Total Molecular Gas Masses of Planck - Herschel Selected Strongly Lensed Hyper Luminous Infrared Galaxies

We report the detection of CO(1 - 0) line emission from seven Planck and Herschel selected hyper luminous (LIR(8-1000um) > 10^13Lsun) infrared galaxies with the Green Bank Telescope (GBT). CO(1 - 0) measurements are a vital tool to trace the bulk molecular gas mass across all redshifts. Our results place tight constraints on the total gas content of these most apparently luminous high-z star-forming galaxies (apparent IR luminosities of LIR > 10^(13-14) Lsun), while we confirm their predetermined redshifts measured using the Large Millimeter Telescope, LMT (zCO = 1.33 - 3.26). The CO(1 - 0) lines show similar profiles as compared to Jup = 2 -4 transitions previously observed with the LMT. We report enhanced infrared to CO line luminosity ratios of = 110 (pm 22) Lsun(K km s^-1 pc^-2)^-1 compared to normal star-forming galaxies, yet similar to those of well-studied IR-luminous galaxies at high-z. We find average brightness temperature ratios of = 0.93 (2 sources), = 0.34 (5 sources), and = 0.18 (1 source). The r31 and r41 values are roughly half the average values for SMGs. We estimate the total gas mass content as uMH2 = (0.9 - 27.2) x 10^11(alphaCO/0.8)Msun, where u is the magnification factor and alphaCO is the CO line luminosity to molecular hydrogen gas mass conversion factor. The rapid gas depletion times are, on average, tau = 80 Myr, which reveal vigorous starburst activity, and contrast the Gyr depletion timescales observed in local, normal star-forming galaxies.Comment: published in MNRAS, 9pages, 5fig

Fucoidan and cancer: A multifunctional molecule with anti-tumor potential

There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of brown seaweed, has anti-cancer activity against various cancer types by targeting key apoptotic molecules. It also has beneficial effects as it can protect against toxicity associated with chemotherapeutic agents and radiation. Thus the synergistic effect of fucoidan with current anti-cancer agents is of considerable interest. This review discusses the mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents. Challenges to the development of fucoidan as an anti-cancer agent will also be discussed

The Case for Space Environmentalism

The shell bound by the Karman line at a height of 80 to 100km above the Earth's surface, and Geosynchronous Orbit, at 36,000km, is defined as the orbital space surrounding the Earth. It is within this region, and especially in Low Earth Orbit (LEO), where environmental issues are becoming urgent because of the rapid growth of the anthropogenic space object population, including satellite "mega-constellations". In this Perspective, we summarise the case that the orbital space around the Earth should be considered an additional ecosystem, and so subject to the same care and concerns and the same broad regulations as, for example, the oceans and the atmosphere. We rely on the orbital space environment by looking through it as well as by working within it. Hence, we should consider damage to professional astronomy, public stargazing and the cultural importance of the sky, as well as the sustainability of commercial, civic and military activity in space. Damage to the orbital space environment has problematic features in common with other types of environmental issue. First, the observed and predicted damage is incremental and complex, with many contributors. Second, whether or not space is formally and legally seen as a global commons, the growing commercial exploitation of what may appear a "free" resource is in fact externalising the true costs.Comment: 19 pages, 6 figures. To be published in Nature Astronomy April 22nd 2022. For consistency with Nature policy, the version posted here is the final submitted author text. The final version is available at the DOI below, and differs slightly in wordin

Optical Morphologies of Millijansky Radio Galaxies Observed by HST and in the VLA FIRST Survey

We report on a statistical study of the 51 radio galaxies at the millijansky flux level from the Faint Images of the Radio Sky at Twenty centimeters, including their optical morphologies and structure obtained with the Hubble Space Telescope. Our optical imaging is significantly deeper (~2 mag) than previous studies with the superior angular resolution of space-based imaging. We that find 8/51 (16%) of the radio sources have no optically identifiable counterpart to AB~24 mag. For the remaining 43 sources, only 25 are sufficiently resolved in the HST images to reliably assign a visual classification: 15 (60%) are elliptical galaxies, 2 (8%) are late-type spiral galaxies, 1 (4%) is an S0, 3 (12%) are point-like objects (quasars), and 4 (16%) are merger systems. We find a similar distribution of optical types with measurements of the Sersic index. The optical magnitude distribution of these galaxies peaks at I~20.7+-0.5 AB mag, which is ~3 mag brighter than the depth of our typical HST field and is thus not due to the WFPC2 detection limit. This supports the luminosity-dependent density evolutionary model, where the majority of faint radio galaxies typically have L*-optical luminosities and a median redshift of z~0.8 with a relatively abrupt redshift cut-off at z>~2. We discuss our results in the context of the evolution of elliptical galaxies and active galactic nuclei.Comment: 20 pages, 8 figures, 51 galaxy images, and 5 tables. Uses emulateapj.cls and natbib.sty. Accepted to ApJS. High resolution images are available upon reques

Patrimoine de marque : le passé au service du management de la marque

Researchers and practitioners talk about brand heritage even though its meaning and its difference from related concepts are not entirely clear. Through a review of the multidisciplinary literature, this article distinguishes brand heritage from the concepts of inheritance, retro, nostalgia, and authenticity. This article defines brand heritage as a dynamic construct based on an inherited or borrowed past, with a view to supporting brand identity and being transmitted. A total of 11 research propositions are presented within an inclusive framework that paves the way for future research and contributes to research on brand management and the role of consumers in creating value

Enriched haloes at redshift z=2z=2 with no star-formation: Implications for accretion and wind scenarios

[Abridged] In order to understand which process (e.g. galactic winds, cold accretion) is responsible for the cool (T~10^4 K) halo gas around galaxies, we embarked on a program to study the star-formation properties of galaxies selected by their MgII absorption signature in quasar spectra. Specifically, we searched for the H-alpha line emission from galaxies near very strong z=2 MgII absorbers (with rest-frame equivalent width EW>2 \AA) because these could be the sign-posts of outflows or inflows. Surprisingly, we detect H-alpha from only 4 hosts out of 20 sight-lines (and 2 out of the 19 HI-selected sight-lines), despite reaching a star-formation rate (SFR) sensitivity limit of 2.9 M/yr (5-sigma) for a Chabrier initial mass function. This low success rate is in contrast with our z=1 survey where we detected 66%\ (14/21) of the MgII hosts. Taking into account the difference in sensitivity between the two surveys, we should have been able to detect >11.4 of the 20 z=2 hosts whereas we found only 4 galaxies. Interestingly, all the z=2 detected hosts have observed SFR greater than 9 M/yr, well above our sensitivity limit, while at z=1 they all have SFR less than 9 M/yr, an evolution that is in good agreement with the evolution of the SFR main sequence. Moreover, we show that the z=2 undetected hosts are not hidden under the quasar continuum after stacking our data and that they also cannot be outside our surveyed area. Hence, strong MgII absorbers could trace star-formation driven winds in low-mass halos (Mhalo < 10^{10.6} Msun). Alternatively, our results imply that z=2 galaxies traced by strong MgII absorbers do not form stars at a rate expected (3--10 M/yr) for their (halo or stellar) masses, supporting the existence of a transition in accretion efficiency at Mhalo ~ 10^{11} Msun. This scenario can explain both the detections and the non-detections.Comment: 14 pages, 4 fig.; MNRAS in press, minor corrections to match proof

Klebsiella pneumoniae bacteraemia complicating rotavirus gastroenteritis in two infants with glucocorticoid deficiency

Rotavirus gastroenteritis was complicated by Klebsiella Pneumoniae bacteraemia in two infants with glucocorticoid deficient conditions who were treated with 'stress dose' hydrocortisone during their illness. Delayed healing in the context of glucocorticoid administration combined with damage from rotavirus infection may result in increased risk of mucosal invasion by gastrointestinal bacteria and subsequent enteric gram-negative bacteraemia

In search of the authentic nation: landscape and national identity in Canada and Switzerland

While the study of nationalism and national identity has flourished in the last decade, little attention has been devoted to the conditions under which natural environments acquire significance in definitions of nationhood. This article examines the identity-forming role of landscape depictions in two polyethnic nation-states: Canada and Switzerland. Two types of geographical national identity are identified. The first – what we call the ‘nationalisation of nature’– portrays zarticular landscapes as expressions of national authenticity. The second pattern – what we refer to as the ‘naturalisation of the nation’– rests upon a notion of geographical determinism that depicts specific landscapes as forces capable of determining national identity. The authors offer two reasons why the second pattern came to prevail in the cases under consideration: (1) the affinity between wild landscape and the Romantic ideal of pure, rugged nature, and (2) a divergence between the nationalist ideal of ethnic homogeneity and the polyethnic composition of the two societies under consideration

Analysis of Star Formation in Galaxy-like Objects

Using cosmological hydrodynamical simulations, we investigate the effects of hierarchical aggregation on the triggering of star formation in galactic-like objects. We include a simple star formation model to transform the cold gas in dense regions into stars. Simulations with different parameters have been performed in order to quantify the dependence of the results on the parameters. We then resort to stellar population synthesis models to trace the color evolution of each object with red-shift and in relation to their merger histories. We find that, in a hierarchical clustering scenario, the process of assembling of the structure is one natural mechanism that may trigger star formation. The resulting star formation rate history for each individual galactic object is composed of a continuous one ($\leq 3 \rm{M_{\odot}/yr}$) and a series of star bursts. We find that even the accretion of a small satellite can be correlated with a stellar burst. Massive mergers are found to be more efficient at transforming gas into starsComment: 11 postscript figures. 2000, ApJ, accepte

Coevolved mutations reveal distinct architectures for two core proteins in the bacterial flagellar motor

Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC) "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM) domains (amino-terminal (FliGN), middle (FliGM) and FliGC) as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM) has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6). FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C) and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM-C could be the convertor element that provides mechanistic and species diversity.JK was supported by Medical Research Council grant U117581331. SK was supported by seed funds from Lahore University of Managment Sciences (LUMS) and the Molecular Biology Consortium