Y-Like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus)

Background: The dorsal raphe nucleus (DRN) of the mesencephalon is a complex multi-functional and multi-transmitter nucleus involved in a wide range of behavioral and physiological processes. The DRN receives a direct input from the retina. However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells. Methodology/Principal Findings: The Mongolian gerbils are highly visual rodents with a diurnal/crepuscular activity rhythm. It has been widely used as experimental animals of various studies including seasonal affective disorders and depression. Young adult gerbils were used in the present study. DRN-projecting RGCs were identified following retrograde tracer injection into the DRN, characterized physiologically by extracellular recording and morphologically after intracellular filling. The result shows that DRN-projecting RGCs exhibit morphological characteristics typical of alpha RGCs and physiological response properties of Y-cells. Melanopsin was not detected in these RGCs and they show no evidence of intrinsic photosensitivity. Conclusions/Significance: These findings suggest that RGCs with alpha-like morphology and Y-like physiology appear to perform a non-imaging forming function and thus may participate in the modulation of DRN activity which includes regulation of sleep and mood

Nazism, Religion, and Human Experimentation

Multiple factors have been identified as contributing to the willingness of physicians and scientists to participate in the development and conduct of experiments carried out on Nazi concentration camp prisoners, including the economic challenges then facing physicians, the potential for increased status and power in the Nazi government, and their own hostility toward Jews and others deemed “not worth living.” They conducted these experiments against a backdrop of their societies’ longstanding anti-Semitic sentiments, the promulgation of anti-Jewish rhetoric by Christian authorities, and the incorporation into law of increasingly severe and restrictive anti-Jewish measures and, ultimately, embraced efforts to eradicate all Jews and evidence of Jewishness. This chapter argues that religion was relevant not only to the question of who was targeted by Nazi medical policy—Jews, conceived of by the Nazis as a race rather than a religion—but also to the question of who was doing the targeting—physicians who appear to have identified religiously primarily as Christians and who interpreted Nazi dogma as congruent with their religious beliefs and teachings.https://doi.org/10.1007/978-3-030-44150-0_