Reflexiones canónicas acerca de Universae Ecclesiae, Instrucción sobre la Aplicación de Summorum Pontificum

En 2011, la Comisión Pontificia Ecclesia Dei publicó la instrucción Universae Ecclesiae para la aplicación del motu proprio Summorum Pontificum. Este artículo analiza brevemente la estructura de esta instrucción y su relevancia jurídica, antes de entrar en el estudio detallado del documento. De acuerdo con la disposición de la materia, el análisis del texto comienza prestando atención a la introducción, que se basa no solo sobre el motu propio del Papa sino también en la carta que lo acompaña, escrita por el Papa a los obispos, y la competencia de la comisión Ecclesia Dei. A continuación, se co- mentan las normas específicas de la instrucción relativas a las siguientes materias: la competencia de los obispos diocesanos, la noción de coetus fidelium, el sacerdos idoneus, la disciplina litúrgica y eclesiástica, la confirmación y el orden sagrado, el Brevia- rium Romanum, el Triduo Pascual, los ritos de las órdenes religiosas y uso del Pontificale Romanum y del Rituale Romanum.In 2011, the Pontifical Commission Ecclesia Dei issued the instruction Universae Ecclesiae on the application of Benedict XVI’s 2007 motu proprio Summorum Pontificum. This article briefly examines the organization of the instruction and its juridic weight before studying the document in more detail. Following the arrangement of the instruction, analysis of the text itself begins by looking at the introduction, which is rooted in the pope’s motu proprio and accompanying letter to bishops, and the competence of the Pontifical Commission Ecclesia Dei. Commentary is provided on the specific norms of the instruction according to the following areas: the competence of diocesan bishops, the notion of the coetus fidelium, the sacerdos idoneus, liturgical and ecclesiastical discipline, confirmation and holy orders, the Breviarium Romanum, the Sacred Triduum, rites of religious orders, and the use of the Pontificale Romanum and Rituale Romanum

Search for supersymmetry with a dominant R-parity violating LQDbar couplings in e+e- collisions at centre-of-mass energies of 130GeV to 172 GeV

A search for pair-production of supersymmetric particles under the assumption that R-parity is violated via a dominant LQDbar coupling has been performed using the data collected by ALEPH at centre-of-mass energies of 130-172 GeV. The observed candidate events in the data are in agreement with the Standard Model expectation. This result is translated into lower limits on the masses of charginos, neutralinos, sleptons, sneutrinos and squarks. For instance, for m_0=500 GeV/c^2 and tan(beta)=sqrt(2) charginos with masses smaller than 81 GeV/c^2 and neutralinos with masses smaller than 29 GeV/c^2 are excluded at the 95% confidence level for any generation structure of the LQDbar coupling.Comment: 32 pages, 30 figure

Search for Bs0B^{0}_{s} oscillations using inclusive lepton events

A search for Bs oscillations is performed using a sample of semileptonic b-hadron decays collected by the ALEPH experiment during 1991-1995. Compared to previous inclusive lepton analyses, the prop er time resolution and b-flavour mistag rate are significantly improved. Additional sensitivity to Bs mixing is obtained by identifying subsamples of events having a Bs purity which is higher than the average for the whole data sample. Unbinned maximum likelihood amplitude fits are performed to derive a lower limit of Dms>9.5 ps-1 at 95% CL. Combining with the ALEPH Ds based analyses yields Dms>9.6 ps-1 at 95% CL.A search for B0s oscillations is performed using a sample of semileptonic b-hadron decays collected by the ALEPH experiment during 1991-1995. Compared to previous inclusive lepton analyses, the proper time resolution and b-flavour mistag rate are significantly improved. Additional sensitivity to B0s mixing is obtained by identifying subsamples of events having a B0s purity which is higher than the average for the whole data sample. Unbinned maximum likelihood amplitude fits are performed to derive a lower limit of Deltam_s>9.5ps^-1 at 95% CL. Combining with the ALEPH D-s based analyses yields Deltam_s>9.6ps^-1 at 95% CL

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Reflexiones canónicas acerca de Universae Ecclesiae, Instrucción sobre la Aplicación de Summorum Pontificum

En 2011, la Comisión Pontificia Ecclesia Dei publicó la instrucción Universae Ecclesiae para la aplicación del motu proprio Summorum Pontificum. Este artículo analiza brevemente la estructura de esta instrucción y su relevancia jurídica, antes de entrar en el estudio detallado del documento. De acuerdo con la disposición de la materia, el análisis del texto comienza prestando atención a la introducción, que se basa no solo sobre el motu propio del Papa sino también en la carta que lo acompaña, escrita por el Papa a los obispos, y la competencia de la comisión Ecclesia Dei. A continuación, se co- mentan las normas específicas de la instrucción relativas a las siguientes materias: la competencia de los obispos diocesanos, la noción de coetus fidelium, el sacerdos idoneus, la disciplina litúrgica y eclesiástica, la confirmación y el orden sagrado, el Brevia- rium Romanum, el Triduo Pascual, los ritos de las órdenes religiosas y uso del Pontificale Romanum y del Rituale Romanum.In 2011, the Pontifical Commission Ecclesia Dei issued the instruction Universae Ecclesiae on the application of Benedict XVI’s 2007 motu proprio Summorum Pontificum. This article briefly examines the organization of the instruction and its juridic weight before studying the document in more detail. Following the arrangement of the instruction, analysis of the text itself begins by looking at the introduction, which is rooted in the pope’s motu proprio and accompanying letter to bishops, and the competence of the Pontifical Commission Ecclesia Dei. Commentary is provided on the specific norms of the instruction according to the following areas: the competence of diocesan bishops, the notion of the coetus fidelium, the sacerdos idoneus, liturgical and ecclesiastical discipline, confirmation and holy orders, the Breviarium Romanum, the Sacred Triduum, rites of religious orders, and the use of the Pontificale Romanum and Rituale Romanum