93 research outputs found

    Resource limitations in bimanual pointing

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    We thank Moritz Durst for his help with data collection and valuable comments on a previous version of this manuscript.Peer reviewe

    The central locus of self-prioritisation

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    Self-related information is under many circumstances processed in a preferred and biased way, leading to what has been termed the self-prioritisation effect (SPE). The SPE has been demonstrated with arbitrary stimuli assigned to self and others, thereby controlling the influence of familiarity, and originally been attributed to facilitated perceptual processing of self-related stimuli. Subsequent studies, however, casted doubts on this interpretation and suggested further possible sources for the SPE. In the present four experiments, we used the well-established psychological refractory period paradigm together with the locus of slack and the effect propagation logic to pinpoint the source of the SPE. The data consistently demonstrated the SPE across all experiments. More important, the results converge on the notion that the SPE has its source in a capacity-limited stage of central processing. The implications of these results are discussed in light of possible candidate processes as sources for the SPE, such as memory-related processing. </jats:p

    Dynamic Virtualized Deployment of Particle Physics Environments on a High Performance Computing Cluster

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    The NEMO High Performance Computing Cluster at the University of Freiburg has been made available to researchers of the ATLAS and CMS experiments. Users access the cluster from external machines connected to the World-wide LHC Computing Grid (WLCG). This paper describes how the full software environment of the WLCG is provided in a virtual machine image. The interplay between the schedulers for NEMO and for the external clusters is coordinated through the ROCED service. A cloud computing infrastructure is deployed at NEMO to orchestrate the simultaneous usage by bare metal and virtualized jobs. Through the setup, resources are provided to users in a transparent, automatized, and on-demand way. The performance of the virtualized environment has been evaluated for particle physics applications

    Maternal Antibiotic-Induced Early Changes in Microbial Colonization Selectively Modulate Colonic Permeability and Inducible Heat Shock Proteins, and Digesta Concentrations of Alkaline Phosphatase and TLR-Stimulants in Swine Offspring

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    Elevated intake of high energy diets is a risk factor for the development of metabolic diseases and obesity. High fat diets cause alterations in colonic microbiota composition and increase gut permeability to bacterial lipopolysaccharide, and subsequent low-grade chronic inflammation in mice. Chronic inflammatory bowel diseases are increasing worldwide and may involve alterations in microbiota-host dialog. Metabolic disorders appearing in later life are also suspected to reflect changes in early programming. However, how the latter affects the colon remains poorly studied. Here, we hypothesized that various components of colonic physiology, including permeability, ion exchange and protective inducible heat shock proteins (HSP) are influenced in the short- and long-terms by early disturbances in microbial colonization. The hypothesis was tested in a swine model. Offspring were born to control mothers (n = 12) or mothers treated with the antibiotic (ATB) amoxicillin around parturition (n = 11). Offspring were slaughtered between 14 and 42 days of age to study short-term effects. For long-term effects, young adult offspring from the same litters consumed a normal or a palm oil-enriched diet for 4 weeks between 140 and 169 days of age. ATB treatment transiently modified maternal fecal microbiota although the minor differences observed for offspring colonic microbiota were nonsignificant. In the short-term, consistently higher HSP27 and HSP70 levels and transiently increased horseradish peroxidase permeability in ATB offspring colon were observed. Importantly, long-term consequences included reduced colonic horseradish peroxidase permeability, and increased colonic digesta alkaline phosphatase (AP) and TLR2- and TLR4-stimulant concentrations in rectal digesta in adult ATB offspring. Inducible HSP27 and HSP70 did not change. Interactions between early ATB treatment and later diet were noted for paracellular permeability and concentrations of colonic digesta AP. In conclusion, our data suggest that early ATB-induced changes in bacterial colonization modulate important aspects of colonic physiology in the short- and longterms

    Parts of Me : Identity-Relevance Moderates Self-Prioritization

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    Recent research has revealed a pervasive bias for self-relevant information during decision-making, a phenomenon termed the self-prioritization effect. Focusing almost exclusively on between-target (e.g., self vs. friend) differences in task performance, however, this work has overlooked the influence stimulus factors potentially exert during decisional processing. Accordingly, based on pertinent socialpsychological theorizing (i.e., Identity-Based Motivation Theory), here we explored the possibility that self-prioritization is sensitive to the identity-based relevance of stimuli. The results of three experiments supported this hypothesis. In a perceptual-matching task, stimulus enhancement was greatest when geometric shapes were associated with identity-related information that was important (vs. unimportant) to participants. In addition, hierarchical drift-diffusion modeling revealed this effect was underpinned by differences in the efficiency of visual processing. Specifically, evidence was extracted more rapidly from stimuli paired with consequential compared to inconsequential identityrelated components. These findings demonstrate how identity-relevance moderates self-prioritization
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