Ermakov Systems with Multiplicative Noise

Using the Euler-Maruyama numerical method, we present calculations of the Ermakov-Lewis invariant and the dynamic, geometric, and total phases for several cases of stochastic parametric oscillators, including the simplest case of the stochastic harmonic oscillator. The results are compared with the corresponding numerical noiseless cases to evaluate the effect of the noise. Besides, the noiseless cases are analytic and their analytic solutions are briefly presented. The Ermakov-Lewis invariant is not affected by the multiplicative noise in the three particular examples presented in this work, whereas there is a shift effect in the case of the phasesComment: 12 pages, 4 figures, 22 reference

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model.

BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5-fluorouracil (5-FU). This therapeutic approach is being tested in a randomized phase II/III trial in recurrent glioblastoma and anaplastic astrocytoma (NCT0241416). The aim of this study was to identify the immune cell subsets contributing to antitumor immune responses following treatment with 5-FC in Toca 511-expressing gliomas in a syngeneic mouse model.MethodsFlow cytometry was utilized to monitor and characterize the immune cell infiltrate in subcutaneous Tu-2449 gliomas in B6C3F1 mice treated with Toca 511 and 5-FC.ResultsTumor-bearing animals treated with Toca 511 and 5-FC display alterations in immune cell populations within the tumor that result in antitumor immune protection. Attenuated immune subsets were exclusive to immunosuppressive cells of myeloid origin. Depletion of immunosuppressive cells temporally preceded a second event which included expansion of T cells which were polarized away from Th2 and Th17 in the CD4+ T cell compartment with concomitant expansion of interferon gamma-expressing CD8+ T cells. Immune alterations correlated with clearance of Tu-2449 subcutaneous tumors and T cell-dependent protection from future tumor challenge.ConclusionsTreatment with Toca 511 and 5-FC has a concentrated effect at the site of the tumor which causes direct tumor cell death and alterations in immune cell infiltrate, resulting in a tumor microenvironment that is more permissive to establishment of a T cell mediated antitumor immune response

EURONU WP6 2009 yearly report: Update of the physics potential of Nufact, superbeams and betabeams

Many studies in the last ten years have shown that we can measure the unknown angle theta13, discover leptonic CP violation and determine the neutrino hierarchy in more precise neutrino oscillation experiments, searching for the subleading channel nue -> numu in the atmospheric range. In this first report of WP6 activities the following new results are reviewed: (1) Re-evaluation of the physics reach of the upcoming generation of experiments to measure theta13 and delta; (2) New tools to explore a larger parameter space as needed beyond the standard scenario; (3) Neutrino Factory: (a) evaluation of the physics reach of a Nufact regards sterile neutrinos; (b) evaluation of the physics reach of a Nufact as regards non-standard interactions; (c) evaluation of the physics reach of a Nufact as regards violation of unitarity; (d) critical assessment on long baseline tau-detection at Nufact; (e) new physics searches at a near detector in a Nufact; (4) Beta-beams: (a) choice of ions and location for a gamma = 100 CERN-based beta-beam; (b) re-evaluation of atmospheric neutrino background for the gamma = 100 beta-beam scenario; (c) study of a two baseline beta-beam; (d) measuring absolute neutrino mass with beta-beams; (e) progress on monochromatic beta-beams; (5) Update of the physics potential of the SPL super-beam. Eventually, we present an updated comparison of the sensitivity to theta13, delta and the neutrino mass hierarchy of several of the different proposed facilities.Comment: 2009 Yearly report of the Working Package 6 (Physics) of the EUROnu FP7 EU project. 55 pages, 21 figures

Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics.

BackgroundThe number of racial/ethnic minority children will exceed the number of white children in the USA by 2018. Although 38% of Americans are minorities, only 12% of pediatricians, 5% of medical-school faculty, and 3% of medical-school professors are minorities. Furthermore, only 5% of all R01 applications for National Institutes of Health grants are from African-American, Latino, and American Indian investigators. Prompted by the persistent lack of diversity in the pediatric and biomedical research workforces, the Academic Pediatric Association Research in Academic Pediatrics Initiative on Diversity (RAPID) was initiated in 2012. RAPID targets applicants who are members of an underrepresented minority group (URM), disabled, or from a socially, culturally, economically, or educationally disadvantaged background. The program, which consists of both a research project and career and leadership development activities, includes an annual career-development and leadership conference which is open to any resident, fellow, or junior faculty member from an URM, disabled, or disadvantaged background who is interested in a career in academic general pediatrics.MethodsAs part of the annual RAPID conference, a Hot Topic Session is held in which the young investigators spend several hours developing a list of hot topics on the most useful faculty and career-development issues. These hot topics are then posed in the form of six "burning questions" to the RAPID National Advisory Committee (comprised of accomplished, nationally recognized senior investigators who are seasoned mentors), the RAPID Director and Co-Director, and the keynote speaker.Results/conclusionsThe six compelling questions posed by the 10 young investigators-along with the responses of the senior conference leadership-provide a unique resource and "survival guide" for ensuring the academic success and optimal career development of young investigators in academic pediatrics from diverse backgrounds. A rich conversation ensued on the topics addressed, consisting of negotiating for protected research time, career trajectories as academic institutions move away from an emphasis on tenure-track positions, how "non-academic" products fit into career development, racism and discrimination in academic medicine and how to address them, coping with isolation as a minority faculty member, and how best to mentor the next generation of academic physicians

Применение метода проектов для формирования знаний о природе у детей дошкольного возраста

В ВКР представлено одно из средств формирования экологического образования у детей дошкольного возраста метод проектов. Это дидактическое средство активизации познавательного и творческого развития ребенка и одновременно формирование его личностных качеств. Знания, приобретаемые детьми в ходе метода проектов, становятся достоянием их личного опыта. Экспериментируя, ребенок ищет ответ на вопрос и тем самым, развивает творческие способности, коммуникативные навыки. Экологическое образование детей дошкольного возраста – это многоаспектное качество, включающее в себя экологические представления и знания ребенка о пользе природе и всего живого, понимание детьми элементарных взаимосвязей, существующих в природе, умения и навыки эмоционально-чувственного взаимодействия с природными объектами и гуманно-действенного взаимодействия человека с ней. Эффективным средством формирования знаний о природе у детей дошкольного возраста является использование метода проектов, цель которого – посредством познавательно-исследовательской деятельности, которая организуется во взаимодействии с детьми и экологические представления и знания, положительное эмоциональное отношение к природе

Radiative corrections to the Higgs boson decay rate Γ(H→ZZ)\Gamma(H\rightarrow ZZ) in the minimal supersymmetric model

We consider radiative corrections to the decay rate $\Gamma(H\rightarrow ZZ)$ of the heavy {\it CP}-even Higgs boson of the minimal supersymmetric model to two $Z$ bosons. We perform a one loop Feynman diagram calculation in the on-mass-shell renormalization scheme, and include the third generation of quarks and squarks. The tree level rate is suppressed by a mixing angle factor and decreases as $1/M_H$ for large $M_H$. The corrected rate overcomes this suppression and increases with $M_H$ for $M_H > 500$~GeV. The corrections can be very large and depend in detail on the top squark masses and $A$-term, as well as the supersymmetric Higgs mass parameter $\mu$.Comment: 22 pages, 9 figures available from authors, UCB-PTH-92/23 and LBL-3249

Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer

INTRODUCTION: Adipose-derived stem cells (ASCs) have the potential to differentiate into cartilage under stimulation with some reported growth and transcriptional factors, which may constitute an alternative for cartilage replacement approaches. In this study, we analyzed the in vitro chondrogenesis of ASCs transduced with adenoviral vectors encoding insulin-like growth factor-1 (IGF-1), transforming growth factor beta-1 (TGF-β1), fibroblast growth factor-2 (FGF-2), and sex-determining region Y-box 9 (SOX9) either alone or in combinations. METHODS: Aggregate cultures of characterized ovine ASCs were transduced with 100 multiplicity of infections of Ad.IGF-1, Ad.TGF-β1, Ad.FGF-2, and Ad.SOX9 alone or in combination. These were harvested at various time points for detection of cartilage-specific genes expression by quantitative real-time PCR or after 14 and 28 days for histologic and biochemical analyses detecting proteoglycans, collagens (II, I and X), and total sulfated glycosaminoglycan and collagen content, respectively. RESULTS: Expression analyses showed that co-expression of IGF-1 and FGF-2 resulted in higher significant expression levels of aggrecan, biglycan, cartilage matrix, proteoglycan, and collagen II (all P ≤0.001 at 28 days). Aggregates co-transduced with Ad.IGF-1/Ad.FGF-2 showed a selective expression of proteoglycans and collagen II, with limited expression of collagens I and × demonstrated by histological analyses, and had significantly greater glycosaminoglycan and collagen production than the positive control (P ≤0.001). Western blot analyses for this combination also demonstrated increased expression of collagen II, while expression of collagens I and × was undetectable and limited, respectively. CONCLUSION: Combined overexpression of IGF-1/FGF-2 within ASCs enhances their chondrogenic differentiation inducing the expression of chondrogenic markers, suggesting that this combination is more beneficial than the other factors tested for the development of cell-based therapies for cartilage repair

The discovery of WASP-151b, WASP-153b, WASP-156b: Insights on giant planet migration and the upper boundary of the Neptunian desert

To investigate the origin of the features discovered in the exoplanet population, the knowledge of exoplanets’ mass and radius with a good precision (≲10%) is essential. To achieve this purpose the discovery of transiting exoplanets around bright stars is of prime interest. In this paper, we report the discovery of three transiting exoplanets by the SuperWASP survey and the SOPHIE spectrograph with mass and radius determined with a precision better than 15%. WASP-151b and WASP-153b are two hot Saturns with masses, radii, densities and equilibrium temperatures of 0.31−0.03+0.04 MJ, 1.13−0.03+0.03 RJ, 0.22−0.02+0.03 ρJ and 1290−10+20 K, and 0.39−0.02+0.02 MJ, 1.55−0.08+0.10 RJ, 0.11−0.02+0.02 ρJ and 1700−40+40 K, respectively. Their host stars are early G type stars (with mag V ~ 13) and their orbital periods are 4.53 and 3.33 days, respectively. WASP-156b is a super-Neptune orbiting a K type star (mag V = 11.6). It has a mass of 0.128−0.009+0.010 MJ, a radius of 0.51−0.02+0.02 RJ, a density of 1.0−0.1+0.1 ρJ, an equilibrium temperature of 970−20+30 K and an orbital period of 3.83 days. The radius of WASP-151b appears to be only slightly inflated, while WASP-153b presents a significant radius anomaly compared to a recently published model. WASP-156b, being one of the few well characterized super-Neptunes, will help to constrain the still debated formation of Neptune size planets and the transition between gas and ice giants. The estimates of the age of these three stars confirms an already observed tendency for some stars to have gyrochronological ages significantly lower than their isochronal ages. We propose that high eccentricity migration could partially explain this behavior for stars hosting a short period planet. Finally, these three planets also lie close to (WASP-151b and WASP-153b) or below (WASP-156b) the upper boundary of the Neptunian desert. Their characteristics support that the ultra-violet irradiation plays an important role in this depletion of planets observed in the exoplanet population