Mieloencefalitis protozoaria equina en un equino en Colombia: reporte de caso

Equine Protozoal Myeloencephalitis (EPM) is an infectious neurological disease with a high percentage of mortality that affects equines that share habitat with their definitive host; however, it has not been widely reported in endemic regions. In Colombia, a country with wide distribution of the host, a veterinarian is consulted for a clinical case of an equine with neurological and muscular symptoms compatible with EPM. Antibiotic and anticoccidial treatment was immediately initiated when this pathology is suspected, and a blood sample was sent to confirm the diagnosis in the laboratory. The sample was positive for the sarcocystin toxin produced by the protozoan S. neurona. The equine responded positively and fully recovered five months after treatment. This case report shows the importance of taking this pathology into account as a differential diagnosis to establish an effective treatment as soon as possible, generating a favourable prognosis and, therefore, a recovery for the patient.La Mieloencefalitis Protozoaria Equina (EPM) es una enfermedad neurológica infecciosa con alto porcentaje de mortalidad que afecta a los equinos que comparten hábitat con su hospedero definitivo; sin embargo no ha sido muy reportada en regiones endémicas. En Colombia, país de amplia distribución del hospedero, es consultado un médico veterinario por un caso clínico de un equino con sintomatología neurológica y muscular compatible con EPM. Se inicia tratamiento con antibiótico y anticoccidial ante la sospecha de esta patología y remite una muestra de sangre para confirmar el diagnóstico en el laboratorio. La muestra fue positiva a la toxina sarcocistina producida por el protozoo S. neurona. El equino respondió positivamente y se recuperó totalmente a los cinco meses del tratamiento. Este reporte evidencia la importancia de tener en cuenta esta patología como diagnóstico diferencial con el fin de instaurar un tratamiento eficaz lo antes posible generando un pronóstico favorable y, por ende, una recuperación del paciente

The Caldera. No. 23

La pandemia, sin lugar a dudas, nos ha cambiado la vida a todos; un viernes nos fuimos para nuestros hogares, en el marco de una educación presencial; al lunes siguiente, después de dos días, estábamos iniciando el camino hacia una educación remota, una educación virtual, que se ha convertido en una gran alternativa para seguir contribuyendo con la formación de nuestros niños y jóvenes caldistas y al mejoramiento de nuestra calidad de vida que halla, en la educación, nuevamente la respuesta; han sido meses de cambios drásticos, inimaginables pero, cambios positivos que nos han permitido crecer como individuos, como familia, como escuela y como sociedad.Especial pandemia. Una generación Resiliente por promoción DINASTIA…06 VII Concurso Intercolegiado departamental de Oratoria. Ulibro 2020…51 Deporte en el Caldas…64 Expresiones Caldistas…71 Celebremos la palabra…93 Nuestros Maestros…102 Galería de Imágenes…107The pandemic, without a doubt, has changed the lives of all of us; One Friday we went to our homes, as part of a face-to-face education; The following Monday, after two days, we were starting the path towards a remote education, a virtual education, which has become a great alternative to continue contributing to the training of our children and young Caldistas and to the improvement of our quality of life. that finds, in education, the answer again; They have been months of drastic changes, unimaginable but positive changes that have allowed us to grow as individuals, as a family, as a school and as a society

Aislamiento de Morganella morganii y Staphylococcus aureus en un paciente canino con lesión cutánea y de tejidos blandos: Reporte de caso

 The clinical case of a canine with deep ulcerative pyoderma with dermal necrosis is presented, where Morganella morganii and Staphylococcus aureus were isolated from the skin lesions. The first is a bacterium from the environment and in the normal flora of the intestinal tract, and rarely reported in canines. S. aureus is a recognized gram-positive staphylococcal bacterium that is associated with suppurative infections. The results that address this study indicate the importance of carrying out a rapid recognition, diagnosis and initiation of treatment based on cultures and antibiograms. Polymicrobial infection makes treatment and its evolution difficult, and the progression of skin lesions and secondary systemic diseases must be avoided.Se presenta el caso clínico de un canino con pioderma profundo ulceroso con necrosis dérmica, donde se aísla Morganella morganii y Staphylococcus aureus de las lesiones cutáneas. El primero es una bacteria del medio ambiente y en la flora normal del tracto intestinal, y poco reportada en caninos. S. Aureus es una bacteria estafilocócica grampositiva reconocida que se asocia con infecciones supurativas. Los resultados que abordan este estudio indican la importancia de llevar a cabo un rápido reconocimiento, diagnóstico e inicio de tratamiento basado en cultivos y antibiogramas. La infección polimicrobiana dificulta el tratamiento y su evolución, debiendo evitarse la progresión de lesiones en piel y enfermedades sistémicas secundarias

Isolation of Morganella morganii and Staphylococcus aureus in a canine patientwith skin and soft tissue injury: case report

Se presenta el caso clínico de un canino con pioderma profundo ulceroso connecrosis dérmica, donde se aísla Morganella morganii y Staphylococcus aureus delas lesiones cutáneas. El primero es una bacteria del medio ambiente y en la flora normaldel tracto intestinal, y poco reportada en caninos. S. aureus es una bacteria estafilocócicagrampositiva reconocida que se asocia con infecciones supurativas. Los resultadosque abordan este estudio indican la importancia de llevar a cabo un rápido reconoci-miento, diagnóstico e inicio de tratamiento basado en cultivos y antibiogramas. Lainfección polimicrobiana dificulta el tratamiento y su evolución, debiendo evitarse laprogresión de lesiones en piel y enfermedades sistémicas secundariasThe clinical case of a canine with deep ulcerative pyoderma with dermal necrosis ispresented, where Morganella morganii and Staphylococcus aureus were isolated fromthe skin lesions. The first is a bacterium from the environment and in the normal flora ofthe intestinal tract, and rarely reported in canines. S. aureus is a recognized gram-positivestaphylococcal bacterium that is associated with suppurative infections. The results thataddress this study indicate the importance of carrying out a rapid recognition, diagnosisand initiation of treatment based on cultures and antibiograms. Polymicrobial infectionmakes treatment and its evolution difficult, and the progression of skin lesions andsecondary systemic diseases must be avoidedIncluye referencias bibliográfica

Comparative evaluation of three laparoscopic cholecystectomy techniques in rabbit’s model

ABSTRACT Purpose: The aim of this randomized study was to compare the complications and perioperative outcome of three different techniques of laparoscopic cholecystectomy (LC). Changes in the liver function test after LC techniques were investigated. Also, we compared the degree of postoperative adhesions and histopathological changes of the liver bed. Methods: Thirty rabbits were divided into three groups: group A) Fundus-first technique by Hook dissecting instrument and Roeder Slipknot applied for cystic duct (CD) ligation; group B) conventional technique by Maryland dissecting forceps and electrothermal bipolar vessel sealing (EBVS) for CD seal; group C) conventional technique by EBVS for gallbladder (GB) dissection and CD seal. Results: Group A presented a longer GB dissection time than groups B and C. GB perforation and bleeding from tissues adjacent to GB were similar among tested groups. Gamma-glutamyl transferase and alkaline phosphatase levels increased (p ≤ 0.05) on day 3 postoperatively in group A. By the 15th postoperative day, the enzymes returned to the preoperative values. Transient elevation of hepatic transaminases occurred after LC in all groups. Group A had a higher adherence score than groups B and C and was associated with the least predictable technique. Conclusions: LC can be performed using different techniques, although the use of EBVS is highly recommended

Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: A systematic review and meta-analysis of individual participant data

Objective: To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. Methods: A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO database (http://www.crd.york.ac.uk/PROSPERO; CRD42012002162). Results: A total of 27 studies (1296 subjects) conducted in eight countries were included. The risk of bias was low for all domains in 17 studies (63.0%). Nine hundred and thirteen subjects were assessed (149 seroreversion events, 83.7% censored data) for enzyme-linked immunosorbent assay (ELISA), 670 subjects (134 events, 80.0% censored) for indirect immunofluorescence assay (IIF), and 548 subjects (99 events, 82.0% censored) for indirect hemagglutination assay (IHA). A higher probability of seroreversion was observed within a shorter time span in subjects aged 1-19 years compared to adults. The chance of seroreversion also varied according to the country where the infection might have been acquired. For instance, the pooled adjusted hazard ratio between children/adolescents and adults for the IIF test was 1.54 (95% confidence interval 0.64-3.71) for certain countries of South America (Argentina, Bolivia, Chile, and Paraguay) and 9.37 (95% confidence interval 3.44-25.50) for Brazil. Conclusions: The disappearance of anti-T. cruzi antibodies was demonstrated along the course of follow-up. An interaction between age at treatment and country setting was found.UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland B20393 European project BERENICE - European Community's 7th Framework Programme HEALTH-3059

Ecuador : la insurrección de Octubre

CLACSO reúne un conjuto de textos breves y ensayos producidos para contribuir a una lectura en diferentes tiempos y desde diferentes perspectivas sobre la insurrección de la sociedad ecuatoriana en octubre de 2019. Nos mueve un doble propósito: aportar en la construcción de una vía para interpretar los acontecimientos que marcaron la historia con temporánea de nuestros pueblos y efectuar un aporte a la memoria de las luchas por sociedades más justas e igualitarias

A global metagenomic map of urban microbiomes and antimicrobial resistance

We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.Funding: the Tri-I Program in Computational Biology and Medicine (CBM) funded by NIH grant 1T32GM083937; GitHub; Philip Blood and the Extreme Science and Engineering Discovery Environment (XSEDE), supported by NSF grant number ACI-1548562 and NSF award number ACI-1445606; NASA (NNX14AH50G, NNX17AB26G), the NIH (R01AI151059, R25EB020393, R21AI129851, R35GM138152, U01DA053941); STARR Foundation (I13- 0052); LLS (MCL7001-18, LLS 9238-16, LLS-MCL7001-18); the NSF (1840275); the Bill and Melinda Gates Foundation (OPP1151054); the Alfred P. Sloan Foundation (G-2015-13964); Swiss National Science Foundation grant number 407540_167331; NIH award number UL1TR000457; the US Department of Energy Joint Genome Institute under contract number DE-AC02-05CH11231; the National Energy Research Scientific Computing Center, supported by the Office of Science of the US Department of Energy; Stockholm Health Authority grant SLL 20160933; the Institut Pasteur Korea; an NRF Korea grant (NRF-2014K1A4A7A01074645, 2017M3A9G6068246); the CONICYT Fondecyt Iniciación grants 11140666 and 11160905; Keio University Funds for Individual Research; funds from the Yamagata prefectural government and the city of Tsuruoka; JSPS KAKENHI grant number 20K10436; the bilateral AT-UA collaboration fund (WTZ:UA 02/2019; Ministry of Education and Science of Ukraine, UA:M/84-2019, M/126-2020); Kyiv Academic Univeristy; Ministry of Education and Science of Ukraine project numbers 0118U100290 and 0120U101734; Centro de Excelencia Severo Ochoa 2013–2017; the CERCA Programme / Generalitat de Catalunya; the CRG-Novartis-Africa mobility program 2016; research funds from National Cheng Kung University and the Ministry of Science and Technology; Taiwan (MOST grant number 106-2321-B-006-016); we thank all the volunteers who made sampling NYC possible, Minciencias (project no. 639677758300), CNPq (EDN - 309973/2015-5), the Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science – MOE, ECNU, the Research Grants Council of Hong Kong through project 11215017, National Key RD Project of China (2018YFE0201603), and Shanghai Municipal Science and Technology Major Project (2017SHZDZX01) (L.S.

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research