1,506 research outputs found
Ownership and attitudes towards technology use in physiotherapy students from seven countries
PURPOSE: To assess differences in prerequisites to blended learning such as technology use and Internet access in an international sample of physiotherapy students from Bangladesh, Belgium, Brazil, Luxembourg, Sudan, Switzerland and South Africa.
RESULTS: Students' digital technology experiences were generally low. They primarily used a smartphone and a laptop to connect to the Internet. However, there was a significant difference between institutions in owning a laptop and access to Internet. Most students preferred learning in environments that included some online components but had never used Twitter or written a blog post and wanted less social media in their learning environments.
CONCLUSION: Physiotherapy students would prefer an increase in the use of digital tools in their learning. However, differences in technology use and access highlight the challenges inherent to offering international online courses. Therefore decisions around online and blended course design in health professions education must be made with caution.Michael Rowe receives funding from the South African National Research Foundation
Entangled Mechanical Oscillators
Hallmarks of quantum mechanics include superposition and entanglement. In the
context of large complex systems, these features should lead to situations like
Schrodinger's cat, which exists in a superposition of alive and dead states
entangled with a radioactive nucleus. Such situations are not observed in
nature. This may simply be due to our inability to sufficiently isolate the
system of interest from the surrounding environment -- a technical limitation.
Another possibility is some as-of-yet undiscovered mechanism that prevents the
formation of macroscopic entangled states. Such a limitation might depend on
the number of elementary constituents in the system or on the types of degrees
of freedom that are entangled. One system ubiquitous to nature where
entanglement has not been previously demonstrated is distinct mechanical
oscillators. Here we demonstrate deterministic entanglement of separated
mechanical oscillators, consisting of the vibrational states of two pairs of
atomic ions held in different locations. We also demonstrate entanglement of
the internal states of an atomic ion with a distant mechanical oscillator.Comment: 7 pages, 2 figure
Foodborne disease outbreaks in United States schools
Background. The objective of this study was to describe the epidemiology of foodborne disease outbreaks in schools and to identify where preventive measures could be targeted. Methods. Reports by state and local health departments of foodborne disease outbreaks occurring in primary and secondary schools, colleges and universities from January 1, 1973, through December 31, 1997, were reviewed. Data from ill persons identified through foodborne outbreak investigations and subsequently reported to the Centers for Disease Control and Prevention in the Foodborne Outbreak Surveillance System were examined. The number and size of foodborne disease outbreaks, as well as the etiologic agents, food vehicles of transmission, site of food preparation and contributing factors associated with outbreaks were also examined. Results. From 1973 through 1997, states and local health departments reported 604 outbreaks of foodborne disease in schools. The median number of school outbreaks annually was 25 (range, 9 to 44). In 60% of the outbreaks an etiology was not determined, and in 45% a specific food vehicle of transmission was not determined. Salmonella was the most commonly identified pathogen, accounting for 36% of outbreak reports with a known etiology. Specific food vehicles of transmission were epidemiologically identified in 333 (55%) of the 604 outbreaks. The most commonly implicated vehicles were foods containing poultry (18.6%), salads (6.0%), Mexican-style food (6.0%), beef (5.7%) and dairy products excluding ice cream (5.0%). The most commonly reported food preparation practices that contributed to these school-related outbreaks were improper food storage and holding temperatures and food contaminated by a food handler. Conclusions. Strengthening food safety measures in schools would better protect students and school staff from outbreaks of foodborne illness. Infection control policies, such as training and certification of food handlers in the proper storage and cooking of foods, meticulous hand washing and paid sick leave for food handlers with gastroenteritis, could make meals safer for American students
Von Bezold assimilation effect reverses in stereoscopic conditions
Lightness contrast and lightness assimilation are opposite phenomena: in contrast,
grey targets appear darker when bordering bright surfaces (inducers) rather than dark ones; in
assimilation, the opposite occurs. The question is: which visual process favours the occurrence
of one phenomenon over the other? Researchers provided three answers to this question. The
first asserts that both phenomena are caused by peripheral processes; the second attributes their
occurrence to central processes; and the third claims that contrast involves central processes,
whilst assimilation involves peripheral ones. To test these hypotheses, an experiment on an IT
system equipped with goggles for stereo vision was run. Observers were asked to evaluate the
lightness of a grey target, and two variables were systematically manipulated: (i) the apparent
distance of the inducers; and (ii) brightness of the inducers. The retinal stimulation was kept
constant throughout, so that the peripheral processes remained the same. The results show that
the lightness of the target depends on both variables. As the retinal stimulation was kept constant, we
conclude that central mechanisms are involved in both lightness contrast and lightness assimilation
The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell Infection
Infection of human B cells with wild-type Epstein-Barr virus (EBV) in vitro leads to activation and proliferation that result in efficient production of lymphoblastoid cell lines (LCLs). Latent Membrane Protein 2 (LMP2) is expressed early after infection and previous research has suggested a possible role in this process. Therefore, we generated recombinant EBV with knockouts of either or both protein isoforms, LMP2A and LMP2B (Î2A, Î2B, Î2A/Î2B) to study the effect of LMP2 in early B cell infection. Infection of B cells with Î2A and Î2A/Î2B viruses led to a marked decrease in activation and proliferation relative to wild-type (wt) viruses, and resulted in higher percentages of apoptotic B cells. Î2B virus infection showed activation levels comparable to wt, but fewer numbers of proliferating B cells. Early B cell infection with wt, Î2A and Î2B viruses did not result in changes in latent gene expression, with the exception of elevated LMP2B transcript in Î2A virus infection. Infection with Î2A and Î2B viruses did not affect viral latency, determined by changes in LMP1/Zebra expression following BCR stimulation. However, BCR stimulation of Î2A/Î2B cells resulted in decreased LMP1 expression, which suggests loss of stability in viral latency. Long-term outgrowth assays revealed that LMP2A, but not LMP2B, is critical for efficient long-term growth of B cells in vitro. The lowest levels of activation, proliferation, and LCL formation were observed when both isoforms were deleted. These results suggest that LMP2A appears to be critical for efficient activation, proliferation and survival of EBV-infected B cells at early times after infection, which impacts the efficient long-term growth of B cells in culture. In contrast, LMP2B did not appear to play a significant role in these processes, and long-term growth of infected B cells was not affected by the absence of this protein. © 2013 Wasil et al
No Detectable Fertility Benefit from a Single Additional Mating in Wild Stalk-Eyed Flies
Background: Multiple mating by female insects is widespread, and the explanation(s) for repeated mating by females has been the subject of much discussion. Females may profit from mating multiply through direct material benefits that increase their own reproductive output, or indirect genetic benefits that increase offspring fitness. One particular direct benefit that has attracted significant attention is that of fertility assurance, as females often need to mate multiply to achieve high fertility. This hypothesis has never been tested in a wild insect population.Methodology/Principal Findings: Female Malaysian stalk-eyed flies (Teleopsis dalmanni) mate repeatedly during their lifetime, and have been shown to be sperm limited under both laboratory and field conditions. Here we ask whether receiving an additional mating alleviates sperm limitation in wild females. In our experiment one group of females received a single additional mating, while a control group received an interrupted, and therefore unsuccessful, mating. Females that received an additional mating did not lay more fertilised eggs in total, nor did they lay proportionately more fertilised eggs. Female fertility declined significantly through time, demonstrating that females were sperm limited. However, receipt of an additional mating did not significantly alter the rate of this decline.Conclusions/Significance: Our data suggest that the fertility consequences of a single additional mating were small. We discuss this effect (or lack thereof), and suggest that it is likely to be attributed to small ejaculate size, a high proportion of failed copulations, and the presence of X-linked meiotic drive in this species
The development and application of a new tool to assess the adequacy of the content and timing of antenatal care
Abstract
Background: Current measures of antenatal care use are limited to initiation of care and number of visits. This
study aimed to describe the development and application of a tool to assess the adequacy of the content and
timing of antenatal care.
Methods: The Content and Timing of care in Pregnancy (CTP) tool was developed based on clinical relevance for
ongoing antenatal care and recommendations in national and international guidelines. The tool reflects minimal
care recommended in every pregnancy, regardless of parity or risk status. CTP measures timing of initiation of care,
content of care (number of blood pressure readings, blood tests and ultrasound scans) and whether the
interventions were received at an appropriate time. Antenatal care trajectories for 333 pregnant women were then
described using a standard tool (the APNCU index), that measures the quantity of care only, and the new CTP tool.
Both tools categorise care into 4 categories, from âInadequateâ (both tools) to âAdequate plusâ (APNCU) or
âAppropriateâ (CTP). Participants recorded the timing and content of their antenatal care prospectively using diaries.
Analysis included an examination of similarities and differences in categorisation of care episodes between the
tools.
Results: According to the CTP tool, the care trajectory of 10,2% of the women was classified as inadequate, 8,4%
as intermediate, 36% as sufficient and 45,3% as appropriate. The assessment of quality of care differed significantly
between the two tools. Seventeen care trajectories classified as âAdequateâ or âAdequate plusâ by the APNCU were
deemed âInadequateâ by the CTP. This suggests that, despite a high number of visits, these women did not receive
the minimal recommended content and timing of care.
Conclusions: The CTP tool provides a more detailed assessment of the adequacy of antenatal care than the
current standard index. However, guidelines for the content of antenatal care vary, and the tool does not at the
moment grade over-use of interventions as âInappropriateâ. Further work needs to be done to refine the content
items prior to larger scale testing of the impact of the new measure
Quantum Communication
Quantum communication, and indeed quantum information in general, has changed
the way we think about quantum physics. In 1984 and 1991, the first protocol
for quantum cryptography and the first application of quantum non-locality,
respectively, attracted a diverse field of researchers in theoretical and
experimental physics, mathematics and computer science. Since then we have seen
a fundamental shift in how we understand information when it is encoded in
quantum systems. We review the current state of research and future directions
in this new field of science with special emphasis on quantum key distribution
and quantum networks.Comment: Submitted version, 8 pg (2 cols) 5 fig
Building capacity for HIV/AIDS program leadership and management in Uganda through mentored Fellowships
Background: Around the world, health professionals and program managers are leading and managing public and private health organizations with little or no formal management and leadership training and experience. Objective: To describe an innovative 2-year, long-term apprenticeship Fellowship training program implemented by Makerere University School of Public Health (MakSPH) to strengthen capacity for leadership and management of HIV/AIDS programs in Uganda. Implementation process: The program, which began in 2002, is a 2-year, full-time, non-degree Fellowship. It is open to Ugandan nationals with postgraduate training in health-related disciplines. Enrolled Fellows are attached to host institutions implementing HIV/AIDS programs and placed under the supervision of host institution and academic mentors. Fellows spend 75% of their apprenticeship at the host institutions while the remaining 25% is dedicated to didactic short courses conducted at MakSPH to enhance their knowledge base. Achievements: Overall, 77 Fellows have been enrolled since 2002. Of the 57 Fellows who were admitted between 2002 and 2008, 94.7% (54) completed the Fellowship successfully and 50 (92.3%) are employed in senior leadership and management positions in Uganda and internationally. Eighty-eight percent of those employed (44/54) work in institutions registered in Uganda, indicating a high level of in-country retention. Nineteen of the 20 Fellows who were admitted between 2009 and 2010 are still undergoing training. A total of 67 institutions have hosted Fellows since 2002. The host institutions have benefited through staff training and technical expertise from the Fellows as well as through grant support to Fellows to develop and implement innovative pilot projects. The success of the program hinges on support from mentors, stakeholder involvement, and the hands-on approach employed in training. Conclusion: The Fellowship Program offers a unique opportunity for hands-on training in HIV/AIDS program leadership and management for both Fellows and host institutions
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