10 research outputs found
Puesta en valor de la ínsula I del Molinete (Barrio del Foro Romano): objetivos, criterios y resultados
En las siguientes páginas se expone la última fase del proyecto museológico desarrollado en la
insula I
del Molinete
(Cartagena, Murcia) desde que se iniciaron las excavaciones arqueológicas en 2008. Esta intervención ha supuesto la
apertura al público del centro de interpretación denominado
Barrio del Foro Romano
, donde se integran dos edificios
alusivos a la vida cotidiana del siglo I, con un singular estado de conservación
Planta de producción de óxido de etileno
Propuesta de diseño para una planta química industrial, situada en La Canonja, cuyo objetivo es una producción anual (320 días/año) de 120.000 toneladas de óxido de etileno (C2H4O) con una pureza del 99% en peso. El producto se obtiene mediante la oxidación directa del etileno (C2H4) con oxígeno (O2) de elevada pureza, y en presencia de un catalizador de plata sobre superficie de alúmina. En los distintos capítulos también son analizados en profundidad aspectos como la seguridad y control en planta, medio ambiente y viabilidad económica del proyecto. Así como mejoras y futuras ampliaciones con la finalidad de perfeccionar la operatividad de la planta.Proposta de disseny per una planta química industrial, situada a La Canonja, amb l'objectiu de produir anualment (320 dies/any) 120.000 tones d'òxid d'etilè (C2H4O) amb una puresa del 99% en pes. El producte s'obté mitjançant l'oxidació directa de l'etilè (C2H4) amb oxigen (O2) d'elevada puresa, i en presència d'un catalitzador de plata sobre superfície d'alúmina. Als diferents capítols també son analitzats en profunditat aspectes com la seguretat i control a la planta, medi ambient i viabilitat econòmica del projecte. Així com millores i futures ampliacions amb la finalitat de perfeccionar la operativitat de la planta
Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism
Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio
Las consecuencias del estigma en familiares de pacientes: un estudio en establecimientos, servicios y programas de salud mental
La Colonia Nacional Montes de Oca es una institución neuropsiquiátrica dependiente del Ministerio de Salud de la Nación en la que se ha desarrollado un programa que comprende la externación y alojamiento de pacientes en Centros de Atención, como hogares y residencias comunitarias. Tales instituciones promueven la convivencia de un pequeño número de pacientes, brindan asistencia integral a cargo de un equipo interdisciplinario de salud y aseguran los servicios de apoyo necesarios para la rehabilitación e integración social. Los objetivos de la investigación fueron: a) caracterizar los procesos de externación asistida destinados a pacientes institucionalizados bajo modalidad de internación crónica; b) indagar diferenciass en la calidad de vida de los usuarios de dispositivos residenciales comunitarios respecto de pacientes alojados en servicios de internación crónica; c) evaluar el prejuicio hacia pacientes atendidos bajo las distintas modalidades asistenciales. El diseño metodológico, transversal y descriptivo, comprendió el empleo de instrumentos de relevamiento adaptados (instrumento GENCAT para evaluación de la calidad de vida) y elaborados por el equipo técnico (guías de relevamiento). Abarcaron a todos los centros residenciales de base comunitaria, según las siguientes variables: a) perfil de usuarios; b) cobertura de Atención; c) modalidad de tratamiento; d) utilización de servicios sociales y sanitarios; e) egresos y retornos a la Institución; e) principales barreras u obstáculos identificados. Se efectuó seguidamente la evaluación de pacientes atendidos en tales dispositivos de base comunitaria y su comparación con aquellos que continuaron recibiendo atención en servicios de internación crónica. Para tal fin, se especificaron las variables de corte para el análisis de los resultados, los cuales arrojaron las siguientes conclusiones: los dispositivos comunitarios exhiben indicadores favorables de gestión administrativa que se expresan en una reducción de los costos por paciente y un menor ausentismo registrado del personal asistencial; se observan mejor desempeño de los indicadores vinculados a la percepción de una mejor calidad de vida en los pacientes tratados bajo la modalidad de externación asistida en dispositivos residenciales comunitarios; las actitudes y conductas discriminatorias hacia los pacientes se incrementan en quienes acreditan más tiempo de internación en la Colonia y expresan mayores niveles de discapacidad funcional.Colonia Montes de Oca National is a neuropsychiatric establishment controlled by the Ministry of Health of the Nation in which it has been developed a program that includes the going out of the main institution and the accommodation of this patients in care centers such as homes and community residences. Such institutions promote the coexistence of a small number of patients, provide complete assistance by an interdisciplinary team of health and assure the necessary support services for rehabilitation and social integration. The objectives of the research were: a) To characterize the process of going out of the institution applied to chronic patients; b) To investigate the differences in quality of life between patients of residential communities and chronic patients; c) To evaluate the prejudice toward patients treated under both modalities. The research design, transversal and descriptive, was carried out by instruments of survey like GENCAT (evaluates the quality of life) and created by the technical team. This was applied to all the residential communities, characterized by the following variables: a) Users profile; b) Care Coverage; c) Outpatient or inpatient modality; d) Use of social and health services; e) Exits and returns to the institution; e) Main obstacles identified. Then, the patients that are in this community centers were evaluated comparing them with the ones who continued like chronic patients. For this purpose, they settled the cut variables for the results analysis, which threw the following conclusions: a) The community devices show a favorable indications of administrative management which are expressed in the reduction of cost per patient and a minor absenteeism registered of the assistance staff; b) A better performance of the indicators linked to the perception of a higher quality of life in patients treated under the modalityof outside-institution in residential communities; c) The attitudes and discriminatory behaviours towards patients increases in people that have more time in the institution and they have higherlevels of functional disability
Informe ampliado: efectos socioeconómicos y culturales de la pandemia COVID-19 y del aislamiento social, preventivo y obligatorio en los Pueblos Indígenas en Argentina -Segunda etapa, junio 2020-
A partir de la pandemia generada por el COVID-19, con el consiguiente Aislamiento Social
Preventivo y Obligatorio (ASPO) dispuesto a partir del 20/03/2020 y demás acciones
implementadas desde el Estado nacional argentino, un conjunto de equipos, instituciones,
investigadores, becaries y tesistas de diferentes ámbitos del país, nos agrupamos con el
objetivo de elaborar un informe acerca de las consecuencias e impactos socioeconómicos y
culturales que atraviesan los pueblos indígenas con los que trabajamos en las regiones
Metropolitana, Pampeana, Noroeste, Noreste, Cuyo y Patagonia.
En una primera instancia, más de 30 autores, participaron en la elaboración de un informe
(1er etapa) presentado el 15 de abril de 20201
. En esta segunda etapa, con más de 100 integrantes de diferentes ámbitos académicos del país, se amplió lo abordado a partir de la
actualización y profundización de las problemáticas y situaciones que experimentan un
conjunto de diversas comunidades y pueblos originarios –qom, mbya, moqoit, mapuche,
guaraní, tupí guaraní, avá guaraní, kolla, diaguita, diaguita-calchaquí, wichí, huarpe,
quechua, aymara, nivaclé, tonokote, omaguaca, tastil, günün a küna, comechingón,
comechingón-camiare, ocloya, iogys, chané, tapiete, chorote, chulupi, sanavirón, ranquel,
wehnayek, atacama, lule, quilmes, mapuche-pehuenches, tehuelches, mapuche-tehuelches, selk‘nam, haush y selk‘nam-haush-.Valdata, Marcela. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Centro de Estudios Aplicados a Problemáticas Socioculturales. Rosario; Argentin
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Clinical and genetic characteristics of late-onset Huntington's disease
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele