Transitional Interface: Concept, Issues and Framework

Transitional Interfaces have emerged as a new way to interact and collaborate between different interaction spaces such as Reality, Virtual Reality and Augmented Reality. In this paper we explore this concept further. We introduce a descriptive model of the concept, its collaborative aspect and how it can be generalized to describe natural and continuous transitions between contexts (e.g. across space, scale, viewpoint, and representation)

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals. In non-mammalian species, only one xenosensor gene has been found. Using chicken as a model organism, the aim of our study was to elucidate whether non-mammalian species only have one or two xenosensors like mammals. RESULTS: To explore the evolutionary aspect of this divergence, we tried to identify additional xenobiotic sensing nuclear receptors in chicken using various experimental approaches. However, none of those revealed novel candidates. Ablation of chicken xenobiotic receptor (CXR) function by RNAi or dominant-negative alleles drastically reduced drug-induction in a chicken hepatoma cell line. Subsequently, we functionally and structurally characterized CXR and compared our results to PXR and CAR. Despite the high similarity in their amino acid sequence, PXR and CAR have very distinct modes of activation. Some aspects of CXR function, e.g. direct ligand activation and high promiscuity are very reminiscent of PXR. On the other hand, cellular localization studies revealed common characteristics of CXR and CAR in terms of cytoplasmic-nuclear distribution. Finally, CXR has unique properties regarding its regulation in comparison to PXR and CAR. CONCLUSION: Our finding thus strongly suggest that CXR constitutes an ancestral gene which has evolved into PXR and CAR in mammals. Future studies should elucidate the reason for this divergence in mammalian versus non-mammalian species

First insights into the ISM at z > 8 with JWST: Possible physical implications of a high [O iii] λ4363/[O iii] λ5007

We present a detailed analysis of the rest-frame optical emission line ratios for three spectroscopically confirmed galaxies at z > 7.5. The galaxies were identified in the James Webb Space Telescope (JWST) Early Release Observations field SMACS J0723.3 - 7327. By quantitatively comparing Balmer and oxygen line ratios of these galaxies with various low-redshift 'analogue' populations (e.g. Green Peas, Blueberries, etc.), we show that no single analogue population captures the diversity of line ratios of all three galaxies observed at z > 7.5. We find that S06355 at z = 7.67 and S10612 at z = 7.66 are similar to local Green Peas and Blueberries. In contrast, S04590 at z = 8.50 appears to be significantly different from the other two galaxies, most resembling extremely low-metallicity systems in the local Universe. Perhaps the most striking spectral feature in S04590 is the curiously high [O iii] λ4363/[O iii] λ5007 ratio (RO3) of 0.048 (or 0.055 when dust-corrected), implying either extremely high electron temperatures, >3 × 104 K, or gas densities >104 cm-3. Observed line ratios indicate that this galaxy is unlikely to host an AGN. Using photoionization modelling, we show that the inclusion of high-mass X-ray binaries or a high cosmic ray background in addition to a young, low-metallicity stellar population can provide the additional heating necessary to explain the observed high RO3 while remaining consistent with other observed line ratios. Our models represent a first step at accurately characterizing the dominant sources of photoionization and heating at very high redshifts, demonstrating that non-thermal processes may become important as we probe deeper into the Epoch of Reionization

Exploring embodiment through martial arts and combat sports: a review of empirical research

Since the late 1970s, social scientists have turned considerable attention to investigating martial arts and combat sports (MACS). In particular, this broad range of fighting disciplines has been shown to offer numerous avenues for scholarly enquiry into social change and personal transformation via processes of embodiment. Adopting a thematic structure, we assess the empirical literature in this area via four interconnecting categories pertaining to MACS and embodiment: (1) body cultures; (2) body pedagogies; (3) the embodiment of gender; and (4) bodily harm. Following this review, we identify several gaps in the existing literature, suggesting potential new topics and strategies for research connecting to the social world of physical culture more generally

Cone-Rod Dystrophy Due to Mutations in a Novel Photoreceptor-Specific Homeobox Gene (CRX) Essential for Maintenance of the Photoreceptor

Genes associated with inherited retinal degeneration have been found to encode proteins required for phototransduction, metabolism, or structural support of photoreceptors. Here we show that mutations in a novel photoreceptor-specific homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13. In affected members of a CORD2-linked family, the highly conserved glutamic acid at the first position of the recognition helix is replaced by alanine (E80A). In another CRD family, a 1 bp deletion (E168 [delta1 bp]) within a novel sequence, the WSP motif, predicts truncation of the C-terminal 132 residues of CRX. Mutations in the CRX gene cause adCRD either by haploinsufficiency or by a dominant negative effect and demonstrate that CRX is essential for the maintenance of mammalian photoreceptorsThis work was supported by the RP Foundation of Canada (R. R. M.), the Foundation Fighting Blindness (R. R. M. and S. G. J.), the Canadian Genetic Disease Network (R. R. M. and A. D.), the Medical Research Council of Canada (R. R. M.), The Wellcome Trust (043825/Z/95) and the Human Genome Mapping Resource Centre (C. Y. G.-E. and S. S. B.), the Howard Hughes Medical Institute and NIH R01 EY0 8064 (C. L. C.), the Canadian Genome Analysis and Technology Genome Resource Facility (S. W. S. and L.-C. T.), the NIH/NEI (EY05627) (S. G. J.), and the Greek National Scholarship Foundation (M. P.). R. R. M. and L.-C. T. are International Research Scholars of the Howard Hughes Medical Institute

How well do computer-generated faces tap face expertise?

The use of computer-generated (CG) stimuli in face processing research is proliferating due to the ease with which faces can be generated, standardised and manipulated. However there has been surprisingly little research into whether CG faces are processed in the same way as photographs of real faces. The present study assessed how well CG faces tap face identity expertise by investigating whether two indicators of face expertise are reduced for CG faces when compared to face photographs. These indicators were accuracy for identification of own-race faces and the other-race effect (ORE)-the well-established finding that own-race faces are recognised more accurately than other-race faces. In Experiment 1 Caucasian and Asian participants completed a recognition memory task for own- and other-race real and CG faces. Overall accuracy for own-race faces was dramatically reduced for CG compared to real faces and the ORE was significantly and substantially attenuated for CG faces. Experiment 2 investigated perceptual discrimination for own- and other-race real and CG faces with Caucasian and Asian participants. Here again, accuracy for own-race faces was significantly reduced for CG compared to real faces. However the ORE was not affected by format. Together these results signal that CG faces of the type tested here do not fully tap face expertise. Technological advancement may, in the future, produce CG faces that are equivalent to real photographs. Until then caution is advised when interpreting results obtained using CG faces

The chemical enrichment in the early Universe as probed by JWST via direct metallicity measurements at z ∼ 8

We analyse the chemical properties of three z∼ 8 galaxies behind the galaxy cluster SMACS J0723.3-7327, observed as part of the Early Release Observations programme of the James Webb Space Telescope. Exploiting [O III]λ4363 auroral line detections in NIRSpec spectra, we robustly apply the direct Te method for the very first time at such high redshift, measuring metallicities ranging from extremely metal poor (12 + log(O/H)≈ 7) to about one-third solar. We also discuss the excitation properties of these sources, and compare them with local strong-line metallicity calibrations. We find that none of the considered diagnostics match simultaneously the observed relations between metallicity and strong-line ratios for the three sources, implying that a proper re-assessment of the calibrations may be needed at these redshifts. On the mass-metallicity plane, the two galaxies at z ∼ 7.6 (log(M∗/M☉) = 8.1, 8.7) have metallicities that are consistent with the extrapolation of the mass-metallicity relation at z∼2-3, while the least massive galaxy at z ∼ 8.5 (log(M∗/M☉) = 7.8) shows instead a significantly lower metallicity. The three galaxies show different level of offset relative to the Fundamental Metallicity Relation, with two of them (at z∼ 7.6) being marginally consistent, while the z∼ 8.5 source deviating significantly, being probably far from the smooth equilibrium between gas flows, star formation, and metal enrichment in place at later epochs

MOONRISE: The Main MOONS GTO Extragalactic Survey

The MOONS instrument possesses an exceptional combination of large multiplexing, high sensitivity, broad simultaneous spectral coverage (from optical to near-infrared bands), large patrol area and high fibre density. These properties provide the unprecedented potential of enabling, for the very first time, SDSS-like surveys around Cosmic Noon (z~1-2.5), when the star formation rate in the Universe peaked. The high-quality spectra delivered by MOONS will sample the same nebular and stellar diagnostics observed in extensive surveys of local galaxies, providing an accurate and consistent description of the evolution of various physical properties of galaxies, and hence a solid test of different scenarios of galaxy formation and transformation. Most importantly, by spectroscopically identifying hundreds of thousands of galaxies at high redshift, the MOONS surveys will be capable of determining the environments in which primeval galaxies lived and will reveal how such environments affected galaxy evolution. In this article, we specifically focus on the main Guaranteed Time Observation (GTO) MOONS extragalactic survey, MOONRISE, by providing an overview of its scientific goals and observing strategy

JWST NIRCam + NIRSpec: Interstellar medium and stellar populations of young galaxies with rising star formation and evolving gas reservoirs

We present an interstellar medium and stellar population analysis of three spectroscopically confirmed z > 7 galaxies in the Early Release Observations JWST/NIRCam and JWST/NIRSpec data of the SMACS J0723.3-7327 cluster. We use the Bayesian spectral energy distribution-fitting code PROSPECTOR with a flexible star formation history (SFH), a variable dust attenuation law, and a self-consistent model of nebular emission (continuum and emission lines). Importantly, we self-consistently fit both the emission line fluxes from JWST/NIRSpec and the broad-band photometry from JWST/NIRCam, taking into account slit-loss effects. We find that these three z=7.6-8.5 galaxies (M-* approximate to 10(8) M-circle dot) are young with rising SFHs and mass-weighted ages of 3-4 Myr, though we find indications for underlying older stellar populations. The inferred gas-phase metallicities broadly agree with the direct metallicity estimates from the auroral lines. The galaxy with the lowest gas-phase metallicity (Z(gas) = 0.06 Z(circle dot)) has a steeply rising SFH, is very compact ( <0.2 kpc), and has a high star formation rate surface density (Sigma(SFR) approximate to 22 M-circle dot yr(-1) kpc(-2)), consistent with rapid gas accretion. The two other objects with higher gas-phase metallicities show more complex multicomponent morphologies on kpc scales, indicating that their recent increase in star formation rate is driven by mergers or internal, gravitational instabilities. We discuss effects of assuming different SFH priors or only fitting the photometric data. Our analysis highlights the strength and importance of combining JWST imaging and spectroscopy for fully assessing the nature of galaxies at the earliest epochs