Comparative analysis of models for adjustment procedure in assets value independent evaluation performed by comparative approach

This paper addresses the field of economic measurements of the value of assets, carried out by the methods of independent expert evaluation. The mathematical principles of application, within a comparative methodical approach, of additive and multiplicative models for correcting the cost of single indicator of compared objects have been considered. The differences of mathematical basis of the compared models were analyzed. It has been shown that the ambiguity in the methodology of correction procedure requires studying the advantages and disadvantages of known models, as well as the justification and elaboration of recommendations for their application. Possible forms of correction representation using several alternative units of measurement have been defined; formulas for their interconnection have been built. Analytic expressions have been derived that mathematically describe the algorithms for performing the evaluation correction procedure using various forms of correction representation. The influence of the correction execution model on the characteristics of uncertainty in the independent evaluation result has been analyzed. The scope of two possible types of correction introduction models has been determined. A specific numerical example was used to demonstrate the methodological advantages of using a multiplicative model when summarizing percentage corrections. The independence of the correction result on the sequence of correction introduction has been confirmed. It is proposed to use the selected measure of partial corrections as a criterion for the adequacy of the correction introduction model. It is proved that the result of the independent expert evaluation depends on the chosen model and does not depend on the sequence of correction introduction. The reported study results are important in terms of theory and practice since they make it possible to improve the accuracy and reliability of the result of independent expert evaluation

Investigation of the Antiremodeling Effects of Losartan, Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model

Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development of chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling of various etiologies. The beta-3 adrenergic receptor agonist mirabegron was reported to improve chronic heart failure. Here we investigated the effects of losartan, mirabegron and their combination on the development of DOXO-induced chronic cardiotoxicity. Male Wistar rats were divided into five groups: (i) control; (ii) DOXO-only; (iii) losartan-treated DOXO; (iv) mirabegron-treated DOXO; (v) losartan plus mirabegron-treated DOXO groups. The treatments started 5 weeks after DOXO administration. At week 8, echocardiography was performed. At week 9, left ventricles were prepared for histology, qRT-PCR, and Western blot measurements. Losartan improved diastolic but not systolic dysfunction and ameliorated SERCA2a repression in our DOXO-induced cardiotoxicity model. The DOXO-induced overexpression of Il1 and Il6 was markedly decreased by losartan and mirabegron. Mirabegron and the combination treatment improved systolic and diastolic dysfunction and significantly decreased overexpression of Smad2 and Smad3 in our DOXO-induced cardiotoxicity model. Only mirabegron reduced DOXO-induced cardiac fibrosis significantly. Mirabegron and its combination with losartan seem to be promising therapeutic tools against DOXO-induced chronic cardiotoxicity.Peer reviewe

Humanization, Eschatology, Theodicy: Metz, Schmitt, and the 'Hidden Nexus'

status: publishe

Semilattices of totally bounded quasi-uniformities

AbstractWe prove that in general the set of all compatible totally bounded quasi-uniformities (ordered by set-theoretic inclusion) on a topological space does not have good lattice theoretic properties. For instance, we show that even if it is a lattice it need not be modular.We also establish that for every nonzero cardinal κ there exists a topological space X such that X admits exactly κ totally bounded quasi-uniformities. Various further results concerning the number of compatible totally bounded quasi-uniformities on topological spaces are obtained

The Need for Innovation of Security Education for Strengthening the Results of Traditional Teaching at Universities

This article deals with security education and the possibilities of innovative methods application in this kind of education at universities. The continuous development of science and technology, as well as constantly changing social needs which are closely tied to the emergence of new security risks and threats, dynamically affect the entire system of education. Therefore, an urgent need for the implementation of these requirements arises. There is a need to address the number of key roles in the framework of security education in the spirit of innovation methods in order to improve teaching and, subsequently increase the efficiency of the process

Порівняльний аналіз моделей виконання процедури коригування при використанні порівняльного підходу у незалежній оцінці вартості активів

This paper addresses the field of economic measurements of the value of assets, carried out by the methods of independent expert evaluation. The mathematical principles of application, within a comparative methodical approach, of additive and multiplicative models for correcting the cost of single indicator of compared objects have been considered. The differences of mathematical basis of the compared models were analyzed. It has been shown that the ambiguity in the methodology of correction procedure requires studying the advantages and disadvantages of known models, as well as the justification and elaboration of recommendations for their application. Possible forms of correction representation using several alternative units of measurement have been defined; formulas for their interconnection have been built. Analytic expressions have been derived that mathematically describe the algorithms for performing the evaluation correction procedure using various forms of correction representation. The influence of the correction execution model on the characteristics of uncertainty in the independent evaluation result has been analyzed. The scope of two possible types of correction introduction models has been determined. A specific numerical example was used to demonstrate the methodological advantages of using a multiplicative model when summarizing percentage corrections. The independence of the correction result on the sequence of correction introduction has been confirmed. It is proposed to use the selected measure of partial corrections as a criterion for the adequacy of the correction introduction model. It is proved that the result of the independent expert evaluation depends on the chosen model and does not depend on the sequence of correction introduction. The reported study results are important in terms of theory and practice since they make it possible to improve the accuracy and reliability of the result of independent expert evaluation.Работа относится к области экономических измерений стоимости активов, осуществляемых методами независимой экспертной оценки. Рассмотрены математические основы применения в сравнительном методическом подходе аддитивной и мультипликативной моделей выполнения корректировок стоимости единичного показателя объектов сравнения. Проанализированы отличия математической основы сравниваемых моделей. Показано, что неоднозначность методологии выполнения процедуры корректировки требует исследования преимуществ и недостатков известных моделей, обоснования и разработки рекомендаций по их применению. Определены возможные формы представления поправок в нескольких альтернативных единицах измерения; получены формулы их взаимной связи. Выведены аналитические выражения, математически описывающие алгоритмы выполнения оценочной процедуры корректировки с применением различных форм представления поправок. Проанализировано влияние модели выполнения корректировки на характеристики неопределенности результата независимой оценки. Определены области применения двух возможных типов моделей ввода поправок. На конкретном численном примере показаны методические преимущества использования мультипликативной модели при обобщении процентных поправок. Предложено в качестве критерия адекватности модели внесения поправок использовать выбранную единицу измерения частных поправок. Доказано, что результат независимой экспертной оценки зависит от выбранной модели и не зависит от последовательности внесения поправок. Полученные результаты исследования имеют важное теоретическое и практическое значение, поскольку позволяют повысить точность и достоверность результата независимой экспертной оценкиРобота відноситься до галузі економічних вимірювань вартості активів, що здійснюються методами незалежної експертної оцінки. Розглянуто математичні засади застосування у порівняльному методичному підході адитивної та мультиплікативної моделей виконання коригувань вартостей одиничного показника об’єктів порівняння. Проаналізовано відмінності математичного підґрунтя порівнюваних моделей. Показано, що неоднозначність методології виконання процедури коригування вимагає дослідження переваг та недоліків відомих моделей, обґрунтування та опрацювання рекомендацій по їх застосуванню. Визначено можливі форми представлення поправок у декількох альтернативних одиницях виміру; отримано формули їх взаємного зв’язку. Виведено аналітичні вирази, що математично описують алгоритми виконання оціночної процедури коригування із застосуванням різних форм представлення поправок. Проаналізовано вплив моделі виконання коригування на характеристики невизначеності результату незалежної оцінки. Визначено області застосування двох можливих типів моделей введення поправок. На конкретному чисельному прикладі продемонстровано методичні переваги використання мультиплікативної моделі при узагальненні відсоткових поправок. Підтверджено незалежність результату коригування від послідовності внесення поправок. Запропоновано у якості критерію адекватності моделі внесення поправок використовувати обраний вимірник часткових поправок. Доведено, що результат виконання незалежної експертної оцінки залежить від обраної моделі і не залежить від послідовності внесення поправок. Отримані результати дослідження мають важливе теоретичне та практичне значення, оскільки дозволяють підвищити точність та достовірність результату незалежної експертної оцінк

Development of A Method for Targeted Financing of Economy Sectors Through Capital Investment in the Innovative Development

The problem of targeted financing of economic sectors is considered. The method of targeted financing of sectors of the economy through investment in innovative development is proposed. On the basis of statistical data on the performance indicators of the sectors of the economy, the calculation of indicators of their innovative potential was carried out, based on the volume of sold innovative products (goods, services) by type of economic activity. In order to stimulate sectors of the economy by investing in innovative development, it is proposed to introduce targeted financing of the latter. The problem of quantitative assessment of targeted financing of economic sectors by means of investment in innovative development based on an integrated approach has been solved. According to the results obtained, sectors of the economy that are identified as the most risky and have the potential for innovative development fall under targeted financing. The proposed technique was tested by an experimental method. On the basis of an integrated approach for the indicators of the riskiness of the economic sector and the indicator of the innovative potential of the economic sector, targeted financing for 3 sectors of the economy (namely: P, N, M, L and J) was determined. Sector P will receive more targeted funding, while sectors N, M, L and J will receive less targeted funding, respectively. The size of these parts will be 47.30 %, 22.31 %, 13.48 %, 9.56 % and 7.34 %, respectively, of 100 % S. The results of the study are of practical interest for government bodies (local, territorial, etc.) in the distribution of funds according to the vector of targeted financing of sectors of the economy through investment in innovative development. Practically valuable for researchers who deal with issues of financial security, targeted financing and public administratio

Influence of the Long-Chain/Short-Chain Amphiphile Ratio on Lateral Diffusion of PEG-Lipid in Magnetically Aligned Lipid Bilayers as Measured via Pulsed-Field-Gradient NMR

Lateral diffusion measurements of polyethylene glycol(PEG)-lipid incorporated into magnetically aligned lipid bilayers, composed of dimyristoyl phosphatidylcholine (DMPC) plus dihexanoyl phosphatidylcholine (DHPC) plus 1 mol % (relative to DMPC) dimyristoyl phosphatidylethanolamine-n-[methoxy(polyethylene glycol)-2000] (DMPE-PEG 2000), were performed using stimulated-echo pulsed-field-gradient proton ((1)H) nuclear magnetic resonance spectroscopy. The DMPE-PEG 2000 (1 mol %, 35°C) lateral diffusion coefficient D varied directly with the mole fraction of DMPC, X(DMPC) = q/(1+q) where q = DMPC/DHPC molar ratio, decreasing progressively from D = 1.65 × 10(−11) m(2) s(−1) at q ≈ 4.7 to D = 0.65 × 10(−11) m(2) s(−1) at q ≈ 2.5. Possible sources of this dependence, including orientational disorder, obstruction, and PEG-lipid sequestration, were simulated using, respectively, a diffusion-in-a-cone model, percolation theory, and a two-phase PEG distribution model. Orientational disorder alone was not capable of reproducing the observations, but in combination with either obstruction or PEG-lipid two-phase distribution models did so satisfactorily. A combination of all three models yielded the most reasonable fit to the observed dependence of lateral diffusion on q. These same effects would be expected to influence lateral diffusion of any bilayer-associating species in such systems