The Recovery of Human Remains in Weapon-Contaminated Settings: Towards Guidance for the Mine Action Community

Mine action and forensic services are critical elements in the response to humanitarian needs during and after armed conflict. Mine action operators will work to identify, mark, and eventually clear areas contaminated with landmines and explosive remnants of war (ERW). Forensic specialists and other related experts will be operational in the search for missing persons and the management of the dead by locating, recovering, and helping to identify human remains, while ensuring maximum protection, dignity of the deceased, and attention to their families.[1] These professions can often intersect in situations where human remains and explosive hazards are both present

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors.

International audienc

Risk minimisation strategies through drug utilisation review

The national pharmaceutical service in Malta provides free medicines and medical devices to outpatients through 219 private community pharmacies. Approval of free entitlement to medicines through the national service provider prioritises meeting pharmacy administrative processes. Development of clinical services during the entitlement review will benefit patients, ensuring treatment continuity across the healthcare system.peer-reviewe

Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches

In academia, compound recycling represents an alternative drug discovery strategy to identify new pharmaceutical targets from a library of chemical compounds available in house. Herein we report the application of a rational target-based drug-repurposing approach to find diverse applications for our in-house collection of compounds. The carbonic anhydrase (CA, EC 4.2.1.1) metalloenzyme superfamily was identified as a potential target of our compounds. The combination of a thoroughly validated docking screening protocol, together with in vitro assays against various CA families and isoforms, allowed us to identify two unprecedented chemotypes as CA inhibitors. The identified compounds have the capacity to preferentially bind pathogenic (bacterial/protozoan) CAs over human isoforms and represent excellent hits for further optimization in hit-to-lead campaigns