49 research outputs found

    Bisphosphonate-related osteonecrosis of the jaws, osteomyelitis and osteoradionecrosis: Comparative immunohistochemical study / Osteonecrose medicamentosa associada ao bisfosfonato, osteomielite e osteorradionecrose: estudo imunohistoquímico comparativo

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    A osteonecrose medicamentosa associada ao uso de bisfosfonatos (OMMBF), osteomielite (OM) e osteorradionecrose (ORN) apresentam muita similaridade nos aspectos clínicos e radiográficos. No intuito de investigar os aspectos microscópicos de cada doença, e diante de poucos estudos comparativos, em especial análises imunohistoquimica, o objetivo deste trabalho foi comparar a imunoexpressão de marcadores relacionados ao ritmo da remodelação óssea e a vascularização entre as três doenças. Foram selecionados prontuários de pacientes que realizaram biópsia prévia com o diagnóstico das três doenças: OM, OMMBF e ORN. As lâminas de cada espécime foram submetidas às imunomarcações utilizando os anticorpos OPG, RANKL, VEGF e CD31. A análise semiquantitativa cega foi realizada por um examinador, sendo conferida por um supervisor. A amostra obtida foi de 34 espécimes oriundos de 34 pacientes, sendo 16 pacientes com OMMBF, 6 com OM crônica e 12 com ORN. Considerando o valor de p<0,05, não foi identificada diferença significante na expressão dos marcadores entre as doenças. Através deste estudo, pode ser afirmado que considerando os marcadores relacionados ao ritmo de remodelação óssea e a vascularização, as doenças analisadas não se diferenciaram.

    Épocas e densidades de semeadura sobre o desempenho agronômico do arroz irrigado no sistema pré-germinado

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    In recent years, paddy rice growers from the south of Santa Catarina, Brazil, have anticipated the sowing date to the beginning of September, aiming to harvest the crop ratoon. In addition to that, they have increased the sowing density to mitigate the smaller plant growth. The objective of this work was to analyze the effects of sowing time and density on the agronomic performance of pregerminated rice. The experiment was set in the city of Praia Grande, SC, Brazil, during the 2018/2019 growing season.  A randomized block design was used, with treatments arranged in split plots. Three sowing dates were tested in the main plots: September 10 (early sowing), October 15 (preferential sowing), and November 20 (late sowing). Four sowing densities were evaluated in the split plots: 80 kg, 120 kg, 160 kg, and 200 kg of seeds per hectare. Morphological characteristics and the yield and components of grains were assessed. Grain yield ranged from 6,277 kg ha-1 to 9,605 kg ha-1 and was affected by the interaction between sowing date and density. The highest yield was achieved when rice was sowed on October 15 at the density of 120 kg ha-1. On the earliest sowing date, grain yield increased linearly by 12.54 kg ha-1 for each kg of added seed above the lowest density evaluated in the trial. The highest grain productivity achieved on this sowing date was 7,858 kg ha-1. Plant density had a small impact on rice yield at the latest sowing date. The highest yield at this planting time (8,546 kg ha-1) was gathered at the density of 120 kg ha-1.  The optimum seed density to maximize pregerminated rice yield in the south of Santa Catarina depends on the sowing date and is higher when the crop is sowed early.Nos últimos anos, os produtores de arroz irrigado do Litoral Sul de Santa Catarina têm antecipado a semeadura da cultura para o início do mês de setembro, visando viabilizar o cultivo do rebrote. Paralelamente a isto, eles têm aumentado a densidade de semeadura para compensar o menor crescimento da cultura. Este trabalho foi conduzido com o objetivo de analisar os efeitos da época e densidade de semeadura sobre o desempenho agronômico do arroz no sistema pré-germinado. O experimento foi implantado no município de Praia Grande, SC, na safra 2018/2019. O trabalho foi conduzido no delineamento experimental de blocos ao acaso, arranjados em parcelas subdivididas. Na parcela principal testaram-se três épocas de semeadura: 10/09 (semeadura antecipada), 15/10 (semeadura preferencial) e 20/11 (semeadura tardia). Nas subparcelas avaliaram-se quatro densidades de semeadura: 80, 120, 160 e 200 kg de sementes ha-1. Foram avaliados caracteres morfológicos, o rendimento de grãos e seus componentes. O rendimento de grãos variou de 6.277 a 9.605 kg ha-1 e foi afetado pela interação entre época e densidade de semeadura. A máxima produtividade foi obtida com a semeadura feita na época preferencial, com densidade de 120 kg ha-1. Na semeadura antecipada, o rendimento aumentou linearmente 12,54 kg ha-1 para cada kg de sementes adicionado à menor densidade. A máxima produtividade obtida nesta época de semeadura foi de 7.858 kg ha-1 com 200 kg  ha-1 de sementes. A densidade de semeadura teve pouco impacto sobre a produtividade na semeadura tardia. Nesta época de semeadura, o maior rendimento (8.546 kg ha-1) foi registrado na densidade de 120 kg ha-1. A densidade ótima para maximizar a produtividade do arroz pré-germinado no Litoral Sul de Santa Catarina depende da época de semeadura, sendo mais alta quando a cultura é semeada antecipadamente

    ABORDAGEM MULTIDISCIPLINAR NO TRATAMENTO DE DOENÇAS CRÔNICA

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    Introdução: Sendo uma das principais causas de morte pelo mundo, as doenças crônicas se caracterizam por patologias com desenvolvimento gradual e de longa duração, podendo se estender por cerca de 6 meses ou se perdurar por toda a vida. Classificando-se em transmissíveis, causadas por um agente infeccioso e não transmissíveis frequentemente relacionadas à predisposição genética e estilo de vida. Objetivos: Revisar a abordagem multidisciplinar no tratamento de doenças crônicas. Metodologia: Pesquisa realizada entre abril e maio do ano de 2024, com base em uma revisão integrativa da literatura científica nas bases de dados SciELo e Biblioteca Virtual em Saúde (BVS), utilizando os descritores: "Doenças crônicas" e "Abordagem no tratamento para doenças crônicas". Resultados e discussão:  Resultados e discussão: A abordagem multidisciplinar no tratamento de doenças crônicas é fundamental para melhorar os resultados clínicos e a qualidade de vida dos pacientes. A participação de diferentes profissionais de saúde facilita a adesão ao tratamento e reduz maiores complicações. Conclusão: É essencial promover e implementar estratégias que incentivem a colaboração entre diferentes profissionais de saúde no manejo dessas condições, a fim de facilitar o processo do tratamento.&nbsp

    Tuberculose pulmonar: perfil epidemiológico do sertão Pernambucano, Brasil / Pulmonary tuberculosis: epidemiological profile of sertão Pernambucano, Brazil

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    Atualmente, observa-se que a tuberculose pulmonar constitui um importante problema de Saúde Pública no mundo, uma vez que esse agravo apresentou, em 2015, 10,4 milhões de casos, dos quais, mais de um milhão de pessoas vieram a óbito. Sob essa perspectiva, o presente artigo tem como objetivo traçar um perfil epidemiológico dos casos de Tuberculose Pulmonar notificados no município de Serra Talhada, entre os anos de 2007 a 2017. Foi realizado um estudo de série histórica observacional do tipo transversal, no intervalo de tempo de 2007 a 2017.  No período investigado o número de casos de tuberculose pulmonar foi de 246 casos, o local que teve a maior prevalência foi Serra Talhada, 287 por 100 mil habitantes. Diante dos dados apresentados, é imprescindível concluir, portanto, que esse estudo corrobora o perfil epidemiológico brasileiro para a Tuberculose Pulmonar, o qual indica variabilidade nos índices de acometimento durante o período analisado

    NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

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    Xenarthrans – anteaters, sloths, and armadillos – have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with 24 domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, ten anteaters, and six sloths. Our dataset includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data-paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the south of the USA, Mexico, and Caribbean countries at the northern portion of the Neotropics, to its austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n=5,941), and Cyclopes sp. has the fewest (n=240). The armadillo species with the most data is Dasypus novemcinctus (n=11,588), and the least recorded for Calyptophractus retusus (n=33). With regards to sloth species, Bradypus variegatus has the most records (n=962), and Bradypus pygmaeus has the fewest (n=12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other datasets of Neotropical Series which will become available very soon (i.e. Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans dataset

    ATLANTIC-PRIMATES: a dataset of communities and occurrences of primates in the Atlantic Forests of South America

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    Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. The dataset includes 700 primate communities, 8,121 single species occurrences and 714 estimates of primate population sizes, covering most natural forest types of the tropical and subtropical Atlantic Forest of Brazil, Paraguay and Argentina and some other biomes. On average, primate communities of the Atlantic Forest harbor 2 ± 1 species (range = 1–6). However, about 40% of primate communities contain only one species. Alouatta guariba (N = 2,188 records) and Sapajus nigritus (N = 1,127) were the species with the most records. Callicebus barbarabrownae (N = 35), Leontopithecus caissara (N = 38), and Sapajus libidinosus (N = 41) were the species with the least records. Recorded primate densities varied from 0.004 individuals/km 2 (Alouatta guariba at Fragmento do Bugre, Paraná, Brazil) to 400 individuals/km 2 (Alouatta caraya in Santiago, Rio Grande do Sul, Brazil). Our dataset reflects disparity between the numerous primate census conducted in the Atlantic Forest, in contrast to the scarcity of estimates of population sizes and densities. With these data, researchers can develop different macroecological and regional level studies, focusing on communities, populations, species co-occurrence and distribution patterns. Moreover, the data can also be used to assess the consequences of fragmentation, defaunation, and disease outbreaks on different ecological processes, such as trophic cascades, species invasion or extinction, and community dynamics. There are no copyright restrictions. Please cite this Data Paper when the data are used in publications. We also request that researchers and teachers inform us of how they are using the data. © 2018 by the The Authors. Ecology © 2018 The Ecological Society of Americ

    Brazilian legislation on genetic heritage harms biodiversity convention goals and threatens basic biology research and education

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    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
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