MGMT 810 Problems in Organizational Behavior

Course syllabus for MGMT 810 Problems in Organizational Behavio

Dodd-Frank\u27s Conflict Minerals Rule: The Tin Ear of Government-Business Regulation

This paper examines an unusual provision included in the Dodd-Frank Wall Street Reform and Consumer Protection Act (2010), Section 1502 known as the Conflict Minerals Rule. This provision, having nothing to do with the subject matter of the act itself, attempts to place a chilling effect on the trade of four identified minerals from the Democratic Republic of Congo. The provision and its subsequent rule, surprisingly delegated to the U.S. Securities and Exchange Commission (an agency lacking subject matter expertise in minerals) presents a case and object lesson of almost every cost, procedural and legal error that can take place in a rushed attempt to do social good through government regulation of commerce. The article presents an overview of the provision and rule, demonstrating the various cost and operational burdens on industry and a host of legal pitfalls leading to its ultimate unintended consequences that in the end suggest an outcome opposite of what its Congressional authors intended

Economic Development Through Local Vendor Preference Policy: The Case of Horry County, South Carolina

In the wake of the worst recession since the 1930\u27s, local communities actively seek ways to stimulate business development, economic activity and job creation. The economic development imperative arises at a time of public pressure to limit government programs and overall reduce size and cost of government. This paper provides an overview of one means by which local governments can achieve economic stimulus inducement by strategic use of its own fiscal resources. The use of local vendor preference purchasing laws provides a means by which communities can focus locally generated tax dollars to prime both public and private economic activity. The article surveys the state of these policies in the context of the case of Horry County, South Carolina. It examines the legal environment of Federal and state laws toward such policies. Horry County\u27s situation is not dissimilar to that faced by other counties in the coastal regions of the Carolinas. The article stimulates new thinking on a theme of local efforts-self reliance to encourage growth and business development

Opportunity Loss and Opportunity Cost: Consequences of Not Attending Class

Business Schools are charged with equipping the next generation of marketing professionals with the skills and knowledge to benefit both the businesses they work in and the country at large. Regional accrediting bodies such as the Southern Association of Colleges and Schools (SACS) and international bodies like the Association to Advance Collegiate Schools of Business (AACSB) review teaching practices in an effort to improve educational effectiveness at the Business School level. This movement, known as Assurance of Learning, is practiced in Business Schools everywhere. This paper explores the effect of students’ skipping classes in a capstone Marketing Strategy course on opportunity loss and opportunity cost. The results show avoiding opportunity costs of tuition and opportunity losses of learning is facilitated by students attending all of their classes. These results also suggest college professors should consider mandatory attendance in courses with high percentages of D, F, W grades that may frequently precede students dropping out of college

Stable isotope analysis using tunable diode laser spectroscopy

Measurements of ratios of stable isotopes are used in such diverse fields as petroleum prospecting, medical diagnostics, and planetary exploration. The narrow emission linewidth available from tunable diode lasers permits high-resolution infrared absorption measurements of closely spaced isotopic rovibrational lines. Our dual beam spectrometer uses the sweep integration technique in a spectral region where adjacent spectral lines are of approximately equal absorbance at the expected isotopic abundances. The experimental results reported here indicate that isotopic ratios of carbon in carbon dioxide can be measured to an accuracy of better than 0.4%. This laser spectroscopic spectrometric technique offers an alternative to the mass technique for in situ isotopic analysis in field studies, as well as flight and space applications

Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn “On” Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model

Glioblastoma multiforme (GBM) is the most commonly occurring primary brain cancer in adults, in whom its highly infiltrative cells prevent total surgical resection, often leading to tumor recurrence and patient death. Our group has discovered a gene therapy approach for GBM that utilizes high-capacity ?gutless? adenoviral vectors encoding regulatable therapeutic transgenes. The herpes simplex type 1-thymidine kinase (TK) actively kills dividing tumor cells in the brain when in the presence of the prodrug, ganciclovir (GCV), whereas the FMS-like tyrosine kinase 3 ligand (Flt3L) is an immune-stimulatory molecule under tight regulation by a tetracycline-inducible ?Tet-On? activation system that induces anti-GBM immunity. As a prelude to a phase I clinical trial, we evaluated the safety and efficacy of Food and Drug Administration (FDA)?approved doses of the tetracycline doxycycline (DOX) allometrically scaled for rats. DOX initiates the expression of Flt3L, which has been shown to recruit dendritic cells to the brain tumor microenvironment?an integral first step in the development of antitumor immunity. The data revealed a highly safe profile surrounding these human-equivalent doses of DOX under an identical therapeutic window as proposed in the clinical trial. This was confirmed through a neuropathological analysis, liver and kidney histopathology, detection of neutralizing antibodies, and systemic toxicities in the blood. Interestingly, we observed a significant survival advantage in rats with GBM receiving the 300?mg/day equivalent dosage of DOX versus the 200?mg/day equivalent. Additionally, rats rejected ?recurrent? brain tumor threats implanted 90 days after their primary brain tumors. We also show that DOX detection within the plasma can be an indicator of optimal dosing of DOX to attain therapeutic levels. This work has significant clinical relevance for an ongoing phase I clinical trial in humans with primary GBM and for other therapeutic approaches using Tet-On transactivation system in humans.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140103/1/hgtb.2015.168.pd

The detection and X-ray evolution of galaxy groups at high redshift

We describe some of the first X-ray detections of groups of galaxies at high redshifts (z~0.4), based on the UK deep X-ray survey of McHardy et al (1998). Combined with other deep ROSAT X-ray surveys with nearly complete optical identifications, we investigate the X-ray evolution of these systems. We find no evidence for evolution of the X-ray luminosity function up to z=0.5 at the low luminosities of groups of galaxies and poor clusters (Lx>3e42 erg/s), although the small sample size precludes very accurate measurements. This result confirms and extends to lower luminosities current results based on surveys at brighter X-ray fluxes. The evolution of the X-ray luminosity function of these low luminosity systems is more sensitive to the thermal history of the intra-group medium (IGM) than to cosmological parameters. Energy injection into the IGM (from for example supernovae or AGN winds) is required to explain the X-ray properties of nearby groups. The observed lack of evolution suggests that the energy injection occured at redshifts z>0.5.Comment: 13 pages, MNRAS accepte

The mass profile of A1413 observed with XMM-Newton: implications for the M-T relation

We present an XMM-Newton observation of A1413, a hot (kT = 6.5 keV) galaxy cluster at z=0.143. We construct gas and temperature profiles up to ~1700 kpc, equivalent to ~0.7 r_200. The gas distribution is well described by a beta model in the outer regions, but is more concentrated in the inner ~250 kpc. We introduce a new parameterisation for the inner regions, allowing a steeper gas density distribution. The projected radial temperature profile declines gradually towards the outer regions, by ~20% between 0.1 r_200 and 0.5 r_200, and is well described by a polytropic model with gamma = 1.07+/-0.01. We find that neither projection nor PSF effects change substantially the form of the temperature profile. Assuming hydrostatic equilibrium (HE) and spherical symmetry, we use the observed temperature profile and the new parametric form for the gas density profile to produce the total mass distribution. The mass profile is remarkably well fitted with the Moore et al. (1999) parameterisation with a concentration parameter in the range expected from numerical simulations. There are several indications that beyond a density contrast delta \~600, the gas may no longer be in HE. There is an offset with respect to adiabatic numerical simulations in the virialised part of the cluster, in that the predicted mass for the cluster temperature is ~40% too high. The gas distribution is peaked in the centre primarily as a result of the cusp in the dark matter profile. The X-ray gas to total mass ratio rises with increasing radius to f_gas ~ 0.2. These data strongly support the validity of the current approach for the modelling of the dark matter collapse, but confirm that understanding the gas specific physics is essential. (Abridged)Comment: To appear in A&