Aspectos epidemiológicos atuais da tuberculose e o impacto da estratégia DOTS no controle da doença

This article aims to present the current situation of tuberculosis and how the DOTS (Directly Observed Treatment Short Course) strategy has impacted national tuberculosis control programs worldwide, in Latin America and in Brazil. Data reveal a tendency towards a slow decline in disease rates (1%) around the world in 2003. In Brazil, data indicate a constant downward tendency of approximately 3% a year in incidence levels. The DOTS strategy has been recommended to all countries. Brazil needs to improve its tuberculosis surveillance efforts, particularly in terms of confirming negative sputum smear results at the end of treatment.La finalidad de este artículo es dibujar la situación actual de la tuberculosis y el impacto de la estrategia DOTS (Directly Observed Treatment Short Course) en los Programas Nacionales de Control de la enfermedad en el mundo, en América Latina y en Brasil. Los datos evidencian una tendencia a la caída lenta de la enfermedad en el mundo (1%) en 2003. En Brasil, los datos indican una tendencia descendente constante en la incidencia, con caída aproximada de unos 3% al año. La estrategia DOTS ha sida recomendada a todos los países. El Brasil necesita mejorar la vigilancia de la enfermedad, principalmente con relación a la confirmación de la conversión de la baciloscopia al término del tratamiento.O artigo tem por objetivo apresentar a situação atual da tuberculose e o impacto da estratégia DOTS (Directly Observed Treatment Short Course) nos Programas Nacionais de Controle da doença no mundo, na América Latina e no Brasil. Os dados evidenciam tendência de declínio lento da doença no mundo (1%), em 2003. No Brasil, os dados indicam tendência descendente constante na incidência, com queda aproximada de 3% ao ano. A estratégia DOTS tem sido recomendada a todos os países. O Brasil necessita melhorar a vigilância da doença, principalmente em relação à confirmação da conversão da baciloscopia ao término do tratamento

Leucemia linfocítica crônica: anormalidades cromossômicas e a sua relação com o estágio clínico CD38 e o ZAP-70

Chronic lymphocytic leukemia is the most prevalent type of leukemia in the West. It is characterized by an extremely variable clinical course. The aim of the study was to detect the most frequent chromosomal abnormalities in patients with CLL using FISH, and assess them regarding age, gender, clinical stage and CD38 and ZAP-70 expressions. We found 51.7% of the patients with chromosome abnormalities. The most frequent one was del 13q14 in 34.5% of cases. It was associated to other alterations in 17.2%. 17p13 deletions were found in 17.2% and trisomy 12 in 13.8% (in isolation in 6.9% and associated to del 13q14, in 6.9% of the cases). An 11q22 deletion was found in one case associated to a 13q14 deletion. To better evaluate the relationship between chromosome aberrations and other prognostic factors in CLL, two cytogenetics groups were considered: favorable (13q deletion in isolation and no alteration) and unfavorable outcomes (trisomy 12, 17p13 deletion, 11q22 deletion and two simultaneous alterations).The unfavorable alterations were more frequently seen among young individuals (<60y). There were more females (70%) than males in this group (p=0.04). In relation to the Binet's staging system, patients with unfavorable cytogenetic alterations, tended to be B and C stages, while in the favorable group prevailed patients in stage A. Additionally, patients with poor prognostic cytogenetics tended to express CD38 and ZAP-70 proteins.A leucemia linfocítica crônica (LLC) é o tipo de leucemia mais prevalente no Ocidente e é caracterizada por curso clínico extremamente variável. O objetivo deste estudo foi detectar as anomalias cromossômicas mais freqüentes em pacientes com LLC, empregando a técnica FISH, e correlacioná-las com idade, sexo, estádio clínico, expressão de CD 38 e ZAP-70. Foram encontradas alterações cromossômicas em 51,7% dos pacientes. A mais freqüente foi a del 13q14, observada em 34,5% dos casos e que esteve associada a outras anomalias em 17,2%. Deleção 17p13 foi encontrada em 17,2% e trissomia 12 em 13,8% (isolada em 6,9% e associada à del 13q14 em 6,9%). Deleção 11q22 foi observada em um caso em concomitância à del 13q14. Para melhor avaliar a relação entre alteração cromossômica e outros fatores prognósticos em LLC, dois grupos citogenéticos foram considerados: favorável (deleção 13q isolada e ausência de alterações) e desfavorável (trissomia 12, deleção 17p13, deleção 11q22 e duas anomalias simultâneas). As alterações desfavoráveis foram mais freqüentemente observadas em indivíduos jovens (<60 anos) e em mulheres (70%)(p=0,04). Em relação ao sistema de estadiamento de Binet, houve tendência dos pacientes com alterações cromossômicas desfavoráveis apresenteram-se nos estágios B e C enquanto no grupo favorável prevaleceram aqueles com estágio A. Em adição, pacientes com achados citogenéticos de prognóstico desfavorável tiveram tendência a expressar proteínas CD 38 e ZAP-70.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciEL

The Acacia controversy resulting from minority rule at the Vienna Nomenclature Section : much more than arcane arguments and complex technicalities

The arguments towards resolving the Acacia nomenclatural controversy put forth by Thiele & al. (2011) are reviewed and rebutted. We argue that a truly pragmatic and, moreover, defensible and equitable alternative to accepting the retypification of Acacia Mill. with a conserved type would be to have the 2006 International Code of Botanical Nomenclature, excluding this retypification, serve as the basis for discussions at the Nomenclature Section of the Melbourne International Botanical Congress in 2011. We, and a large component of the international taxonomic community, and beyond, remain convinced that the minority rule voting procedure used at Vienna on Acacia was inappropriate, resulting in animosity that will without any doubt linger until this situation is rectified. Such a minority rule procedure has never in the history of Nomenclature Sections been implemented before. Exclusion of the Acacia retypification can be achieved through a democratic process by objecting to its inclusion when the printed (2006) Code comes up for adoption at the start of the Nomenclature Section. This is perfectly within the established process that has been used in past Section meetings. The integrity of the Code will suffer permanent damage if the retypification of Acacia Mill. with a conserved type is not removed from the ICBN, especially as it ended up there through a minority decision.http://www.botanik.univie.ac.at/iapt/s_taxon.ph

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV