A manometric feature descriptor with linear-SVM to distinguish esophageal contraction vigor

n clinical, if a patient presents with nonmechanical obstructive dysphagia, esophageal chest pain, and gastro esophageal reflux symptoms, the physician will usually assess the esophageal dynamic function. High-resolution manometry (HRM) is a clinically commonly used technique for detection of esophageal dynamic function comprehensively and objectively. However, after the results of HRM are obtained, doctors still need to evaluate by a variety of parameters. This work is burdensome, and the process is complex. We conducted image processing of HRM to predict the esophageal contraction vigor for assisting the evaluation of esophageal dynamic function. Firstly, we used Feature-Extraction and Histogram of Gradients (FE-HOG) to analyses feature of proposal of swallow (PoS) to further extract higher-order features. Then we determine the classification of esophageal contraction vigor normal, weak and failed by using linear-SVM according to these features. Our data set includes 3000 training sets, 500 validation sets and 411 test sets. After verification our accuracy reaches 86.83%, which is higher than other common machine learning methods

Related-Tweakey Impossible Differential Attack on Reduced-Round SKINNY-AEAD M1/M3

SKINNY-AEAD is one of the second-round candidates of the Lightweight Cryptography Standardization project held by NIST. SKINNY-AEAD M1 is the primary member of six SKINNY-AEAD schemes, while SKINNY-AEAD M3 is another member with a small tag. In the design document, only security analyses of their underlying primitive SKINNY-128-384 are provided. Besides, there are no valid third-party analyses on SKINNY-AEAD M1/M3 according to our knowledge. Therefore, this paper focuses on constructing the first third-party security analyses on them under a nonce-respecting scenario. By taking the encryption mode of SKINNY-AEAD into consideration and exploiting several properties of SKINNY, we can deduce some necessary constraints on the input and tweakey differences of related-tweakey impossible differential distinguishers. Under these constraints, we can find distinguishers suitable for mounting powerful tweakey recovery attacks. With the help of the automatic searching algorithms based on STP, we find some 14-round distinguishers. Based on one of these distinguishers, we mount a 20-round and an 18-round tweakey recovery attack on SKINNY-AEAD M1/M3. To the best of our knowledge, all these attacks are the best ones so far

Abundance, Major Element Composition and Size of Components and Matrix in CV, CO and Acfer 094 Chondrites

The relative abundances and chemical compositions of the macroscopic components or "inclusions" (chondrules and refractory inclusions) and fine-grained mineral matrix in chondritic meteorites provide constraints on astrophysical theories of inclusion formation and chondrite accretion. We present new techniques for analysis of low count per pixel Si, Mg, Ca, Al, Ti and Fe x-ray intensity maps of rock sections, and apply them to large areas of CO and CV chondrites, and the ungrouped Acfer 094 chondrite. For many thousands of manually segmented and type-identified inclusions, we are able to assess, pixel-by-pixel, the major element content of each inclusion. We quantify the total fraction of those elements accounted for by various types of inclusion and matrix. Among CO chondrites, both matrix and inclusion Mg to Si ratios approach the solar (and bulk CO) ratio with increasing petrologic grade, but Si remains enriched in inclusions relative to matrix. The oxidized CV chondrites with higher matrix-inclusion ratios exhibit more severe aqueous alteration (oxidation), and their excess matrix accounts for their higher porosity relative to reduced CV chondrites. Porosity could accommodate an original ice component of matrix as the direct cause of local alteration of oxidized CV chondrites. We confirm that major element abundances among inclusions differ greatly, across a wide range of CO and CV chondrites. These abundances in all cases add up to near-chondritic (solar) bulk abundance ratios in these chondrites, despite wide variations in matrix-inclusion ratios and inclusion sizes: chondrite components are complementary. This "complementarity" provides a robust meteoritic constraint for astrophysical disk models

Tuftsin Promotes an Anti-Inflammatory Switch and Attenuates Symptoms in Experimental Autoimmune Encephalomyelitis

Multiple sclerosis (MS) is a demyelinating autoimmune disease mediated by infiltration of T cells into the central nervous system after compromise of the blood-brain barrier. We have previously shown that administration of tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. We now show that tuftsin-mediated microglial activation results in shifting microglia to an anti-inflammatory phenotype. Moreover, the T cell phenotype is shifted towards immunoprotection after exposure to tuftsin-treated activated microglia; specifically, downregulation of pro-inflammatory Th1 responses is triggered in conjunction with upregulation of Th2-specific responses and expansion of immunosuppressive regulatory T cells (Tregs). Finally, tuftsin-shifted T cells, delivered into animals via adoptive transfer, reverse the pathology observed in mice with established EAE. Taken together, our findings demonstrate that tuftsin decreases the proinflammatory environment of EAE and may represent a therapeutic opportunity for treatment of MS

Structure and Dynamics of Quiescent Prominence Eruptions

<p>Final presentations of the Center for Astrophysics HEA/SSP Solar Summer Intern Program.</p

Patients with Asian-type DEL can safely be transfused using RhD-positive blood

Red blood cells (RBCs) of the Asian-type DEL phenotype express few RhD proteins and are typed as serologic RhD-negative (D-) in routine testing. RhD-positive (D+) RBC transfusion for Asian-type DEL patients has been proposed but has not been generally adopted due to a lack of direct evidence regarding its safety and underlying mechanism. We performed a single-arm multicenter clinical trial to document the outcome of D+ RBC transfusion in Asian-type DEL patients; none of the recipients (0/42; 95% confidence interval, 0%-8.40%) developed alloanti-D after a median follow-up of 226 days. We conducted a large retrospective study to detect alloanti-D immunization in 4,045 serologic D- pregnant women throughout China; alloanti-D was found only in true D- individuals (2.63%, 79/3,009), but not in those with Asian-type DEL (0/1,032). We further retrospectively examined 127 serologic D- pregnant women who had developed alloanti-D and found none with Asian-type DEL (0/127). Finally, we analyzed RHD transcripts from Asian-type DEL erythroblasts and examined antigen epitopes expressed by various RHD transcripts in vitro, finding a low abundance of full-length RHD transcripts (0.18% of the total) expressing RhD antigens carrying the entire repertoire of epitopes, which could explain the immune tolerance against D+ RBCs. Our results provide multiple lines of evidence that individuals with Asian-type DEL cannot produce alloanti-D when exposed to D+ RBCs following transfusion or pregnancy. Therefore, we recommend considering D+ RBC transfusion and discontinuing anti-D prophylaxis in Asian-type DEL patients, including pregnant women. This clinical trial is registered at www.clinicaltrials.gov as NCT03727230