Photodissociation dynamics of methyl iodide probed using femtosecond extreme ultraviolet photoelectron spectroscopy

Femtosecond pump-probe photoelectron spectroscopy measurements using an extreme ultraviolet probe have been made on the photodissociation dynamics of UV (269 nm) excited CH3I. The UV excitation leads to population of the 3Q0 state which rapidly dissociates. The dissociation is manifested as shifts in the measured photoelectron kinetic energy that map the extending C-I bond. The increased energy available in the XUV probe relative to a UV probe means the dynamics are followed over the chemically important region as far as C-I bond lengths of approximately 4 Å

Absence of long-range ordered reconstruction on the GaAs(311)A surface

We have investigated the decapped GaAs(311)A surface using both scanning tunneling microscopy and synchrotron-radiation photoemission. While our data are in broad agreement with the structural model of GaAs(311)A proposed in a recent study [Wassermeier et al., Phys. Rev. B 51, 14 721 (1995)], we find considerable differences in the surface order. In particular, the As dimer rows are unbroken over much shorter length scales and are highly kinked. We observe a correspondingly lower degree of anisotropy in the surface roughness than that previously reported. An (8×1) reconstruction was not observed. An analysis of As 3d and Ga 3d core-level photoemission spectra suggests that surface As atoms are in only one bonding configuration while surface Ga adopts two different bonding states. We discuss possible origins for the core-level spectra surface components

The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department

Background: Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department. Methods: A historical control study was undertaken comparing 58 patients who required physical restraint and parenteral sedation with the structured IM sedation protocol, to 73 historical controls treated predominantly by intravenous sedation, according to individual clinician preference. The primary outcome was the duration of the ABD defined as the time security staff were required. Secondary outcomes were the requirement for additional sedation, drug related-adverse effects and patient and staff injuries. Results: The median duration of the ABD in patients with the new sedation protocol was 21 minutes (IQR: 15 to 35 minutes; Range: 5 to 78 minutes) compared to a median duration of 30 minutes (IQR: 15 to 50 minutes; Range: 5 to 135 minutes) in the historical controls which was significantly different (p = 0.03). With IM sedation only 27 of 58 patients (47%; 95% CI: 34% to 60%) required further sedation compared to 64 of 73 historical controls (88%; 95%CI: 77% to 94%). There were six (10%) drug-related adverse events with the new IM protocol [oxygen desaturation (5), oxygen desaturation/airway obstruction (1)] compared to 10 (14%) in the historical controls [oxygen desaturation (5), hypoventilation (4) and aspiration (1)]. Injuries to staff occurred with three patients using the new sedation protocol and in seven of the historical controls. Two patients were injured during the new protocol and two of the historical controls. Conclusion: The use of a standardised IM sedation protocol was simple, more effective and as safe for management of ABD compared to predominantly intravenous sedation

The Growth of Massive Black Holes in Galaxy Merger Simulations with Feedback by Radiation Pressure

We study the growth of massive black holes (BH) in galaxies using smoothed particle hydrodynamic simulations of major galaxy mergers with new implementations of BH accretion and feedback. The effect of BH accretion on gas in its host galaxy is modeled by depositing momentum at a rate ~ tau L/c into the ambient gas, where L is the luminosity produced by accretion onto the BH and tau is the wavelength-averaged optical depth of the galactic nucleus to the AGN's radiation (a free parameter of our model). The accretion rate onto the BH is relatively independent of our subgrid accretion model and is instead determined by the BH's dynamical impact on its host galaxy: BH accretion is thus self-regulated rather than `supply limited.' We show that the final BH mass and total stellar mass formed during a merger are more robust predictions of the simulations than the time dependence of the star formation rate or BH accretion rate. In particular, the latter depend on the assumed interstellar medium physics, which determines when and where the gas fragments to form star clusters; this in turn affects the fuel available for further star formation and BH growth. Simulations over a factor of ~ 30 in galaxy mass are consistent with the observed M_BH-sigma relation for a mean optical depth of tau ~ 25. This requires that most BH growth occur when the galactic nucleus is optically thick to far-infrared radiation, consistent with the hypothesized connection between ultra-luminous infrared galaxies and quasars. We find tentative evidence for a shallower M_BH-sigma relation in the lowest mass galaxies, sigma < 100 km/s. Our results demonstrate that feedback-regulated BH growth and consistency with the observed M_BH-sigma relation do not require that BH feedback terminate star formation in massive galaxies or unbind large quantities of cold gas.Comment: 21 pages, 17 figures, submitted MNRA

Function and dysfunction of the PI system in membrane trafficking

The phosphoinositides (PIs) function as efficient and finely tuned switches that control the assembly–disassembly cycles of complex molecular machineries with key roles in membrane trafficking. This important role of the PIs is mainly due to their versatile nature, which is in turn determined by their fast metabolic interconversions. PIs can be tightly regulated both spatially and temporally through the many PI kinases (PIKs) and phosphatases that are distributed throughout the different intracellular compartments. In spite of the enormous progress made in the past 20 years towards the definition of the molecular details of PI–protein interactions and of the regulatory mechanisms of the individual PIKs and phosphatases, important issues concerning the general principles of the organisation of the PI system and the coordination of the different PI-metabolising enzymes remain to be addressed. The answers should come from applying a systems biology approach to the study of the PI system, through the integration of analyses of the protein interaction data of the PI enzymes and the PI targets with those of the ‘phenomes' of the genetic diseases that involve these PI-metabolising enzymes

SPT 0538-50: Physical conditions in the ISM of a strongly lensed dusty star-forming galaxy at z=2.8

We present observations of SPT-S J053816-5030.8, a gravitationally-lensed dusty star forming galaxy (DSFG) at z = 2.7817, first discovered at millimeter wavelengths by the South Pole Telescope. SPT 0538-50 is typical of the brightest sources found by wide-field millimeter-wavelength surveys, being lensed by an intervening galaxy at moderate redshift (in this instance, at z = 0.441). We present a wide array of multi-wavelength spectroscopic and photometric data on SPT 0538-50, including data from ALMA, Herschel PACS and SPIRE, Hubble, Spitzer, VLT, ATCA, APEX, and the SMA. We use high resolution imaging from HST to de-blend SPT 0538-50, separating DSFG emission from that of the foreground lens. Combined with a source model derived from ALMA imaging (which suggests a magnification factor of 21 +/- 4), we derive the intrinsic properties of SPT 0538-50, including the stellar mass, far-IR luminosity, star formation rate, molecular gas mass, and - using molecular line fluxes - the excitation conditions within the ISM. The derived physical properties argue that we are witnessing compact, merger-driven star formation in SPT 0538-50, similar to local starburst galaxies, and unlike that seen in some other DSFGs at this epoch.Comment: 16 pages, 11 figures. Accepted for publication in Ap

The physical scale of the far-infrared emission in the most luminous submillimetre galaxies II: evidence for merger-driven star formation

We present high-resolution 345 GHz interferometric observations of two extreme luminous (L_{IR}>10^{13} L_sun), submillimetre-selected galaxies (SMGs) in the COSMOS field with the Submillimeter Array (SMA). Both targets were previously detected as unresolved point-sources by the SMA in its compact configuration, also at 345 GHz. These new data, which provide a factor of ~3 improvement in resolution, allow us to measure the physical scale of the far-infrared in the submillimetre directly. The visibility functions of both targets show significant evidence for structure on 0.5-1 arcsec scales, which at z=1.5 translates into a physical scale of 5-8 kpc. Our results are consistent with the angular and physical scales of two comparably luminous objects with high-resolution SMA followup, as well as radio continuum and CO sizes. These relatively compact sizes (<5-10 kpc) argue strongly for merger-driven starbursts, rather than extended gas-rich disks, as the preferred channel for forming SMGs. For the most luminous objects, the derived sizes may also have important physical consequences; under a series of simplifying assumptions, we find that these two objects in particular are forming stars close to or at the Eddington limit for a starburst.Comment: 9 pages, 3 Figures, submitted to MNRA

STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G<inf>2</inf> Arrest in the Absence of DNA Damage

STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G2 phase arrest without invoking DNA damage. Further analysis shows that STK295900 inhibits DNA relaxation that is mediated by topoisomerase 1 (Top 1) and topoisomerase 2 (Top 2) in vitro. In addition, STK295900 also exhibits protective effect against DNA damage induced by camptothecin. However, STK295900 does not affect etoposide-induced DNA damage. Moreover, STK295900 preferentially exerts cytotoxic effect on cancer cell lines while camptothecin, etoposide, and Hoechst 33342 affected both cancer and normal cells. Therefore, STK295900 has a potential to be developed as an anticancer chemotherapeutic agent. © 2013 Kim et al

Self-Regulated Black Hole Growth via Momentum Deposition in Galaxy Merger Simulations

We perform hydrodynamical simulations of major galaxy mergers using new methods for calculating the growth of massive black holes (BH) in galactic nuclei and their impact on the surrounding galaxy. We model BH growth by including a subgrid model for accretion produced by angular momentum transport on unresolved scales. The impact of the BHs radiation on surrounding gas is approximated by depositing momentum into the ambient gas, which produces an outward force away from the BH. We argue that these phenomenological models for BH growth and feedback better approximate the interaction between the BH and dense gas in galaxies than previous models. We show that this physics leads to self-regulated black hole growth: during the peak of activity, the accretion rate onto the BH is largely determined by the physics of BH feedback, not the subgrid accretion model. The BH significantly modifies the gas dynamics in the galactic nucleus (< 300 pc), but does not generate large-scale galactic outflows. Integrated over an entire galaxy merger, BH feedback has little effect on the total number of stars formed, but is crucial for setting the BHs mass.Comment: 5 pages, 3 figures; final version accepted by MNRAS Letters; conclusions unchange