Difficult patients or difficult encounters?

Universidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilWeb of Scienc

Stellar tracers of the Cygnus Arm. II: A young open cluster in Cam OB3

Cam OB3 is the only defined OB association believed to belong to the Outer Galactic Arm or Cygnus Arm. Very few members have been observed and the distance modulus to the association is not well known. We attempt a more complete description of the population of Cam OB3 and a better determination of its distance modulus. We present uvby photometry of the area surrounding the O-type stars BD +56 864 and LS I +57 138, finding a clear sequence of early-type stars that define an uncatalogued open cluster, which we call Alicante 1. We also present spectroscopy of stars in this cluster and the surrounding association. From the spectral types for 18 very likely members of the association and UBV photometry found in the literature, we derive individual reddenings, finding a extinction law close to standard and an average distance modulus DM=13.0+-0.4. This value is in excellent agreement with the distance modulus to the new cluster Alicante 1 found by fitting the photometric sequence to the ZAMS. In spite of the presence of several O-type stars, Alicante 1 is a very sparsely populated open cluster, with an almost total absence of early B-type stars. Our results definitely confirm Cam OB3 to be located on the Cygnus Arm and identify the first open cluster known to belong to the association.Comment: Accepted for publication in Astronomy & Astrophysics. Tables 7 & 8 to appear only in electronic forma

On the terminal velocity of sedimenting particles in a flowing fluid

The influence of an underlying carrier flow on the terminal velocity of sedimenting particles is investigated both analytically and numerically. Our theoretical framework works for a general class of (laminar or turbulent) velocity fields and, by means of an ordinary perturbation expansion at small Stokes number, leads to closed partial differential equations (PDE) whose solutions contain all relevant information on the sedimentation process. The set of PDE's are solved by means of direct numerical simulations for a class of 2D cellular flows (static and time dependent) and the resulting phenomenology is analysed and discussed.Comment: 13 pages, 2 figures, submitted to JP

Coarse-grained description of a passive scalar

The issue of the parameterization of small-scale dynamics is addressed in the context of passive-scalar turbulence. The basic idea of our strategy is to identify dynamical equations for the coarse-grained scalar dynamics starting from closed equations for two-point statistical indicators. With the aim of performing a fully-analytical study, the Kraichnan advection model is considered. The white-in-time character of the latter model indeed leads to closed equations for the equal-time scalar correlation functions. The classical closure problem however still arises if a standard filtering procedure is applied to those equations in the spirit of the large-eddy-simulation strategy. We show both how to perform exact closures and how to identify the corresponding coarse-grained scalar evolution.Comment: 22 pages; submitted to Journal of Turbulenc

Bisphosphonate-associated jaws osteonecrosis: an important complication of oncology treatment

Os bisfosfonatos são um grupo de medicamentos utilizados no tratamento de doenças malignas metastáticas e em outras doenças ósseas como osteoporose e doença de Paget. A despeito dos seus benefícios, uma importante complicação denominada de osteonecrose dos maxilares vem sendo observada nos pacientes usuários crônicos dos bisfosfonatos que se caracteriza clinicamente por exposições ósseas na região maxilofacial persistente, acompanhadas de osteomielite, geralmente sintomáticas e cujo tratamento é complexo. Este estudo tem por objetivo revisar a literatura sobre a osteonecrose associada ao uso dos bisfosfonatos, em especial, em oncologia, no período de 2003 a 2008. Serão apresentados e discutidos os fatores de risco, aspectos etiopatogênicos, clínicos, imagenológicos, terapêuticos e preventivos desta doença. Devido à dificuldade de tratamento da osteonecrose associada aos bisfosfonatos, o foco deve ser a prevenção, sendo o ideal a eliminação de quadros infecciosos orais antes da terapia com os bisfosfonatos ter sido iniciada e minimizar traumas em boca após o uso destes medicamentos.Bisphosphonates are drugs used in the treatment of malignant metastatic diseases and in other bone lesions such as osteoporosis and Paget´s disease. Besides their benefits, jaw osteonecrosis, an important side effect, has been observed in long-term users of these drugs. Jaw osteonecrosis is clinically characterized by prolonged maxillary and mandible bone exposure accompanied by osteomyelitis. These lesions are usually symptomatic and difficult to treat. This study has the objective of reviewing publications from 2003 to 2008 about bisphosphonate-associated jaw osteonecrosis, in particular in relation to oncology. Risk factors, and etiopathological, clinical, radiographic, therapeutic, and preventive aspects of this condition are presented and discussed. Due to the difficulty to treat this disease, the focus must be prevention, with the ideal therapy being the elimination of oral infections before treatment with bisphosphonates is initiated thereby attempting to minimize possible traumas to the mouth with the use of these medications

Pre-main-sequence stars in the young open cluster NGC 1893: II. Evidence for triggered massive star formation

(Abridged) The open cluster NGC 1893, illuminating the HII region IC410, contains a moderately large population of O-type stars and is one of the youngest clusters observable in the optical range. We have probed the stellar population of NGC 1893 in an attempt to determine its size and extent. We classify a large sample of cluster members with new intermediate resolution spectroscopy. We use H-alpha slitless spectroscopy of the field to search for emission line objects, identifying 18 emission-line PMS stars. We then combine existing optical photometry with 2MASS JHKs photometry to detect stars with infrared excesses, finding close to 20 more PMS candidates. While almost all stars earlier than B2 indicate standard reddening, all later cluster members show strong deviations from a standard reddening law, which we interpret in terms of infrared excess emission. Emission-line stars and IR-excess objects show the same spatial distribution, concentrating around two localised areas, the immediate vicinity of the pennant nebulae Sim 129 and Sim 130 and the area close to the cluster core where the rim of the molecular cloud associated with IC 410 is illuminated by the nearby O-type stars. In and around the emission nebula Sim 130 we find three Herbig Be stars with spectral types in the B1-4 range and several other fainter emission-line stars. We obtain a complete census of B-type stars by combining Stroemgren, Johnson and 2MASS photometry and find a deficit of intermediate mass stars compared to massive stars. We observe a relatively extended halo of massive stars surrounding the cluster without an accompanying population of intermediate-mass stars. The overall picture of star formation in NGC 1893 suggests a very complex process.Comment: Acepted for publication in Astronomy & Astrophysics, 11 figures, uses new aa macro. For a version with full resolution figures (Fig. 7 and 8 in colour) use http://www.dfists.ua.es/~ignacio/download/aa6654.pd

Noninvasive system of transcranial magnetic stimulation focused and deep

Peer Reviewe

Behavioural stress responses predict environmental perception in European sea bass (Dicentrarchus labrax)

Individual variation in the response to environmental challenges depends partly on innate reaction norms, partly on experience-based cognitive/emotional evaluations that individuals make of the situation. The goal of this study was to investigate whether pre-existing differences in behaviour predict the outcome of such assessment of environmental cues, using a conditioned place preference/avoidance (CPP/CPA) paradigm. A comparative vertebrate model (European sea bass, Dicentrarchus labrax) was used, and ninety juvenile individuals were initially screened for behavioural reactivity using a net restraining test. Thereafter each individual was tested in a choice tank using net chasing as aversive stimulus or exposure to familiar conspecifics as appetitive stimulus in the preferred or non preferred side respectively (called hereafter stimulation side). Locomotor behaviour (i.e. time spent, distance travelled and swimming speed in each tank side) of each individual was recorded and analysed with video software. The results showed that fish which were previously exposed to appetitive stimulus increased significantly the time spent on the stimulation side, while aversive stimulus led to a strong decrease in time spent on the stimulation side. Moreover, this study showed clearly that proactive fish were characterised by a stronger preference for the social stimulus and when placed in a putative aversive environment showed a lower physiological stress responses than reactive fish. In conclusion, this study showed for the first time in sea bass, that the CPP/CPA paradigm can be used to assess the valence (positive vs. negative) that fish attribute to different stimuli and that individual behavioural traits is predictive of how stimuli are perceived and thus of the magnitude of preference or avoidance behaviour.European Commission [265957]; Portuguese Fundacao para a Ciencia e Tecnologia (FCT) [FRH/BPD/72952/2010]; FCT [SFRH/BD/80029/2011

PN fast winds: Temporal structure and stellar rotation

To diagnose the time-variable structure in the fast winds of central stars of planetary nebulae (CSPN), we present an analysis of P Cygni line profiles in FUSE satellite far-UV spectroscopic data. Archival spectra are retrieved to form time-series datasets for the H-rich CSPN NGC 6826, IC 418, IC 2149, IC 4593 and NGC 6543. Despite limitations due to the fragmented sampling of the time-series, we demonstrate that in all 5 CSPN the UV resonance lines are variable primarily due to the occurrence of blueward migrating discrete absorption components (DACs). Empirical (SEI) line-synthesis modelling is used to determine the range of fluctuations in radial optical depth, which are assigned to the temporal changes in large-scale wind structures. We argue that DACs are common in CSPN winds, and their empirical properties are akin to those of similar structures seen in the absorption troughs of massive OB stars. Constraints on PN central star rotation velocities are derived from Fast-Fourier Transform analysis of photospheric lines for our target stars. Favouring the causal role of co-rotating interaction regions, we explore connections between normalised DAC accelerations and rotation rates of PN central stars and O stars. The comparative properties suggest that the same physical mechanism is acting to generate large-scale structure in the line-driven winds in the two different settings.Comment: Accepted for publication in MNRAS; 10 pages, 5 figure