8,429 research outputs found
Real-time optical manipulation of cardiac conduction in intact hearts
Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion. Although these interventions have clearly demonstrated the feasibility of cardiac manipulation, current optical stimulation strategies do not take into account cardiac wave dynamics in real time. Here, we developed an allâoptical platform complemented by integrated, newly developed software to monitor and control electrical activity in intact mouse hearts. The system combined a wideâfield mesoscope with a digital projector for optogenetic activation. Cardiac functionality could be manipulated either in freeârun mode with submillisecond temporal resolution or in a closedâloop fashion: a tailored hardware and software platform allowed realâtime intervention capable of reacting within 2 ms. The methodology was applied to restore normal electrical activity after atrioventricular block, by triggering the ventricle in response to optically mapped atrial activity with appropriate timing. Realâtime intraventricular manipulation of the propagating electrical wavefront was also demonstrated, opening the prospect for realâtime resynchronization therapy and cardiac defibrillation. Furthermore, the closedâloop approach was applied to simulate a reâentrant circuit across the ventricle demonstrating the capability of our system to manipulate heart conduction with high versatility even in arrhythmogenic conditions. The development of this innovative optical methodology provides the first proofâofâconcept that a realâtime optically based stimulation can control cardiac rhythm in normal and abnormal conditions, promising a new approach for the investigation of the (patho)physiology of the heart
Debris disks in main sequence binary systems
We observed 69 A3-F8 main sequence binary star systems using the Multiband
Imaging Photometer for Spitzer onboard the Spitzer Space Telescope. We find
emission significantly in excess of predicted photospheric flux levels for
9(+4/-3)% and 40(+7/-6)% of these systems at 24 and 70 microns, respectively.
Twenty two systems total have excess emission, including four systems that show
excess emission at both wavelengths. A very large fraction (nearly 60%) of
observed binary systems with small (<3 AU) separations have excess thermal
mission. We interpret the observed infrared excesses as thermal emission from
dust produced by collisions in planetesimal belts. The incidence of debris
disks around main sequence A3-F8 binaries is marginally higher than that for
single old AFGK stars. Whatever combination of nature (birth conditions of
binary systems) and nurture (interactions between the two stars) drives the
evolution of debris disks in binary systems, it is clear that planetesimal
formation is not inhibited to any great degree. We model these dust disks
through fitting the spectral energy distributions and derive typical dust
temperatures in the range 100--200 K and typical fractional luminosities around
10^-5, with both parameters similar to other Spitzer-discovered debris disks.
Our calculated dust temperatures suggest that about half the excesses we
observe are derived from circumbinary planetesimal belts and around one third
of the excesses clearly suggest circumstellar material. Three systems with
excesses have dust in dynamically unstable regions, and we discuss possible
scenarios for the origin of this short-lived dust.Comment: ApJ, in press. 57 pages, including 7 figures (one of which is in
color
Age-Related Differences in Moral Judgment: The Role of Probability Judgments
This is the final version. Available on open access from Wiley via the DOI in this recordData availability: The data and Supplementary Material are available on the Open Science Framework, see https://osf.io/8hac5/Research suggests that moral evaluations change during adulthood. Older adults (75+) tend to judge accidentally harmful acts more severely than younger adults do, and this age-related difference is in part due to the greater negligence older adults attribute to the accidental harmdoers. Across two studies (N = 254), we find support for this claim and report the novel discovery that older adults' increased attribution of negligence, in turn, is associated with a higher perceived likelihood that the accident would occur. We propose that, because older adults perceive accidents as more likely than younger adults do, they condemn the agents and their actions more and even infer that the agents' omission to exercise due care is intentional. These findings refine our understanding of the cognitive processes underpinning moral judgment in older adulthood and highlight the role of subjective probability judgments in negligence attribution
La grande crociata. Il 18 aprile nel Veneto
Il fascicolo analizza il tornante decisivo delle lezioni politiche dell'aprile 1948 analizzando la mobilitazione del clero e dell'associazionismo cattolico in alcune province venete
The Copyright Directive: Articles 11 and 13 must go, Statement from European Academics in advance of the Plenary Vote on 26 March 2019
Symbiotic stars on Asiago archive plates. II
The Asiago photographic archive has been searched for plates containing the
symbiotic stars Hen 2-468, QW Sge, LT Del, V407 Cyg, K 3-9, V335 Vul, FG Ser
and Draco C-1. A total of 635 plates imaging the program stars have been found
and the brightness estimated using the Henden & Munari (2000) UBVRI photometric
sequences. These historical data have allowed for the first time the
determination of the orbital periods of Hen 2-468 (774 days) and QW Sge (390.5
days), a significant improvement in the orbital period of LT Del (465.6 days)
and for V407 Cyg an evaluation of the Mira's pulsation period and complex
lightcurve shape in the red (R and I bands). Some previously unknown outbursts
have been discovered too. (Paper I: Munari et al. 2001, A&A 370, 503)Comment: A&A, in pres
Recommended from our members
Measurement of B(B-->X_s {\gamma}), the B-->X_s {\gamma} photon energy spectrum, and the direct CP asymmetry in B-->X_{s+d} {\gamma} decays
The photon spectrum in B --> X_s {\gamma} decay, where X_s is any strange
hadronic state, is studied using a data sample of (382.8\pm 4.2) \times 10^6
e^+ e^- --> \Upsilon(4S) --> BBbar events collected by the BABAR experiment at
the PEP-II collider. The spectrum is used to measure the branching fraction B(B
--> X_s \gamma) = (3.21 \pm 0.15 \pm 0.29 \pm 0.08)\times 10^{-4} and the
first, second, and third moments = 2.267 \pm 0.019 \pm 0.032 \pm
0.003 GeV,, )^2> = 0.0484 \pm 0.0053 \pm 0.0077 \pm
0.0005 GeV^2, and )^3> = -0.0048 \pm 0.0011 \pm 0.0011
\pm 0.0004 GeV^3, for the range E_\gamma > 1.8 GeV, where E_{\gamma} is the
photon energy in the B-meson rest frame. Results are also presented for
narrower E_{\gamma} ranges. In addition, the direct CP asymmetry A_{CP}(B -->
X_{s+d} \gamma) is measured to be 0.057 \pm 0.063. The spectrum itself is also
unfolded to the B-meson rest frame; that is the frame in which theoretical
predictions for its shape are made.Comment: 37 pages, 19 postscript figures, submitted to Phys. Rev. D. No
analysis or results have changed from previous version. Some changes to
improve clarity based on interactions with Phys. Rev. D referees, including
one new Figure (Fig. 13), and some minor wording/punctuation/spelling
mistakes fixe
Measurement of ISR-FSR interference in the processes e+ e- --> mu+ mu- gamma and e+ e- --> pi+ pi- gamma
Charge asymmetry in processes e+ e- --> mu+ mu- gamma and e+ e- --> pi+ pi-
gamma is measured using 232 fb-1 of data collected with the BABAR detector at
center-of-mass energies near 10.58 GeV. An observable is introduced and shown
to be very robust against detector asymmetries while keeping a large
sensitivity to the physical charge asymmetry that results from the interference
between initial and final state radiation. The asymmetry is determined as
afunction of the invariant mass of the final-state tracks from production
threshold to a few GeV/c2. It is compared to the expectation from QED for e+ e-
--> mu+ mu- gamma and from theoretical models for e+ e- --> pi+ pi- gamma. A
clear interference pattern is observed in e+ e- --> pi+ pi- gamma, particularly
in the vicinity of the f_2(1270) resonance. The inferred rate of lowest order
FSR production is consistent with the QED expectation for e+ e- --> mu+ mu-
gamma, and is negligibly small for e+ e- --> pi+ pi- gamma.Comment: 32 pages,29 figures, to be submitted to Phys. Rev.
Recommended from our members
Measurement of the Time-Dependent CP Asymmetry of Partially Reconstructed B0->D*+D*- Decays
We present a new measurement of the time-dependent CP asymmetry of B0->D*+D*-
decays using (471+-5) million BBbar pairs collected with the BaBar detector at
the PEP-II B Factory at the SLAC National Accelerator Laboratory. Using the
technique of partial reconstruction, we measure the time-dependent CP asymmetry
parameters S=-0.34+-0.12+-0.05$ and C=+0.15+-0.09+-0.04. Using the value for
the CP-odd fraction R_perp=0.158+-0.028+-0.006, previously measured by BaBar
with fully reconstructed B0->D*+D*- events, we extract the CP-even components
S+=-0.49+-0.18+-0.07+-0.04 and C+=+0.15+-0.09+-0.04. In each case, the first
uncertainty is statistical and the second is systematic; the third uncertainty
on S+ is the contribution from the uncertainty on R_perp. The measured value of
the CP-even component S+ is consistent with the value of sin(2Beta) measured in
b->(ccbar)s transitions, and with the Standard Model expectation of small
penguin contributions.Comment: 17 pages, 7 figures, submitted to Physical Review
Observation of time-reversal violation in the B0 meson system
The individually named authors work collectively as The BABAR Collaboration. Copyright @ 2012 American Physical Society.Although CP violation in the B meson system has been well established by the B factories, there has been no direct observation of time-reversal violation. The decays of entangled neutral B mesons into definite flavor states (B0 or BÂŻÂŻÂŻ0), and J/ÏK0L or ccÂŻK0S final states (referred to as B+ or Bâ), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, BÂŻÂŻÂŻ0âBâ and BââBÂŻÂŻÂŻ0, as a function of the time difference between the two B decays. Using 468Ă106 BBÂŻÂŻÂŻ pairs produced in ΄(4S) decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding ÎS+T=â1.37±0.14(stat)±0.06(syst) and ÎSâT=1.17±0.18(stat)±0.11(syst). These nonzero results represent the first direct observation of T violation through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation.DOE and NSF (USA), NSERC (Canada), CEA and CNRS-IN2P3 (France), BMBF and
DFG(Germany), INFN (Italy), FOM (The Netherlands),
NFR (Norway), MES (Russia), MINECO (Spain), STFC
(United Kingdom). Individuals have received support from
the Marie Curie EIF (European Union), the A. P. Sloan
Foundation (USA) and the Binational Science Foundation
(USA-Israel)
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