Effects of sowing dates and irrigation regimes on grain quality of wheat grown under semi-arid condition of India

An experiment was conducted with aim to investigate the effect of sowing dates and irrigation regimes on wheat grain quality. There was four sowing dates [November 1(S1), November 16 (S2), December 1(S3) and December 16 (S4)], in main plots and four irrigation regimes [25% (I1), 50% (I2) and 75% (I3) maximum allowable depletion (MAD) of available soil moisture (ASM) and I4 – four critical growth stages in sub plots. The results revealed that hectolitre weight decreased from 80.2 and 81.4 kg hl-1 in S1 treatment to 78.3 and 79.4 kg hl-1 in S4 treatment and 79.9 and 81.5 kg hl-1 in I1 treatment to 79.0 and 79.9 kg hl-1 in I3 treatment in 2010-11 and 2011-12, respectively. Grain hardness outcome was ?75 in 2010-11 while it was <75 in 2011-12 irrespective of sowing dates and irrigation regimes. The highest percentage of flour recovery obtained in S1 treatment (68.2 and 63.2%) and I1 treatment (68.0 and 62.8%) with lowest coarse bran. On average, dry gluten content increased by 16.5 and 7.1% in S4 over S1 treatment in 2010-11 and 2011-12, respectively. Grain protein content increased from 11.9 and 12.8% in S1 treatment to 12.6 and 13.8% in S4 treatment in respective seasons. The milling and technological properties in S2 and I2 treatment was at par with S1 and I2 treatment. Therefore, it may be inferred that optimum milling and technological properties of wheat grain can be maintained by sowing till mid-November and irrigation scheduling up to 50% depletion of ASM

Indian consensus on durability of glycemic control in type 2 diabetes management and role of oral antidiabetic drugs

The prevalence of type 2 diabetes mellitus (T2DM) is increasing in an alarming way in India as well as across the globe. In order to minimize complications, there is a need to maintain good glycemic control in patients with T2DM and long-term durable glycemic control remains a challenge. Clinically, this challenge was addressed by step-wise intensification of therapy with additional antidiabetic drugs to maintain glycemic control. Various disease and patient-related factors as well as different antidiabetic agents influenced the durability of glycemic control differently. While understanding of the factors that influenced therapeutic outcomes had evolved, there was paucity of information about the durability of glycemic control and the role of oral antidiabetic drugs (OADs) in achieving it. With an objective to understand the role of durability of glycemic response in the management of Indian patients with T2DM, 4 advisory board meetings attended by 48 physicians from across the country were conducted in Mumbai, Delhi, Kolkata and Bengaluru. There was consensus to consider durability of glycemic control as an important goal in the management of T2DM. Personalized approach in T2DM management along with early initiation of dual combination therapy were recommended to achieve durability. Age group of patients, body mass index, glycated hemoglobin levels at diagnosis, presence or absence of comorbidities and complications are important factors that need to be considered before initiating dual combination therapy for patients with T2DM

Effect of different nitrogen sources and nitrification inhibitors on soil nitrogen distribution in Kinnow orchard

This record was migrated from the OpenDepot repository service in June, 2017 before shutting down

Design and management guidelines for contour basin irrigation layouts in southeast Australia

Abstract Contour basin irrigation layouts are used in Australia for sequential cultivation of rice and other crops on soils with low infiltration rates. Multiple interconnected basins through gates installed in the check banks and backflow at the inlet end are unique features of contour basin layouts used in southeast Australia. Design and management guidelines were developed using a two-dimensional computer simulation model (COBASIM) for contour basin layouts. The computer model was used to simulate and analyse the performance of single-and multiple-basin layouts in response to key design variables including aspect ratio, inflow rates, microtopography, vertical interval between basins and number of interconnecting drainage outlets. The main aim of this study was to provide designers and practitioners with an overall view of the likely impact trends arising from variations in key design factors and to improve design practices. Irrigation performance was measured by the time of advance needed to cover the entire basin area, application efficiency, water requirement efficiency and distribution uniformity. The study revealed that the aspect ratio and local microtopography have a significant impact on the performance in these layouts. A mild slope in the advance direction can improve performance when a small depth of irrigation is required, while there are no significant benefits from increasing the elevation difference between adjacent basins. Crow

RAPID DETECTION OF MULTI DRUG RESISTANCE AMONG MULTI DRUG RESISTANT TUBERCULOSIS SUSPECTS USING LINE PROBE ASSAY

Objective: GenoType MTBDRplus line probe assay (LPA) is developed for performing drug susceptibility testing (DST) for Rifampicin (RIF) and isoniazid in sputum specimens from smear-positive pulmonary tuberculosis (TB) patients and revised national TB control Programme (RNTCP) has endorsed LPA for the diagnosis of multi drug resistant TB (MDR-TB). This study was conducted to assess the potential utility of LPA for MDR-TB patient management.Methods: MDR-TB suspects under RNTCP PMDT criteria C referred from different districts in Delhi state were included in the study January 2013 toDecember 2014. Sputum specimens found acid-fast bacilli positive by fluorescent microscopy were processed for LPA.Results: Out of 3062 specimens, 2055 (67.1%) MDR-TB suspects were read as positive and specimens from 1007 (32.9%) suspects were read as negative in sputum smear microscopy. Out of 2019 specimens valid LPA results, 1427 were found to be pan-sensitive, 280 were MDR-TB, 40 were RIF monoresistant, 183 were Isoniazid (INH) monoresistant, and 89 specimens were found negative for Mycobacterium tuberculosis.Conclusion: Routine use of LPA can substantially reduce the time to diagnosis of RIF and/or INH-resistant TB and can hence potentially enable earlier commencement of appropriate drug therapy and thereby facilitate prevention of further transmission of drug resistant strains.Keywords: Multi drug resistant tuberculosis, Line probe assay, Rifampicin, Isoniazid

Productivity and profitability of drip fertigated wheat (Triticum aestivum) – mungbean (Vigna radiata) – maize (Zea mays) cropping system

An experiment was conducted at the research farm of ICAR-Indian Agricultural Research Institute, New Delhi during 2019–20 and 2020–21 to study the productivity and economic viability of wheat (Triticum aestivum L.)– mungbean (Vigna radiata (L.) R. Wilczek)–maize (Zea mays L.) fertigated with 0, 60, 80, 100% recommended doses of NPK and irrigated at 0.6 and 0.8 crop evapotranspiration (ETc) through subsurface (SSDI) and surface drip irrigation (SDI). The results were compared with the conventional practice of surface irrigation and soil application of 100% recommended doses of NPK. Grain yields of wheat, mungbean, maize and system wheat equivalent yield (SWEY) improved by 22.9, 7.2, 21.9 and 19.4%, respectively with increase in NPK fertigation doses from 60 to 100% and by 15.6, 9.2, 4.9 and 9.7% with the increase in irrigation frequency from 0.6 to 0.8 ETc. However, SDI and SSDI had equal system productivity (12.48 and 12.85 Mg/ha). The SWEY at 0.8ETc fertigated either with NPK80 or NPK100 was statistically at par (14.2–15.9 Mg/ha) with the conventional practice (14.3–15.2 Mg/ha). The cash inflow, net income and benefit cost ratio (BCR) of the cropping system also increased successively with increase in fertigation doses and irrigation frequency. The net income and BCR followed the order maize>wheat>mungbean. The net income under SSDI at 0.8 ETc with NPK80 or NPK100 in wheat, mungbean, maize and system was 11–13, 88–105, 1-9 and 8–14% higher than the conventional practice. At 0.8 ETc and NPK100, BCR in SSDI (1.86) was higher than in SDI (1.71) and conventional system (1.67).

Temporal characterization of biogas slurry: a pre-requisite for sustainable nutrigation in crop production

Biogas slurry serves as a useful organic fertilizer due to its substantial nutrient content, and its characterization enables the evaluation of nutrient content and its efficient utilization. This study focuses on the variations in the nutrient content of biogas slurry from different dairy farm systems located near the ICAR-Indian Agricultural Research Institute (IARI) (New Delhi), Daryapur Kalan (New Delhi), and Madanpur (Uttar Pradesh) during the pre-monsoon, monsoon, and post-monsoon seasons. The study reveals significant variations in macronutrient levels, particularly nitrogen (N), which showed variations exceeding 3% and a wider range of almost 6% during the pre-monsoon and post-monsoon periods. Spatial differences between dairy farms also contributed to the variance, with more than 10% differences observed between IARI and Daryapur Kalan and between IARI and Madanpur. Phosphorus (P) remained stable across seasons with spatial variation, while potassium (K) exhibited a reverse trend. Correlation analysis highlighted strong positive associations between N content and phosphorus (0.959), organic carbon (0.954), pH (0.813), and electrical conductivity (0.806). The findings suggest the use of biogas slurry has a potential to reduce the synthetic fertilizer consumption of N, P, and K by approximately 8.78%, 11.01%, and 14.33%, respectively and using them for further for nutrigation

Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma

Treatment of metastatic renal cell carcinoma (mRCC) with agents that block signaling through vascular endothelial growth factor receptor 2 (VEGFR2) induces disease regression or stabilization in some patients; however, these responses tend to be short-lived. Therefore, development of combination therapies that can extend the efficacy of VEGFR antagonists in mRCC remains a priority. We studied murine xenograft models of RCC that become refractory to treatment with the VEGFR tyrosine kinase inhibitor (TKI) sunitinib. Dalantercept is a novel antagonist of Activin receptor-like kinase 1 (ALK1)/Bone morphogenetic protein (BMP) 9 signaling. Dalantercept inhibited growth in the murine A498 xenograft model which correlated with hyperdilation of the tumor vasculature and an increase in tumor hypoxia. When combined with sunitinib, dalantercept induced tumor necrosis and prevented tumor regrowth and revascularization typically seen with sunitinib monotherapy in two RCC models. Combination therapy led to significant downregulation of angiogenic genes as well as downregulation of endothelial specific gene expression particularly of the Notch signaling pathway. We demonstrate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 and VEGFR, is a valid strategy for treatment of mRCC. At the molecular level, combination therapy leads to downregulation of Notch signaling

Sensor-based precision nutrient and irrigation management enhances the physiological performance, water productivity, and yield of soybean under system of crop intensification

Sensor-based decision tools provide a quick assessment of nutritional and physiological health status of crop, thereby enhancing the crop productivity. Therefore, a 2-year field study was undertaken with precision nutrient and irrigation management under system of crop intensification (SCI) to understand the applicability of sensor-based decision tools in improving the physiological performance, water productivity, and seed yield of soybean crop. The experiment consisted of three irrigation regimes [I1: standard flood irrigation at 50% depletion of available soil moisture (DASM) (FI), I2: sprinkler irrigation at 80% ETC (crop evapo-transpiration) (Spr 80% ETC), and I3: sprinkler irrigation at 60% ETC (Spr 60% ETC)] assigned in main plots, with five precision nutrient management (PNM) practices{PNM1-[SCI protocol], PNM2-[RDF, recommended dose of fertilizer: basal dose incorporated (50% N, full dose of P and K)], PNM3-[RDF: basal dose point placement (BDP) (50% N, full dose of P and K)], PNM4-[75% RDF: BDP (50% N, full dose of P and K)] and PNM5-[50% RDF: BDP (50% N, full P and K)]} assigned in sub-plots using a split-plot design with three replications. The remaining 50% N was top-dressed through SPAD assistance for all the PNM practices. Results showed that the adoption of Spr 80% ETC resulted in an increment of 25.6%, 17.6%, 35.4%, and 17.5% in net-photosynthetic rate (Pn), transpiration rate (Tr), stomatal conductance (Gs), and intercellular CO2 concentration (Ci), respectively, over FI. Among PNM plots, adoption of PNM3 resulted in a significant (p=0.05) improvement in photosynthetic characters like Pn (15.69 µ mol CO2 m−2 s−1), Tr (7.03 m mol H2O m−2 s−1), Gs (0.175 µmol CO2 mol−1 year−1), and Ci (271.7 mol H2O m2 s−1). Enhancement in SPAD (27% and 30%) and normalized difference vegetation index (NDVI) (42% and 52%) values were observed with nitrogen (N) top dressing through SPAD-guided nutrient management, helped enhance crop growth indices, coupled with better dry matter partitioning and interception of sunlight. Canopy temperature depression (CTD) in soybean reduced by 3.09–4.66°C due to adoption of sprinkler irrigation. Likewise, Spr 60% ETc recorded highest irrigation water productivity (1.08 kg ha−1 m−3). However, economic water productivity (27.5 INR ha−1 m−3) and water-use efficiency (7.6 kg ha−1 mm−1 day−1) of soybean got enhanced under Spr 80% ETc over conventional cultivation. Multiple correlation and PCA showed a positive correlation between physiological, growth, and yield parameters of soybean. Concurrently, the adoption of Spr 80% ETC with PNM3 recorded significantly higher grain yield (2.63 t ha−1) and biological yield (8.37 t ha−1) over other combinations. Thus, the performance of SCI protocols under sprinkler irrigation was found to be superior over conventional practices. Hence, integrating SCI with sensor-based precision nutrient and irrigation management could be a viable option for enhancing the crop productivity and enhance the resource-use efficiency in soybean under similar agro-ecological regions

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODErn), to generate cause fractions and cause specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings At the broadest grouping of causes of death (Level 1), non-communicable diseases (NC Ds) comprised the greatest fraction of deaths, contributing to 73.4% (95% uncertainty interval [UI] 72.5-74.1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional (CMNN) causes accounted for 186% (17.9-19.6), and injuries 8.0% (7.7-8.2). Total numbers of deaths from NCD causes increased from 2007 to 2017 by 22.7% (21.5-23.9), representing an additional 7.61 million (7. 20-8.01) deaths estimated in 2017 versus 2007. The death rate from NCDs decreased globally by 7.9% (7.08.8). The number of deaths for CMNN causes decreased by 222% (20.0-24.0) and the death rate by 31.8% (30.1-33.3). Total deaths from injuries increased by 2.3% (0-5-4-0) between 2007 and 2017, and the death rate from injuries decreased by 13.7% (12.2-15.1) to 57.9 deaths (55.9-59.2) per 100 000 in 2017. Deaths from substance use disorders also increased, rising from 284 000 deaths (268 000-289 000) globally in 2007 to 352 000 (334 000-363 000) in 2017. Between 2007 and 2017, total deaths from conflict and terrorism increased by 118.0% (88.8-148.6). A greater reduction in total deaths and death rates was observed for some CMNN causes among children younger than 5 years than for older adults, such as a 36.4% (32.2-40.6) reduction in deaths from lower respiratory infections for children younger than 5 years compared with a 33.6% (31.2-36.1) increase in adults older than 70 years. Globally, the number of deaths was greater for men than for women at most ages in 2017, except at ages older than 85 years. Trends in global YLLs reflect an epidemiological transition, with decreases in total YLLs from enteric infections, respirator}, infections and tuberculosis, and maternal and neonatal disorders between 1990 and 2017; these were generally greater in magnitude at the lowest levels of the Socio-demographic Index (SDI). At the same time, there were large increases in YLLs from neoplasms and cardiovascular diseases. YLL rates decreased across the five leading Level 2 causes in all SDI quintiles. The leading causes of YLLs in 1990 neonatal disorders, lower respiratory infections, and diarrhoeal diseases were ranked second, fourth, and fifth, in 2017. Meanwhile, estimated YLLs increased for ischaemic heart disease (ranked first in 2017) and stroke (ranked third), even though YLL rates decreased. Population growth contributed to increased total deaths across the 20 leading Level 2 causes of mortality between 2007 and 2017. Decreases in the cause-specific mortality rate reduced the effect of population growth for all but three causes: substance use disorders, neurological disorders, and skin and subcutaneous diseases. Interpretation Improvements in global health have been unevenly distributed among populations. Deaths due to injuries, substance use disorders, armed conflict and terrorism, neoplasms, and cardiovascular disease are expanding threats to global health. For causes of death such as lower respiratory and enteric infections, more rapid progress occurred for children than for the oldest adults, and there is continuing disparity in mortality rates by sex across age groups. Reductions in the death rate of some common diseases are themselves slowing or have ceased, primarily for NCDs, and the death rate for selected causes has increased in the past decade. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.Peer reviewe