Equivalence between the real time Feynman histories and the quantum shutter approaches for the "passage time" in tunneling

We show the equivalence of the functions $G_{\rm p}(t)$ and $|\Psi(d,t)|^2$ for the ``passage time'' in tunneling. The former, obtained within the framework of the real time Feynman histories approach to the tunneling time problem, using the Gell-Mann and Hartle's decoherence functional, and the latter involving an exact analytical solution to the time-dependent Schr\"{o}dinger equation for cutoff initial waves

Syzygies in equivariant cohomology for non-abelian Lie groups

We extend the work of Allday-Franz-Puppe on syzygies in equivariant cohomology from tori to arbitrary compact connected Lie groups G. In particular, we show that for a compact orientable G-manifold X the analogue of the Chang-Skjelbred sequence is exact if and only if the equivariant cohomology of X is reflexive, if and only if the equivariant Poincare pairing for X is perfect. Along the way we establish that the equivariant cohomology modules arising from the orbit filtration of X are Cohen-Macaulay. We allow singular spaces and introduce a Cartan model for their equivariant cohomology. We also develop a criterion for the finiteness of the number of infinitesimal orbit types of a G-manifold.Comment: 28 pages; minor change

Information measures and classicality in quantum mechanics

We study information measures in quantu mechanics, with particular emphasis on providing a quantification of the notions of classicality and predictability. Our primary tool is the Shannon - Wehrl entropy I. We give a precise criterion for phase space classicality and argue that in view of this a) I provides a measure of the degree of deviation from classicality for closed system b) I - S (S the von Neumann entropy) plays the same role in open systems We examine particular examples in non-relativistic quantum mechanics. Finally, (this being one of our main motivations) we comment on field classicalisation on early universe cosmology.Comment: 35 pages, LATE

Planar N=4 Gauge Theory and the Hubbard Model

Recently it was established that a certain integrable long-range spin chain describes the dilatation operator of N=4 gauge theory in the su(2) sector to at least three-loop order, while exhibiting BMN scaling to all orders in perturbation theory. Here we identify this spin chain as an approximation to an integrable short-ranged model of strongly correlated electrons: The Hubbard model.Comment: 35 pages, 2 figures; v2: typos and references fixed, published versio

Consistent histories of systems and measurements in spacetime

Traditional interpretations of quantum theory in terms of wave function collapse are particularly unappealing when considering the universe as a whole, where there is no clean separation between classical observer and quantum system and where the description is inherently relativistic. As an alternative, the consistent histories approach provides an attractive "no collapse" interpretation of quantum physics. Consistent histories can also be linked to path-integral formulations that may be readily generalized to the relativistic case. A previous paper described how, in such a relativistic spacetime path formalism, the quantum history of the universe could be considered to be an eignestate of the measurements made within it. However, two important topics were not addressed in detail there: a model of measurement processes in the context of quantum histories in spacetime and a justification for why the probabilities for each possible cosmological eigenstate should follow Born's rule. The present paper addresses these topics by showing how Zurek's concepts of einselection and envariance can be applied in the context of relativistic spacetime and quantum histories. The result is a model of systems and subsystems within the universe and their interaction with each other and their environment.Comment: RevTeX 4; 37 pages; v2 is a revision in response to reviewer comments, connecting the discussion in the paper more closely to consistent history concepts; v3 has minor editorial corrections; accepted for publication in Foundations of Physics; v4 has a couple minor typographical correction

An Extended Technicolor Model

An extended technicolor model is constructed. Quark and lepton masses, spontaneous CP violation, and precision electroweak measurements are discussed. Dynamical symmetry breaking is analyzed using the concept of the BIG MAC.Comment: 35 pages, Latex, YCTP-P21-93, BUHEP-93-2

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favours pro- or anti-inflammatory CD4+ T cell responses. Using selective gene ablation of MHC II in IECs and IEC organoid cultures, we assessed the impact of MHC II expression by IECs on CD4+ T cell responses and disease outcomes in response to enteric bacterial pathogens. We found that intestinal bacterial infections elicit inflammatory cues that greatly increase expression of MHC II processing and presentation molecules in colonic IECs. Whilst IEC MHC II expression had little impact on disease severity following Citrobacter rodentium or Helicobacter hepaticus infection, using a colonic IEC organoid-CD4+ T cell co-culture system, we demonstrate that IECs can activate antigen-specific CD4+ T cells in an MHC II-dependent manner, modulating both regulatory and effector Th cell subsets. Furthermore, we assessed adoptively transferred H. hepaticus-specific CD4+ T cells during intestinal inflammation in vivo and report that IEC MHC II expression dampens pro-inflammatory effector Th cells. Our findings indicate that IECs can function as non-conventional antigen presenting cells and that IEC MHC II expression fine-tunes local effector CD4+ T cell responses during intestinal inflammation

Clustering Algorithms: Their Application to Gene Expression Data

Gene expression data hide vital information required to understand the biological process that takes place in a particular organism in relation to its environment. Deciphering the hidden patterns in gene expression data proffers a prodigious preference to strengthen the understanding of functional genomics. The complexity of biological networks and the volume of genes present increase the challenges of comprehending and interpretation of the resulting mass of data, which consists of millions of measurements; these data also inhibit vagueness, imprecision, and noise. Therefore, the use of clustering techniques is a first step toward addressing these challenges, which is essential in the data mining process to reveal natural structures and iden-tify interesting patterns in the underlying data. The clustering of gene expression data has been proven to be useful in making known the natural structure inherent in gene expression data, understanding gene functions, cellular processes, and subtypes of cells, mining useful information from noisy data, and understanding gene regulation. The other benefit of clustering gene expression data is the identification of homology, which is very important in vaccine design. This review examines the various clustering algorithms applicable to the gene expression data in order to discover and provide useful knowledge of the appropriate clustering technique that will guarantee stability and high degree of accuracy in its analysis procedure

AD51B in Familial Breast Cancer

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11–1.19, P = 8.88 x 10−16) and among familial cases (OR: 1.24, 95% CI: 1.16–1.32, P = 6.19 x 10−11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk