O destino da casa do Visconde

A pesquisa investiga as representações construídas sobre o edifício do Colégio Nossa Senhora de Lourdes na imprensa periódica, indagando como a ideia de patrimônio é aí formada. Instalado na casa do Visconde de Ouro Preto em 1922, no bairro de Vila Isabel, Rio de Janeiro, o Colégio mantém-se até hoje no mesmo local, atendendo estudantes de setores médios da população. Compondo uma pesquisa maior, os resultados aqui apresentados respondem às seguintes questões: como o espaço e as construções do Colégio apareciam na imprensa? Quais as ideias de patrimônio aí veiculadas? Para isso, recorremos à catalogação das ocorrências encontradas na Hemeroteca Digital da Biblioteca Nacional, sua leitura e análise ancorada nos conceitos de materialidade escolar, patrimônio e território

Device for the Evaluation of Carotid Arterial Pressure Based on IoT and 3D-Printing: uFISIO

El análisis de la forma de onda de presión aórtica central (PAC) permite un seguimiento más específico de patologías tales como la hipertensión arterial, la enfermedad coronaria y la diabetes. Se diseñó un dispositivo inalámbrico, portátil y ergonómico (uFISIO) para realizar evaluaciones morfológicas de la presión de la arteria carótida (PACar), que está estrechamente vinculada al comportamiento de la PAC. La forma de onda PACar fue adquirida por la técnica de tonometría de aplanamiento y enviada a un nodo central de una red inalámbrica local, para ser procesada en un dispositivo móvil. Los resultados fueron posteriormente transmitidos a un servidor central, en virtud del concepto 'Internet de las Cosas' (IoT). Complementariamente se utilizó tecnología de impresión 3D, para el desarrollo del diseño. El dispositivo fue probado en 6 individuos jóvenes, donde fueron evaluados parámetros morfológicos de PCar tales como el factor de forma, índice de aumento, tiempos característicos e integrales temporales a través de la aplicación móvil. Las formas de onda fueron adquiridas, transmitidas, procesadas y almacenadas adecuadamente, obteniendo valores de acuerdo con publicaciones anteriores. El dispositivo mostró versatilidad y confortabilidad en su utilización para evaluar PACar, así como para la gestión de la información resultante. Se requieren estudios futuros para determinar su aplicabilidad clínica, especialmente en diferentes grupos etarios.Pulse wave analysis of central aortic pressure waveform (CAP) allows a detailed follow-up of pathologies such as hypertension, coronary artery disease and diabetes. A wireless, portable and ergonomic device (uFISIO) was designed to perform morphological evaluations of carotid artery pressure (APCar), which is closely linked to CAP behavior. APCar waveform was acquired by the applanation tonometry technique and sent to a hub node of a local wireless network, in order to be processed in a mobile device. The results were posteriorly transmitted to a central server, in virtue of the ‘Internet of Things’ (IoT) concept. 3D printing technology was also used to develop the design. The device was tested in 6 young individuals, where APCar morphological parameters such as form factor, augmentation index, characteristic times and temporal integrals were assessed by the mobile application. Waveforms were acquired, transmitted, processed and stored adequately, obtaining values in agreement with previous publications. The device showed versatility and comfortability in its use for APCar evaluation, as well as for the management of the resulting information. Future studies are required to determine its clinical applicability, especially in different age groups.Fil: De Luca, Martín A.. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; ArgentinaFil: Cymberknop, Leandro Javier. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; ArgentinaFil: Meyer, Iván. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; ArgentinaFil: Percunte, Maia Daniela. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; ArgentinaFil: Chatterjee, Parag. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; ArgentinaFil: Arbeitman, Claudia Roxana. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Armentano, Ricardo Luis. Universidad Tecnologica Nacional. Facultad Regional Buenos Aires. Grupo de Investigacion y Desarrollo En Bioingenieria.; Argentin

Anticoagulação em grávidas com valva metálica : Anticoagulation in pregnant women with metallic valve

Este artigo analisou a produção científica sobre mulheres grávidas portadoras de Válvula Cardíaca Mecânica (VCM), que necessitam fazer o uso de anticoagulação, considerando as melhores opções terapêuticas, baseado no risco do uso de cada droga durante a gestação. A gravidez gera um estado de hipercoagulabilidade, que atrelado ao material sintético da prótese cardíaca, aumenta a chance de formação de trombo em relação às mulheres não grávidas. A literatura indica a possibilidade da utilização de Antagonista da Vitamina K (AVK) e Heparina de Baixo Peso Molecular (HBPM), tendo o AVK menos efeitos adversos na gestação. Porém, é aceito que o uso de heparina deve ser preconizado no primeiro trimestre de gestação, devido à possibilidade do AVK transpor a barreira placentária e gerar danos ao feto. Os resultados apontam a necessidade de adequação e monitorização da terapêutica desde o primeiro trimestre até o parto, conforme o impacto do fármaco em cada período gestacional. Apesar de haver um consenso sobre a necessidade das drogas, há discussão em relação aos riscos do uso na gestação, pois a incidência de efeitos adversos ainda é considerável

Expansion of activated regulatory T cells inversely correlates with clinical severity in septic neonates.

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Antimicrobial Prophylaxis for Urologic Procedures in Paediatric Patients: A RAND/UCLA Appropriateness Method Consensus Study in Italy

The main aim of surgical antimicrobial prophylaxis (SAP) in urologic procedures is to prevent bacteraemia, surgical site infections (SSIs), and postoperative urinary tract infections (ppUTIs). Guidelines for SAP in paediatric urology are lacking. Only some aspects of this complex topic have been studied, and the use of antibiotic prophylaxis prior to surgical procedures seems to be more often linked to institutional schools of thought or experts' opinions than to rules dictated by studies demonstrating the most correct and preferred management. Therefore, the aim of this Consensus document realized using the RAND/UCLA appropriateness method is to provide clinicians with a series of recommendations on SAP for the prevention of bacteraemia, SSIs, and ppUTIs after urologic imaging and surgical procedures in paediatric patients. Despite the few available studies, experts agree on some basilar concepts related to SAP for urologic procedures in paediatric patients. Before any urological procedure is conducted, UTI must be excluded. Clean procedures do not require SAP, with the exception of prosthetic device implantation and groin and perineal incisions where the SSI risk may be increased. In contrast, SAP is needed in clean-contaminated procedures. Studies have also suggested the safety of eliminating SAP in paediatric hernia repair and orchiopexy. To limit the emergence of resistance, every effort to reduce and rationalize antibiotic consumption for SAP must be made. Increased use of antibiotic stewardship can be greatly effective in this regard

Two Brothers with Atypical UNC13D-Related Hemophagocytic Lymphohistiocytosis Characterized by Massive Lung and Brain Involvement

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory condition. Variants in different genes have been associated with the familial forms of the syndrome (FHL), usually presenting within the first 2 years of life. Due to increasing awareness of the signs and symptoms of HLH and a better understanding of the genetic basis of the disease, FHL has been increasingly diagnosed in patients presenting beyond infancy. Here, we report on two brothers with atypical, late-onset HLH in which whole exome sequencing revealed a homozygous pathogenic UNC13D variant. In the first brother, the clinical phenotype was dominated by a massive lung involvement. In the second brother a progressive neurological deterioration was observed. In both cases, the clinical manifestations at symptom onset were misleading, making the diagnosis difficult to achieve. This report expands the spectrum of clinical presentations of FLH3. Moreover, it highlights the importance to warn clinicians to keep a high level of suspicion in patients presenting with fever, cytopenia, splenomegaly of unknown origin, and unresponsiveness to conventional treatment even beyond early childhood. Moreover, this report emphasizes that insidious neurologic symptoms may represent the initial or sole presenting sign of FHL, even in the absence of peripheral signs of activation

XIPE: the X-ray Imaging Polarimetry Explorer

X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017 but not selected. XIPE is composed of two out of the three existing JET-X telescopes with two Gas Pixel Detectors (GPD) filled with a He-DME mixture at their focus and two additional GPDs filled with pressurized Ar-DME facing the sun. The Minimum Detectable Polarization is 14 % at 1 mCrab in 10E5 s (2-10 keV) and 0.6 % for an X10 class flare. The Half Energy Width, measured at PANTER X-ray test facility (MPE, Germany) with JET-X optics is 24 arcsec. XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil).Comment: 49 pages, 14 figures, 6 tables. Paper published in Experimental Astronomy http://link.springer.com/journal/1068

Chemical evolution in Sersic 159-03 observed with XMM-Newton

Using a new long X-ray observation of the cluster of galaxies Sersic 159-03 with XMM-Newton, we derive radial temperature and abundance profiles using single- and multi-temperature models. The fits to the EPIC and RGS spectra prefer multi-temperature models especially in the core. The radial profiles of oxygen and iron measured with EPIC/RGS and the line profiles in RGS suggest that there is a dip in the O/Fe ratio in the centre of the cluster compared to its immediate surroundings. A possible explanation for the large scale metallicity distribution is that SNIa and SNII products are released in the ICM through ram-pressure stripping of in-falling galaxies. This causes a peaked metallicity distribution. In addition, SNIa in the central cD galaxy enrich mainly the centre of the cluster with iron. This excess of SNIa products is consistent with the low O/Fe ratio we detect in the centre of the cluster. We fit the abundances we obtain with yields from SNIa, SNII and Population-III stars to derive the clusters chemical evolution. We find that the measured abundance pattern does not require a Population-III star contribution. The relative contribution of the number of SNIa with respect to the total number of SNe which enrich the ICM is about 25-50%. Furthermore, we discuss the possible presence of a non-thermal component in the EPIC spectra. A potential source of this non-thermal emission can be inverse-Compton scattering between Cosmic Microwave Background (CMB) photons and relativistic electrons, which are accelerated in bow shocks associated with ram-pressure stripping of in-falling galaxies.Comment: 18 pages, 11 figures, Accepted for publication in Astronomy & Astrophysic