Alien Registration- Macdonald, Raymond J. (Waterville, Kennebec County)

https://digitalmaine.com/alien_docs/14850/thumbnail.jp

The Reanalysis of the ROSAT Data of GQ Mus (1983) Using White Dwarf Atmosphere Emission Models

The analyses of X-ray emission from classical novae during the outburst stage have shown that the soft X-ray emission below 1 keV, which is thought to originate from the photosphere of the white dwarf, is inconsistent with the simple blackbody model of emission. Thus, $ROSAT$ Position Sensitive Proportional Counter (PSPC) archival data of the classical novae GQ Mus 1983 (GQ Mus) have been reanalyzed in order to understand the spectral development in the X-ray wavelengths during the outburst stage. The X-ray spectra are fitted with the hot white dwarf atmosphere emission models developed for the remnants of classical novae near the Eddington luminosity. The post-outburst X-ray spectra of the remnant white dwarf is examined in the context of evolution on the Hertzsprung-Russell diagram using C-O enhanced atmosphere models. The data obtained in 1991 August (during the ROSAT All Sky Survey) indicate that the effective temperature is kT_e<54 eV (<6.2x10^5 K). The 1992 February data show that the white dwarf had reached an effective temperature in the range 38.3-43.3 eV (4.4-5.1x10^5 K) with an unabsorbed X-ray flux (i.e., $\sim$ bolometric flux) between 2.5x10^-9 and 2.3x10^-10 erg s^-1 cm^-2. We show that the H burning at the surface of the WD had most likely ceased at the time of the X-ray observations. Only the 1991 August data show evidence for ongoing H burning.Comment: 17 pages and 3 figures. Accepted to be published in MNRA

A new radiative cooling curve based on an up to date plasma emission code

This work presents a new plasma cooling curve that is calculated using the SPEX package. We compare our cooling rates to those in previous works, and implement the new cooling function in the grid-adaptive framework `AMRVAC'. Contributions to the cooling rate by the individual elements are given, to allow for the creation of cooling curves tailored to specific abundance requirements. In some situations, it is important to be able to include radiative losses in the hydrodynamics. The enhanced compression ratio can trigger instabilities (such as the Vishniac thin-shell instability) that would otherwise be absent. For gas with temperatures below 10,000 K, the cooling time becomes very long and does not affect the gas on the timescales that are generally of interest for hydrodynamical simulations of circumstellar plasmas. However, above this temperature, a significant fraction of the elements is ionised, and the cooling rate increases by a factor 1000 relative to lower temperature plasmas.Comment: 11 pages, 6 figures. Typos fixed to match version on A&A 'forthcoming' website. Tables in text format online available at http://www.phys.uu.nl/~schure/coolin

Musical identities mediate musical development

This article has two main aims. The first is to identify those aspects of developmental psychology as a whole that are most useful in trying to explain musical development in particular. The second is to develop the central argument that the study of people's musical identities is an essential part of the explanation of their musical development. The article is organized as follows. The first section summarizes the main theoretical perspectives on musical development since the 1980s. The second section provides representative examples of empirical research from three broad areas—cognitive, social, and affective— and then looks at the cognitive aspects of musical development and learning: This was the predominant emphasis of developmental studies in the 1980s. The third section focuses on the social aspects of musical development, which have come to include the study of personality. The fourth section considers the development of the affective aspects of musical behavior, that is, those concerning emotion

Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants

Drug eluting coatings that can direct the host tissue response to implanted medical devices have the potential to ameliorate both the medical and financial burden of complications from implantation. However, because many drugs useful in this arena are biologic in nature, a paucity of delivery strategies for biologics, including growth factors, currently limits the control that can be exerted on the implantation environment. Layer-by-Layer (LbL) polyelectrolyte multilayer films are highly attractive as ultrathin biologic reservoirs, due to the capability to conformally coat difficult geometries, the use of aqueous processing likely to preserve fragile protein function, and the tunability of incorporation and release profiles. Herein, we describe the first LbL films capable of microgram-scale release of the biologic Bone Morphogenetic Protein 2 (BMP-2), which is capable of directing the host tissue response to create bone from native progenitor cells. Ten micrograms of BMP-2 are released over a period of two weeks in vitro; less than 1% is released in the first 3 h (compared with commercial collagen matrices which can release up to 60% of BMP-2, too quickly to induce differentiation). BMP-2 released from LbL films retains its ability to induce bone differentiation in MC3T3 E1S4 pre-osteoblasts, as measured by induction of alkaline phosphatase and stains for calcium (via Alizarin Red) and calcium matrix (via Von Kossa). In vivo, BMP-2 film coated scaffolds were compared with film coated scaffolds lacking BMP-2. BMP-2 coatings implanted intramuscularly were able to initiate host progenitor cells to differentiate into bone, which matured and expanded from four to 9 weeks as measured by MicroCT and histology. Such LbL films represent new steps towards controlling and tuning host response to implanted medical devices, which may ultimately increase the success of implanted devices, provide alternative new approaches toward bone wound healing, and lay the foundation for development of a multi-therapeutic release coating.National Institutes of Health (U.S.) (Grant 1-R01-AG029601-01)Deshpande Center for Technological Innovation (Grant 009216-1)National Science Foundation (U.S.). Graduate Research Fellowshi

Tunable dual growth factor delivery from polyelectrolyte multilayer films

A promising strategy to accelerate joint implant integration and reduce recovery time and failure rates is to deliver a combination of certain growth factors to the integration site. There is a need to control the quantity of growth factors delivered at different times during the healing process to maximize efficacy. Polyelectrolyte multilayer (PEM) films, built using the layer-by-layer (LbL) technique, are attractive for releasing controlled amounts of potent growth factors over a sustained period. Here, we present PEM films that sequester physiological amounts of osteogenic rhBMP-2 (recombinant human bone morphogenetic protein - 2) and angiogenic rhVEGF[subscript 165] (recombinant human vascular endothelial growth factor) in different ratios in a degradable [poly(β-amino ester)/polyanion/growth factor/polyanion] LbL tetralayer repeat architecture where the biologic load scaled linearly with the number of tetralayers. No burst release of either growth factor was observed as the films degraded. The release of rhBMP-2 was sustained over a period of 2 weeks, while rhVEGF[subscript 165] eluted from the film over the first 8 days. Both growth factors retained their efficacy, as quantified with relevant in vitro assays. rhBMP-2 initiated a dose dependent differentiation cascade in MC3T3-E1S4 pre-osteoblasts while rhVEGF[subscript 165] upregulated HUVEC proliferation, and accelerated closure of a scratch in HUVEC cell cultures in a dose dependent manner. In vivo, the mineral density of ectopic bone formed de novo by rhBMP-2/rhVEGF[subscript 165] PEM films was approximately 33% higher than when only rhBMP-2 was introduced, with a higher trabecular thickness, which would indicate a decrease in the risk of osteoporotic fracture. Bone formed throughout the scaffold when both growth factors were released, which suggests more complete remodeling due to an increased local vascular network. This study demonstrates a promising approach to delivering precise doses of multiple growth factors for a variety of implant applications where control over spatial and temporal release profile of the biologic is desired.National Institutes of Health (U.S.) (National Institute on Aging Grant 5R01AG029601-04

Functional status after blast-plus-impact complex concussive traumatic brain injury in evacuated United States military personnel

Fundamental questions remain unanswered about the longitudinal impact of blast-plus-impact complex traumatic brain injuries (TBI) from wars in Iraq and Afghanistan. This prospective, observational study investigated measures of clinical outcome in US military personnel evacuated to Landstuhl Regional Medical Center (LRMC) in Germany after such “blast-plus” concussive TBIs. Glasgow Outcome Scale-Extended assessments completed 6–12 months after injury indicated a moderate overall disability in 41/47 (87%) blast-plus TBI subjects and a substantial but smaller number (11/18, 61%, p=0.018) of demographically similar US military controls without TBI evacuated for other medical reasons. Cognitive function assessed with a neuropsychological test battery was not different between blast-plus TBI subjects and controls; performance of both groups was generally in the normal range. No subject was found to have focal neurological deficits. However, 29/47 (57%) of blast-plus subjects with TBI met all criteria for post-traumatic stress disorder (PTSD) versus 5/18 (28%) of controls (p=0.014). PTSD was highly associated with overall disability; 31/34 patients with PTSD versus 19/31 patients who did not meet full PTSD criteria had moderate to severe disability (p=0.0003). Symptoms of depression were also more severe in the TBI group (p=0.05), and highly correlated with PTSD severity (r=0.86, p<0.0001). Thus, in summary, high rates of PTSD and depression but not cognitive impairment or focal neurological deficits were observed 6–12 months after concussive blast-plus-impact complex TBI. Overall disability was substantially greater than typically reported in civilian non-blast concussive (“mild”) patients with TBI, even with polytrauma. The relationship between these clinical outcomes and specific blast-related aspects of brain injuries versus other combat-related factors remains unknown

Flow-weighted values of runoff tracers (δ18O, DOC, Ba, alkalinity) from the six largest Arctic rivers

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 35 (2008): L18606, doi:10.1029/2008GL035007.We present new flow-weighted data for δ 18OH2O, dissolved organic carbon (DOC), dissolved barium and total alkalinity from the six largest Arctic rivers: the Ob', Yenisey, Lena, Kolyma, Yukon and Mackenzie. These data, which can be used to trace runoff, are based upon coordinated collections between 2003 and 2006 that were temporally distributed to capture linked seasonal dynamics of river flow and tracer values. Individual samples indicate significant variation in the contributions each river makes to the Arctic Ocean. Use of these new flow-weighted estimates should reduce uncertainties in the analysis of freshwater transport and fate in the upper Arctic Ocean, including the links to North Atlantic thermohaline circulation, as well as regional water mass analysis. Additional improvements should also be possible for assessing the mineralization rate of the globally significant flux of terrigenous DOC contributed to the Arctic Ocean by these major rivers.Supported by the U.S. National Science Foundation (OPP-0229302), the U.S. Geological Survey and the Water Resources Division of Canada’s Department of Indian Affairs and Northern Development

Large scale pantelleritic ash flow eruptions during the Late Miocene in central Kenya and evidence for significant environmental impact

In the area south-east of Mount Kenya, four previously unrecorded peralkaline rhyolitic (pantelleritic) ash flow tuffs have been located. These predominantly greyish welded and non-welded tuffs form up to 12 m thick units, which are sometimes characterized by a basal vitrophyre. The four flow units yielded 40Ar/39Ar ages ranging from 6.36 to 8.13 Ma, indicating a period of ~ 1.8 Ma of pantelleritic volcanic activity during the Late Miocene in central Kenya. Tentative compositional and age correlations with other known tuff deposits suggest that the pantelleritic tuffs originally covered 40,000 km2 in central Kenya, extending much further than earlier recorded Pliocene tuffs. This newly identified magmatic phase occurred between the phonolitic flood eruptions (16–8 Ma) and the Pliocene tuff eruptions (6–4 Ma). The occurrence of multiple ash flow tuff deposits up to 150 km away from the inferred eruptive center(s) in the central sector of the Kenya Rift, indicates multi-cyclic peralkaline supereruptions during the Late Miocene. By analogy with more recent pantelleritic eruptions, the tuffs are thought to have been sulfur-rich; during eruption, they formed stratospheric aerosols, with significant environmental impact. The timing of the eruptions coincides with the shift towards more savannah-dominated environments in East Africa