Opportunistic screening for atrial fibrillation versus detecting symptomatic patients aged 65 years and older: a cluster-controlled clinical trial.

Objective: The goal of this study was to assess the effectiveness of opportunistic screening through pulse palpation in the early detection of atrial fibrillation in subjects aged ≥ 65 years versus detection through an active search for patients with symptoms and/or complications and sequelae associated. -Material and methods: This was a cluster randomized controlled trial performed in 48 primary care centers of the Spanish National Healthcare System. A total of 368 physicians and nurses were randomized. The researchers in the Experimental Group (EG) performed opportunistic screening for auricular fibrillation, whereas the researchers in the Control Group (CG) actively searched for symptomatic patients. An ECG was performed on patients found to have an irregular heartbeat to confirm the diagnosis of auricular fibrillation. -Results: A total of 5,465 patients with a mean age of 75.61 were recruited for the EG, and 1,525 patients with a mean age of 74.07 were recruited for the CG. Of these, 58.6% were female, without significant differences between groups. Pulse was irregular in 4.3% and 15.0% of the patients in the EG and the CG, respectively (p<0.001). A total of 165 new cases of atrial fibrillation were detected (2.3%), 1.1% in the EG and 6.7% in the CG (adjusted OR: 0.29; 95%CI: 0.18-0.45). -Conclusions: Case finding for atrial fibrilation in patients aged ≥ 65 years with symptoms or signs suggestive of atrial fibrilation is a more effective strategy than opportunistic screening through pulse palpation in asymptomatic patients.pre-print325 K

ICT education policies in Spain after School Program 2.0: Emerging Trends

En este artículo se analiza la situación actual de las políticas educativas destinadas a laincorporación de las TIC a las escuelas en una muestra de ocho comunidades autónomasde España (Andalucía, Canarias, Cataluña, Extremadura, Madrid, País Valenciano, PaísVasco y Principado de Asturias) después del proceso impulsado por el Programa Escuela2.0. Este programa estuvo vigente durante el periodo 2009­2012 y respondió al modelo 1:1,de un ordenador por estudiante. Este análisis se guió por las siguientes cuestiones: ¿Quéefectos permanecen de las experiencias de políticas educativas del modelo 1:1?; ¿Quénuevos proyectos o programas están vigentes en los sistemas educativos de lascomunidades autónomas? ¿Qué nuevas tendencias con relación a las TIC estánemergiendo en la agenda educativa de las políticas autonómicas? Se concluye que lasnuevas políticas TIC, entre otras acciones, apuntan a centrar su atención en laincorporación de las PDI a todas las aulas, a la dotación de tabletas a los estudiantes envez de miniportátiles, a políticas de sustitución de los libros de texto de papel porplataformas de contenidos digitales y a la creación de portales de recursos en la nube. Seconstata también la ausencia de un programa o política educativa TIC coordinada a nivelde todo el estado como fue la experiencia del Programa Escuela 2.0.In this article the current situation of educational policies for the incorporation of ICT inschools in a sample of eight regions of Spain (Andalusia, Canary Islands, Catalonia,Extremadura, Madrid, Valencia, the Basque Country and the Principality of analyzesAsturias) after the process driven by the Escuela 2.0 program. This program was in effectduring the period 2009­2012 and responded to the 1:1 model of a computer per student.This analysis was guided by the following questions: What effects remain from theexperiences of educational policies of the 1:1 model?; What new projects or programs arein place in the educational systems of the regions? What new trends in relation to ICT areemerging in the educational agenda of regional policies? We conclude that the new ICTpolicy, among other things, aim to focus on the integration of IDPs to all classrooms toequipping students tablets instead of netbooks, a substitution policies textbooks paper fordigital content platforms, to create portals of cloud resources. The absence of aneducational program or policy level ICT coordinated statewide as was the experience ofSchool Program 2.0 has been observed

Las políticas educativas TIC en España después del Programa Escuela 2.0: las tendencias que emergen

En este artículo se analiza la situación actual de las políticas educativas destinadas a la incorporación de las TIC a las escuelas en una muestra de ocho comunidades autónomas de España (Andalucía, Canarias, Cataluña, Extremadura, Madrid, País Valenciano, País Vasco y Principado de Asturias) después del proceso impulsado por el Programa Escuela 2.0. Este programa estuvo vigente durante el periodo 20092012 y respondió al modelo 1:1, de un ordenador por estudiante. Este análisis se guió por las siguientes cuestiones: ¿Qué efectos permanecen de las experiencias de políticas educativas del modelo 1:1?; ¿Qué nuevos proyectos o programas están vigentes en los sistemas educativos de las comunidades autónomas? ¿Qué nuevas tendencias con relación a las TIC están emergiendo en la agenda educativa de las políticas autonómicas? Se concluye que las nuevas políticas TIC, entre otras acciones, apuntan a centrar su atención en la incorporación de las PDI a todas las aulas, a la dotación de tabletas a los estudiantes en vez de miniportátiles, a políticas de sustitución de los libros de texto de papel por plataformas de contenidos digitales y a la creación de portales de recursos en la nube. Se constata también la ausencia de un programa o política educativa TIC coordinada a nivel de todo el estado como fue la experiencia del Programa Escuela 2.0. In this article the current situation of educational policies for the incorporation of ICT in schools in a sample of eight regions of Spain (Andalusia, Canary Islands, Catalonia, Extremadura, Madrid, Valencia, the Basque Country and the Principality of analyzes Asturias) after the process driven by the Escuela 2.0 program. This program was in effect during the period 20092012 and responded to the 1:1 model of a computer per student. This analysis was guided by the following questions: What effects remain from the experiences of educational policies of the 1:1 model?; What new projects or programs are in place in the educational systems of the regions? What new trends in relation to ICT are emerging in the educational agenda of regional policies? We conclude that the new ICT policy, among other things, aim to focus on the integration of IDPs to all classrooms to equipping students tablets instead of netbooks, a substitution policies textbooks paper for digital content platforms, to create portals of cloud resources. The absence of an educational program or policy level ICT coordinated statewide as was the experience of School Program 2.0 has been observed

Two functional variants of IRF5 influence the development of macular edema in patients with non-anterior uveitis.

Objective Interferon (IFN) signaling plays a crucial role in autoimmunity. Genetic variation in interferon regulatory factor 5 (IRF5), a major regulator of the type I interferon induction, has been associated with risk of developing several autoimmune diseases. In the current study we aimed to evaluate whether three sets of correlated IRF5 genetic variants, independently associated with SLE and with different functional roles, are involved in uveitis susceptibility and its clinical subphenotypes. Methods Three IRF5 polymorphisms, rs2004640, rs2070197 and rs10954213, representative of each group, were genotyped using TaqMan® allelic discrimination assays in a total of 263 non-anterior uveitis patients and 724 healthy controls of Spanish origin. Results A clear association between two of the three analyzed genetic variants, rs2004640 and rs10954213, and the absence of macular edema was observed in the case/control analysis (PFDR=5.07E-03, OR=1.48, CI 95%=1.14-1.92 and PFDR=3.37E-03, OR=1.54, CI 95%=1.19-2.01, respectively). Consistently, the subphenotype analysis accordingly with the presence/absence of this clinical condition also reached statistical significance (rs2004640: P=0.037, OR=0.69, CI 95%=0.48-0.98; rs10954213: P=0.030, OR=0.67, CI 95%=0.47-0.96), thus suggesting that both IRF5 genetic variants are specifically associated with the lack of macular edema in uveitis patients. Conclusion Our results clearly showed for the first time that two functional genetic variants of IRF5 may play a role in the development of macular edema in non-anterior uveitis patients. Identifying genetic markers for macular edema could lead to the possibility of developing novel treatments or preventive therapies

Applications of non-intrusive methods to study the sand cat: a field study in the Sahara Desert

Surveys based on indirect signs and camera trapping are two non-invasive methods extensively used for monitoring elusive mammals. Both approaches can be useful to obtain key information on wildlife in remote areas, since they may allow for the logistically viable design of optimal field frameworks. The sand cat (Felis margarita) is a feline that inhabits the Sahara Desert, the Arabian Peninsula, and western Asian deserts. Its basic ecology is poorly known and the status and impacts of threats are difficult to assess. Some local population declines have been detected, and more research is needed. Based on field surveys carried out in the Atlantic Sahara, we have evaluated the applications of both methods to study this species. Our results show that (a) camera trapping provided reliable data on several key aspects of its ecology, (b) walking surveys to collect feces for molecular data failed completely, and (c) for footprints, identification problems and the marked effects of the absence of optimal substrates and the prevalence of wind are relevant handicaps. Beyond this evaluation, we provide for the first time some key aspects of the ecology of sand cats in the Sahara Desert, including habitat selection, density, diel activity, and predator–prey relationships.Funding for open access publishing: Universidad de Granada/CBUA. This study was partially supported by Fundación Barcelona Zoo (PRIC Project 2017 grant)

Trajectories of alcohol consumption during life and the risk of developing breast cancer

Background Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (= 15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, >= 15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.This study was funded by the Fundacion Cientifica Asociacion Espanola Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016) (Marina Pollan), Sociedad Espanola de Oncologia Medica (SEOM) (Spanish Society of Medical Oncology) (Miguel Martin), Scholarship 'Contrato de atraccion de talento' from Community of Madrid (Carolina Donat-Vargas), Fundacion Cerveza y Salud 2005 (Beer and Health Foundation 2005) (Miguel Martin) and Federacion de Asociaciones de Mujeres con Cancer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer) (Miguel Martin, Marina Pollan)

Integración de arquitecturas Edge-Fog-Cloud en procesamiento distribuido, aspectos de eficiencia y resiliencia

El eje de esta línea de I/D lo constituye el estudio de la integración de arquitecturas distribuidas que van desde el nivel de los nodos sensores basados en microcontroladores (Edge Computing), pasando por una capa intermedia de preprocesamiento (Fog Computing) y finalmente la capa de procesamiento en la nube (Cloud Computing). Los temas centrales son: ▪ Distribución equilibrada del procesamiento y almacenamiento de datos en cada nivel. ▪ Análisis de integridad y performance en las comunicaciones, según el grado de distribución del procesamiento. ▪ Migración de “inteligencia” al nivel “Edge” para reducir consumo y comunicaciones. ▪ Control de tolerancia a fallos de la arquitectura. ▪ Evaluación e integración de plataformas y servicios ▪ Desarrollo y evaluación de aplicaciones que integran niveles de procesamiento. ▪ Análisis de eficiencia en tiempo, consumo energético y comunicaciones.Red de Universidades con Carreras en Informátic

Arquitecturas Edge-Fog-Cloud en procesamiento distribuido

El eje de esta línea de I/D lo constituye el estudio de la integración de arquitecturas distribuidas que van desde el nivel de sensores (Edge Computing) a la capa de procesamiento en la nube (Cloud Computing), con una posible capa intermedia que se conoce como Fog Computing. Los temas centrales son: ▪ Distribución de la capacidad de procesamiento en cada nivel. ▪ Análisis de performance en las comunicaciones, según el grado de distribución del procesamiento. ▪ Administración de recursos en cada nivel. ▪ Migración de “inteligencia” al nivel “Edge” para reducir consumo y comunicaciones. ▪ Desarrollo y evaluación de aplicaciones que integran niveles de procesamiento. ▪ Análisis de eficiencia en tiempo, consumo y comunicaciones.Eje: Procesamiento distribuido y paralelo.Red de Universidades con Carreras en Informátic

Clinical and Sociodemographic Determinants of Adherence to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Recommendations in Breast Cancer Survivors-Health-EpiGEICAM Study

Breast cancer (BC) survivors are advised to follow the WCRF/AICR cancer prevention recommendations, given their high risk of developing a second tumour. We aimed to explore compliance with these recommendations in BC survivors and to identify potentially associated clinical and sociodemographic factors. A total of 420 BC survivors, aged 31-80, was recruited from 16 Spanish hospitals. Epidemiological, dietary and physical activity information was collected through questionnaires. A 7-item score to measure compliance with the recommendations was built according to the 2018 WCRF/AICR scoring criteria. Standardized prevalences and standardized prevalence ratios of moderate and high compliance across participant characteristics were estimated using multinomial and binary logistic regression models. The mean score was 3.9 (SD: 1.0) out of 7 points. Recommendations with the worst adherence were those of limiting consumption of red/processed meats (12% of compliance, 95% CI: 8.2-15.0) and high fibre intake (22% of compliance, 95% CI: 17.6-27.0), while the best compliance was observed for the consumption of fruits and vegetables (73% of compliance, 95% CI: 69.2-77.7). Overall, adherence was worse in women with university education and in those with first-degree relatives with BC. This information may be of interest to design and implement personalized preventive measures adapted to the characteristics of these patients.This research was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2016). This article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health.S

Software de base, modelos y aplicaciones en arquitecturas multiprocesador

El eje de esta línea de I/D lo constituye el estudio de las arquitecturas multiprocesador que integran sistemas distribuidos y paralelos. Incluye como temas centrales: - Arquitecturas many-core (GPU, procesadores MIC, TPUs), FPGAs, híbridas (diferentes combinaciones de multicores y aceleradores), y asimétricas. - Desarrollo y evaluación de algoritmos paralelos sobre nuevas arquitecturas y su evaluación de rendimiento computacional y energético. - Estudio y optimización de código heredado. - Desarrollo y evaluación de estrategias de resiliencia. - Modelado y simulación de E/S en HPC.Red de Universidades con Carreras en Informátic