse decreased more for people who did not live with their partner. Increase of alcohol consumption and loss of job decreased satisfaction with sex life. Controversial data about contraception availability and intimate partner violence were obtained showing no impact in survey, but revealing contraception access restrictions and intimate partner violence increase during qualitative research interviews.publishersversionPeer reviewe

Socioeconomic Factors and Changes in Food Choice and Availability During COVID-19 Restrictions in Latvia

Publisher Copyright: © 2022 Ieva Pitkevica et al., published by Sciendo.The COVID-19 pandemic changed the life of many. The study aimed to identify fragile groups ofthe population regarding nutrition during the COVID-19 restriction period. An online survey wasconducted from 26 July to 3 September 2020. A total of 1173 answers were received from per-sons aged 18–68 years living in Latvia. The results showed that food availability mainly was notlimited, although for 15.3% responders restrictions caused increased worries about not havingenough food, and 12.2% noted a decrease in the ability to eat preferred food. Responders aged40–54 noted that they ate less, and that their food stocks were scarce in comparison with otherage groups. Almost 50% of responders increased food consumption. One-fifth of responders in-creased consumption of foods of low nutritional value, especially among 25–39 year old personsand in households where the economic situation became worse. Fragile groups regarding nutri-tion in times of COVID-19 restrictions included households whose economic situation becameworse during the COVID-19 restrictions, younger people who increased food consumption to-gether with consumption of food of low nutritional value, and persons aged 40–54 years. The datafrom the study serve as an indicator that more detailed research is needed to determine whethercrises such as the COVID-19 pandemic are changing dietary habits and food availability in thepopulation.publishersversionPeer reviewe

Relationship between pregnant women and their partners during COVID-19 and the role of accompanying persons during childbirth

Objective: Although the World Health Organization (WHO) recommends the presence of a support person, several hospitals in Latvia have restricted the presence of supporting persons due to COVID-19. This study was conducted to understand the importance of partnership and the role of the accompanying person in childbirth in the context of COVID-19 in Latvia.Methods: A mixed method study with sequential explanatory design was conducted from 26 July to 30 October 2020. The quantitative study consisted of a behavioral cross-sectional online survey with convenience sampling. The survey items, methods, and implementation were performed as part of the I-SHARE study carried out in 33 countries, with standardized survey instruments that were focused on sexual and reproductive health issues. In Latvia it was supported by the National Research Program to lessen the effects of COVID-19. Our study analyses only one part of all data. To answer the research question besides quantitative data the qualitative study that consisted of 7 semi-structured in-depth interviews and 11 focus group discussions was integrated.Results: 1,173 people of Latvia have participated in the I-SHARE online survey. The answers of 662 women of reproductive age and 70 pregnant women have been analyzed. Pregnant women had less tension with their partners and received higher partner emotional support before the COVID-19 pandemic than other women of reproductive age, and pregnant women were less frustrated during COVID-19 than non-pregnant women of reproductive age (p < .05). More than half (61.4%) of the pregnant women felt anxiety and depression due to COVID-19 restrictions. The qualitative part of the study revealed that having a partner during childbirth was an important aspect when choosing a facility to give birth in, as the lack of an accompanying person caused anxiety and additional stress.Conclusions: COVID-19 has increased anxiety and depression among pregnant women. Birth companions should not be considered third parties, and establishing a delivery unit visitor policy is necessary to balance the benefits and risks in an evidence-based and compassionate manner.publishersversionPeer reviewe

Actions to strengthen the contribution of small farms and small food businesses to food security in Europe

This study stems from a participatory foresight exercise conducted in nine Mediterranean, Baltic, Nordic and Eastern European regions, aiming to strengthen the role of small farms and small food businesses in ensuring food security. A wide range of stakeholders participated by attending workshops. They represented farmers’ organisations, food businesses, consumers’ organisations, NGOs, researchers, extension services, professional groups, and administration and public bodies. The actions proposed by participants are scanned and categorised around six broad objectives, stakeholders’ priorities and their underlying beliefs and preconceptions are discussed around the current debates of the literature, and the drivers that influence the feasibility of the proposed actions are discussed. Furthermore, the alignment of stakeholders’ -driven objectives with the European Strategies on food, agriculture, and rural areas is examined, with a focus on: (i) the EU Farm to Fork Strategy, (ii) the Rural Action Plan contained in the Long-Term Vision of Rural Areas developed by the EU Commission, and (iii) the Common Agricultural Policy in force since January 2023

Molecular Investigation of Tularemia Outbreaks, Spain, 1997–2008

Tularemia outbreaks occurred in northwestern Spain in 1997–1998 and 2007–2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002–00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection.project PEP 2009/1422 of the Junta de Castilla y León (Spain)

O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction

Background: The DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction (MSP) the most commonly used for promoter methylation study, while immunohistochemistry (IHC) has become the most frequently used for the detection of MGMT protein expression. Agreement on the best and most reliable technique for evaluating MGMT status remains unsettled. The aim of this study was to perform a systematic review and meta-analysis of the correlation between IHC and MSP. Methods A computer-aided search of MEDLINE (1950-October 2009), EBSCO (1966-October 2009) and EMBASE (1974-October 2009) was performed for relevant publications. Studies meeting inclusion criteria were those comparing MGMT protein expression by IHC with MGMT promoter methylation by MSP in the same cohort of patients. Methodological quality was assessed by using the QUADAS and STARD instruments. Previously published guidelines were followed for meta-analysis performance. Results Of 254 studies identified as eligible for full-text review, 52 (20.5%) met the inclusion criteria. The review showed that results of MGMT protein expression by IHC are not in close agreement with those obtained with MSP. Moreover, type of tumour (primary brain tumour vs others) was an independent covariate of accuracy estimates in the meta-regression analysis beyond the cut-off value. Conclusions Protein expression assessed by IHC alone fails to reflect the promoter methylation status of MGMT. Thus, in attempts at clinical diagnosis the two methods seem to select different groups of patients and should not be used interchangeably

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts

We thank the Peggy and Charles Stephenson Cancer Center at the University of Oklahoma, Oklahoma City, OK, for funding, who received an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103639 for the use of the Histology and Immunohistochemistry Core for providing immunohistochemistry and photographic services. This work was also supported by Oklahoma State University, Center of Veterinary Health Science (Support Grant AE-1-50060 to P.C.S.), the Musella Foundation (R.A.T.), and the Childhood Brain Tumor Foundation (R.A.T.).Pediatric glioblastomas (pGBM), although rare, are one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. Here, we describe the use of conventional and advanced in vivo magnetic resonance imaging (MRI) techniques to assess a novel orthotopic xenograft pGBM mouse (IC-3752GBM patient-derived culture) model, and to monitor the effects of the anti-cancer agent OKN-007 as an inhibitor of pGBM tumor growth. Immunohistochemistry support data is also presented for cell proliferation and tumor growth signaling. OKN-007 was found to significantly decrease tumor volumes (p<0.05) and increase animal survival (p<0.05) in all OKN-007-treated mice compared to untreated animals. In a responsive cohort of treated animals, OKN-007 was able to significantly decrease tumor volumes (p<0.0001), increase survival (p<0.001), and increase diffusion (p<0.01) and perfusion rates (p<0.05). OKN-007 also significantly reduced lipid tumor metabolism in responsive animals (Lip1.3 and Lip0.9)-to-creatine ratio (p<0.05), as well as significantly decrease tumor cell proliferation (p<0.05) and microvessel density (p<0.05). Furthermore, in relationship to the PDGFRα pathway, OKN-007 was able to significantly decrease SULF2 (p<0.05) and PDGFR-α (platelet-derived growth factor receptor-α) (p<0.05) immunoexpression, and significantly increase decorin expression (p<0.05) in responsive mice. This study indicates that OKN-007 may be an effective anti-cancer agent for some patients with pGBMs by inhibiting cell proliferation and angiogenesis, possibly via the PDGFRα pathway, and could be considered as an additional therapy for pediatric brain tumor patients.Yeshttp://www.plosone.org/static/editorial#pee