Protein Tyrosine Kinase Panel As a Tool for Anticancer Drug Design

The discovery of the pharmaceutical potential of small molecule inhibitors of oncogenic protein tyrosine kinases is one of the directions in target therapy in oncology. Presently, investigations aiming at developing new therapeutically important inhibitors have to be based on a combination of computational and experimental approaches including biochitalicical, cell-based or in silico screening and the study of the three-dimensional structure of the kinase active center, in complex with an inhibitor, using crystallography and X-ray analysis or molecular modeling. This work is an example of a combination of inhibitor experimental search with the computational analysis of the potential mechanism of the inhibitors' action, which allowed to propose the 2-hydroxyphenol group as a scaffold for the design of new tyrosine kinase inhibitors

Cranked Relativistic Hartree-Bogoliubov Theory: Superdeformed Bands in the A∼190A\sim 190 Region

Cranked Relativistic Hartree-Bogoliubov (CRHB) theory is presented as an extension of Relativistic Mean Field theory with pairing correlations to the rotating frame. Pairing correlations are taken into account by a finite range two-body force of Gogny type and approximate particle number projection is performed by Lipkin-Nogami method. This theory is applied to the description of yrast superdeformed rotational bands observed in even-even nuclei of the $A\sim 190$ mass region. Using the well established parameter sets NL1 for the Lagrangian and D1S for the pairing force one obtains a very successful description of data such as kinematic ($J^{(1)}$) and dynamic ($J^{(2)}$) moments of inertia without any adjustment of new parameters. Within the present experimental accuracy the calculated transition quadrupole moments $Q_t$ agree reasonably well with the observed data.Comment: 6 pages including 4 PostScript figures, uses RevTex, revised version, Phys.Rev. C, Rapid Communications, in pres

From Tetraquark to Hexaquark: A Systematic Study of Heavy Exotics in the Large NcN_c Limit

A systematic study of multiquark exotics with one or $N_c-1$ heavy quarks in the large $N_c$ limit is presented. By binding a chiral soliton to a heavy meson, either a normal $N_c$-quark baryon or an exotic $(N_c+2)$-quark baryon is obtained. By replacing the heavy quark with $N_c-1$ heavy antiquarks, exotic $(2N_c-2)$-quark and $2N_c$-quark mesons are obtained. When $N_c = 3$, they are just the normal triquark baryon $Qqq$, the exotic pentaquark baryon $Q\bar q\bar q\bar q\bar q$, tetraquark di-meson $\bar Q \bar Q qq$ and the hexaquark di-baryon $\bar Q \bar Q \bar q \bar q\ bar q \bar q$ respectively. Their stabilities and decays are also discussed. In particular, it is shown that the ``heavy to heavy'' semileptonic decays are described by the Isgur--Wise form factors of the normal baryons.Comment: 14 pages in REVTeX, no Figure

Roto-vibrational spectrum and Wigner crystallization in two-electron parabolic quantum dots

We provide a quantitative determination of the crystallization onset for two electrons in a parabolic two-dimensional confinement. This system is shown to be well described by a roto-vibrational model, Wigner crystallization occurring when the rotational motion gets decoupled from the vibrational one. The Wigner molecule thus formed is characterized by its moment of inertia and by the corresponding sequence of rotational excited states. The role of a vertical magnetic field is also considered. Additional support to the analysis is given by the Hartree-Fock phase diagram for the ground state and by the random-phase approximation for the moment of inertia and vibron excitations.Comment: 10 pages, 8 figures, replaced by the published versio

Strong Decays of Strange Quarkonia

In this paper we evaluate strong decay amplitudes and partial widths of strange mesons (strangeonia and kaonia) in the 3P0 decay model. We give numerical results for all energetically allowed open-flavor two-body decay modes of all nsbar and ssbar strange mesons in the 1S, 2S, 3S, 1P, 2P, 1D and 1F multiplets, comprising strong decays of a total of 43 resonances into 525 two-body modes, with 891 numerically evaluated amplitudes. This set of resonances includes all strange qqbar states with allowed strong decays expected in the quark model up to ca. 2.2 GeV. We use standard nonrelativistic quark model SHO wavefunctions to evaluate these amplitudes, and quote numerical results for all amplitudes present in each decay mode. We also discuss the status of the associated experimental candidates, and note which states and decay modes would be especially interesting for future experimental study at hadronic, e+e- and photoproduction facilities. These results should also be useful in distinguishing conventional quark model mesons from exotica such as glueballs and hybrids through their strong decays.Comment: 69 pages, 5 figures, 39 table

Final-State Phases in Charmed Meson Two-Body Nonleptonic Decays

Observed decay rates indicate large phase differences among the amplitudes for the charge states in $D \to \bar K \pi$ and $D \to \bar K^* \pi$ but relatively real amplitudes in the charge states for $D \to \bar K \rho$. This feature is traced using an SU(3) flavor analysis to a sign flip in the contribution of one of the amplitudes contributing to the latter processes in comparison with its contribution to the other two sets. This amplitude may be regarded as an effect of rescattering and is found to be of magnitude comparable to others contributing to charmed particle two-body nonleptonic decays.Comment: 19 pages, latex, 4 figures, to be submitted to Phys. Rev.

Charmed Exotics in Heavy Ion Collisions

Based on the color-spin interaction in diquarks, we argue that charmed multiquark hadrons are likely to exist. Because of the appreciable number of charm quarks produced in central nucleus-nucleus collisions at ultrarelativistic energies, production of charmed multiquark hadrons is expected to be enhanced in these collisions. Using both the quark coalescence model and the statistical hadronization model, we estimate the yield of charmed tetraquark meson $T_{cc}$ and pentaquark baryon $\Theta_{cs}$ in heavy ion collisions at RHIC and LHC. We further discuss the decay modes of these charmed exotic hadrons in order to facilitate their detections in experiments

Cranked Relativistic Hartree-Bogoliubov Theory: Formalism and Application to the Superdeformed Bands in the A∼190A\sim 190 region

Cranked Relativistic Hartree-Bogoliubov theory without and with approximate particle number projection by means of the Lipkin-Nogami method is presented in detail as an extension of Relativistic Mean Field theory with pairing correlations to the rotating frame. Pairing correlations are taken into account by a finite range two-body force of Gogny type. The applicability of this theory to the description of rotating nuclei is studied in detail on the example of superdeformed bands in even-even nuclei of the $A\sim 190$ mass region. Different aspects such as the importance of pairing and particle number projection, the dependence of the results on the parametrization of the RMF Lagrangian and Gogny force etc. are investigated in detail. It is shown that without any adjustment of new parameters the best description of experimental data is obtained by using the well established parameter sets NL1 for the Lagrangian and D1S for the pairing force. Contrary to previous studies at spin zero it is found that the increase of the strength of the Gogny force is not necessary in the framework of Relativistic Hartree-Bogoliubov theory provided that particle number projection is performed.Comment: 34 pages, 24 figures, 3 tables, uses Revtex and epsf.sty, submitted to Nuclear Physics

Energy and system size dependence of \phi meson production in Cu+Cu and Au+Au collisions

We study the beam-energy and system-size dependence of \phi meson production (using the hadronic decay mode \phi -- K+K-) by comparing the new results from Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4 and 200 GeV measured in the STAR experiment at RHIC. Data presented are from mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the transverse momentum distributions for \phi mesons are observed to be similar in yield and shape for Cu+Cu and Au+Au colliding systems with similar average numbers of participating nucleons. The \phi meson yields in nucleus-nucleus collisions, normalised by the average number of participating nucleons, are found to be enhanced relative to those from p+p collisions with a different trend compared to strange baryons. The enhancement for \phi mesons is observed to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision energies, the source of enhancement of strange hadrons is related to the formation of a dense partonic medium in high energy nucleus-nucleus collisions and cannot be alone due to canonical suppression of their production in smaller systems.Comment: 20 pages and 5 figure

The theta^+ baryon in soliton models: large Nc QCD and the validity of rigid-rotor quantization

A light collective theta+ baryon state (with strangeness +1) was predicted via rigid-rotor collective quantization of SU(3) chiral soliton models. This paper explores the validity of this treatment. A number of rather general analyses suggest that predictions of exotic baryon properties based on this approximation do not follow from large Nc QCD. These include an analysis of the baryon's width, a comparison of the predictions with general large Nc consistency conditions of the Gervais-Sakita-Dashen-Manohar type; an application of the technique to QCD in the limit where the quarks are heavy; a comparison of this method with the vibration approach of Callan and Klebanov; and the 1/Nc scaling of the excitation energy. It is suggested that the origin of the problem lies in an implicit assumption in the that the collective motion is orthogonal to vibrational motion. While true for non-exotic motion, the Wess-Zumino term induces mixing at leading order between collective and vibrational motion with exotic quantum numbers. This suggests that successful phenomenological predictions of theta+ properties based on rigid-rotor quantization were accidental.Comment: 19 pages; A shorter more readable versio