Emprendimiento Social en Ciencias de la Salud: Creación del Aula ApS-Salud en la Facultad de Farmacia de la Universitat de València

[EN] Service-Learning (SL) aligned to Sustainable Development Goals (SDG) is an educational tool that is used in the Faculty of Pharmacy of the University of Valencia in an interdisciplinary way. The Study Plans of the five Degrees taught in this center do not explicitly cover subjects or content in entrepreneurship, business creation and / or development of projects that may originate business.However, there are certain contents that are oriented in a different way could be used to promote these abilities in students. SL-Health Classroom aims to cover this aspect and has been created with the aim of designing, planning and executing SL projects that serve as a driving idea for a subsequent Social Entrepreneurship project. In the first semester of this academic year 2020-2021, the first actions of this Classroom have been carried out: obtaining aid, publicity and dissemination, training workshops for teachers and students in social entrepreneurship. The evaluation by the participants has been very positive. This innovation project covers practically all the transversal competences of five degrees and will introduce social entrepreneurship in a much more practical way to both students and teachers.[ES] El Aprendizaje basado en Servicio Social (ApS) vinculado a los Objetivos del Desarrollo Sostenible (ODS) es una herramienta educativa que se emplea en la Facultad de Farmacia de la Universitat de València de forma interdisciplinar. Los planes de estudio de los cinco Grados impartidos en este centro no abarcan de forma explícita materias o asignaturas en emprendimiento, creación de empresas y/o desarrollo de proyectos que puedan originar negocios No obstante, existen ciertos contenidos que orientados de una manera diferente podrían ser utilizados para fomentar estas capacidades en el alumnado. El Aula ApS-Salud pretende cubrir este aspecto y ha sido creada con el objetivo de diseñar, planificar y ejecutar proyectos de ApS que sirvan de idea motor para un posterior proyecto de Emprendimiento Social. En el primer semestre de este curso académico 2020-2021 se han realizado las primeras acciones del Aula: obtención de ayudas, publicitación, difusión y formación de talleres para profesorado y alumnado en emprendimiento social. La evaluación por parte de los participantes ha sido muy positiva. Este proyecto de innovación abarca gran número de las competencias transversales de las cinco titulaciones y dará a conocer de manera mucho más práctica el emprendimiento social tanto al alumnado como al profesorado.La creación y desarrollo del Aula ApS-Salud de la Facultad de Farmacia de la Universitat de València ha sido posible gracias a las ayudas recibidas por el programa de innovación “Global Innovation Collider” del Sutardja Center for Entrepreneurship & Technology (SCET) de la University of California at Berkeley y por el programa de proyectos de innovación educativa en emprendimiento universitario (UVemprén, Campus Santander Universidades). Este último programa de innovación docente está promovido por el Vicerrectorado de Empleo y Programas Formativos de la Universitat de València a través de la Unidad de Emprendimiento UVemprén.Blesa, J.; Ferragud Domingo, C.; Pereda Cervera, J.; Ferrándiz, M.; Garrigues, T.; Guillén, M. (2021). Emprendimiento Social en Ciencias de la Salud: Creación del Aula ApS-Salud en la Facultad de Farmacia de la Universitat de València. En IN-RED 2021: VII Congreso de Innovación Edicativa y Docencia en Red. Editorial Universitat Politècnica de València. 1081-1092. https://doi.org/10.4995/INRED2021.2021.13732OCS1081109

Metodología Aprendizaje-Servicio adaptada al confinamiento por COVID-19: Utilización en la prevención de adicciones

[EN] In the Faculty of Pharmacy, the activity "Specific Service Learning (SL)" is carried out. SL allows a team of the center's teaching staff to work voluntarily and in a coordinated manner in the training of people who study the five degrees taught at the center. The suspension of all face-to-face educational and training activities in March 2020 due to the COVID-19 pandemic completely altered the continuation of the tasks and actions related to the SL projects. The objective of this work is to describe the design and implementation of a SL project on addictions that had to be adapted to the digital field for a receiving group with certain characteristics. It will also be described how a "pseudo-SL" was carried out with the students of one of the subjects of the same degree to address this same content using audiovisual material among equals. The results of both services were positively valued by the students; the learning objects created served to increase their knowledge of the subject and acquire skills in digital technology. The receiving group also highly valued the service provided by the students.[ES] En la Facultad de Farmacia se realiza la actividad denominada “Aprendizaje Servicio (ApS) puntual” en la cual un equipo del profesorado del centro trabaja de manera voluntaria, coordinada y transversal en la formación de personas que estudian los cinco grados que se imparten en el centro. La suspensión de todas las actividades de carácter educativo y formativo presenciales en marzo de 20020 por la pandemia por COVID-19 alteró completamente la continuación de las tareas y acciones vinculadas a este tipo de actividades. El objetivo de este trabajo es describir el diseño y realización de un ApS sobre adicciones que hubo de adaptar al ámbito digital y que estaba destinado a un colectivo receptor con unas determinadas características . Se describirá también como se realizó un “pseudo-ApS” con el alumnado de una de las asignaturas del mismo grado para abordar este mismo contenido utilizando material audiovisual entre iguales. Los resultados de ambos servicios fueron valorados positivamente por el alumnado; los objetos de aprendizaje creados sirvieron para aumentar los conocimientos del alumnado en la materia y adquirir destreza en la tecnología digital. El colectivo receptor valoró también muy positivamente el servicio realizado.Machi, C.; Martí, R.; Andrés, L.; Guillén, M.; Ferragud, C.; Garrigues, T.; Ferrándiz, M.... (2021). Metodología Aprendizaje-Servicio adaptada al confinamiento por COVID-19: Utilización en la prevención de adicciones. En IN-RED 2021: VII Congreso de Innovación Edicativa y Docencia en Red. Editorial Universitat Politècnica de València. 1070-1080. https://doi.org/10.4995/INRED2021.2021.13727OCS1070108

Evaluation of School Children Nutritional Status in Ecuador Using Nutrimetry: A Proposal of an Education Protocol to Address the Determinants of Malnutrition

The education sector is a cornerstone in the battle against malnutrition in children. However, there are still no consolidated protocols that outline strategies for how nutrition programs in low- and middle-income countries can be delivered through the education sector. Establishing the correct community diagnosis is essential prior to the elaboration of an intervention plan for a school population that takes into account more than just traditional variables related to the nutritional status. A total of 574 boys and girls aged 3-11 years from three educational institutions in different municipalities in Ecuador participated in the study. Sociodemographic, anthropometric (weight and height) and coproparasitological data were obtained. Nutrimetry, which is a combination of two classical anthropometrics indicators, was used for the analysis of the nutritional status, and the indicators' frequencies varied among the schools. In order to improve the nutritional status of children, we proposed a framework mainly focusing on establishing alliances with the education sector and taking into account gender equality; respect for the environment; and the customs, beliefs and traditions of each population. The results obtained from the analyses of other variables demonstrated the importance of an adequate diagnosis prior to any type of intervention at the nutritional level, since characteristics could vary by local area and have an impact on the successfulness of the intervention

Effects of Chrysosporum (Aphanizomenon) ovalisporum extracts containing cylindrospermopsin on growth, photosynthetic capacity, and mineral content of carrots (Daucus carota)

Natural toxins produced by freshwater cyanobacteria, such as cylindrospermopsin, have been regarded as an emergent environmental threat. Despite the risks for food safety, the impact of these water contaminants in agriculture is not yet fully understood. Carrots (Daucus carota) are root vegetables, extensively consumed worldwide with great importance for human nourishment and economy. It is, therefore, important to evaluate the possible effects of using water contaminated with cyanotoxins on carrot cultivation. The aim of this work was to investigate cylindrospermopsin effects on D. carota grown in soil and irrigated for 30 days, with a Chrysosporum ovalisporum extract containing environmentally relevant concentrations of cylindrospermopsin (10 and 50 μg/L). The parameters evaluated were plant growth, photosynthetic capacity, and nutritional value (mineral content) in roots of carrots, as these are the edible parts of this plant crop. The results show that, exposure to cylindrospermopsin did not have a clear negative effect on growth or photosynthesis of D. carota, even leading to an increase of both parameters. However, alterations in mineral contents were detected after exposure to crude extracts of C. ovalisporum containing cylindrospermopsin. A general decline was observed for most minerals (Ca, Mg, Na, Fe, Mn, Zn, Mo, and P), although an increase was shown in the case of K and Cu, pointing to a possible interference of the cyanobacterial extract in mineral uptake. This study is the first to evaluate the effects of C. ovalisporum extracts on a root vegetable, however, more research is necessary to understand the effects of this toxin in environmentally relevant scenarios.info:eu-repo/semantics/publishedVersio

Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature

Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long-term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out

Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

The SERPINE1 (serpin peptidase inhibitor, clade E, member 1) gene, better known by its previous symbol PAI-1 (plasminogen activator inhibitor 1), has been associated with cardiovascular phenotypes with differing results. Our aim was to examine the association between the rs6950982 (G > A) near the SERPINE1 gene, blood pressure (BP) and plasma lipid concentrations as well as the modulation of the polymorphism effects by adherence to Mediterranean diet (AMD). We studied 945 high-cardiovascular-risk subjects. Biochemical, clinical, dietary and genetic data (rs6950982) were obtained. We also determined the common rs1799768 (4G/5G), for checking independent effects. AMD was measured by a validated questionnaire, and four groups were considered. rs6950982 (A > G) and rs1799768 (4G/5G) were only in moderate–low linkage disequilibrium (D′ = 0.719; r2 = 0.167). The most significant associations we obtained were with rs6950982 (A > G). In males, the G allele was nominally associated with higher diastolic BP (AA: 81.5 ± 10.9, AG: 82.1 ± 11.4, GG: 85.7 ± 10.5 mmHg; Padditive = 0.030) and systolic BP (AA + AG: 141.4 ± 6.9 mmHg vs. GG: 149.8 ± 8.0 mmHg; Precessive = 0.036). In the whole population, the rs6950982 was also associated with plasma lipids. Subject with the G allele presented higher total cholesterol (Padditive = 0.016, Precessive = 0.011), low-density lipoprotein cholesterol (Padditive = 0.032, Precessive = 0.031) and triglycerides (Padditive = 0.040, Precessive = 0.029). AMD modulated the effect of rs6950982 on triglyceride concentrations (P for interaction = 0.036). Greater AMD reduced the higher triglyceride concentrations in GG subjects. No significant interactions were found for the other parameters. The rs6950982 was associated with higher BP in men and higher triglycerides in the whole population, this association being modulated by AMD

Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes