Questions and answers regarding character education in Latin-American countries (Mexico, Colombia and Argentina). An exploratory Delphi study.

Abstract: In the project Researching and Promoting Character Education in Latin Ameri-can Secondary Schools funded by the Templeton World Charity Foundation,we address how Character Education is perceived in three Latin-American countries (Argentina, Colom-bia and Mexico). To carry out this research we produced a pilot study based on the Delphi method, in order to find the most relevant issues regarding the subject of Character Educa-tion in those Countries. This methodology offers us a rigorous and easily managed means of obtaining in-depth knowledge of the current problems of Character Education. For the Delphi study, we relied on the participation of various experts from the academic, school and administrative areas. During the process, we carried out three sessions with the experts in order to reach the highest possible consensus. Thus, we used two rounds of closed and open questions to obtain a good perspective of the situation. The result confirmed that Character Education is not a common term in the world of education in these countries. Moreover, this type of education is affected by the influence and relationship between the actors and the explicit-hidden curricula.En el proyecto Researching and Promoting Character Education in Latin American Secondary Schools, financiado por la Templeton World Charity Foundation, nos aproximamos a la percepción que de la Educación del Carácter se tiene en Argentina, Colombia y México. La Educación del Carácter nos interesó dado que integra algunas de las propuestas para promover la ciudadanía. Para el inicio de esta investigación elaboramos un estudio piloto basándonos en la metodología Delphi, con el objetivo de discernir cuáles son los temas más candentes alrededor de la Educación del Carácter en estos países. Esta metodología -rigurosa y de fácil manejo- permite la obtención de un conocimiento en profundidad sobre la problemática de la Educación del Carácter. Contamos con la participación de diferentes expertos del ámbito académico, escolar y administrativo. Durante el proceso realizamos tres interacciones con los expertos para alcanzar un mayor consenso en sus opiniones. Para ello aplicamos dos rondas de preguntas cerradas y abiertas con las que obtener una mayor riqueza y convergencia en los datos obtenidos. Como resultado, constatamos que la Educación del Carácter no es un término habitual en el ámbito educativo de estos países. Además, en este tipo de educación incide la influencia y relación entre los agentes y el currículum explícito-oculto en la escuela

Paleogeografía sísmica de zonas costeras en la Península Ibérica: su impacto en el análisis de terremotos antiguos e históricos en España

This paper presents three examples of ancient earthquakes occurring in coastal areas of the S and SE of the Iberian Peninsula (218 BC, AD 40-60 and AD 1048) with the aim of illustrating the use of geological and archaeological data in their macroseismic characterization. Historical information for ancient earthquakes that occurred in Spain prior to the 10th century is scarce or non-existent. This paper shows that the current state of knowledge on palaeoseismology and archaeoseismology on these ancient events clearly exceeds the existing historical information allowing the increase of macroseismic information points by using the ESI-07 scale (Environmental Seismic Intensity). Consequently, the geologic analyses of ancient earthquakes contribute to their understanding and parametric evaluations, and improve further advances in seismic hazard assessments. The most significant issue outlined in the present paper is the analysis of the ancient palaeogeography of the affected areas. The studied examples analysed were located in open estuarine areas that have been filled by fluvial sediments or anthropogenic fills over time. The effects of the 218 BC earthquake-tsunami event in the Gulf of Cadiz are analysed in estuarine areas, and especially in the ancient Roman Lagus Ligustinus (Guadalquivir Depression marshes); the effects of the earthquake in AD 40-60 is analysed in the old Roman city of Baelo Claudia located in the Bolonia Bay (Strait of Gibraltar); and the effects of the earthquake of AD 1048on the ancient Sinus Ilicitanus (Bajo Segura Depression) during Muslim times. Descriptions from Roman and Arabic geographers are cross-checked with existing palaeogeographic models based on geological data. This type of analysis results in ancient macroseismic scenarios for the interpretation of theoretical distributions of intensities and environmental effects supporting the concept of “seismic palaeogeography” proposed in this paperEl presente trabajo recoge tres ejemplos de terremotos antiguos (218 AC, 40-60 AD y 1048 AD) ocurridos en zonas litorales del S y SO de la Península Ibérica con la intención de ilustrar el uso de datos geológicos y ar¬queológicos en la caracterización macrosísmica de los mismos. En la mayor parte de los sísmos ocurridos con anterioridad al siglo X d.C. la información documental histórica que se posee es muy escasa o inexistente. El presente trabajo muestra que el actual estado de conocimiento en paleosismología y arqueosismologia sobre este tipo de terremotos sobrepasa con creces la información documental histórica, permitiendo la multiplica¬ción de los puntos de información macrosísmica mediante el uso de la escala ESI-07 (Environmental Seismic Intensity). Consecuentemente, el análisis geológico de los terremotos antiguos mejora su conocimiento y análisis paramétrico, permitiendo avanzar la evaluación de la peligrosidad sísmica de las zonas afectadas. El aspecto que se pone de especial relieve en este trabajo es el análisis de la paleogeografía existente en la antigüedad, ya que todas las zonas (afectadas) analizadas en este trabajo corresponden a zonas estuarinas abiertas que se han ido rellenado por aportes fluviales o de forma artificial con el tiempo. Se analizan los efectos del terremoto de 218 AC en las zonas estuarinas del Golfo de Cádiz y muy especialmente en el antiguo Lacus Ligustinus (marismas del Guadalquivir) durante época romana; los efectos del terremoto de 40-60 AD en la antigua Bahía de Baelo Claudia (Estrecho de Gibraltar); y los efectos del terremoto de 1048 AD en el antiguo Sinus ilicitanus (Depresión del Bajo Segura) durante época musulmana. Se han cotejado descripciones de geógrafos romanos y árabes con modelos basados en datos geológicos. Este tipo de análisis ha permitido generar antiguos escenarios macrosísmicos basados en la paleogeografía y reinterpretar las distribuciones teóricas de intensidades y los efectos ambientales de los terremotos estudiados que es a lo que se refiere el concepto de “paleogeografía sísmica” propuesto en este trabajoThis work has been funded by the Spanish-FEDER research projects CGL2012-37281 C02.01 (QTECTBETICA-USAL), CGL2012-33430 (CSIC) and CGL2013-42847-R (UNED

SEOM clinical guidelines in hereditary breast and ovarian cancer (2019)

Mutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian cancer families by 50%. Multigene cancer panels provide new challenges related to increased frequency of variants of uncertain significance, new gene-specific cancer risk assessments, and clinical recommendations for carriers of mutations of new genes. Although clinical criteria for genetic testing continue to be largely based on personal and family history with around a 10% detection rate, broader criteria are being applied with a lower threshold for detecting mutations when there are therapeutic implications for patients with breast or ovarian cancer. In this regard, new models of genetic counselling and testing are being implemented following the registration of PARP inhibitors for individuals who display BRCA mutations. Massive sequencing techniques in tumor tissue is also driving a paradigm shift in genetic testing and potential identification of germline mutations. In this paper, we review the current clinical criteria for genetic testing, as well as surveillance recommendations in healthy carriers, risk reduction surgical options, and new treatment strategies in breast cancer gene-mutated carriers

NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma

CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma cells. CARs can be designed through the use of receptors, such as NKG2D, which recognizes a wide range of ligands to provide broad target specificity. Here, we test this approach by analyzing the antitumor activity of activated and expanded NK cells (NKAE) and CD45RA− T cells from MM patients that were engineered to express an NKG2D-based CAR. NKAE cells were cultured with irradiated Clone9.mbIL21 cells. Then, cells were transduced with an NKG2D-4-1BB-CD3z-CAR. CAR-NKAE cells exhibited no evidence of genetic abnormalities. Although memory T cells were more stably transduced, CAR-NKAE cells exhibited greater in vitro cytotoxicity against MM cells, while showing minimal activity against healthy cells. In vivo, CAR-NKAE cells mediated highly efficient abrogation of MM growth, and 25% of the treated mice remained disease free. Overall, these results demonstrate that it is feasible to modify autologous NKAE cells from MM patients to safely express a NKG2D-CAR. Additionally, autologous CAR-NKAE cells display enhanced antimyeloma activity demonstrating that they could be an effective strategy against MM supporting the development of NKG2D-CAR-NK-cell therapy for MM.This study was supported by a grant from the Spanish Society for Hematology and Hemotherapy to Alejandra Leivas, the CRIS Foundation to Beat Cancer and the Instituto de Salud Carlos III (PI18/01519)

Introducción al patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera

160 p.Esta publicación se ha realizado con el objetivo de describir el origen y formación de una buena parte del patrimonio geológico de interés turístico de la Red Española de Reservas de la Biosfera para que éste sea conocido y pueda ser utilizado como motor de desarrollo económico local. La necesidad de dar a conocer este sorprendente patrimonio natural de la Red español de Reservas de la Biosfera fue constatada por su Consejo de Gestores que encargó el trabajo a su Consejo Científico. La publicación tiene la vocación de ser accesible para todos los públicos. Sin embargo, parte de un trabajo bibliográfico profundo abordado con una rigurosa metodología científica. Es además el fruto de una continua colaboración de los editores con las personas gestoras de las Reservas de la Biosfera españolas, así como con varios miembros de su Consejo Científico asesor.Instituto Geológico y Minero de España, Españ

Augmented Reality in a Hiking Tour of the Miocene Geoheritage of the Central Algarve Cliffs (Portugal)

Acceso electrónico sólo desde el IGMEEight sites with geological (including palaeontological and geomorphological) interest (geosites) representative of the Lower and Middle Miocene carbonate deposits near Albufeira in central Algarve (southern Portugal) have been selected based on our extended working experience. The sites can be visited by hiking in a 1-day field trip. A virtual 3D tour of the georeferenced sites was produced using augmented reality technique and geoinformatic tools which integrate thematic digital layers such as geological maps and orthophotos. Every stop in the tour includes descriptive and graphic elements that can be viewed in free virtual globes (e.g. Google Earth) combined with diagrams, photographs and information sheets that quantitatively assess the cultural-touristic, educational and scientific value of the geosites. A virtual flight itinerary compatible with video formats in the new free technologies (smartphones, tablets and iPads) is also presented.Departamento de Geología, Universidad de Salamanca, EspañaGeoBioTec, Departamento de Ciências da Terra, Universidade Nova de Lisboa, PortugalDepartamento de Estratigrafía, Universidad Complutense de Madrid, EspañaMuseo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Científicas, EspañaLaboratório Nacional de Geologia e Energia, Portuga

Aportaciones a la flora de Galicia, VIII

Se citan 37 plantas de variado interés para la flora gallega. Se incluyen 8 novedades de carácter regional (Pteris incompleta Cav., Potentilla recta L., Myriophyllum spicatum L., Solanum sisymbrifolium Lam., Knautia integrifolia (L.) Bertol., Senecio inaequidens DC. Melica arrecta G. Kunze y Stipa clausa Trab.), 17 novedades provinciales (Vandenboschia speciosa (Willd.) G. Kunkel, Ranunculus bupleuroides Brot., Silene niceensis All., Armeria transmontana (Samp.) Lawr., Alcea rosea L., Crambe hispanica L., Rorippa microphylla (Rchb.) Hyl., Saxifraga lepismigena Planellas, Cytisus commutatus subsp. merinoi Laínz & M. Laínz, Galega officinalis L., Melilotus spicatus (Sm.) Breistr., Calystegia silvatica (Kit.) Griseb., Orobanche hederae Baucher ex Duby, Aegilops triuncialis L., Eleusine tristachya (Lam.) Lam., Gagea nevadensis Boiss. y Paradisea lusitanica (Cout.) Samp.) y 12 de interés corológico pero que no suponen novedad gallega o provincial (Lycopodiella inundata (L.) Holub., Corydalis cava (L.) Schweigg. & Körte, Quercus cerris L., Genista sanabrensis Valdés Berm., Castrov. & Casaseca, Oenothera speciosa Nutt., Ligustrum vulgare L., Stachys sylvatica L., Antirrhinum meonanthum Hoffmanns. & Link, Cynara cardunculus L., Nardus stricta L., Gagea pratensis (Pers.) Dumort. y Narcissus rupicola Dufour). Como en anteriores aportaciones, cada taxon va acompañado de diversos comentarios que indican su relevancia corológica o ecológica

Artificial intelligence within the interplay between natural and artificial computation:Advances in data science, trends and applications

Artificial intelligence and all its supporting tools, e.g. machine and deep learning in computational intelligence-based systems, are rebuilding our society (economy, education, life-style, etc.) and promising a new era for the social welfare state. In this paper we summarize recent advances in data science and artificial intelligence within the interplay between natural and artificial computation. A review of recent works published in the latter field and the state the art are summarized in a comprehensive and self-contained way to provide a baseline framework for the international community in artificial intelligence. Moreover, this paper aims to provide a complete analysis and some relevant discussions of the current trends and insights within several theoretical and application fields covered in the essay, from theoretical models in artificial intelligence and machine learning to the most prospective applications in robotics, neuroscience, brain computer interfaces, medicine and society, in general.BMS - Pfizer(U01 AG024904). Spanish Ministry of Science, projects: TIN2017-85827-P, RTI2018-098913-B-I00, PSI2015-65848-R, PGC2018-098813-B-C31, PGC2018-098813-B-C32, RTI2018-101114-B-I, TIN2017-90135-R, RTI2018-098743-B-I00 and RTI2018-094645-B-I00; the FPU program (FPU15/06512, FPU17/04154) and Juan de la Cierva (FJCI-2017–33022). Autonomous Government of Andalusia (Spain) projects: UMA18-FEDERJA-084. Consellería de Cultura, Educación e Ordenación Universitaria of Galicia: ED431C2017/12, accreditation 2016–2019, ED431G/08, ED431C2018/29, Comunidad de Madrid, Y2018/EMT-5062 and grant ED431F2018/02. PPMI – a public – private partnership – is funded by The Michael J. Fox Foundation for Parkinson’s Research and funding partners, including Abbott, Biogen Idec, F. Hoffman-La Roche Ltd., GE Healthcare, Genentech and Pfizer Inc

Computational Approaches to Explainable Artificial Intelligence:Advances in Theory, Applications and Trends

Deep Learning (DL), a groundbreaking branch of Machine Learning (ML), has emerged as a driving force in both theoretical and applied Artificial Intelligence (AI). DL algorithms, rooted in complex and non-linear artificial neural systems, excel at extracting high-level features from data. DL has demonstrated human-level performance in real-world tasks, including clinical diagnostics, and has unlocked solutions to previously intractable problems in virtual agent design, robotics, genomics, neuroimaging, computer vision, and industrial automation. In this paper, the most relevant advances from the last few years in Artificial Intelligence (AI) and several applications to neuroscience, neuroimaging, computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-of-the-art in AI methods, models and applications within a collection of works presented at the 9 International Conference on the Interplay between Natural and Artificial Computation (IWINAC). The works presented in this paper are excellent examples of new scientific discoveries made in laboratories that have successfully transitioned to real-life applications