25 research outputs found
The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory
- Author
- A Bakker
- AC Pereira
- AJ Mitchell
- AM Brickman
- AM Daugherty
- AN Voineskos
- B Wood
- CJ Hodgetts
- CQ Huang
- CR Doxey
- D Berron
- D Marr
- E Drapeau
- HM Holden
- IJ Bennett
- JL Winterburn
- JM Schott
- LE Wisse
- LE Wisse
- M Jenkinson
- M Ly
- MA Kheirbek
- MA Yassa
- MA Yassa
- MP Witter
- MS Albert
- N Raz
- R Joie La
- RM Baron
- S Baker
- S O’Mara
- SA Small
- SA Small
- SG Mueller
- SG Mueller
- SL Leal
- SM Stark
- SM Stark
- SM Stark
- SN Burke
- W Deng
- Y Geinisman
- ZM Reagh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2017
- Field of study
© 2017 The Author(s). Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate gyrus is intimately connected to CA3 where, in animals, an autoassociative network enables recall of complete memories to underpin object/event recognition. Despite huge motivation to treat age-related human memory disorders, interaction between human CA3 and dentate subfields is difficult to investigate due to small size and proximity. We tested the hypothesis that human dentate gyrus is critical for pattern separation, whereas, CA3 underpins identical object recognition. Using 3 T MR hippocampal subfield volumetry combined with a behavioural pattern separation task, we demonstrate that dentate gyrus volume predicts accuracy and response time during behavioural pattern separation whereas CA3 predicts performance in object recognition memory. Critically, human dentate gyrus volume decreases with age whereas CA3 volume is age-independent. Further, decreased dentate gyrus volume, and no other subfield volume, mediates adverse effects of aging on memory. Thus, we demonstrate distinct roles for CA3 and dentate gyrus in human memory and uncover the variegated effects of human ageing across hippocampal regions. Accurate pinpointing of focal memory-related deficits will allow future targeted treatment for memory loss
Effect of Hochuekkito on Alveolar Macrophage Inflammatory Responses in Hyperglycemic Mice
- Author
- A Chino
- A Kuroiwa
- AA Sima
- BN Lambrecht
- DL Doxey
- ET Fuse
- GE Ranges
- H Amano
- H Koziel
- H Yamasawa
- Hideaki Yamasawa
- I Sugawara
- J-M Cho
- JB Kornum
- JC O’Connor
- K Oshikawa
- M Harada
- M Utsuyama
- Manabu Soda
- Masashi Bando
- Masayuki Nakayama
- MK Mohammad
- MP Morran
- N Chaudhuri
- N Mato
- N Sato
- Naoko Mato
- PH Lapchak
- R Chen
- R Tamura
- S Cho
- SN Zykova
- Tatsuya Hosono
- TR Hawn
- V Mohsenin
- W Ptak
- Y Lin
- Y Mita
- Yukihiko Sugiyama
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei CM
- Abid MB
- Abramowitz MK
- Abu-Zaid A
- Afnan M
- Agarabi C
- Ahmad R
- Aizat WM
- Al-Farha AA
- Al-Lawama M
- Alanio A
- Alaux C
- Albiol J
- Albrecht DR
- Albuquerque LG
- Alimba CG
- Allardyce J
- Almeida GMF
- Alonso-Caneiro D
- Alper OM
- Amer SEDR
- Amiya E
- Ammerman BA
- Amorim RM
- An Q
- Andersen SU
- Aplin JD
- Argyropoulos C
- Armitage C
- Ascher DB
- Ashry M
- Asmann YW
- Assaeed AM
- Atack JM
- Atanasov AG
- Atchison DA
- Atkins GJ
- Atlas L
- Avery SV
- Avillach P
- Baade PD
- Backman L
- Badie C
- Bae T
- Baier D
- Baker CI
- Bakkach J
- Baldi A
- Ball E
- Bannon R
- Bansal A
- Bardot O
- Barnett AG
- Barraud P
- Basharat Z
- Basner M
- Batra J
- Baumert P
- Bazanova OM
- Beale A
- Beck CR
- Becker D
- Beddoe T
- Bell ML
- Benezeth Y
- Bengtsson-Palme J
- Berbesque C
- Berezikov E
- Bergsland N
- Berners-Price S
- Bernhardt P
- Berrevoet F
- Berry E
- Berthold M
- Bessa TB
- Beyene TJ
- Biedermann PHW
- Bijleveld E
- Billington C
- Birch J
- Bittner F
- Bitzer M
- Blakely RD
- Blanck O
- Blaskovich MAT
- Bleackley M
- Blombach F
- Blum R
- Boehme KA
- Boelaert M
- Bogdanos D
- Bonvin AMJJ
- Bosch C
- Bosch O
- Boudreau SA
- Bourgoin T
- Bourke E
- Bouvard D
- Boykin LM
- Bradley G
- Bradshaw W
- Bramoweth AD
- Brand T
- Braubach O
- Braun D
- Braun RJ
- Brenneisen P
- Bridges KM
- Brown JAL
- Brown P
- Browngardt C
- Brownlie J
- Bruhl A
- Bukowy-Bieryllo Z
- Bull JA
- Burt A
- Bush SJ
- Butler LM
- Byrareddy SN
- Byrne HJ
- Cabantous S
- Cai Y
- Calatayud S
- Campana LG
- Campbell M
- Candal E
- Cao Z
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- Cardoso P
- Carlson K
- Carter D
- Cascella M
- Casillas S
- Castelvetro V
- Caswell PT
- Catry T
- Cavalli G
- Cernava T
- Cerovsky V
- Chacko G
- Chagoyen M
- Chakraborty S
- Chan SS
- Chandrasekaran AR
- Chatzitheochari S
- Chavez-Fumagalli MA
- Chen B
- Chen C-E
- Chen C-S
- Chen DF
- Chen H
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- Chen J-T
- Chen X
- Chen Y
- Cheng C
- Cheng J
- Cheng S
- Cheung JTK
- Chinapaw M
- Chinopoulos C
- Cho WCS
- Chong L
- Chowdhury D
- Chung H-J
- Chwalibog A
- Ciresi A
- Cobine PA
- Cockcroft S
- Coelho LP
- Colella V
- Conesa A
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- Dahms TES
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- Dalgleish R
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- Darras S
- Daulatabad SV
- Davidson SM
- Day DA
- de Keersmaecker K
- de Leeuw F-E
- Dean LT
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- Degirmenci V
- del Tredici AL
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- Dhariwal R
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- Dogan Y
- Domingues HS
- Dong XC
- Donner CF
- Dono M
- Doxey AC
- Dressick W
- Drevon CA
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- Dumaz N
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- Ecke T
- Eckweiler D
- Eerola T
- Effiong A
- Ehret F
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- Eixarch E
- El-Adawy H
- El-Esawi MA
- Elkum N
- Emmrich JV
- Engel MS
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- Epp T
- Erickson TB
- Esfahlani SS
- Eskelinen E-L
- Eskew EA
- Esnakul AK
- Eustace AJ
- Evangelou E
- Fairhead M
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- Falter-Wagner CM
- Fan X
- Farber DB
- Faville MJ
- Feghali KA
- Fejzo MS
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- Festa F
- Feteira A
- Feyerabend F
- Fierz W
- Filipp FV
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- Flegel WA
- Flood-Page P
- Florio T
- Forano E
- Forsayeth J
- Fox SA
- Franks SJ
- Frentiu FD
- Friebe M
- Frilander MJ
- Fu X
- Fujita S
- Furuta S
- Fuss J
- Gabrielsen M
- Gajda M
- Galea I
- Galluzzi L
- Gani F
- Ganpule AP
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- Garcia-Alix A
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- Gaullier G
- Gedye K
- Gelfer Y
- Ghelardi E
- Gill MR
- Gilliham M
- Giordano M
- Giunta C
- Gladue DP
- Gleeson PA
- Gloyn L
- Gnasso A
- Goarant C
- Gobet A
- Goggs R
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- Gonzalezlez-Prendes R
- Goodin A
- Goodyear CS
- Gora D
- Gough MJ
- Govender P
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- Greenwald NF
- Greidanus H
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- Groen EJN
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- Guisado JL
- Gumede N
- Gumulya Y
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- Gurevich VV
- Gurney-Champion OJ
- Gusev O
- Gutierrez-Sacristan A
- Habes M
- Hacker E
- Hage SR
- Hagen G
- Hahn S
- Haller DM
- Hammerschmidt S
- Han H
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- Harder T
- Hardingham JE
- Harrison P
- Hartmann MD
- Harvey DJ
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- Heck M
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- Heffler E
- Heinrich M
- Helantera H
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- Hew KF
- Higginbottom DB
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- Jibb LA
- Jin Y
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- Jorens PG
- Jorgensen JOL
- Josse C
- Joubert JW
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- Klump H
- Kluz T
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- Kobayashi T
- Kobold S
- Koch K-W
- Kohanbash G
- Kohls G
- Kohonen-Corish MRJ
- Koleva-Kolarova RG
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- Konkle-Parker D
- Korpela KM
- Kostrikis LG
- Kraiczy P
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- Krause G
- Krebsbach PH
- Kristensen SR
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- Yalcin S
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- Yang SY
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- Yeung AWK
- Yin C-C
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- Yoneyama H
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- Yuh C-H
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- Zaccolo M
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- Zeng C
- Zeng E
- Zevnik B
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- Zhang X
- Zhang Y
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- Zhang Z
- Zhang Z-Y
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- Zhou K
- Zhou M
- Zhu S
- Ziegler A
- Zinke K
- Zuberbier T
- Publication venue
- OXFORD UNIV PRESS
- Publication date
- 29/10/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
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- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
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- Vakilian A
- Valdez PR
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- Venketasubramanian N
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- Wickramasinghe ND
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- Woldu G
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- Wondmeneh TG
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- Wu A-M
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- Wunrow HY
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- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
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- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
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- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
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- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
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- Arnlov J
- Arowosegbe OO
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- Arzani A
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- Asadi-Pooya AA
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- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
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- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
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- Bibi S
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- Bilano V
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- Birihane BM
- Bisanzio D
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- Biswas RK
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- Breitner S
- Brenner H
- Breusov AV
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- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
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- Camera LA
- Campos-Nonato IR
- Cao J
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- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
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- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
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- Chang K-L
- Charan J
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- Chin KL
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- Dahlawi SMA
- Dai H
- Dai H
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- Damiani G
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- Demoz GT
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- Dereje ND
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- Dervenis N
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- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
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- Dichgans M
- Didarloo A
- Dingels ZV
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- Dirac MA
- Djalalinia S
- Do HT
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- Doku DT
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- Dolgert AJ
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- Doshi CP
- Doshi PP
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- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
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- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
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- Elyazar IRF
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- Erskine HE
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- Faro A
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- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
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- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
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- Flohr C
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- Folayan MO
- Fomenkov AA
- Force LM
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- Forooshani ZSD
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- Fox JT
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- Frank TD
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- Freitas M
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- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
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- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
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- Gilani SA
- Gill PS
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- Guled RA
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- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
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- A Akhaddar
- A Wesolowska
- Astrid Sehested
- Atte Karppinen
- B Hockey
- Barbara Zetterqvist
- Bengt Gustavsson
- C Raybaud
- C Shyu
- Camilla Klausen
- CE Catsman-Berrevoets
- CE Catsman-Berrevoets
- CF Van
- CH Rickert
- Charlotte Castor
- CJ Stoodley
- CJ Stoodley
- D Doxey
- E Dardiotis
- EA Livesey
- EB Morris
- EM Wells
- EM Wells
- FE Mekitarian
- H Baillieux
- H Caner
- Harald Thomassen
- HJ McMillan
- HJ Smet De
- I Roberts
- IF Pollack
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- J Radcliffe
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- JF Huber
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- Johan Cappelen
- K Kotil
- Karin Persson
- Karsten Nysom
- Kjeld Schmiegelow
- KM Baarsen van
- L Ellenberg
- M Gelabert-Gonzalez
- M Kuper
- M Pitsika
- Marianne Juhler
- Mats Heyman
- MD Taylor
- Morten Wibroe
- MP Korah
- N Law
- NG Miller
- Niels Clausen
- Olof Rask
- P Edwards
- P Marien
- Pelle Nilsson
- Pernilla Grillner
- PL Robertson
- R Reed-Berendt
- Ramneek Gupta
- RC Di
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- RJ Waters
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An evaluation of the use of cisapride in horses with chronic grass sickness (Equine dysautonomia)
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- Publication date
- 01/01/1996
- Field of study
An evaluation of the use of cisapride in horses with chronic grass sickness (Equine dysautonomia)
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- Publication date
- 01/01/1996
- Field of study
Relationship between Multiple Predictor Variables and Normal Biodex Eversion-Inversion Peak Torque and Angular Work
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- 'Journal of Orthopaedic & Sports Physical Therapy (JOSPT)'
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The European Union and Belarus: Sanctions and Partnership?
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- A Sahm
- A Tostensen
- AW De Vries
- B Brandtner
- B Jarabik
- BW Jentleson
- C Portela
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- D Cortright
- D Kochenov
- E Fierro
- F Schimmelfennig
- G Bosse
- GC Hufbauer
- GC Hufbauer
- H Grabbe
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- KA Elliot
- M Brzoska
- MP Doxey
- N Haass
- P Zurawski
- PA van Bergeijk
- SG Jones
- T Beichelt
- T Biersteker
- T De Wilde d′Estmael
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2011
- Field of study