Pre and post processing using the IBM 3277 display station graphics attachment (RPQ7H0284)

A graphical interactive procedure operating under TSO and utilizing two CRT display terminals is shown to be an effective means of accomplishing mesh generation, establishing boundary conditions, and reviewing graphic output for finite element analysis activity

Chromospheric and photospheric evolution of an extremely active solar region in solar cycle 19

a comprehensive investigation was made of phenomena attending the disk passage, July 7 to 21, 1959, of active solar center HAO-59Q. At the photospheric level that comprised an aggregate of groups of sunspots of which one group, Mt. Wilson 14284, showed all the attributes deemed typical of solar regions associated with the production of major flares. A special characteristic of 59Q was its capability to eject dark material. Part of this material remained trapped in the strong magnetic fields above group 14284 where it formed a system of interrelated arches, the legs of which passed through components of the bright chromospheric network of the plage and were rooted in various underlying umbrae. Two apparently diffeent kinds of flare were identified in 59Q; namely, prominence flares (which comprised brightenings within part of the suspended dark prominence) and plage flares (which comprised brightenings within part of the chromospheric network). Prominence flares were of three varieties described as 'impact', 'stationary' and 'moving' prominence flares. Plage flares were accompanied in 3 percent of cases by Type III bursts. These latter radio events indicate the associated passage through the corona of energetic electrons in the approximate energy range 10 to 100 keV. At least 87.5 percent, and probably all, impulsive brightenings in 59Q began directly above minor spots, many of which satellites to major umbrae. Stationary and moving prominence flares were individually triggered at sites beneath which magnetic changes occurred within intervals which included each flare's flash phase

Maternal thyroid function and child educational attainment: prospective cohort study

Objective: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. Design: Prospective cohort study. Setting: Avon Longitudinal Study of Parents and Children cohort in the UK. Participants: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). Exposures: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function. Main outcome measures: Five age-specific national curriculum assessments in 3580 children at entry stage assessment at 54 months, increasing up to 4461 children at their final school assessment at age 15. Results: No strong evidence of clinically meaningful associations of first trimester free thyroxine and thyroid stimulating hormone levels with entry stage assessment score or Standard Assessment Test scores at any of the key stages was found. Associations of maternal free thyroxine or thyroid stimulating hormone with the total number of General Certificates of Secondary Education (GCSEs) passed (range 0-16) were all close to the null: free thyroxine, rate ratio per pmol/L 1.00 (95% confidence interval 1.00 to 1.01); and thyroid stimulating hormone, rate ratio 0.98 (0.94 to 1.02). No important relationship was observed when more detailed capped scores of GCSEs allowing for both the number and grade of pass or when language, mathematics, and science performance were examined individually or when all educational assessments undertaken by an individual from school entry to leaving were considered. 200 (4.3%) mothers were newly identified as having hypothyroidism or subclinical hypothyroidism and 97 (2.1%) subclinical hyperthyroidism or hyperthyroidism. Children of mothers with thyroid dysfunction attained an equivalent number of GCSEs and equivalent grades as children of mothers with euthyroidism. Conclusions: Maternal thyroid dysfunction in early pregnancy does not have a clinically important association with impaired child performance at school or educational achievement

Friedel oscillations in graphene:sublattice asymmetry in doping

Symmetry breaking perturbations in an electronically conducting medium are known to produce Friedel oscillations (FOs) in various physical quantities of an otherwise pristine material. Here we show in a mathematically transparent fashion that FOs in graphene have a strong sublattice asymmetry. As a result, the presence of impurities and/or defects may impact the distinct graphene sublattices very differently. Furthermore, such an asymmetry an be used to explain the recent observations that Nitrogen atoms and dimers are not randomly distributed in graphene but prefer to occupy one of its two distinct sublattices. We argue that this feature is not exclusive of Nitrogen and that it can be seen with other substitutional dopants.Comment: 11 Pages, 7 Figure

Behavioural early-life exposures and body composition at age 15 years

BACKGROUND/OBJECTIVES: Previous studies have demonstrated associations between some early-life exposures and later obesity, but most have used body mass index in childhood or adulthood as the outcome. The objective of this study was to investigate whether early-life exposures were associated with directly measured fat and lean mass in adolescence. SUBJECTS/METHODS: This study used data on 4750 mother–offspring pairs, collected as a part of the Avon Longitudinal Study of Parents and Children, Bristol, UK between 1991 and 1992; associations between behavioural exposures occurring from conception up to 5 years of age (maternal and paternal smoking during pregnancy, breastfeeding, age at introduction to solids, dietary patterns and physical inactivity during early childhood) and offspring body composition measured by dual-energy X-ray absorptiometry at ~ 15 years were assessed. RESULTS: After full adjustment for potential confounders, maternal smoking during pregnancy, having a junk food diet and spending more time watching television in early childhood were all associated with higher fat mass at age 15, whereas maternal smoking, having a healthy diet and playing computer games more frequently in early childhood were all associated with a higher lean mass at age 15. Associations with paternal smoking were generally weaker for both fat and lean mass, but as there was no strong statistical evidence for maternal vs paternal differences, confounding by social factors rather than a direct effect of maternal smoking cannot be ruled out. Early feeding was not associated with fat or lean mass at age 15. CONCLUSIONS: This study does not provide compelling evidence for associations between most early-life factors and body composition in adolescence. However, possible associations with dietary patterns and physical inactivity in early childhood require further investigation in other cohorts that have direct measurements of adolescent body composition.SD Leary, DA Lawlor, G Davey Smith, MJ Brion and AR Nes

On the systematics of asteroseismological mass determinations of PG1159 stars

We analyze systematics in the asteroseismological mass determination methods in pulsating PG 1159 stars. We compare the seismic masses resulting from the comparison of the observed mean period spacings with the usually adopted asymptotic period spacings, and the average of the computed period spacings. Computations are based on full PG1159 evolutionary models with stellar masses ranging from 0.530 to 0.741 Mo that take into account the complete evolution of progenitor stars. We conclude that asteroseismology is a precise and powerful technique that determines the masses to a high internal accuracy, but it depends on the adopted mass determination method. In particular, we find that in the case of pulsating PG 1159 stars characterized by short pulsation periods, like PG 2131+066 and PG 0122+200, the employment of the asymptotic period spacings overestimates the stellar mass by about 0.06 Mo as compared with inferences from the average of the period spacings. In this case, the discrepancy between asteroseismological and spectroscopical masses is markedly reduced when use is made of the mean period spacing instead of the asymptotic period spacing.Comment: 7 pages, 4 figures, 1 table. To be published in Astronomy and Astrophysic

Gene transfer in bacteria from soils contaminated with heavy metals

Transfer of metal resistance plasmids into two pseudomonad recipients, Pseudomonas aureofaciens and Ps. putida, from soil bacteria donor populations, was investigated in agricultural soil contaminated predominantly with Zn and Cu. The putative donor and recipient numbers on selective agar were not affected by the concentration of metals in the soils, nor were the number of transconjugants. However, there were differences in transfer frequencies of Hg and Cu resistance from the different soil samples. This is the first time that transfer of Cu resistance has been observed from native bacteria present in agricultural soils

A Review of the ACID Synthetic Aperture Sonar and other Sidescan Sonar Systems

The ACID project was part of the MAST Programme and was funded by the European Communities, to develop a synthetic aperture sonar for high resolution mapping of the seafloor. The collaboration of several European Institutions has enabled the ACID synthetic aperture sonar to be developed and tested during sea trials in May 1993. This paper discusses how the ACID synthetic aperture sonar system fits into the existing field of conventional sidescan sonar systems and the potential advantages to be gained using synthetic aperture processing techniques. The main advantage of the ACID sonar is that its azimuth resolution is independent of range and of the transmitted signal frequency. Sonar designers can, therefore, use lower operating frequencies and still obtain high azimuth resolutions. However, this paper also highlights the need for developing techniques which can increase the area mapping rate of synthetic aperture sonars which is essentially limited by the azimuth sampling constraint. Images from sea trials during May 1993 are presented which show areas of the seafloor before and after synthetic aperture sonar processing

Cohort profile: the avon longitudinal study of parents and children: ALSPAC mothers cohort

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19–22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17–18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile

Hyperglycaemia and risk of adverse perinatal outcomes: Systematic review and meta-analysis

Objectives: To assess the association between maternal glucose concentrations and adverse perinatal outcomes in women without gestational or existing diabetes and to determine whether clear thresholds for identifying women at risk of perinatal outcomes can be identified. Design: Systematic review and meta-analysis of prospective cohort studies and control arms of randomised trials. Data sources: Databases including Medline and Embase were searched up to October 2014 and combined with individual participant data from two additional birth cohorts. Eligibility criteria for selecting studies: Studies including pregnant women with oral glucose tolerance (OGTT) or challenge (OGCT) test results, with data on at least one adverse perinatal outcome. Appraisal and data extraction: Glucose test results were extracted for OGCT (50 g) and OGTT (75 g and 100 g) at fasting and one and two hour post-load timings. Data were extracted on induction of labour; caesarean and instrumental delivery; pregnancy induced hypertension; pre-eclampsia; macrosomia; large for gestational age; preterm birth; birth injury; and neonatal hypoglycaemia. Risk of bias was assessed with a modified version of the critical appraisal skills programme and quality in prognostic studies tools. Results: 25 reports from 23 published studies and two individual participant data cohorts were included, with up to 207 172 women (numbers varied by the test and outcome analysed in the meta-analyses). Overall most studies were judged as having a low risk of bias. There were positive linear associations with caesarean section, induction of labour, large for gestational age, macrosomia, and shoulder dystocia for all glucose exposures across the distribution of glucose concentrations. There was no clear evidence of a threshold effect. In general, associations were stronger for fasting concentration than for post-load concentration. For example, the odds ratios for large for gestational age per 1 mmol/L increase of fasting and two hour post-load glucose concentrations (after a 75 g OGTT) were 2.15 (95% confidence interval 1.60 to 2.91) and 1.20 (1.13 to 1.28), respectively. Heterogeneity was low between studies in all analyses. Conclusions: This review and meta-analysis identified a large number of studies in various countries. There was a graded linear association between fasting and post-load glucose concentration across the whole glucose distribution and most adverse perinatal outcomes in women without pre-existing or gestational diabetes. The lack of a clear threshold at which risk increases means that decisions regarding thresholds for diagnosing gestational diabetes are somewhat arbitrary. Research should now investigate the clinical and cost-effectiveness of applying different glucose thresholds for diagnosis of gestational diabetes on perinatal and longer term outcomes