Editorial

A realização do IV Colóquio Michel Foucault – a judicialização da vida, em 2021, foi marcada por condições absolutamente inéditas àquelas das três edições anteriores. Vivíamos a pandemia da Covid-19 e os efeitos de uma forma de governo operada pela desestabilização das instituições, ataques ao que se entende como direitos humanos, perseguição e anuência da morte de lideranças e populações consideradas periféricas, como moradores de favelas e povos indígenas. A excepcionalidade colocada para o mundo pelo avanço acelerado do contágio e a mutabilidade do vírus, aliadas aos exíguos conhecimentos e recursos para prevenção e cuidados, provocaram variadas frentes de mobilização e de incidência para um combate mais imediato, ainda que incerto em seus resultados

Estado, justiça, militarização

A eclosão, em 2020, da pandemia Covid-19 agudizou certos problemas brasileiros, a exemplo da pobreza que fica escancarada e da clara exposição do caráter discriminatório do chamado Estado de Direito. É possível amalgamar essas duas referências, pobreza e direitos, ao campo da chamada justiça social, quando ela traz a crença no Estado com o seu enunciado de igualdade, afirmado pela sociedade liberal. Entretanto, não é apenas nesse momento pandêmico que constatamos para quais humanos os direitos são destinados e como se dão suas maciças violações, pois, quando percorremos a história brasileira, vislumbramos a insustentabilidade da proposta de um mundo comum e igual para todos. A aplicação diferenciada da lei e a naturalização da violência que recai sobre alguns como prática de proteção de alguns outros põem a nu as relações militarizadas de poder. É com tais problematizações que propomos, no presente artigo, análises da relação Estado, justiça e militarização do cotidiano

Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex

Mucopolysaccharidosis type I (MPS I) is caused by genetic deficiency of alpha-l-iduronidase and impairment of lysosomal catabolism of heparan sulfate and dermatan sulfate. In the brain, these substrates accumulate in the lysosomes of neurons and glial cells, leading to neuroinflammation and neurodegeneration. Their storage also affects lysosomal homeostasis-inducing activity of several lysosomal proteases including cathepsin B (CATB). In the central nervous system, increased CATB activity has been associated with the deposition of amyloid plaques due to an alternative pro-amyloidogenic processing of the amyloid precursor protein (APP), suggesting a potential role of this enzyme in the neuropathology of MPS I. In this study, we report elevated levels of protein expression and activity of CATB in cortex tissues of 6-month-old MPS I (Idua -/- mice. Besides, increased CATB leakage from lysosomes to the cytoplasm of Idua -/- cortical pyramidal neurons was indicative of damaged lysosomal membranes. The increased CATB activity coincided with an elevated level of the 16-kDa C-terminal APP fragment, which together with unchanged levels of beta-secretase 1 was suggestive for the role of this enzyme in the amyloidogenic APP processing. Neuronal accumulation of Thioflavin-S-positive misfolded protein aggregates and drastically increased levels of neuroinflammatory glial fibrillary acidic protein (GFAP)-positive astrocytes and CD11b-positive activated microglia were observed in Idua -/- cortex by confocal fluorescent microscopy. Together, our results point to the existence of a novel CATB-associated alternative amyloidogenic pathway in MPS I brain induced by lysosomal storage and potentially leading to neurodegeneration

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Background and aim: This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults. Methods and results: The PubMed/Medline, Scopus, Web of sciences, and Google Scholar were systematically searched for randomized controlled trials available in English and published before February 2019. The meta-analysis was conducted using fixed effects models, and between-study heterogeneity was assessed by Cochran's Q test and I2. A total of 17 effect sizes were included in the meta-analysis. Combined effect sizes on serum total cholesterol concentrations revealed significant effects of GCBE supplementation on serum total cholesterol weighted mean difference (WMD): �4.51 mg/dL, 95% confidence interval (CI): �6.89, �2.12, p < 0.001, low density lipoprotein-cholesterol (LDL-C) (WMD: �4.38 mg/dL, 95% CI: �6.44, �2.31, p < 0.001), and high density lipoprotein-cholesterol (HDL-C) (WMD: 2.63 mg/dL, 95% CI: 2.20, 3.07, p < 0.001) compared to controls. Nevertheless, no significant changes were observed in serum triglycerides levels (WMD: �4.34 mg/dL, 95% CI: �9.00, 0.32, p = 0.068). Conclusion: The evidence from available studies suggests that the GCBE supplementation leads to significant reductions in total cholesterol, HDL-C, and LDL-C levels, and has modest, but, non-significant effects on triglycerides levels. © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II Universit

Nursing Students' Perceptions on Healthcare-Associated Infection Control and Prevention Teaching and Learning Experience: Development and Validation of a Scale in Four European Countries

Healthcare-associated infections are one of the major concerns worldwide. This study presents the development and the validation process of the InovSafeCare scale and aimed at identifying and measuring the ecosystem variables related to healthcare-associated infection (HCAI) prevention and control practices in European nurse students. Qualitative and quantitative approaches were used to (1) elaborate an item pool related to the educational environment, the healthcare setting environment, and the attitudes, beliefs, and performance of the nursing students regarding HCAI prevention and control and (2) analyze psychometric properties of the scale using factor analysis. The validated InovSafeCare scale was applied to undergraduate nursing students of five European Higher Education Institutions. The partial least square structural equation modeling (PLS-SEM) method with SMART-PLS3 software was used. The study sample consists of 657 nursing students, who responded a self-report inventory. From the analyzed data were identified 14 factors. The InovSafeCare scale reveals good validity and reliability of the dimensions in different European countries.info:eu-repo/semantics/publishedVersio

Percentages of cooled Artemia Nauplii for pacam? larvae culture

Todos os textos, informa??es e resultados apresentados s?o de inteira responsabilidade dos autores.O pacam? ? uma esp?cie nativa e end?mica da bacia hidrografia do Rio S?o Francisco. Os n?uplios de Artemia sp. constituem um importante insumo, principalmente para a cria??o de larvas de peixes, de camar?es marinhos e de ?gua doce. Portanto o objetivo desse trabalho foi avaliar diferentes porcentagens de n?uplios de Artemia sp.resfriada na alimenta??o de larvas de pacam?. Os n?uplios de Artemia sp. s?o adequadas para a alimenta??o de larvas de pacam?, sendo recomendado o fornecimento de 70 a 100% do seu peso vivo.The pacam? is a native and endemic species of the basin hydrography basin of the S?o Francisco River. Artemia sp. nauplii constituted an important ingredient especially for fish larvae breeding of marine, and freshwater prawns. Therefore the aim of this study was to evaluate different percentages of Artemia sp.resfriada the power pacam? larvae. Artemia sp. nauplii. are suitable for pacam? larvae feeding, being recommended 70 to 100% of body weight

A systematic study of the optical properties of mononuclear hybrid organo-inorganic lanthanoid complexes

A series of hybrid organo-inorganic mononuclear lanthanoid complexes, [n-NBu4]3[LnH(PW11O39)(phen)2]·H2O, denoted as LM4-1-Ln (Ln = DyIII, TbIII, EuIII, NdIII, ErIII, HoIII and GdIII), were synthesized via hydrothermal synthesis and were structurally characterized by X-ray diffraction. The optical properties of all complexes have been investigated in the solid state. The temperature-dependent emission spectra of LM4-1-Dy, LM4-1-Tb and LM4-1-Eu complexes show intense lanthanoid emissions in the visible region, while LM4-1-Nd shows near-infrared (NIR) luminescence. The EuIII complex shows typical strong red emissions from the 5D0 → 7F0,1,2,3,4 transitions, with the CIE colour coordinates (0.631,0.364), the colour purity value of 83.9% and a quantum yield of up to 4.3%, suggesting that the organic fragment has an effect on the optical properties compared to fully inorganic systems, making this complex very attractive as a red component of light-emitting diodes. The luminescence decays of LM4-1-Dy, LM4-1-Tb and LM4-1-Eu exhibit a biexponential behaviour, with τAV = 4.1(7) μs, 0.35(2) ms and 0.94(3) ms, respectively. The values obtained for Judd-Ofelt intensity parameters Ω2 and Ω4 support the interaction between the EuIII and the ligands. Furthermore, those with ErIII and HoIII present weak emissions in the visible region. The T-dependent photoluminescence results show that the LM4-1-Dy, LM4-1-Tb and LM4-1-Nd complexes have good temperature sensitivity, demonstrating that the materials have the potential to be used as a sensing element for luminescent thermometers in different temperature ranges