Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Ectopic infraorbital nerve in a maxillary sinus septum: Another potentially dangerous variant for sinus surgery

We report on two patients with ectopic infraorbital nerve and canal located in a maxillary sinus septum. This very rare anatomic variation may possibly generate complications during sinus surgery if it passes unnoticed during the preoperative CT work-up

Exceptional Extension of Benign Angiomyolipoma in the Renal Vein.

TEACHING POINT: When a renal angiomyolipoma (AML) is incidentally detected on imaging, the venous system should be assessed for intravascular fat component

Retrodural cysts bridging a bilateral lumbar spondylolysis: a report of two symptomatic cases

We report the MR features in two patients presenting with symptomatic thecal impingement by posterior epidural cysts linking a bilateral lumbar spondylolysis. Large fluid-filled channels bridging the ruptured partes interarticulares were present in spite of the absence of significant arthritic changes within the adjacent facet joints

A specific database for providing local and national level of integration of clinical data in cystic fibrosis

It has recently been stated that a database is an essential tool in the management of CF. The purpose of this work is to create a specific database allowing optimal performance of storage, search and retrieval functions on patients with CF. A specific database was developed using a Windev licence, for application via Microsoft supported platforms or Intranet system. The database allows real-time point of care data management of medical, investigational and administrative data. It is currently being used in the 6 Belgian reference centres. It represents a useful tool for gathering information on routine clinical and lab data, bacteriology, treatments, complications and specific outcomes for clinical and research purposes. The ongoing evolution of the database includes enhancements toward research data orientation including comparison of patient data between different centres and completeness of the National CF registry questionnaire. A complimentary copy of the software can be provided to multidisciplinary accredited CF centres worldwide upon request

Exclusive percutaneous approach for surgical transaortic transcatheter valve replacement

Direct transaortic implantation (TAo) has been described as a new alternative approach for transcatheter aortic valve implantation in patients with unsuitable transfemoral access. TAo is usually achieved through an upper ministernotomy or, more recently, through a right thoracotomy in the second intercostal space. We describe here our first experience with a fully thoracoscopic approach that allowed successful deployment of a 23-mm Edwards SAPIEN valve

Are subject-specific connectomics the key for understanding clinical outcomes in children with unilateral cerebral palsy?

status: publishe