Centralized and Modular Architectures for Photovoltaic Panels with Improved Efficiency: Preprint

The most common type of photovoltaic installation in residential applications is the centralized architecture, but the performance of a centralized architecture is adversely affected when it is subject to partial shading effects due to clouds or surrounding obstacles, such as trees. An alternative modular approach can be implemented using several power converters with partial throughput power processing capability. This paper presents a detailed study of these two architectures for the same throughput power level and compares the overall efficiencies using a set of rapidly changing real solar irradiance data collected by the Solar Radiation Research Laboratory at the National Renewable Energy Laboratory

IoT Smart Parking System Based on the Visual-Aided Smart Vehicle Presence Sensor: SPIN-V

Humanity is currently experiencing one of the short periods of transition thanks to novel sensing solutions for smart cities that bring the future to today. Overpopulation of cities demands the development of solid strategic plannings that uses infrastructure, innovation, and technology to adapt to rapid changes. To improve mobility in cities with a larger and larger vehicle fleet, a novel sensing solution that is the cornerstone of a smart parking system, the smart vehicular presence sensor (SPIN-V, in its Spanish abbreviation), is presented. The SPIN-V is composed of a small single-board computer, distance sensor, camera, LED indicator, buzzer, and battery and devoted to obtain the status of a parking space. This smart mobility project involves three main elements, namely the SPIN-V, a mobile application, and a monitoring center, working together to monitor, control, process, and display the parking space information in real-time to the drivers. In addition, the design and implementation of the three elements of the complete architecture are presented.ITESO, A.C

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana. Whereas the deletion had no obvious effect on cultured promastigote forms of the parasite, the Δtkt cells were not infective to mice. Δtkt promastigotes were more susceptible to oxidative stress and various leishmanicidal drugs than wild-type, and metabolomics analysis revealed profound changes to metabolism in these cells. In addition to changes consistent with those directly related to the role of TKT in the PPP, central carbon metabolism was substantially decreased, the cells consumed significantly less glucose, flux through glycolysis diminished, and production of the main end products of metabolism was decreased. Only minor changes in RNA abundance from genes encoding enzymes in central carbon metabolism, however, were detected although fructose-1,6-bisphosphate aldolase activity was decreased two-fold in the knock-out cell line. We also showed that the dual localisation of TKT between cytosol and glycosomes is determined by the C-terminus of the enzyme and by engineering different variants of the enzyme we could alter its sub-cellular localisation. However, no effect on the overall flux of glucose was noted irrespective of whether the enzyme was found uniquely in either compartment, or in both

Current and prospective pharmacological targets in relation to antimigraine action

Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

A globally convergent wind speed estimator for wind turbine systems

International audienceAn estimator of the wind speed of a wind turbine coupled to a generator is proposed in this paper. Wind speed enters into the generator dynamics through a highly nonlinear function; hence, we are confronted with a difficult problem of estimation of a nonlinearly parameterized system. To solve this problem, we use the technique of immersion and invariance, recently introduced in the literature. It is assumed that the rotor speed and electrical torque of the generator are measured, which is the case for the machines typically used in this application. The result is of interest for the design of controllers of maximum power extraction, where the knowledge of the wind speed is necessary to express the control objective as a speed tracking problem. Detailed computer simulations are presented to assess the performance of the proposed estimator

A Neural Network-Based Low-Cost Solar Irradiance Sensor

Measuring solar irradiance allows for direct maximization of the efficiency in photovoltaic power plants. However, devices for solar irradiance sensing, such as pyranometers and pyrheliometers, are expensive and difficult to calibrate and thus seldom utilized in photovoltaic power plants. Indirect methods are instead implemented in order to maximize efficiency. This paper proposes a novel approach for solar irradiance measurement based on neural networks, which may, in turn, be used to maximize efficiency directly. An initial estimate suggests the cost of the sensor proposed herein may be price competitive with other inexpensive solutions available in the market, making the device a good candidate for large deployment in photovoltaic power plants. The proposed sensor is implemented through a photovoltaic cell, a temperature sensor, and a low– cost microcontroller. The use of a microcontroller allows for easy calibration, updates, and enhancement by simply adding code libraries. Furthermore, it can be interfaced via standard communication means with other control devices; integrated into control schemes; and remote–controlled through its embedded web server. The proposed approach is validated through experimental prototyping and compared against a commercial device

Reduced–Form of the Photovoltaic Five–parameter Model for Efficient Computation of Parameters

"This brief note presents a reduced–form of the five–parameter model introduced. by Desoto et al. (2006) and subsequently generalized by Tian et al.. (2012). The five–parameter model computes five reference parameters utilized. to synthesize performance curves in photovoltaic panels from information. available in datasheets. The improvement resulting from the reduced–. form is two–fold: (i ) the model is reduced from five to two parameters and. (ii ) as a result of (i ) a domain of attraction of the solution space is defined. analytically, which guarantees nonlinear solvers will provide the correct, that. is, physically feasible, solution for the parameters at first launch.

Static and dynamic first hyperpolarizabilities from time-dependent auxiliary density perturbation theory

The aim of this paper is to present reconfiguration schemes for a 3-Level Neutral Point-Clamped 48-pulse Static Synchronous Series Compensator under unconventional operating conditions, e.g. operation with an incomplete topology or a system unbalance. Combinations of converter modules that generate suitable injection voltages for both conditions are obtained. Calculation of the conduction times for each module minimizes voltage harmonics when one of them fails. Moreover, line-frequency and Pulse Width Modulated switched modules are combined when an unbalanced condition is detected. Simulations are carried out that confirm the validity of the proposal. " 2014 IEEE.",,,,,,"10.1109/ROPEC.2014.7036329",,,"http://hdl.handle.net/20.500.12104/44735","http://www.scopus.com/inward/record.url?eid=2-s2.0-84925250115&partnerID=40&md5=053704b136ba9f6cb7aa7393ac4bb147",,,,,,,,"2014 IEEE International Autumn Meeting on Power, Electronics and Computing, ROPEC 2014",,,,,,"Scopus",,,,,,"faulted converter; THD; unbalanced operation",,,,,,"Static synchronous series compensator for active power flow control during unconventional operating conditions",,"Conference Paper" "46509","123456789/35008",,,,"Scopu