10 research outputs found
Importance of Metabolism. Mechanistic Considerations Relevant for Toxicological Regulation
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance
- Author
- Publication venue
- 'American Society for Pharmacology & Experimental Therapeutics (ASPET)'
- Publication date
- Field of study
Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structures
- Author
- Afzelius
- Case
- Cheng
- Connolly
- Crivori
- Cruciani
- de
- Ekroos
- Frauenfelder
- Hegde
- Hennemann
- Heyer
- Hoffmann
- Hritz
- Jones
- Jones
- Jung
- Kim
- Korzekwa
- Koshland
- Kua
- Li
- Li
- Lill
- Ma
- Markus A. Lill
- Matthew L. Danielson
- McGovern
- Michael A. Mohutsky
- Mohamadi
- Murray
- Oh
- Olsen
- Park
- Pearlman
- Prashant V. Desai
- Prusis
- Rowland
- Rydberg
- Rydberg
- Rydberg
- Rydberg
- Singh
- Steven A. Wrighton
- Stjernschantz
- Sykes
- Tarcsay
- Trott
- Tsai
- Vasanthanathan
- Vermeulen
- Warren
- Wester
- Wienkers
- Word
- Wrighton
- Yano
- Yano
- Zamora
- Zheng
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The potential of Epimedium koreanum
- Author
- Bjornsson
- Cespedes-Garro
- Cheng
- Cheng
- Chiangsom
- Dan Liu
- Darwich
- E. Sun
- Edwards
- Gao
- Gong
- Grimm
- Hao Wu
- Hedrich
- Hou
- Hwang
- Indran
- Jie Song
- Jing Wang
- Karkhanis
- Lau
- Li
- Li Zhang
- Liang
- Liang Feng
- Liu
- Ma
- Martignoni
- Mohutsky
- Nelson
- Obach
- Oh
- Or
- Pal
- Perera
- Pinto
- Qingxiang Zhong
- Rongling Zhong
- Sekiguchi
- Shen
- Sui
- Tachibana
- Wang
- Wang
- Wang
- Wang
- Xiaobin Jia
- Yingjie Wei
- Yu
- Yutong Jiang
- Zheng
- Zheng
- Zhenhai Zhang
- Zhi Xia
- Ziqi Shi
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro
- Author
- A Pilotto
- AS Etheridge
- BH Cheng
- BY Kim
- C Jenkinson
- C Liu
- CD King
- E Khodarahmi
- EJ Choi
- F Thiebaut
- H Jung
- H Rastogi
- HJ Cho
- JH Gong
- Jin-Mu Yi
- JM Mathews
- JM Mathews
- JS Choi
- K Sun
- K Sun
- K Sun
- K Thelen
- KN Dijk van
- L Teng
- M Nimrouzi
- M Zheng
- MA Mohutsky
- MZ Liu
- NH Mohamed
- No Soo Kim
- NP Bekker
- Ok-Sun Bang
- PS Fasinu
- R Hermann
- R Singh
- S Hori
- S Ramasamy
- SM Ock
- WM Kong
- XW Chen
- Y Feng
- Y Pan
- Y Wang
- YH Jeong
- YH Wang
- YJ Lee
- You Jin Lee
- Young Ah Kim
- YQ Chen
- ZY Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
In Vitro Experimental Models for Studying Drug Biotransformation
- Author
- Abdel-Razzak
- Anders
- Argoti
- Bachmann
- Baillie
- Balani
- Barker
- Barter
- Bateman
- Bertelsen
- Blanchard
- Bohnert
- Brown
- Brown
- Ceccarelli
- Chen
- Chen
- Chien
- Chowdhury
- Chu
- Constanzer
- Cooper
- Cooper
- Dalvie
- Dalvie
- De Graaf
- Dekant
- Dekant
- Delbressine
- Dieckhaus
- Duret
- Dvorak
- Einolf
- Evans
- Fagerholm
- Fagerholm
- Fahmi
- Fang
- Fisher
- Fisher
- Fontana
- Fowler
- Fuhr
- Galetin
- Gan
- Geick
- Ghibellini
- Ghibellini
- Gillotin
- Gomez-Lechon
- Gomez-Lechon
- Gorrod
- Gu
- Guengerich
- Guillouzo
- Hakooz
- Hamberg
- Hariparsad
- Harper
- Hein
- Hein
- Hein
- Hewitt
- Hewitt
- Hewitt
- Houston
- Ingelman-Sundberg
- Ingelman-Sundberg
- Ingelman-Sundberg
- Izzo
- Kaji
- Kalgutkar
- Kalgutkar
- Kalgutkar
- Kent
- Kent
- Kilicarslan
- Kirchheiner
- Lam
- LeCluyse
- Li
- Lim
- Lim
- Lim
- Lin
- Lin
- Lin
- Lin
- Liu
- Lock
- Lu
- Luo
- Luo
- Luo
- Ma
- Ma
- Ma
- Maitland
- Masubuchi
- Matheny
- Maurer
- Mohutsky
- Munns
- Mutlib
- Mutlib
- Naritomi
- Nassar
- Neuberger
- Nielsen
- Niwa
- Obach
- Obach
- Obach
- Obach
- Obach
- Obach
- Obach
- Ogilvie
- Pang
- Pang
- Parkinson
- Patel
- Pearce
- Polasek
- Ponsoda
- Proctor
- Puga
- Rashed
- Reddy
- Riedmaier
- Riley
- Riley
- Ripp
- Rodrigues
- Rodrigues
- Rousu
- Sakaguchi
- Schaefer
- Scholz
- Shenfield
- Sinz
- Sinz
- Soars
- Soglia
- Soglia
- Suzuki
- Takakusa
- Takeda
- Tang
- Thompson
- Tirona
- Townsend
- Uttamsingh
- Van
- Venkatakrishnan
- Venkatakrishnan
- Venkatakrishnan
- Venkatakrishnan
- Von Moltke
- Voorhis
- Voorman
- Walsky
- Wang
- Watanabe
- Weaver
- Wilkinson
- Wilkinson
- Williams
- Williams
- Xu
- Xu
- Yan
- Yang
- Yao
- Yao
- You
- Zhang
- Zhang
- Zhao
- Zhao
- Zhou
- Zhu
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Rationalizing underprediction of drug clearance from enzyme and transporter kinetic data: From in vitro tools to mechanistic modeling
- Author
- A Aitio
- A Dokoumetzidis
- A Galetin
- A Galetin
- A Guillouzo
- A Poirier
- A Poirier
- A Poirier
- A Rostami-Hodjegan
- A Rostami-Hodjegan
- A Rowland
- A Rowland
- A Rowland
- AF Sasso
- AJ Parker
- AN Edginton
- AS Darwich
- B Agoram
- B Davies
- BJ Ring
- C Ghobadi
- C Sall
- D Dalvie
- D Hallifax
- D Hallifax
- D Hallifax
- D Hallifax
- D Tam
- DC Pryde
- DJ Carlile
- E Jigorel
- E Kimoto
- E Steeg van de
- F Bouzom
- G Camenisch
- H Hiraoka
- H Kusuhara
- H Kusuhara
- H Lennernas
- H Zhang
- HE Cubitt
- HE Cubitt
- HM Jones
- HM Jones
- HM Jones
- HM Jones
- HS Brown
- I Nestorov
- I Nestorov
- IA Nestorov
- International Commission on Radiological Protection
- J Yang
- JA Grillo
- JB Houston
- JB Houston
- JJ Engtrakul
- JK Lee
- JM Hutzler
- JO Miners
- K Ball
- K Ito
- K Ito
- K Ito
- K Menochet
- K Menochet
- K Rowland Yeo
- K Sugano
- K Yoshida
- KL Gill
- KL Gill
- KM Giacomini
- KP Kanebratt
- KR Korzekwa
- KS Pang
- KS Pang
- KS Pang
- L Badolo
- L Di
- L Di
- L Sivertsson
- LX Yu
- LX Yu
- M Baker
- M Chiba
- M Darnell
- M Gertz
- M Gertz
- M Gertz
- M Gertz
- M Jamei
- M Jamei
- M Jamei
- M Rowland
- M Ulvestad
- M Ulvestad
- M Zientek
- MA Mohutsky
- MB Fisher
- MD Harwood
- MF Paine
- MF Paine
- MG Soars
- MG Soars
- MG Soars
- MJ Zamek-Gliszczynski
- MV Varma
- MV Varma
- N Chalasani
- N Kotani
- N Parrott
- O Schaefer
- P Gaganis
- P Poulin
- P Poulin
- P Zhao
- P Zhao
- PJ Kilford
- PJ Kilford
- PJ Webborn
- RJ Riley
- RK Kuester
- RP Brown
- RS Obach
- RS Obach
- S Berggren
- S Bjorkman
- S Ohtsuki
- SK Quinney
- SK Quinney
- SM Huang
- SS Buck De
- T Lave
- T Takashima
- T Watanabe
- T Watanabe
- TG Tucker
- U Zanelli
- VK Sinha
- WS Al-Jahdari
- X Chu
- X Zhang
- Y Chen
- Y Shitara
- Y Shitara
- Y Yabe
- YA Bi
- ZE Barter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
- Author
- A Dokoumetzidis
- A Dokoumetzidis
- A Fura
- A Galetin
- BG Reigner
- BG Reigner
- BM Agoram
- C Huang
- C Pidgeon
- C Zhu
- CA Lipinski
- CL Stoner
- CR Gibson
- CW Andrews
- D Sun
- Duxin Sun
- EI Ashforth
- F Kesisoglou
- F Yoshida
- G Ghibellini
- G Schneider
- G Suntharalingam
- H Boxenbaum
- H Tang
- H Tang
- H Tang
- H Tang
- H Tang
- Hayley J. Paholak
- HM Jones
- HS Brown
- I Mahmood
- I Mahmood
- I Mahmood
- I Mahmood
- I Mahmood
- I Mahmood
- I Mahmood
- I Mahmood
- J Kotecha
- J Yang
- J Zuegge
- JB Houston
- JB Houston
- JF Contrera
- K Goteti
- K Goteti
- K Ito
- K Ito
- K Nikolic
- K Sugano
- KW Ward
- L Iavarone
- Lawrence X. Yu
- M Chiba
- M Kansy
- MA Mohutsky
- MG Soars
- N Hakooz
- NA Hosea
- Nan Zheng
- P Artursson
- Peng Zou
- PJ Kilford
- PJ Lowe
- PJ Lowe
- PY Muller
- R Badhan
- R Dedrick
- R Nagilla
- R Niro
- R Stringer
- RA Stringer
- RS Obach
- RS Obach
- RS Obach
- RS Obach
- S Yee
- SM Skaggs
- SS Buck De
- T Akabane
- T Heimbach
- T Lave
- T Lave
- T Lave
- T Lave
- T Wajima
- T Wajima
- U Fagerholm
- U Fagerholm
- U Fagerholm
- U Fagerholm
- U Fagerholm
- U Fagerholm
- V Sharma
- VK Sinha
- W Rubas
- WN Charman
- X Cao
- Y Naritomi
- Y Naritomi
- Y Shibata
- Yanke Yu
- Yongsheng Yang
- Publication venue
- 'American Association of Pharmaceutical Scientists (AAPS)'
- Publication date
- Field of study
Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data
- Author
- Abdul MMI
- Ahmed SM
- Al Faraj S
- Alemdaroglu NC
- Almeida JC
- Alscher DM
- Andrade AS
- Andrén L
- Angelo A. Izzo
- Anke J
- Ansell J
- Arold G
- Aruna D
- Aslam M
- Aston JL
- Barbenel DM
- Barone GW
- Beckert BW
- Beer AM
- Bell EC
- Berginc K
- Bilgi N
- Bon S
- Bone KM
- Bonetto N
- Borrelli F
- Breidenbach T
- Breidenbach T
- Bryant SM
- Burstein AH
- Bush TM
- Cambria-Kiely JA
- Capasso R
- Caraci F
- Carrasco MC
- Chan TY
- Chen MF
- Chow HH
- Colalto C
- Corrigan
- Cox MC
- Crowe S
- Dalvi SS
- Dannawi M
- de Maat MM
- De Smet PA
- Deahl M
- Deng JW
- DiCenzo R
- Donovan JL
- Donovan JL
- Dresser GK
- Dresser GK
- Eich-Höchli D
- Ellis GR
- Eltayeb IB
- Engelsen J
- Etogo-Asse F
- Fan L
- Fan L
- Frye RF
- Fuhr U
- Gallicano K
- Galluzzi S
- Gin H
- González-Stuart A
- Gordon JB
- Gordon RY
- Gorski JC
- Grant P
- Greenblatt DJ
- Greenblatt DJ
- Grenier J
- Griffiths AP
- Gurley B
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gurley BJ
- Gwilt PR
- Hafner V
- Hajda J
- Hall SD
- Hanselin MR
- Harrigan JT
- Hebert MF
- Hojo Y
- Holman CP
- Homma M
- Howland RH
- Huupponen R
- Imai H
- Irefin S
- Izzat MB
- Izzo AA
- Jabbari A
- Janetzky K
- Jiang W
- Jiang X
- Jiang X
- Jiang X
- Johne A
- Johne A
- Jones BD
- Karliova M
- Kawaguchi A
- Kennedy DA
- Kerr BM
- Khawaja IS
- King AR
- Kolawole JA
- Krüth P
- Kuncl RW
- Kupiec T
- Lam AY
- Lambert JP
- Lantz MS
- Laroche M
- Leber HW
- Lee A
- Lee LS
- Lee SH
- Lee YH
- Lei HP
- Leung H
- Li HY
- Li Z
- Lilja JJ
- Lin YY
- Lu Y
- López Galera RM
- Macan H
- Mahmoud BM
- Mai I
- Mai I
- Mai I
- Mandelbaum A
- Markowitz JS
- Markowitz JS
- Markowitz JS
- Markowitz JS
- Mathijssen RH
- Matthews
- Maurer A
- Mauro VF
- McRae S
- Meisel C
- Mergenhagen KA
- Mills E
- Milton JC
- Mohammed Abdul MI
- Mohutsky MA
- Moltó J
- Morimoto T
- Moschella C
- Mueller SC
- Mueller SC
- Mueller SC
- Mueller SC
- Murphy PA
- Nebel A
- Ohkawa S
- Paeng CH
- Paeng CH
- Page RL
- Pathak A
- Pfrunder A
- Pham DQ
- Pham DQ
- Piscitelli SC
- Piscitelli SC
- Piscitelli SC
- Portolés A
- Prasad GV
- Qiu F
- Rajnarayana K
- Rengelshausen J
- Rey JM
- Richter WO
- Rindone JP
- Robertson SM
- Roby CA
- Rosenblatt M
- Rubin D
- Ruschitzka F
- Sandhu RS
- Schelosky L
- Schwarz UI
- Schwarz UI
- Segal R
- Shader RI
- Shon JH
- Smith P
- Sobieraj DM
- Sugimoto K
- Sunter WH
- Suvarna R
- Tam LS
- Tankanow R
- Tannergren C
- Taylor JR
- Tomlinson B
- Tu JH
- Turton-Weeks SM
- Uchida S
- Ueng YF
- Ushijima K
- van Erp NP
- Wang G
- Wang LS
- Wang LS
- Wang PH
- Wang XD
- Wang XD
- Wang Z
- Wanwimolruk S
- Wanwimolruk S
- Wenk M
- Werba JP
- Wiegman DJ
- Will-Shahab L
- Xie R
- Xin HW
- Xin HW
- Yin OQ
- Yoshioka M
- Yu CM
- Yuan CS
- Yue QY
- Zhang W
- Zhou SF
- Zhou SF
- Zikria J
- Zuo XC
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2012
- Field of study
Rationalizing Underprediction of Drug Clearance from Enzyme and Transporter Kinetic Data: From In Vitro Tools to Mechanistic Modeling
- Author
- A Aitio
- A Dokoumetzidis
- A Galetin
- A Galetin
- A Guillouzo
- A Poirier
- A Poirier
- A Poirier
- A Rostami-Hodjegan
- A Rostami-Hodjegan
- A Rowland
- A Rowland
- A Rowland
- AF Sasso
- AJ Parker
- AN Edginton
- AS Darwich
- B Agoram
- B Davies
- BJ Ring
- C Ghobadi
- C Sall
- D Dalvie
- D Hallifax
- D Hallifax
- D Hallifax
- D Hallifax
- D Tam
- DC Pryde
- DJ Carlile
- E Jigorel
- E Kimoto
- E Steeg van de
- F Bouzom
- G Camenisch
- H Hiraoka
- H Kusuhara
- H Kusuhara
- H Lennernas
- H Zhang
- HE Cubitt
- HE Cubitt
- HM Jones
- HM Jones
- HM Jones
- HM Jones
- HS Brown
- I Nestorov
- I Nestorov
- IA Nestorov
- International Commission on Radiological Protection
- J Yang
- JA Grillo
- JB Houston
- JB Houston
- JJ Engtrakul
- JK Lee
- JM Hutzler
- JO Miners
- K Ball
- K Ito
- K Ito
- K Ito
- K Menochet
- K Menochet
- K Rowland Yeo
- K Sugano
- K Yoshida
- KL Gill
- KL Gill
- KM Giacomini
- KP Kanebratt
- KR Korzekwa
- KS Pang
- KS Pang
- KS Pang
- L Badolo
- L Di
- L Di
- L Sivertsson
- LX Yu
- LX Yu
- M Baker
- M Chiba
- M Darnell
- M Gertz
- M Gertz
- M Gertz
- M Gertz
- M Jamei
- M Jamei
- M Jamei
- M Rowland
- M Ulvestad
- M Ulvestad
- M Zientek
- MA Mohutsky
- MB Fisher
- MD Harwood
- MF Paine
- MF Paine
- MG Soars
- MG Soars
- MG Soars
- MJ Zamek-Gliszczynski
- MV Varma
- MV Varma
- N Chalasani
- N Kotani
- N Parrott
- O Schaefer
- P Gaganis
- P Poulin
- P Poulin
- P Zhao
- P Zhao
- PJ Kilford
- PJ Kilford
- PJ Webborn
- RJ Riley
- RK Kuester
- RP Brown
- RS Obach
- RS Obach
- S Berggren
- S Bjorkman
- S Ohtsuki
- SK Quinney
- SK Quinney
- SM Huang
- SS Buck De
- T Lave
- T Takashima
- T Watanabe
- T Watanabe
- TG Tucker
- U Zanelli
- VK Sinha
- WS Al-Jahdari
- X Chu
- X Zhang
- Y Chen
- Y Shitara
- Y Shitara
- Y Yabe
- YA Bi
- ZE Barter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study