Kolmogorov-Smirnov method for the determination of signal time-shifts

A new method for the determination of electric signal time-shifts is introduced. As the Kolmogorov-Smirnov test, it is based on the comparison of the cumulative distribution functions of the reference signal with the test signal. This method is very fast and thus well suited for on-line applications. It is robust to noise and its performances in terms of precision are excellent for time-shifts ranging from a fraction to several sample durations. PACS. 29.40.Gx (Tracking and position-sensitive detectors), 29.30.Kv (X- and -ray spectroscopy), 07.50.Qx (Signal processing electronics)Comment: 8 pages, 7 figure

Fast analytical methods for the correction of signal random time-shifts and application to segmented HPGe detectors

Detection systems rely more and more on on-line or off-line comparison of detected signals with basis signals in order to determine the characteristics of the impinging particles. Unfortunately, these comparisons are very sensitive to the random time shifts that may alter the signal delivered by the detectors. We present two fast algebraic methods to determine the value of the time shift and to enhance the reliability of the comparison to the basis signals.Comment: 13 pages, 8 figure

A influência da diferenciação das relações líder-membro no comprometimento com a unidade de trabalho: o papel mediador do clima de apoio

We investigated whether the influence of LMX differentiation (the extent to which the quality of the leader-member relationships within a work unit varies) on work unit commitment is mediated by support climate. We tested this mediated relationship in a sample composed of 30 health care units. The results obtained showed that LMX differentiation measured at Time 1 was negatively related to work unit support climate measured one year later (Time 2), which in turn was positively related to work unit commitment measured at Time 2. The negative indirect effect of LMX differentiation on work unit commitment through support climate was statistically significant. Our study contributes to having a better understanding of the role of LMX differentiation in work unit functioning.Investigámos se a influência da diferenciação de LMX (o quanto a qualidade das relações de líder-membro dentro de uma unidade de trabalho varia) no comprometimento com a unidade de trabalho é mediada pelo clima de apoio. Testámos essa relação mediada em uma amostra composta por 30 unidades de saúde. Os resultados obtidos mostraram que a diferenciação da LMX medida no Tempo 1 foi negativamente relacionada ao clima de suporte da unidade de trabalho medido um ano depois (Tempo 2), que por sua vez foi positivamente relacionado ao comprometimento com a unidade de trabalho medido no Tempo 2. O efeito indireto negativo da diferenciação da LMX no comprometimento com a unidade de trabalho por meio do clima de apoio foi estatisticamente significativo. O nosso estudo contribui para uma melhor compreensão do papel da diferenciação do LMX no funcionamento da unidade de trabalho

5-(Hy­droxy­meth­yl)furan-2-carbaldehyde

The title compound (HMF), C6H6O3, is one of the products of acid-catalyzed dehydration of high-fructose corn syrup, and has been shown to be toxic to honey bees. The compound was crystallized at 276 K, and it was found that the two independent mol­ecules in the asymmetric unit form an infinite O—H⋯O hydrogen-bonding chain that is linked into a three-dimensional network structure by weak inter­molecular C—H⋯O contacts

Factory Gate Pricing: An Analysis of the Dutch Retail Distribution

Factory Gate Pricing (FGP) is a relatively new phenomenon in retail distribution. Under FGP, products are no longer delivered at the retailer distribution center, but collected by the retailer at the factory gates of the suppliers. Owing to both the asymmetry in the distribution networks (the supplier sites greatly outnumber the retailer distribution centers) and the better inventory and transport coordination mechanisms, this is likely to result in high savings. A mathematical model was used to analyze the benefits of FGP for a case study in the Dutch retail sector. Extensive numerical results are presented to show the effect of the orchestration shift from supplier to retailer, the improved coordination mechanisms, and sector-wide cooperation

Immunomodulation by Mesenchymal Stem Cells : A Potential Therapeutic Strategy for Type 1 Diabetes

Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found in virtually all postnatal tissues. The main criteria currently used to characterize and identify these cells are the capacity for self-renewal and differentiation into tissues of mesodermal origin, combined with a lack in expression of certain hematopoietic molecules. Because of their developmental plasticity, the notion of MSC-based therapeutic intervention has become an emerging strategy for the replacement of injured tissues. MSCs have also been noted to possess the ability to impart profound immunomodulatory effects in vivo. Indeed, some of the initial observations regarding MSC protection from tissue injury once thought mediated by tissue regeneration may, in reality, result from immunomodulation. Whereas the exact mechanisms underlying the immunomodulatory functions of MSC remain largely unknown, these cells have been exploited in a variety of clinical trials aimed at reducing the burden of immune-mediated disease. This article focuses on recent advances that have broadened our understanding of the immunomodulatory properties of MSC and provides insight as to their potential for clinical use as a cell-based therapy for immune-mediated disorders and, in particular, type 1 diabetes

Second-generation antihistamines: a study of poisoning in children

The toxicity of second-generation antihistamines after an overdose by a child is still unknown. The objective of this study is to use data from Poisons Centres in France to describe the toxicity profile of second-generation antihistamines for children and to compare the severity of poisoning observed from these with a first-generation antihistamine. This was a retrospective, multi-centre and observational study focusing on human cases of single-substance exposure to a second-generation antihistamine and to mequitazine, reported between 1 January 2001 and 31 December 2016 in Poisons Centres in France. From a total of 9403 children included, 5980 were exposed to a second-generation antihistamine and 3423 were exposed to mequitazine. The severity of exposure to second-generation antihistamines in children is low: among the children followed until a known outcome, 9% of children were symptomatic and in 97% of cases, the symptoms shown were of a minor-level severity (primarily drowsiness or restlessness). Depending on the substance, children who ingested doses 16 to 69 times the maximum recommended therapeutic dose remained asymptomatic. No deaths or severe symptoms were observed. No cases of lengthening of the QT interval or arrhythmias were identified. Mequitazine led to more symptoms than other substances (14.8% symptomatic children vs. 7.5%, Odd ratio (OR): 2.3 (2.0-2.6), p < 0.0001), more symptoms of moderate intensity (1.4 vs. 0.2%, OR: 8.3 (4.1-18.5), p < 0.0001) and more hospitalisation (19.1 vs. 8.7%, OR: 2.5, 95% CI: (2.2-2.8), p < 0.0001). The severity of poisoning from second-generation antihistamines appears to be low among children and considerably lower than poisoning caused by mequitazine

STM Imaging of Flux Line Arrangements in the Peak Effect Regime

We present the results of a study of vortex arrangements in the peak-effect regime of 2H-NbSe_2 by scanning tunneling microscopy. By slowly increasing the temperature in a constant magnetic field, we observed a sharp transition from collective vortex motion to positional fluctuations of individual vortices at the temperature which coincides with the onset of the peak effect in ac-susceptibility. We conclude that the peak effect is a disorder driven transition, with the pinning energy winning from the elastic energy.Comment: 4 pages, 4 figures included Manuscript has been submitte

Experimental and theoretical study of the elliptic instability in a rotating stratified flow

The combined effects of Coriolis force and buoyancy effects on the dynamics of a weakly elliptical bounded vortex are treated theoretically as well as experimentally. As predicted theoretically, stratification and rotation have antagonist contributions to the stability of an elliptical vortex. Thus if the stratification is strong enough (Nb>Omega_c, Nb and Omega_c being respectively the Brunt-Väisälä frequency and the rotation rate of the flow in a frame rotating with the elliptical deformation at angular velocity Omega_t), we have observed that only anticyclones (such that |Wa|<Omega_c with Wa=2(Omega_c+Omega_t)) are unstable, whereas the cyclones are always stable. In addition if the stratification is weak, instability areas over change. These instability thresholds found theoretically have been observed experimentally with a good accuracy and the measured growth rate are in a good agreement with those predicted by a linear stability analysis in the limit of small deformation