5,322 research outputs found
The origin of the Acheulean: the 1.7 million-year-old site of FLK West, Olduvai Gorge (Tanzania)
The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the
emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with
standardized forms, implying more advance forethought and planning by hominins than those required
by the precedent Oldowan technology. The earliest known evidence of this technology dates back to
c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack fauna.
The functionality of these earliest Acheulean assemblages remains unknown. Here we present the
discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides
evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in
which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and
elaborate large-cutting tools (LCT) and handaxes co-exist at FLK West, showing that complex cognition
was present from the earliest stages of the Acheulean. Here we provide a detailed technological study
and evidence of the use of these tools on the butchery and consumption of fauna, probably by early
Homo erectus sensu lato
The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins
BRCA2-c.2808_2811del (3036delACAA) is one of the most reported
germ line mutations in non-Ashkenazi breast cancer patients. We
investigated its genetic origin in 51 Spanish carrier families that
were genotyped with 11 13q polymorphic markers. Three independent
associated haplotypes were clearly distinguished accounting for
23 [west Castilla y León (WCL)], 20 [east Castilla y León (ECL)]
and 6 (South of Spain) families. Mutation age was estimated with
the Disequilibrium Mapping using Likelihood Estimation software
in a range of 45–68 and 45–71 generations for WCL and ECL haplotypes,
respectively. The most prevalent variants, c.2808_2811del
and c.2803G > A, were located in a double-hairpin loop structure
(c.2794–c.2825) predicted by Quikfold that was proposed as a mutational
hotspot. To check this hypothesis, random mutagenesis was
performed over a 923 bp fragment of BRCA2, and 86 DNA variants
were characterized. Interestingly, three mutations reported in the
mutation databases (c.2680G > A, c.2944del and c.2957dup) were
replicated and 20 affected the same position with different nucleotide
changes. Moreover, five variants were placed in the same hairpin loop
of c.2808_2811del, and one affected the same position (c.2808A > G).
In conclusion, our results support that at least three different mutational
events occurred to generate c.2808_2811del. Other highly
prevalent DNA variants, such as BRCA1-c.68_69delAG, BRCA2-
c.5946delT and c.8537delAG, are concentrated in hairpin loops, suggesting
that these structures may represent mutational hotspots
Experimental analysis of the effect of local base blowing on three-dimensional wake modes
Wake modes of a three-dimensional blunt-based body near a wall are investigated at a Reynolds number . The targeted modes are the static symmetry-breaking mode and two antisymmetric periodic modes. The static mode orientation is aligned with the horizontal major -axis of the base and randomly switches between a positive and a negative state leading to long-time bistable dynamics of the turbulent wake. The modifications of these modes are studied when continuous blowing is applied at different locations through four slits along the base edges (denoted L for left, R for right, T for top and B for bottom) in either four single asymmetric configurations or two double symmetric configurations (denoted LR and TB). Two regimes, referred to as mass and momentum, are clearly identifiable for all configurations. The mass regime, which is fairly insensitive to blowing momentum and location, is characterized by the growth of the recirculating bubble as the total injected flow rate is increased, and is associated with a base drag reduction and interpreted as resulting from the equilibrium between mass fluxes feeding and emptying the recirculating region. A simple budget model is shown to be in agreement with entrainment velocities measured for isolated turbulent mixing layers. The strength of the static mode is reduced up to 20 % when the bubble length is maximum, whereas no change in the periodic mode frequencies is found. On the other hand, the momentum regime is characterized by the deflating of the recirculating bubble, leading to base drag increase, and it is interpreted by the free shear layer forcing, which increases the entrainment velocity, thus emptying the recirculating bubble. In this regime the static mode orientation is imposed by the blowing symmetry. Lateral L and R (respectively top/bottom T and B) blowing configurations select or states in the horizontal (respectively vertical) direction, while bistable dynamics persists for the symmetric LR and TB configurations. The shape of periodic modes follows the changes in wake static orientation. The transition between the two regimes is governed by both the total injected flow rate and the location of the injection
HIFI observations of warm gas in DR21: Shock versus radiative heating
The molecular gas in the DR21 massive star formation region is known to be
affected by the strong UV field from the central star cluster and by a fast
outflow creating a bright shock. The relative contribution of both heating
mechanisms is the matter of a long debate. By better sampling the excitation
ladder of various tracers we provide a quantitative distinction between the
different heating mechanisms. HIFI observations of mid-J transitions of CO and
HCO+ isotopes allow us to bridge the gap in excitation energies between
observations from the ground, characterizing the cooler gas, and existing ISO
LWS spectra, constraining the properties of the hot gas. Comparing the detailed
line profiles allows to identify the physical structure of the different
components. In spite of the known shock-excitation of H2 and the clearly
visible strong outflow, we find that the emission of all lines up to > 2 THz
can be explained by purely radiative heating of the material. However, the new
Herschel/HIFI observations reveal two types of excitation conditions. We find
hot and dense clumps close to the central cluster, probably dynamically
affected by the outflow, and a more widespread distribution of cooler, but
nevertheless dense, molecular clumps.Comment: Accepted for publication by A&
Study of vascular risk in Navarre: objectives and design. Prevalence of metabolic syndrome and of vascular risk factors
BACKGROUND: To determine in a representative sample of the population the prevalence of risk factors and metabolic syndrome; their association with sub-clinical atherosclerotic lesions and their impact on cardiocerebrovascular disease 10 years after.
MATERIAL AND METHODS: (Phase 1) Cross sectional survey of a random sample stratified by age and sex of the population of Navarre aged between 35 and 84. Antecedents, risk factors, physical and analytical exploration. (Phase II) Ten year follow-up cohort study, in 500 exposed to MS and 500 not exposed persons, aged between 45 and 74 years; with an 82.25% power to detect a risk ratio of 2; with analytical and image markers of sub-clinical atherosclerosis. (Phase III) Follow up of vascular events at ten years.
RESULTS: The subjects recruited were 6,553; excluded or not found 871; the final sample was 5,682 (2,644 men and 3,038 women); 4,168 (73,4%) took part in the study. The prevalence of MS was 22.1% (95%CI 20.5 - 23.7) for men and 17,2% (95%CI 15.8 - 18.5) for women. The main cardiovascular RF were high compared to other geographical areas except for HDL cholesterol. The rate was 8.5% (95%CI 7.4 - 9.6) for men and 1.7% (95%CI 1.3 - 2.2)
CONCLUSIONS: There are important differences in risk between sex, being worst for men. The high figures for HDL cholesterol and the low prevalence of MS might mean a lower risk of vascular events in Navarra
Transition between Variscan and Alpine cycles in the Pyrenean-Cantabrian Mountains (N Spain): Geodynamic evolution of near-equator European Permian basins
In the northern Iberian Peninsula, the Pyrenean-Cantabrian orogenic belt extends E-W for ca. 1000 km between the Atlantic Ocean and Mediterranean Sea. This orogen developed from the collision between Iberia and Eurasia, mainly in Cenozoic times. Lower-middle Permian sediments crop out in small, elongated basins traditionally considered independent from each other due to misinterpretations on incomplete lithostratigraphic data and scarce radiometric ages. Here, we integrate detailed stratigraphic, sedimentary, tectonic, paleosol and magmatic data from well-dated lithostratigraphic units. Our data reveal a similar geodynamic evolution across the Pyrenean-Cantabrian Ranges at the end of the Variscan cycle. Lower-middle Permian basins started their development under an extensional regime related to the end of the Variscan Belt collapse, which stars in late Carboniferous times in the Variscan hinterland. This orogenic collapse transitioned to Pangea breakup at the middle Permian times in the study region. Sedimentation occurred as three main tectono-sedimentary extensional phases. A first phase (Asselian-Sakmarian), which may have even started at the end of the Carboniferous (Gzhelian) in some sections, is mainly represented by alluvial sedimentation associated with calc-alkaline magmatism. A second stage (late Artinskian-early Kungurian), represented by al-luvial, lacustrine and palustrine sediments with intercalations of calc-alkaline volcanic beds, shows a clear up-ward aridification trend probably related to the late Paleozoic icehouse-greenhouse transition. The third and final stage (Wordian-Capitanian) comprised of alluvial deposits with intercalations of alkaline and mafic beds, rarely deposited in the Cantabrian Mountains, and underwent significant pre-and Early Mesozoic erosion in some segments of the Pyrenees. This third stage can be related to a transition towards the Pangea Supercontinent breakup, not generalized until the Early/Middle Triassic at this latitude because the extensional process stopped about 10 Myr (Pyrenees) to 30 Myr (Cantabrian Mountains). When compared to other well-dated basins near the paleoequator, the tectono-sedimentary and climate evolution of lower-middle Permian basins in Western and Central Europe shows common features. Specifically, we identify coeval periods with magmatic activity, extensional tectonics, high subsidence rates and thick sedi-mentary record, as well as prolonged periods without sedimentation. This comparison also identifies some evolutionary differences between Permian basins that could be related to distinct locations in the hinterland or foreland of the Variscan orogen. Our data provide a better understanding of the major crustal re-equilibration and reorganization that took place near the equator in Western-Central Europe during the post-Variscan period
Reversal of infall in SgrB2(M) revealed by Herschel/HIFI observations of HCN lines at THz frequencies
To investigate the accretion and feedback processes in massive star
formation, we analyze the shapes of emission lines from hot molecular cores,
whose asymmetries trace infall and expansion motions. The high-mass star
forming region SgrB2(M) was observed with Herschel/HIFI (HEXOS key project) in
various lines of HCN and its isotopologues, complemented by APEX data. The
observations are compared to spherically symmetric, centrally heated models
with density power-law gradient and different velocity fields (infall or
infall+expansion), using the radiative transfer code RATRAN. The HCN line
profiles are asymmetric, with the emission peak shifting from blue to red with
increasing J and decreasing line opacity (HCN to HCN). This is most
evident in the HCN 12--11 line at 1062 GHz. These line shapes are reproduced by
a model whose velocity field changes from infall in the outer part to expansion
in the inner part. The qualitative reproduction of the HCN lines suggests that
infall dominates in the colder, outer regions, but expansion dominates in the
warmer, inner regions. We are thus witnessing the onset of feedback in massive
star formation, starting to reverse the infall and finally disrupting the whole
molecular cloud. To obtain our result, the THz lines uniquely covered by HIFI
were critically important.Comment: A&A, HIFI special issue, accepte
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Women’s pelvic floor muscle strength and urinary and anal incontinence after childbirth: a cross-sectional study
Abstract OBJECTIVE To analyse pelvic floor muscle strength (PFMS) and urinary and anal incontinence (UI and AI) in the postpartum period. METHOD Cross-sectional study carried out with women in their first seven months after child birth. Data were collected through interviews, perineometry (Peritron™), and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). RESULTS 128 women participated in the study. The PFMS mean was 33.1 (SD=16.0) cmH2O and the prevalence of UI and AI was 7.8% and 5.5%, respectively. In the multiple analyses, the variables associated with PFMS were type of birth and cohabitation with a partner. Newborn’s weight, previous pregnancy, UI during pregnancy, and sexual activity showed an association with UI after child birth. Only AI prior to pregnancy was associated with AI after childbirth. CONCLUSION Vaginal birth predisposes to the reduction of PFMS, and caesarean section had a protective effect to its reduction. The occurrence of UI during pregnancy is a predictor of UI after childbirth, and women with previous pregnancies and newborns with higher weights are more likely to have UI after childbirth.AI prior to pregnancy is the only risk factor for its occurrence after childbirth. Associations between PFMS and cohabitation with a partner, and between UI and sexual activity do not make possible to conclude that these variables are directly associated
Herschel observations of extra-ordinary sources: Detecting spiral arm clouds by CH absorption lines
We have observed CH absorption lines ()
against the continuum source Sgr~B2(M) using the \textit{Herschel}/HIFI
instrument. With the high spectral resolution and wide velocity coverage
provided by HIFI, 31 CH absorption features with different radial velocities
and line widths are detected and identified. The narrower line width and lower
column density clouds show `spiral arm' cloud characteristics, while the
absorption component with the broadest line width and highest column density
corresponds to the gas from the Sgr~B2 envelope. The observations show that
each `spiral arm' harbors multiple velocity components, indicating that the
clouds are not uniform and that they have internal structure. This
line-of-sight through almost the entire Galaxy offers unique possibilities to
study the basic chemistry of simple molecules in diffuse clouds, as a variety
of different cloud classes are sampled simultaneously. We find that the linear
relationship between CH and H column densities found at lower by UV
observations does not continue into the range of higher visual extinction.
There, the curve flattens, which probably means that CH is depleted in the
denser cores of these clouds.Comment: Accepted for publication in A&A, HIFI Special Issu
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