1,045 research outputs found
PATIENTS’ DIRECT ACCESS TO THEIR ELECTRONIC MEDICAL RECORD USING THE INTERNET: A LITERATURE REVIEW
Patient-accessible medical record is an important element of evolution in the patient-physician relationship: patients want to become more active in their health care process. We want to highlight the results of studies that analyse the impact of patients having access to their electronic medical record using the Internet on patients, on physicians and on their relationship. The studies were identified using “Pub Med” and “Web of Knowledge”. The search was limited to articles published between 2000 and October 2012. We focused on articles about patients accessing, through Internet, their electronic medical record that are created and filled in by physicians. 26 studies were selected and analysed. Quantitative data were obtained through questionnaires, analysis of the log-ins and analysis of the records, while qualitative data were obtained through interviews and focus groups. The specificity of our review refers to the electronic means through which patients access their electronic medical (and particularly Internet)
Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities
PDE4 as a target in preterm labour
Cyclic nucleotide phosphodiesterases (PDE) are the enzymes catalyzing the hydrolysis and inactivation of the second messengers, cAMP and cGMP. Eleven PDE families are described to date, and selective inhibitors of some PDEs families are currently used in clinic for treating cardiovascular disorders, erectile dysfunction, and pulmonary hypertension. Isoforms of the PDE4 family are involved in smooth muscle contraction and inflammation. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state. Using human myometrial cells in culture, we demonstrated that PDE4B2 can be induced by its own substrate, under the control of one of the major utero-contractile agonists, PGE2, itself upregulated by the proinflammatory cytokine IL-1β. Functionally, augmentation of global PDE4 activity decreases the ability of β-adrenergic agonists (the most commonly used tocolytic drugs) to inhibit myometrial contraction at the end of pregnancy and during pathophysiological situations, such as persistent intrauterine inflammation which is a major cause of very preterm delivery. Currently exploring the anti-inflammatory properties of PDE4 inhibitors in gestational tissues, we recently demonstrated the ability of these drugs to block a persistent inflammatory response of the foetal membranes in Humans and to prevent inflammation-driven preterm delivery and foetal demise in mice. These data open up a new therapeutical strategy to prevent inflammation-induced preterm delivery and its sequelae in very preterm infants
Quantifying Photoinduced Polaronic Distortions in Inorganic Lead Halide Perovskites Nanocrystals
The development of next generation perovskite-based optoelectronic devices
relies critically on the understanding of the interaction between charge
carriers and the polar lattice in out-of-equilibrium conditions. While it has
become increasingly evident for CsPbBr3 perovskites that the Pb-Br framework
flexibility plays a key role in their light-activated functionality, the
corresponding local structural rearrangement has not yet been unambiguously
identified. In this work, we demonstrate that the photoinduced lattice changes
in the system are due to a specific polaronic distortion, associated with the
activation of a longitudinal optical phonon mode at 18 meV by electron-phonon
coupling, and we quantify the associated structural changes with atomic-level
precision. Key to this achievement is the combination of time-resolved and
temperature-dependent studies at Br K-edge and Pb L3-edge X-ray absorption with
refined ab-initio simulations, which fully account for the screened core-hole
final state effects on the X-ray absorption spectra. From the temporal
kinetics, we show that carrier recombination reversibly unlocks the structural
deformation at both Br and Pb sites. The comparison with the
temperature-dependent XAS results rules out thermal effects as the primary
source of distortion of the Pb-Br bonding motif during photoexcitation. Our
work provides a comprehensive description of the CsPbBr3 perovskites
photophysics, offering novel insights on the light-induced response of the
system and its exceptional optoelectronic properties.Comment: Main: 27 pages, 4 figures SI: 16 pages, 8 figure
SPIRAL II Project (electron option) - Preliminary Design Study
This document presents a Preliminary Design Study (PDS) of the electron option of the SPIRAL II project
Measurement of the ratio of branching fractions BR(B0 -> K*0 gamma)/BR(Bs0 -> phi gamma)
The ratio of branching fractions of the radiative B decays B0 -> K*0 gamma
and Bs0 -> phi gamma has been measured using 0.37 fb-1 of pp collisions at a
centre of mass energy of sqrt(s) = 7 TeV, collected by the LHCb experiment. The
value obtained is BR(B0 -> K*0 gamma)/BR(Bs0 -> phi gamma) = 1.12 +/- 0.08
^{+0.06}_{-0.04} ^{+0.09}_{-0.08}, where the first uncertainty is statistical,
the second systematic and the third is associated to the ratio of fragmentation
fractions fs/fd. Using the world average for BR(B0 -> K*0 gamma) = (4.33 +/-
0.15) x 10^{-5}, the branching fraction BR(Bs0 -> phi gamma) is measured to be
(3.9 +/- 0.5) x 10^{-5}, which is the most precise measurement to date.Comment: 15 pages, 1 figure, 2 table
Search for CP violation in decays
A model-independent search for direct CP violation in the Cabibbo suppressed
decay in a sample of approximately 370,000 decays is
carried out. The data were collected by the LHCb experiment in 2010 and
correspond to an integrated luminosity of 35 pb. The normalized Dalitz
plot distributions for and are compared using four different
binning schemes that are sensitive to different manifestations of CP violation.
No evidence for CP asymmetry is found.Comment: 13 pages, 8 figures, submitted to Phys. Rev.
Opposite-side flavour tagging of B mesons at the LHCb experiment
The calibration and performance of the oppositeside
flavour tagging algorithms used for the measurements
of time-dependent asymmetries at the LHCb experiment
are described. The algorithms have been developed using
simulated events and optimized and calibrated with
B
+ →J/ψK
+, B0 →J/ψK
∗0 and B0 →D
∗−
μ
+
νμ decay
modes with 0.37 fb−1 of data collected in pp collisions
at
√
s = 7 TeV during the 2011 physics run. The oppositeside
tagging power is determined in the B
+ → J/ψK
+
channel to be (2.10 ± 0.08 ± 0.24) %, where the first uncertainty
is statistical and the second is systematic
Measurement of the CP-violating phase phi_s in the decay Bs->J/psi phi
We present a measurement of the time-dependent CP-violating asymmetry in B_s
-> J/psi phi decays, using data collected with the LHCb detector at the LHC.
The decay time distribution of B_s -> J/psi phi is characterized by the decay
widths Gamma_H and Gamma_L of the heavy and light mass eigenstates of the
B_s-B_s-bar system and by a CP-violating phase phi_s. In a sample of about 8500
B_s -> J/psi phi events isolated from 0.37 fb^-1 of pp collisions at sqrt(s)=7
TeV we measure phi_s = 0.15 +/- 0.18 (stat) +/- 0.06 (syst) rad. We also find
an average B_s decay width Gamma_s == (Gamma_L + Gamma_H)/2 = 0.657 +/- 0.009
(stat) +/- 0.008 (syst) ps^-1 and a decay width difference Delta Gamma_s ==
Gamma_L - Gamma_H} = 0.123 +/- 0.029 (stat) +/- 0.011 (syst) ps^-1. Our
measurement is insensitive to the transformation (phi_s,DeltaGamma_s --> pi -
phi_s, - Delta Gamma_s.Comment: 9 pages, 3 figure
Observation of excited Lambda_b0 baryons
Using pp collision data corresponding to 1.0 fb-1 integrated luminosity
collected by the LHCb detector, two narrow states are observed in the
Lambda_b0pi+pi- spectrum with masses 5911.97 +- 0.12(stat) +- 0.02(syst) +-
0.66(Lambda_b0 mass) MeV/c^2 and 5919.77 +- 0.08(stat) +- 0.02(syst) +-
0.66(Lambda_b0 mass) MeV/c^2. The significances of the observations are 5.2 and
10.2 standard deviations, respectively. These states are interpreted as the
orbitally-excited Lambda_b0 baryons, Lambda_b*0(5912) and Lambda_b*0(5920).Comment: Replaced by version published in Phys. Rev. Lett, modified fit with
better mass resolution treatmen
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