148 research outputs found
Local Difference Measures between Complex Networks for Dynamical System Model Evaluation
- Author
- A Berkopec
- A Dai
- A Levermann
- A Radebach
- A Rheinwalt
- AA Tsonis
- AA Tsonis
- AH Murphy
- B Orlowsky
- B Rockel
- B Rockel
- BL Welch
- C Jones
- C Spearman
- C Vera
- C Zhou
- CJ Stam
- CL Castro
- D Hartman
- Daniele Marinazzo
- DP Dee
- E Bullmore
- E Kalnay
- E Ravasz
- E Ward
- EA Leicht
- EC Fieller
- EC Fieller
- Ez Erbach-Schoenberg
- F Giorgi
- F Lorrain
- FA Huff
- G Nikulin
- G Salton
- G Smiatek
- GJ Huffman
- GJ Marshall
- H de Jong
- HJ Thiébaux
- I Fountalis
- J Heitzig
- J Ludescher
- J Nogués-Paegle
- J Zhou
- JA Marengo
- Jan Volkholz
- JF Donges
- JF Donges
- Jonathan F. Donges
- JWK Ho
- Jürgen Kurths
- K Steinhaeuser
- KE Trenberth
- L Barnett
- LA Zager
- LMV Carvalho
- LS Scott
- M Bagnoli
- M Baldauf
- M Newman
- MD Greicius
- ME Lynall
- MG Kendall
- MK Agoston
- N Boers
- N Malik
- O Woolley-Meza
- P Bechtold
- P Bechtold
- P Braconnot
- P Erdős
- P Jaccard
- P Papadimitriou
- PC Werner
- PE Vértes
- PW Jones
- RA Fisher
- RA Fisher
- RFS Andrade
- RL Graham
- RQ Quiroga
- RW Hamming
- S Achard
- S Bachner
- S Boccaletti
- SL Bressler
- SL Simpson
- Stefan Lange
- T Lux
- TR Loveland
- V Blondel
- VI Spoormaker
- W Hörmann
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 09/04/2015
- Field of study
Acknowledgments We thank Reik V. Donner for inspiring suggestions that initialized the work presented herein. Jan H. Feldhoff is credited for providing us with the STARS simulation data and for his contributions to fruitful discussions. Comments by the anonymous reviewers are gratefully acknowledged as they led to substantial improvements of the manuscript.Peer reviewedPublisher PD
Oral-Derived Bacterial Flora Defends Its Domain by Recognizing and Killing Intruders—A Molecular Analysis Using Escherichia coli as a Model Intestinal Bacterium
- Author
- A Aderem
- A Hector
- A Poltorak
- A Shimizu
- BJ Paster
- BL Triggs-Raine
- CE deRivera
- CRH Raetz
- CS Elton
- D Rao
- David R. Zusman
- DM Baltz
- F Guarner
- H Masayuki
- I Huber
- IL Jung
- J Kreth
- J Maukonen
- JF Rawls
- JF Rawls
- JJ Stachowicz
- JS Kim
- KA Remer
- Lihong Guo
- M Burmølle
- M Rajilić-Stojanović
- MK Chattopadhyay
- R Landmann
- R Medzhitov
- RE Ley
- RE Ley
- Renate Lux
- RR Lobene
- S Gorbach
- SD Ford
- SJ Padayatty
- T Baba
- T Huichun
- TJ Case
- Wenyuan Shi
- Xuesong He
- Y Li
- Y Uehara
- Y Uehara
- Yan Tian
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Within the same human gastrointestinal tract, substantial differences in the bacterial species that inhabit oral cavity and intestinal tract have been noted. Previous research primarily attributed the differences to the influences of host environments and nutritional availabilities (“host habitat” effect). Our recent study indicated that, other than the host habitat effect, an existing microbial community could impose a selective pressure on incoming foreign bacterial species independent of host-mediated selection (“community selection” effect). In this study, we employed in vitro microbial floras representing microorganisms that inhabit the oral cavities and intestinal tract of mice in combination with Escherichia coli as a model intestinal bacterium and demonstrated that E. coli displays a striking community preference. It thrived when introduced into the intestinal microbial community and survived poorly in the microbial flora of foreign origin (oral community). A more detailed examination of this phenomenon showed that the oral community produced oxygen-free radicals in the presence of wild-type E. coli while mutants deficient in lipopolysaccharides (LPS) did not trigger significant production of these cell-damaging agents. Furthermore, mutants of E. coli defective in the oxidative stress response experienced a more drastic reduction in viability when cocultivated with the oral flora, while the exogenous addition of the antioxidant vitamin C was able to rescue it. We concluded that the oral-derived microbial community senses the E. coli LPS and kills the bacterium with oxygen-free radicals. This study reveals a new mechanism of community invasion resistance employed by established microflora to defend their domains
The influence of early exposure to vitamin D for development of diseases later in life
- Author
- Allan A Vaag
- B Abrahamsen
- B Carstensen
- B Hamilton
- B Norgaard-Pedersen
- Berit L Heitmann
- Bo Abrahamsen
- BW Hollis
- BW Hollis
- C Brot
- Camilla B Jensen
- Claus Holst
- D Eyles
- DW Eyles
- E Hypponen
- E Hypponen
- E Hypponen
- GV Krishnaveni
- H Glerup
- J Bua
- J Kong
- J McGrath
- JL Baker
- JL Baker
- Joachim Knop
- Kyle Raymond
- L Harvey
- L Mosekilde
- Lone B Rasmussen
- Maria Stougaard
- Marta Bauerek
- MJ Barger-Lux
- MJ McKenna
- MK Javaid
- P Lips
- PR von Hurst
- Ramune Jacobsen
- RD Levitan
- S Eising
- S Laitinen
- S Lewis
- SV Ramagopalan
- Thorkild IA Sørensen
- TN Nickelsen
- YJ Foss
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Aktas S
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Alegria ZL
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amirie KJ
- Amor Dos Santos SP
- Amos KR
- An S
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Arbiol Val SJ
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Astrand KSV
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Baer TM
- Bagnaia P
- Bahmani M
- Bahner D
- Bai K
- Bailey AJ
- Baines JT
- Baines L
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beaucamp JY
- Beauchemin PH
- Bechtle P
- Beck HP
- Becker K
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
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- Behera A
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- Beisiegel F
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- Bhopatkar VS
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- Billingsley CS
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- Birch-sykes CJ
- Bird GA
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- Bomben M
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- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borissov G
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- Brooijmans G
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- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
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- Bruschi M
- Bruscino N
- Brüers B
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- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burlayenko O
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
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- Cadamuro L
- Caforio D
- Cai H
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- Cairo VMM
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- Calafiura P
- Calderini G
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- Camerlingo MT
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- Cooke HG
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- Cortes-Gonzalez A
- Costa MJ
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- Cremonini D
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- Crosby JE
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- Yin P
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- Zabinski B
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- Zakharchuk N
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- Zanzi D
- Zaplatilek O
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- Zenger DT
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- Zerradi S
- Zerwas D
- Zhai M
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- Zhang R
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- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Polyamines and cancer: old molecules, new understanding
- Author
- A Crozat
- A De Benedetti
- A Hughes
- A Pena
- AC Wolff
- AE Pegg
- AJ Bitonti
- AR Simoneau
- B Fisher
- C Bello-Fernandez
- CA Mackintosh
- CE Weeks
- CJ Fabian
- CV Rao
- CW Tabor
- D Bevec
- D Bishop-Bailey
- D Russell
- D Zuk
- DS Alberts
- EW Gerner
- F Doua
- FA Eskens
- FL Meyskens Jr
- FL Meyskens Jr
- FL Meyskens Jr
- FL Meyskens Jr.
- FM Giardiello
- G Andersson
- G Bai
- G Wilding
- GD Lux
- GN Levy
- H Hermeking
- H Hoshiai
- H Pendeville
- H Tabor
- HA Kang
- HG Williams-Ashman
- HM Wallace
- IM Thompson
- J Groden
- J Schnier
- JA Gastaut
- JE Trosko
- JL Mitchell
- JO Boyle
- JP Marsh
- JT Yarrington
- JY Wang
- JY Wang
- KE Boyd
- KE Fultz
- KJ Doyle
- KR Lawson
- KW Kinzler
- L Shore
- LJ Hixson
- LM Shantz
- M Itoh
- M Iwamoto
- M Oshima
- M Takigawa
- MA Cornbleet
- ME Martinez
- ME Tome
- MF Mitchell
- MH Humphreys
- MH Park
- MK Croghan
- MK Smith
- N Ahmad
- N Babbar
- N Seiler
- N Seiler
- NA Ignatenko
- NA Ignatenko
- O Erez
- P Babal
- P Bey
- PM Bauer
- PP Carbone
- PP McCann
- PP McCann
- PS Mamont
- PS Mamont
- RA Casero Jr
- RA Casero Jr.
- RF Jacoby
- RK Phillips
- RR Love
- RR Mohan
- RS Calandra
- S Bardocz
- S Eimer
- S Hayashi
- S Matsufuji
- SH Erdman
- SH Min
- SK Guha
- SM Morris Jr.
- SS Cohen
- T Brzozowski
- T Thomas
- T Thomas
- T Tsuji
- TC He
- TG O'Brien
- TR Pasic
- V Ahuja
- V Milovic
- VA Levin
- WK Hong
- X Guo
- X Xie
- X Xie
- Y Takahashi
- Y Wang
- ZF Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2004
- Field of study
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues
Association analysis identifies 65 new breast cancer risk loci
- Author
- ABCTB Investigators
- Adams M
- Adank MA
- Ahsan H
- Aittomäki K
- Allen J
- Amos CI
- Andrulis IL
- Anton-Culver H
- Antonenkova NN
- Antoniou AC
- Arndt V
- Aronson KJ
- Arun B
- Auer PL
- Bacot F
- Bader GD
- Barrdahl M
- Baynes C
- Beckmann MW
- Beesley J
- Behrens S
- Benitez J
- Bermisheva M
- Bernstein L
- Beth Terry M
- Blomqvist C
- Bogdanova NV
- Bojesen SE
- Bolla MK
- Bonanni B
- Brand JS
- Brauch H
- Brennan P
- Brenner H
- Brinton L
- Broberg P
- Brock IW
- Broeks A
- Brooks-Wilson A
- Brucker SY
- Brüning T
- Burwinkel B
- Butterbach K
- Børresen-Dale A-L
- Cai H
- Cai Q
- Caldés T
- Canzian F
- Carracedo A
- Carroll JS
- Carter BD
- Castelao JE
- Chan TL
- Chang-Claude J
- Chanock SJ
- Chenevix-Trench G
- Choi J-Y
- Christiansen H
- Clarke CL
- Collée M
- ConFab/AOCS Investigators
- Conroy DM
- Cordina-Duverger E
- Cornelissen S
- Couch FJ
- Cox A
- Cox DG
- Cross SS
- Cunningham JM
- Czene K
- Daly MB
- David Cheng T-Y
- Dennis J
- Devilee P
- Dicks E
- Doheny KF
- Dos-Santos-Silva I
- Droit A
- Dumont M
- Dunning AM
- Durcan L
- Dwek M
- Dörk T
- Easton DF
- Eccles DM
- Edwards SL
- Eilber U
- Ekici AB
- Eliassen AH
- Ellberg C
- Elvira M
- Engel C
- Eriksson M
- Fachal L
- Fasching PA
- Figueroa J
- Finucane H
- Flesch-Janys D
- Fletcher O
- Flyger H
- French JD
- Fritschi L
- Gaborieau V
- Gabrielson M
- Gago-Dominguez M
- Gao Y-T
- Gapstur SM
- García-Closas M
- García-Sáenz JA
- Gaudet MM
- Georgoulias V
- Ghoussaini M
- Giles GG
- Glendon G
- Glubb D
- Goldberg MS
- Goldgar DE
- González-Neira A
- Grenaker Alnæs GI
- Grip M
- Gronwald J
- Grundy A
- Guénel P
- Haeberle L
- Hahnen E
- Haiman CA
- Hall P
- Hamann U
- Hamel N
- Hankinson S
- Har Yip C
- Harrington P
- Hart SN
- Hartikainen JM
- Hartman M
- Hein A
- Heyworth J
- Hicks B
- Hillemanns P
- Ho DN
- Hollestelle A
- Hooning MJ
- Hoover RN
- Hopper JL
- Hou M-F
- Hsiung C-N
- Huang G
- Hui S
- Humphreys K
- Hunter DJ
- Håkansson N
- Ishiguro J
- Ito H
- Iwasaki M
- Iwata H
- Jakubowska A
- Janni W
- Jiang X
- John EM
- Johnson N
- Jones K
- Jones M
- Jukkola-Vuorinen A
- Kaaks R
- Kabisch M
- Kaczmarek K
- Kang D
- Kar S
- Kasuga Y
- Keeman R
- Kerin MJ
- Khan S
- Khusnutdinova E
- Kiiski JI
- Kim S-W
- Knight JA
- Kosma V-M
- Kostovska IM
- Kraft P
- Kristensen VN
- Krüger U
- Kwong A
- Lakhani SR
- Lambrechts D
- Le Marchand L
- Lee A
- Lee E
- Lee JW
- Lee MH
- Lejbkowicz F
- Lemaçon A
- Li J
- Lilyquist J
- Lindblom A
- Lindström S
- Lissowska J
- Lloyd R
- Lo W-Y
- Loibl S
- Long J
- Lophatananon A
- Lubinski J
- Luccarini C
- Lux MP
- Ma ESK
- MacInnis RJ
- Maishman T
- Makalic E
- Malone KE
- Mannermaa A
- Manoukian S
- Manson JE
- Margolin S
- Mariapun S
- Martinez ME
- Matsuo K
- Mavroudis D
- McCart Reed AE
- McCue K
- McKay J
- McLean C
- Meijers-Heijboer H
- Meindl A
- Menon U
- Menéndez P
- Meyer J
- Miao H
- Michailidou K
- Miller N
- Milne RL
- Muir K
- Mulligan AM
- Mulot C
- NBCS Collaborators
- Neng Lee C
- Neuhausen SL
- Nevanlinna H
- Neven P
- Nielsen SF
- Noh D-Y
- Nordestgaard BG
- Norman A
- Olopade OI
- Olson JE
- Olsson H
- Olswold C
- Orr N
- Pankratz VS
- Park SK
- Park-Simon T-W
- Perez JIA
- Peterlongo P
- Peto J
- Pharoah PDP
- Phillips K-A
- Pinchev M
- Plaseska-Karanfilska D
- Prentice R
- Presneau N
- Prokofyeva D
- Pugh E
- Pylkäs K
- Qing Chen X
- Rack B
- Radice P
- Rahman N
- Rennert G
- Rennert HS
- Rhenius V
- Romero A
- Romm J
- Rostamianfar A
- Ruddy KJ
- Rudolph A
- Ruebner M
- Rutgers EJT
- Rüdiger T
- Saloustros E
- Sandler DP
- Sangrajrang S
- Sawyer EJ
- Schmidt DF
- Schmidt MK
- Schmutzler RK
- Schneeweiss A
- Schoemaker MJ
- Schumacher F
- Schürmann P
- Scott C
- Scott RJ
- Seal S
- Seng Chia K
- Seynaeve C
- Shah M
- Sharma P
- Shen C-Y
- Sheng G
- Sherman ME
- Shrubsole MJ
- Shu X-O
- Simard J
- Smeets A
- Sohn C
- Soucy P
- Southey MC
- Spinelli JJ
- Stegmaier C
- Stewart-Brown S
- Stone J
- Stram DO
- Surowy H
- Swerdlow A
- Taib NAM
- Tamimi R
- Taylor JA
- Tengström M
- Teo SH
- Tessier DC
- Thanasitthichai S
- Thöne K
- Tollenaar RAEM
- Tomlinson I
- Tong L
- Torres D
- Truong T
- Tseng C-C
- Tsugane S
- Tyrer J
- Ulmer H-U
- Untch M
- Ursin G
- Vachon C
- van Asperen CJ
- Van Den Berg D
- van den Ouweland AMW
- van der Kolk L
- van der Luijt RB
- Vincent D
- Vollenweider J
- Waisfisz Q
- Wang Q
- Wang Z
- Wang-Gohrke S
- Weinberg CR
- Wendt C
- Whittemore AS
- Wildiers H
- Willett W
- Winqvist R
- Wolk A
- Wu AH
- Xia L
- Yamaji T
- Yang XR
- Yoo K-Y
- Yu J-C
- Zheng W
- Zheng Y
- Zhu B
- Ziogas A
- Ziv E
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out. Genotyping of the OncoArray was principally funded from three sources: the PERSPECTIVE project, funded by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the ‘Ministère de l’Économie, de la Science et de l’Innovation du Québec’ through Genome Québec, and the Quebec Breast Cancer Foundation; the NCI Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative and Discovery, Biology and Risk of Inherited Variants in Breast Cancer (DRIVE) project (NIH Grants U19 CA148065 and X01HG007492); and Cancer Research UK (C1287/A10118 and C1287/A16563). BCAC is funded by Cancer Research UK (C1287/A16563), by the European Community’s Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS) and by the European Union’s Horizon 2020 Research and Innovation Programme under grant agreements 633784 (B-CAST) and 634935 (BRIDGES). Genotyping of the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710), the Canadian Institutes of Health Research for the ‘CIHR Team in Familial Risks of Breast Cancer’ program, and the Ministry of Economic Development, Innovation and Export Trade of Quebec, grant PSR-SIIRI-701. Combining of the GWAS data was supported in part by The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant U19 CA 148065 (DRIVE, part of the GAME-ON initiative)
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.
- Author
- Adank MA
- Aghmesheh M
- Ahearn T
- Aittomaki K
- Allen J
- Alnaes GIG
- Amor D
- Andrews L
- Andrulis IL
- Antill Y
- Anton-Culver H
- Antonenkova NN
- Antoniou AC
- Arndt V
- Aronson KJ
- Auer PL
- Auvinen P
- Balleine R
- Balleine R-M
- Barrdahl M
- Baxter R
- Beckmann MW
- Beesley J
- Behrens S
- Benitez J
- Bermisheva M
- Bernstein L
- Blackburn A
- Blomqvist C
- Bogdanova NV
- Bogwitz M
- Bojesen SE
- Bolla MK
- Bonanni B
- Borresen-Dale A-L
- Brauch H
- Braye S
- Bremer M
- Brenner H
- Brentnall A
- Brock IW
- Brooks-Wilson A
- Brown M
- Brucker SY
- Bruening T
- Burgess M
- Burke J
- Burwinkel B
- Butow P
- Caldon L
- Campa D
- Campbell I
- Carpenter J
- Carter BD
- Castelao JE
- Chang-Claude J
- Chanock SJ
- Chatterjee N
- Chen T-H
- Chenevix-Trench G
- Chlebowski R
- Christian A
- Christiansen H
- Clarke C
- Clarke C
- Clarke CL
- Cohen P
- Collaborators NBCS
- Collee JM
- Cordina-Duverger E
- Cornelissen S
- Couch FJ
- Cox A
- Crook A
- Cross SS
- Cui J
- Cummings M
- Czene K
- Dahlstrom J
- Daly MB
- Dawson S-J
- De Fazio A
- Delatycki M
- Dennis J
- Devilee P
- Dobrovic A
- Doerk T
- dos-Santos-Silva I
- Dudding T
- Duijf P
- Dumont M
- Dunning AM
- Durcan L
- Dwek M
- Easton DF
- Eccles DM
- Edkins E
- Edwards S
- Ekici AB
- Eliassen AH
- Ellberg C
- Engebraten O
- Engel C
- Eriksson M
- Evans DG
- Fachal L
- Farshid G
- Fasching PA
- Fellows A
- Field M
- Figueroa J
- Flanagan J
- Fletcher O
- Flyger H
- Foersti A
- Fong P
- Forbes J
- Forbs J
- Forrest L
- Fossa A
- Fox S
- Freeman LEB
- French J
- Friedlander M
- Fritschi L
- Gabrielson M
- Gago-Dominguez M
- Gapstur SM
- Garcia-Closas M
- Garcia-Saenz JA
- Gattas M
- Gaudet MM
- Geisler J
- Georgoulias V
- Giles G
- Giles GG
- Gill G
- Gilyazova IR
- Gleeson M
- Glendon G
- Goldberg MS
- Goldgar DE
- Gonzalez-Neira A
- Greening S
- Grip M
- Gronwald J
- Grundy A
- Guenel P
- Haakensen V
- Haan E
- Haeberle L
- Hahnen E
- Haiman CA
- Hakansson N
- Hall P
- Hamann U
- Hankinson SE
- Harkness EF
- Harris M
- Hart SN
- Hayward N
- He W
- Hein A
- Helland A
- Heyworth J
- Hickie I
- Hillemanns P
- Hollestelle A
- Holmen MM
- Hooning MJ
- Hoover RN
- Hopper J
- Hopper JL
- Howell A
- Huang G
- Humphreys K
- Hunt C
- Hunter DJ
- Investigators ABCTB
- Investigators KAOCS
- Jakimovska M
- Jakubowska A
- James P
- Janni W
- Jenkins M
- John EM
- Johnson N
- Jones ME
- Jukkola-Vuorinen A
- Jung A
- Kaaks R
- Kaczmarek K
- Karesen R
- Kataja V
- Keeman R
- Kefford R
- Kentwell M
- Kerin MJ
- Khusnutdinova E
- Kiiski JI
- Kirk J
- Kiserud CE
- Knight JA
- Ko Y-D
- Kollias J
- Kosma V-M
- Kostovska IM
- Koutros S
- Kraft P
- Kristensen VN
- Kruger U
- Kuehl T
- Lakhani S
- Lambrechts D
- Le Marchand L
- Lee A
- Lee CS
- Lee E
- Lejbkowicz F
- Lilyquist J
- Lindblom A
- Lindeman G
- Lindstrom S
- Lipton L
- Lissowska J
- Lo W-Y
- Lobb L
- Loibl S
- Lok S
- Long J
- Lubinski J
- Lush M
- Lux MP
- MacInnis RJ
- Macrea F
- Maishman T
- Makalic E
- Mann G
- Mannermaa A
- Manoukian S
- Margolin S
- Marsh D
- Marsh D
- Martens JWM
- Martinez ME
- Mavaddat N
- Mavroudis D
- McLachlan S-A
- McLean C
- Meindl A
- Meiser B
- Menon U
- Michailidou K
- Middha P
- Miller N
- Milne RL
- Moreno F
- Morey A
- Mulligan AM
- Mulot C
- Munoz-Garzon VM
- Naume B
- Neuhausen SL
- Nevanlinna H
- Neven P
- Newman WG
- Nielsen SF
- Nightingale S
- Nordestgaard BG
- Norman A
- O'connell S
- Offit K
- Olson JE
- Olsson H
- Orr N
- Ortega DG
- Ottestad L
- Pachter N
- Pankratz VS
- Park-Simon T-W
- Pathmanathan N
- Patterson B
- Perez JIA
- Perez-Barrios C
- Peterlongo P
- Peto J
- Pharoah PDP
- Phillips K
- Pinchev M
- Plaseska-Karanfilska D
- Polley EC
- Prentice R
- Presneau N
- Prokofyeva D
- Purrington K
- Pylkas K
- Rack B
- Radice P
- Rau-Murthy R
- Reinertsen KV
- Rennert G
- Rennert HS
- Rhenius V
- Riis M
- Robson M
- Romero A
- Ruddy KJ
- Ruebner M
- Sahlberg KK
- Saleh M
- Salisbury E
- Saloustros E
- Sandler DP
- Sauer T
- Saunders C
- Saunus J
- Sawyer EJ
- Schlichting E
- Schmidt DF
- Schmidt MK
- Schmutzler RK
- Schneeweiss A
- Schoemaker MJ
- Schuermann P
- Schumacher F
- Schwentner L
- Scott C
- Scott C
- Scott R
- Scott RJ
- Sexton A
- Seynaeve C
- Shah M
- Shelling A
- Sherman ME
- Shrubsole MJ
- Shu X-O
- Simard J
- Simpson P
- Simpson P
- Slager S
- Smeets A
- Sohn C
- Soucy P
- Southey M
- Southey MC
- Spigelman A
- Spinelli JJ
- Spurdle M
- Stegmaier C
- Stone J
- Swerdlow AJ
- Tamimi RM
- Tapper WJ
- Taylor J
- Taylor JA
- Terry MB
- Thoene K
- Thompson DJ
- Thorne H
- Tollenaar RAEM
- Tomlinson I
- Trainer A
- Trench G
- Truong T
- Tucker K
- Tyrer JP
- Tzardi M
- Ulmer H-U
- Untch M
- Vachon CM
- van Veen EM
- Vijai J
- Visvader J
- Walker L
- Wallis M
- Wang Q
- Weinberg CR
- Wendt C
- Whittemore AS
- Wilcken N
- Wildiers H
- Willett W
- Williams R
- Winqvist R
- Winship I
- Wolk A
- Wu K
- Yang X
- Yang XR
- Yannoukakos D
- Yip D
- Young MA
- Zeps N
- Zhang Y
- Zheng W
- Ziogas A
- Publication venue
- CELL PRESS
- Publication date
- 13/12/2018
- Field of study
Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs
Combined measurement of the Higgs boson mass from the H → γγ and H → ZZ∗ → 4ℓ decay channels with the ATLAS detector using √s = 7, 8, and 13 TeV pp collision data
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arbiol Val SJ
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assahsah J
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- ATLAS Collaboration
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Baer TM
- Bagnaia P
- Bahmani M
- Bailey AJ
- Bailey VR
- Baines JT
- Baines L
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beaucamp JY
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Benchekroun D
- Bendebba F
- Benhammou Y
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berrocal Guardia A
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhalla NK
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-Sykes CJ
- Bird GA
- Birman M
- Biros M
- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- Bitadze A
- Bjørke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blumenthal J
- Bobbink GJ
- Bobrovnikov VS
- Boehler M
- Boehm B
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bracinik J
- Brahimi N
- Brandt G
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- Braren F
- Brau B
- Brau JE
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brooks WK
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Brüers B
- Buanes T
- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burlayenko O
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabrera Urbán S
- Cadamuro L
- Caforio D
- Cai H
- Cai Y
- Cai Y
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capocasa F
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- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlotto JI
- Carlson BT
- Carlson EM
- Carminati L
- Carnelli A
- Carnesale M
- Caron S
- Carquin E
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- Carter JWS
- Carter TM
- Casado MP
- Caspar M
- Castillo Garcia L
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- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cavaliere V
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- Cavasinni V
- Cekmecelioglu YC
- Celebi E
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- Centonze MS
- Cepaitis V
- Cerny K
- Cerqueira AS
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- Cetin SA
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- Chapman JD
- Chapon E
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chauhan C
- Chekanov S
- Chekulaev SV
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- Chen Y
- Cheng CL
- Cheng HC
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- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cherkaoui El Moursli R
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- Chiarella V
- Chiarelli G
- Chiedde N
- Chiodini G
- Chisholm AS
- Chitan A
- Chitishvili M
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow EYS
- Chowdhury T
- Chu KL
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark PJ
- Clarry C
- Clavijo Columbie JM
- Clawson SE
- Clement C
- Clercx J
- Clissa L
- Coadou Y
- Cobal M
- Coccaro A
- Codina E Perez
- Coelho Barrue RF
- Coelho Lopes De Sa R
- Coelli S
- Cohen H
- Coimbra AEC
- Cole B
- Collot J
- Conde Muiño P
- Connell MP
- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cordeiro Oudot Choi A
- Corpe LD
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Cowan G
- Cranmer K
- Cremonini D
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosby JE
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cui Z
- Cunningham WR
- Curcio F
- Czodrowski P
- Czurylo MM
- D'amen G
- D'Amico V
- D'Auria S
- D'Eramo L
- D'Onofrio A
- D'Onofrio M
- D'uffizi M
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- Zhang Z
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- Zhao P
- Zhao T
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- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
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- Zhong D
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- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2023
- Field of study
A measurement of the mass of the Higgs boson combining the
H
→
Z
Z
∗
→
4
ℓ
and
H
→
γ
γ
decay channels is presented. The result is based on
140
fb
−
1
of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of
125.11
±
0.09
(
stat
)
±
0.06
(
syst
)
=
125.11
±
0.11
GeV
. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics
The Effect of a Specific Strength-Development Exercise on Bone Mineral Density in Perimenopausal and Postmenopausal Women
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- 'Mary Ann Liebert Inc'
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Aboriginal-Specific Health Initiatives and Accessible Health Care in Canada; Are Goodwill Initiatives Enough
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- 'Springer Science and Business Media LLC'
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- …