Egg production of Baltic cod (Gadus morhua) in relation to variable sex ratio, maturity, and fecundity

Observed fluctuations in relative fecundity of Eastern Baltic cod (Gadus morhua L.) were related to food availability during the main feeding period and were used to develop a predictive model that explained 72% of the interannual variations in fecundity. Time series of sex ratios, maturity ogives, and relative fecundity were combined with mean weights-at-age and stock sizes from an analytical multispecies model to estimate the potential egg production (PEP). Relationships between PEP and independent estimates of realized daily and seasonal egg production from egg surveys were highly significant. The difference between estimates of potential and realized seasonal egg production was of a magnitude corresponding to the expected loss of eggs as a result of atresia, fertilization failure, and early egg mortality. The removal of interannual variability in sex ratio, maturity, and fecundity on estimates of PEP deteriorated the relationships in all three cases. PEP proved to be superior to spawning stock biomass as measure of the reproductive potential in a stock-recruitment relationship of Eastern Baltic cod. PEP in combination with the reproductive volume explained 61% of the variation in year-class strength at age 2

Guidelines for the management of pregnancy in women with cystic fibrosis

Women with cystic fibrosis (CF) now regularly survive into their reproductive years in good health and wish to have a baby. Many pregnancies have been reported in the literature and it is clear that whilst the outcome for the baby is generally good and some mothers do very well, others find either their CF complicates the pregnancy or is adversely affected by the pregnancy. For some, pregnancy may only become possible after transplantation. Optimal treatment of all aspects of CF needs to be maintained from the preconceptual period until after the baby is born. Clinicians must be prepared to modify their treatment to accommodate the changing physiology during pregnancy and to be aware of changing prescribing before conception, during pregnancy, after birth and during breast feeding. This supplement offers consensus guidelines based on review of the literature and experience of paediatricians, adult and transplant physicians, and nurses, physiotherapists, dietitians, pharmacists and psychologists experienced in CF and anaesthetist and obstetricians with experience of CF pregnancy. It is hoped they will provide practical guidelines helpful to the multidisciplinary CF teams caring for pregnant women with CF

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories. By performing molecular analyses of 2,579 TCGA gynecological (OV, UCEC, CESC, and UCS) and breast tumors, Berger et al. identify five prognostic subtypes using 16 key molecular features and propose a decision tree based on six clinically assessable features that classifies patients into the subtypes

APPLICATIONS OF a-Si FIELD EFFECT TRANSISTORS IN LIQUID CRYSTAL DISPLAYS AND IN INTEGRATED LOGIC CIRCUITS

This paper reviews the development and applications of a-Si insulated gate field effect transistors which have become a subject of much current interest. The physical principles underlying the operation of the devices, their fabrication and their static and dynamic characteristics are discussed in the first part of the paper. Recent work on the application of these devices in addressable liquid crystal display panels, in basic integrated logic circuits and in addressable image sensing arrays is then reviewed in some detail