2,482 research outputs found
Meiosis in Budding Yeast
Meiosis is a specialized cell division program that is essential for sexual reproduction. The two meiotic divisions reduce chromosome number by half, typically generating haploid genomes that are packaged into gametes. To achieve this ploidy reduction, meiosis relies on highly unusual chromosomal processes including the pairing of homologous chromosomes, assembly of the synaptonemal complex, programmed formation of DNA breaks followed by their processing into crossovers, and the segregation of homologous chromosomes during the first meiotic division. These processes are embedded in a carefully orchestrated cell differentiation program with multiple interdependencies between DNA metabolism, chromosome morphogenesis, and waves of gene expression that together ensure the correct number of chromosomes is delivered to the next generation. Studies in the budding yeast Saccharomyces cerevisiae have established essentially all fundamental paradigms of meiosis-specific chromosome metabolism and have uncovered components and molecular mechanisms that underlie these conserved processes. Here, we provide an overview of all stages of meiosis in this key model system and highlight how basic mechanisms of genome stability, chromosome architecture, and cell cycle control have been adapted to achieve the unique outcome of meiosis
Searching for the expelled hydrogen envelope in Type I supernovae via late-time H-alpha emission
We report the first results from our long-term observational survey aimed at
discovering late-time interaction between the ejecta of hydrogen-poor Type I
supernovae and the hydrogen-rich envelope expelled from the progenitor star
several decades/centuries before explosion. The expelled envelope, moving with
a velocity of ~10 -- 100 km s, is expected to be caught up by the
fast-moving SN ejecta several years/decades after explosion depending on the
history of the mass-loss process acting in the progenitor star prior to
explosion. The collision between the SN ejecta and the circumstellar envelope
results in net emission in the Balmer-lines, especially in H-alpha. We look for
signs of late-time H-alpha emission in older Type Ia/Ibc/IIb SNe having
hydrogen-poor ejecta, via narrow-band imaging. Continuum-subtracted H-alpha
emission has been detected for 13 point sources: 9 SN Ibc, 1 SN IIb and 3 SN Ia
events. Thirty-eight SN sites were observed on at least two epochs, from which
three objects (SN 1985F, SN 2005kl, SN 2012fh) showed significant temporal
variation in the strength of their H-alpha emission in our DIAFI data. This
suggests that the variable emission is probably not due to nearby H II regions
unassociated with the SN, and hence is an important additional hint that
ejecta-CSM interaction may take place in these systems. Moreover, we
successfully detected the late-time H-alpha emission from the Type Ib SN 2014C,
which was recently discovered as a strongly interacting SN in various (radio,
infrared, optical and X-ray) bands.Comment: 8 pages, 7 figures, accepted in Ap
A Dedicated M-Dwarf Planet Search Using The Hobby-Eberly Telescope
We present first results of our planet search program using the 9.2 meter
Hobby-Eberly Telescope (HET) at McDonald Observatory to detect planets around
M-type dwarf stars via high-precision radial velocity (RV) measurements.
Although more than 100 extrasolar planets have been found around solar-type
stars of spectral type F to K, there is only a single M-dwarf (GJ 876, Delfosse
et al. 1998; Marcy et al. 1998; Marcy et al. 2001) known to harbor a planetary
system. With the current incompleteness of Doppler surveys with respect to
M-dwarfs, it is not yet possible to decide whether this is due to a fundamental
difference in the formation history and overall frequency of planetary systems
in the low-mass regime of the Hertzsprung-Russell diagram, or simply an
observational bias. Our HET M-dwarf survey plans to survey 100 M-dwarfs in the
next 3 to 4 years with the primary goal to answer this question. Here we
present the results from the first year of the survey which show that our
routine RV-precision for M-dwarfs is 6 m/s. We found that GJ 864 and GJ 913 are
binary systems with yet undetermined periods, while 5 out of 39 M-dwarfs reveal
a high RV-scatter and represent candidates for having short-periodic planetary
companions. For one of them, GJ 436 (rms = 20.6 m/s), we have already obtained
follow-up observations but no periodic signal is present in the RV-data.Comment: 12 pages, 14 figures, accepted for publication in the Astronomical
Journa
Phylogenetic reclassification of vertebrate melatonin receptors to include Mel1d
The circadian and seasonal actions of melatonin are mediated by high affinity G-protein coupled receptors (melatonin receptors, MTRs), classified into phylogenetically distinct subtypes based on sequence divergence and pharmacological characteristics. Three vertebrate MTR subtypes are currently described: MT1 (MTNR1A), MT2 (MTNR1B), and Mel1c (MTNR1C / GPR50), which exhibit distinct affinities, tissue distributions and signaling properties. We present phylogenetic and comparative genomic analyses supporting a revised classification of the vertebrate MTR family. We demonstrate four ancestral vertebrate MTRs, including a novel molecule hereafter named Mel1d. We reconstructed the evolution of each vertebrate MTR, detailing genetic losses in addition to gains resulting from whole genome duplication events in teleost fishes. We show that Mel1d was lost separately in mammals and birds and has been previously mistaken for an MT1 paralogue. The genetic and functional diversity of vertebrate MTRs is more complex than appreciated, with implications for our understanding of melatonin actions in different taxa. The significance of our findings, including the existence of Mel1d, are discussed in an evolutionary and functional context accommodating a robust phylogenetic assignment of MTR gene family structure
Comprehensive Analysis of Coronal Mass Ejection Mass and Energy Properties Over a Full Solar Cycle
The LASCO coronagraphs, in continuous operation since 1995, have observed the
evolution of the solar corona and coronal mass ejections (CMEs) over a full
solar cycle with high quality images and regular cadence. This is the first
time that such a dataset becomes available and constitutes a unique resource
for the study of CMEs. In this paper, we present a comprehensive investigation
of the solar cycle dependence on the CME mass and energy over a full solar
cycle (1996-2009) including the first in-depth discussion of the mass and
energy analysis methods and their associated errors. Our analysis provides
several results worthy of further studies. It demonstrates the possible
existence of two event classes; 'normal' CMEs reaching constant mass for
R_{\sun} and 'pseudo' CMEs which disappear in the C3 FOV. It shows that the
mass and energy properties of CME reach constant levels, and therefore should
be measured, only above \sim 10 R_\sun. The mass density (g/R_\sun^2) of
CMEs varies relatively little ( order of magnitude) suggesting that the
majority of the mass originates from a small range in coronal heights. We find
a sudden reduction in the CME mass in mid-2003 which may be related to a change
in the electron content of the large scale corona and we uncover the presence
of a six-month periodicity in the ejected mass from 2003 onwards.Comment: 42 pages, 16 figures, To appear in Astrophysical Journa
A New Approach to Time Domain Classification of Broadband Noise in Gravitational Wave Data
Broadband noise in gravitational wave (GW) detectors, also known as triggers,
can often be a deterrant to the efficiency with which astrophysical search
pipelines detect sources. It is important to understand their instrumental or
environmental origin so that they could be eliminated or accounted for in the
data. Since the number of triggers is large, data mining approaches such as
clustering and classification are useful tools for this task. Classification of
triggers based on a handful of discrete properties has been done in the past. A
rich information content is available in the waveform or 'shape' of the
triggers that has had a rather restricted exploration so far. This paper
presents a new way to classify triggers deriving information from both trigger
waveforms as well as their discrete physical properties using a sequential
combination of the Longest Common Sub-Sequence (LCSS) and LCSS coupled with
Fast Time Series Evaluation (FTSE) for waveform classification and the
multidimensional hierarchical classification (MHC) analysis for the grouping
based on physical properties. A generalized k-means algorithm is used with the
LCSS (and LCSS+FTSE) for clustering the triggers using a validity measure to
determine the correct number of clusters in absence of any prior knowledge. The
results have been demonstrated by simulations and by application to a segment
of real LIGO data from the sixth science run.Comment: 16 pages, 16 figure
Recommended from our members
Livermore Big Trees Park: 1998 summary results
This report summarizes work conducted in 1998 by the Lawrence Livermore National Laboratory (LLNL) to determine the extent and origin of plutonium at concentrations above background levels at Big Trees Park in the city of Livermore. This summary includes the project background and sections that explain the sampling, radiochemical and data analysis, and data interpretation. This report is a summary report only and is not intended as a rigorous technical or statistical analysis of the data
Automatic Reconstruction of Fault Networks from Seismicity Catalogs: 3D Optimal Anisotropic Dynamic Clustering
We propose a new pattern recognition method that is able to reconstruct the
3D structure of the active part of a fault network using the spatial location
of earthquakes. The method is a generalization of the so-called dynamic
clustering method, that originally partitions a set of datapoints into
clusters, using a global minimization criterion over the spatial inertia of
those clusters. The new method improves on it by taking into account the full
spatial inertia tensor of each cluster, in order to partition the dataset into
fault-like, anisotropic clusters. Given a catalog of seismic events, the output
is the optimal set of plane segments that fits the spatial structure of the
data. Each plane segment is fully characterized by its location, size and
orientation. The main tunable parameter is the accuracy of the earthquake
localizations, which fixes the resolution, i.e. the residual variance of the
fit. The resolution determines the number of fault segments needed to describe
the earthquake catalog, the better the resolution, the finer the structure of
the reconstructed fault segments. The algorithm reconstructs successfully the
fault segments of synthetic earthquake catalogs. Applied to the real catalog
constituted of a subset of the aftershocks sequence of the 28th June 1992
Landers earthquake in Southern California, the reconstructed plane segments
fully agree with faults already known on geological maps, or with blind faults
that appear quite obvious on longer-term catalogs. Future improvements of the
method are discussed, as well as its potential use in the multi-scale study of
the inner structure of fault zones
Exploring The Frequency Of Close-In Jovian Planets Around M Dwarfs
We discuss our high precision radial velocity results of a sample of 90 M dwarfs observed with the Hobby-Eberly Telescope and the Harlan J. Smith 2.7 m Telescope at McDonald Observatory, as well as the ESO VLT and the Keck I telescopes, within the context of the overall frequency of Jupiter-mass planetary companions to main sequence stars. None of the stars in our sample show variability indicative of a giant planet in a short period orbit, with a 3.8 M_Jup and a 3.5 M_Jup and a < 0.7 AU. Our results point toward a generally lower frequency of close-in Jovian planets for M dwarfs as compared to FGK-type stars. This is an important piece of information for our understanding of the process of planet formation as a function of stellar mass
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