528 research outputs found
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice
- Author
- A Celada
- A Papadimitriou
- BC Ko
- BC Ko
- Beatriz Morancho
- BJ Wilkins
- BW McDill
- C Lopez-Rodriguez
- C Lopez-Rodriguez
- C Lopez-Rodriguez
- CE Irarrazabal
- CE Irarrazabal
- CR Cooke
- Cristina LĂłpez-RodrĂguez
- D Kultz
- E Dogan
- F Macian
- H Miyakawa
- H Wu
- J Aramburu
- J Aramburu
- J Bain
- J Bain
- J Jain
- J Minguillon
- J Trama
- J Trama
- J Yun
- JC Stroud
- JD Ferraris
- JD Molkentin
- Jeffery D Molkentin
- JH Esensten
- Jordi MinguillĂłn
- Jose Aramburu
- LA Chilton
- M Diehn
- ML Loyher
- NA Clipstone
- O Paut
- RG Jones
- S Maallem
- S Ranjbar
- SK Woo
- SP Davies
- SW Lim
- SZ Li
- T Ka
- T Ma
- T Schorn
- TT Tsai
- US Jeon
- WY Go
- Z Zhang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that trigger its transcriptional activity in primary cells. Wilkins et al. recently developed a transgenic mouse carrying a luciferase reporter (9xNFAT-Luc) driven by a cluster of NFAT sites, that was activated by calcineurin-dependent NFATc proteins. Since the NFAT site of this reporter was very similar to an optimal NFAT5 site, we tested whether this reporter could detect the activation of NFAT5 in transgenic cells.</p> <p>Results</p> <p>The 9xNFAT-Luc reporter was activated by hypertonicity in an NFAT5-dependent manner in different types of non-transformed transgenic cells: lymphocytes, macrophages and fibroblasts. Activation of this reporter by the phorbol ester PMA plus ionomycin was independent of NFAT5 and mediated by NFATc proteins. Transcriptional activation of NFAT5 in T lymphocytes was detected at hypertonic conditions of 360â380 mOsm/kg (isotonic conditions being 300 mOsm/kg) and strongly induced at 400 mOsm/kg. Such levels have been recorded in plasma in patients with osmoregulatory disorders and in mice deficient in aquaporins and vasopressin receptor. The hypertonicity threshold required to activate NFAT5 was higher in bone marrow-derived macrophages (430 mOsm/kg) and embryonic fibroblasts (480 mOsm/kg). Activation of the 9xNFAT-Luc reporter by hypertonicity in lymphocytes was insensitive to the ERK inhibitor PD98059, partially inhibited by the PI3-kinase inhibitor wortmannin (0.5 ÎŒM) and the PKA inhibitor H89, and substantially downregulated by p38 inhibitors (SB203580 and SB202190) and by inhibition of PI3-kinase-related kinases with 25 ÎŒM LY294002. Sensitivity of the reporter to FK506 varied among cell types and was greater in primary T cells than in fibroblasts and macrophages.</p> <p>Conclusion</p> <p>Our results indicate that NFAT5 is a sensitive responder to pathologic increases in extracellular tonicity in T lymphocytes. Activation of NFAT5 by hypertonicity in lymphocytes was mediated by a combination of signaling pathways that differed from those required in other cell types. We propose that the 9xNFAT-Luc transgenic mouse model might be useful to study the physiopathological regulation of both NFAT5 and NFATc factors in primary cells.</p
Comparing large-scale computational approaches to epidemic modeling: Agent-based versus structured metapopulation models
- Author
- A Barrat
- A Flahault
- A Flahault
- AL Lloyd
- Alessandro Vespignani
- BJ Coburn
- Bruno Gonçalves
- BS Cooper
- C Viboud
- CE Mills
- CT Bauch
- D Balcan
- D Balcan
- D Ort'uzar J de
- DJ Watts
- DL Chao
- Duygu Balcan
- Hao Hu
- IM Longini
- IM Longini
- Italian Institute of Statistics
- Italian Institute of Statistics
- Italian Institute of Statistics
- Italian Ministry of University and Research
- J Wallinga
- JM Epstein
- José J Ramasco
- L Hufnagel
- L Sattenspiel
- LA Rvachev
- M Ajelli
- M Ajelli
- M Ajelli
- Marco Ajelli
- ME Halloran
- MJ Keeling
- ML Ciofi degli Atti
- NM Ferguson
- NM Ferguson
- O Diekmann
- PD Stroud
- R Pastor-Satorras
- RF Grais
- RM Anderson
- S Eubank
- S Merler
- S Merler
- S Riley
- Stefano Merler
- TC Germann
- V Colizza
- V Colizza
- V Colizza
- V Colizza
- Vittoria Colizza
- VJ Davey
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>In recent years large-scale computational models for the realistic simulation of epidemic outbreaks have been used with increased frequency. Methodologies adapt to the scale of interest and range from very detailed agent-based models to spatially-structured metapopulation models. One major issue thus concerns to what extent the geotemporal spreading pattern found by different modeling approaches may differ and depend on the different approximations and assumptions used.</p> <p>Methods</p> <p>We provide for the first time a side-by-side comparison of the results obtained with a stochastic agent-based model and a structured metapopulation stochastic model for the progression of a baseline pandemic event in Italy, a large and geographically heterogeneous European country. The agent-based model is based on the explicit representation of the Italian population through highly detailed data on the socio-demographic structure. The metapopulation simulations use the GLobal Epidemic and Mobility (GLEaM) model, based on high-resolution census data worldwide, and integrating airline travel flow data with short-range human mobility patterns at the global scale. The model also considers age structure data for Italy. GLEaM and the agent-based models are synchronized in their initial conditions by using the same disease parameterization, and by defining the same importation of infected cases from international travels.</p> <p>Results</p> <p>The results obtained show that both models provide epidemic patterns that are in very good agreement at the granularity levels accessible by both approaches, with differences in peak timing on the order of a few days. The relative difference of the epidemic size depends on the basic reproductive ratio, <it>R</it><sub>0</sub>, and on the fact that the metapopulation model consistently yields a larger incidence than the agent-based model, as expected due to the differences in the structure in the intra-population contact pattern of the approaches. The age breakdown analysis shows that similar attack rates are obtained for the younger age classes.</p> <p>Conclusions</p> <p>The good agreement between the two modeling approaches is very important for defining the tradeoff between data availability and the information provided by the models. The results we present define the possibility of hybrid models combining the agent-based and the metapopulation approaches according to the available data and computational resources.</p
Rapid assembly of customized TALENs into multiple
- Author
- AJ Bogdanove
- AJ Walhout
- B Davies
- BP Zambrowicz
- C Engler
- C Mussolino
- C Uhde-Stone
- Christina Chan
- CJ Friddle
- D Reyon
- DA Stroud
- DF Carlson
- DL Cheo
- E Weber
- EL Doyle
- F Zhang
- FE Moore
- GK Taylor
- H Wang
- H Wang
- J Boch
- J Liu
- JC Miller
- JL Hartley
- JL Schmid-Burgk
- K Jacoby
- Kyle E. Orwig
- L Cong
- L Cong
- L Tesson
- M Holkers
- M Jinek
- M Li
- M Rostovskaya
- M Rostovskaya
- MA Li
- MA Li
- MJ Moscou
- ML Christian
- N Sun
- N Sun
- NE Sanjana
- P Mali
- Q Ding
- R Alba
- R Geissler
- R Hu
- R Li
- R Takeuchi
- S Ansai
- S Baxter
- S Chen
- S Cristea
- Siliang Zhang
- SM Choi
- T Cathomen
- T Cermak
- T Gaj
- T Li
- T Li
- T Li
- T Mashimo
- T Sakuma
- VM Bedell
- Xin Huang
- Y Fu
- Y Kim
- Y Zhang
- Y Zu
- YH Sung
- YH Sung
- Yi Sheng
- Z Qiu
- Z Zhang
- Zhengxing Zhang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
Transcriptional activator-like effector nucleases (TALENs) have become a powerful tool for genome editing. Here we present an efficient TALEN assembly approach in which TALENs are assembled by direct Golden Gate ligation into GatewayŸ Entry vectors from a repeat variable di-residue (RVD) plasmid array. We constructed TALEN pairs targeted to mouse Ddx3 subfamily genes, and demonstrated that our modified TALEN assembly approach efficiently generates accurate TALEN moieties that effectively introduce mutations into target genes. We generated "user friendly" TALEN Entry vectors containing TALEN expression cassettes with fluorescent reporter genes that can be efficiently transferred via Gateway (LR) recombination into different delivery systems. We demonstrated that the TALEN Entry vectors can be easily transferred to an adenoviral delivery system to expand application to cells that are difficult to transfect. Since TALENs work in pairs, we also generated a TALEN Entry vector set that combines a TALEN pair into one PiggyBac transposon-based destination vector. The approach described here can also be modified for construction of TALE transcriptional activators, repressors or other functional domains. © 2013 Zhang et al
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation
- Author
- A He
- A Mery
- A Reiner
- A Wessels
- AC Houweling
- AFM Moorman
- Andreas Kispert
- Antoon F. M. Moorman
- BG Bruneau
- C Marionneau
- DE Clouthier
- DM Stroud
- DS Sohal
- EP Walsh
- FJ Lange de
- H Chen
- H Luche
- Henk Buermans
- Henner F. Farin
- IP Moskowitz
- James F. Martin
- JJ Goeman
- JM Ruijter
- K Mesbah
- L Dupays
- L Luna-Zurita
- L Ma
- LA Naiche
- M Shirai
- M Yamada
- M. Sameer Rana
- Marianne Petry
- MD Combs
- ME Lingbeek
- ML Bakker
- MTM Mommersteeg
- NE Hellman
- NV Butz
- NV Munshi
- PEMH Habets
- Peter A. C. ât Hoen
- Phil Barnett
- R Agah
- R Singh
- Reena Singh
- RL Chandler
- RM Baxter
- S Grotegut
- S Zirzow
- TD Camenisch
- Thomas Grieskamp
- TK Ghosh
- Todd Heallen
- Vincent M. Christoffels
- VM Christoffels
- VM Christoffels
- W Huber
- Willem M. Hoogaars
- WM Hoogaars
- WT Aanhaanen
- WT Aanhaanen
- Y Sugi
- Z Harrelson
- Publication venue
- SP BirkhÀuser Verlag Basel
- Publication date
- 01/01/2012
- Field of study
A key step in heart development is the coordinated development of the atrioventricular canal (AVC), the constriction between the atria and ventricles that electrically and physically separates the chambers, and the development of the atrioventricular valves that ensure unidirectional blood flow. Using knock-out and inducible overexpression mouse models, we provide evidence that the developmentally important T-box factors Tbx2 and Tbx3, in a functionally redundant manner, maintain the AVC myocardium phenotype during the process of chamber differentiation. Expression profiling and ChIP-sequencing analysis of Tbx3 revealed that it directly interacts with and represses chamber myocardial genes, and induces the atrioventricular pacemaker-like phenotype by activating relevant genes. Moreover, mutant mice lacking 3 or 4 functional alleles of Tbx2 and Tbx3 failed to form atrioventricular cushions, precursors of the valves and septa. Tbx2 and Tbx3 trigger development of the cushions through a regulatory feed-forward loop with Bmp2, thus providing a mechanism for the co-localization and coordination of these important processes in heart development
The âconscious pilotââdendritic synchrony moves through the brain to mediate consciousness
- Author
- A Draguhn
- A Freitas da Rocha
- A Hodgkin
- A Lutz
- A Matus
- A Mercer
- A Viswanathan
- AK Engel
- AN Whitehead
- AN Whitehead
- B Libet
- B Naundorf
- BJ Baars
- C Aoki
- C Frisch
- C Koch
- C Koch
- C Malsburg Von der
- C OâConnell
- C Pantev
- C Tallon-Baudry
- C Tallon-Baudry
- CM Gray
- CM Gray
- D Friedmand
- D Hodgson
- D Schmitz
- DJ Chalmers
- DL Buhl
- E Garcia-Rill
- E Schrodinger
- EA Zee Van der
- ER John
- ER John
- ER Kandel
- F Crick
- F Rosenblatt
- F Varela
- FC Crick
- FE LeBeau
- G Buszaki
- G Perea
- G Tamas
- GA Mashour
- GI Hatton
- GM Shepherd
- GS Engel
- GVW Johnson
- H Hosseinzadeh
- H Tiitinen
- HP Stapp
- I Goldberg
- J McFadden
- J Xi
- JC Eccles
- JC Herve
- JD Desmedt
- JE Rash
- JJ Fahrenfort
- JL Perez Velazquez
- JL Vincent
- JM Christie
- JM Christie
- JM Schoffelen
- JM Stroud
- JR Gibson
- JW Deitmer
- K Bittman
- K Wentlandt
- K Wu
- KA Kasischke
- KH Pribram
- L Melloni
- L Venance
- M Fischer
- M Galarreta
- M Galarreta
- M Joliot
- MB Lassen
- ML Steyn-Ross
- MM Froes
- MM Froes
- MN Shadlen
- MS Gazzaniga
- MT Alkire
- MV Bennett
- MVL Bennett
- N Block
- N Maier
- N Rouach
- NJ Woolf
- NJ Woolf
- NJ Woolf
- NK Logothetis
- OA Imas
- OA Imas
- P Bezzi
- P Fries
- P Siekevitz
- P Stoerig
- PF Poirazi
- R Bruzzone
- R Dermietzel
- R Llinas
- R Malach
- R Penrose
- R Rozental
- R VanRullen
- R VanRullen
- RD Traub
- RD Traub
- RD Traub
- RM Shaw
- S Halpain
- S Hameroff
- S Hameroff
- S Hameroff
- S Hameroff
- S Pockett
- S Zeki
- SG Hormuzdi
- SG Hormuzdi
- SR Hameroff
- SR Hameroff
- Stuart Hameroff
- T Fukuda
- T Fukuda
- U Ribary
- V Sourdet
- V Zsiros
- VJ Whatley
- W James
- W McCulloch
- WE Theurkauf
- WHR Miltner
- WJ Freeman
- WJ Freeman
- Y Amitai
- Y Mouchetant-Rostaing
- Z Khuchua
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2009
- Field of study
Cognitive brain functions including sensory processing and control of behavior are understood as âneurocomputationâ in axonalâdendritic synaptic networks of âintegrate-and-fireâ neurons. Cognitive neurocomputation with consciousness is accompanied by 30- to 90-Hz gamma synchrony electroencephalography (EEG), and non-conscious neurocomputation is not. Gamma synchrony EEG derives largely from neuronal groups linked by dendriticâdendritic gap junctions, forming transient syncytia (âdendritic websâ) in input/integration layers oriented sideways to axonalâdendritic neurocomputational flow. As gap junctions open and close, a gamma-synchronized dendritic web can rapidly change topology and move through the brain as a spatiotemporal envelope performing collective integration and volitional choices correlating with consciousness. The âconscious pilotâ is a metaphorical description for a mobile gamma-synchronized dendritic web as vehicle for a conscious agent/pilot which experiences and assumes control of otherwise non-conscious auto-pilot neurocomputation
Selenium-rich dissolved organic matter determines selenium uptake in wheat grown on Low-selenium arable land soils
- Author
- A Ghani
- A Zayed
- AFE Mehdawi
- AM Hurd-Karrer
- C Zhao
- D Curtin
- D Wang
- DL Jones
- G Gissel-Nielsen
- G Gissel-Nielsen
- H Hartikainen
- H Li
- H Yamada
- J Kikkert
- J SzĂĄkovĂĄ
- J Tolu
- J Yanai
- JA McKeague
- JL Hopper
- JL Stroud
- JL Stroud
- JP Gustafsson
- K Kalbitz
- L Johnsson
- L Johnsson
- L Roca-Perez
- L Temmerman De
- L Weng
- Liping Weng
- MC Williams
- MJ Hawkesford
- ML Adams
- MM Abrams
- MM Abrams
- MM Abrams
- MR Gardiner
- PS Homann
- R Keskinen
- Rob N. J. Comans
- S Eich-Greatorex
- S Supriatin
- S Supriatin
- Supriatin Supriatin
- T YlÀranta
- UC Gupta
- VJG Houba
- W Hartfiel
- W Zech
- WM Post
- Y Jiang
- Y Kang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the ttÂŻttÂŻ production cross section in pp collisions at âs=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alunno Camelia E
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Aranzabal N
- Araujo Ferraz V
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Arrubarrena Tame ZP
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Badea A
- Bagnaia P
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Bakshi Gupta D
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barends KN
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro GuimarĂŁes da Costa J
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bashta I
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirao Da Cruz E Silva C
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bessidskaia Bylund O
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Biebel O
- Bielski R
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birch-sykes CJ
- Bird GA
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- BjĂžrke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Breaden Madden WD
- Brendlinger K
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Bruckman de Renstrom PA
- Bruncko D
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Bryngemark L
- BrĂŒers B
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- BĂŒscher V
- Cabras G
- Cabrera UrbĂĄn S
- Caforio D
- Cai H
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cano Bret M
- Cantero J
- Cao Y
- Capua M
- Carbone A
- Cardarelli R
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carminati L
- Carnesale M
- Carney RMD
- Caron S
- Carquin E
- Carratta G
- CarrĂĄ S
- Carter JWS
- Carter TM
- Casadei D
- Casado MP
- Casha AF
- Castiglia EG
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavalli N
- Cavasinni V
- Celebi E
- Celli F
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chala M
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y
- Chen Y-H
- Cheng CL
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fbâ1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17â15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7â6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
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- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fbâ1 of proton-proton collision data recorded at a centre-of-mass energy of âs = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Measurements of W+Wâ+ â„ 1 jet production cross-sections in pp collisions at sâ = 13 TeV with the ATLAS detector
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Fiducial and differential cross-section measurements of W+Wâ production in
association with at least one hadronic jet are presented. These measurements are sensitive
to the properties of electroweak-boson self-interactions and provide a test of perturbative
quantum chromodynamics and the electroweak theory. The analysis is performed using
proton-proton collision data collected at p
s = 13TeV with the ATLAS experiment, corresponding
to an integrated luminosity of 139 fbâ1. Events are selected with exactly one oppositely
charged electron-muon pair and at least one hadronic jet with a transverse momentum
of pT > 30 GeV and a pseudorapidity of |ïżœ| < 4.5. After subtracting the background
contributions and correcting for detector effects, the jet-inclusive W+Wâ+ ïżœ 1 jet fiducial
cross-section and W+Wâ+ jets differential cross-sections with respect to several kinematic
variables are measured. These measurements include leptonic quantities, such as the lepton
transverse momenta and the transverse mass of the W+Wâ system, as well as jet-related
observables such as the leading jet transverse momentum and the jet multiplicity. Limits on
anomalous triple-gauge-boson couplings are obtained in a phase space where interference
between the Standard Model amplitude and the anomalous amplitude is enhanced
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at â=13TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
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- Ăncel ĂO
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fbâ1 of sâ=13TeV protonâproton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38â0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
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