The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Health Behavior and Cancer Control, 1976 (M895 and M004)

This study document the wide-ranging significance for the health of the person's sense of control, i.e., the sense of mastery vs. fate-orientation. Health behavior is examined in three domains: 1) preventive care; 2) health knowledge and perspectives; and 3) physical status, e.g. acute and chronic illness. A representative metropolitan sample was interviewed at the beginning (1976) and at the close (1977) of a year-long investigation that included telephone call-backs at six-week intervals to trace health-related incidents. Data collection consisted of initial and final face-to-face interviews with intervening telephone call-backs at approximately six-week intervals. There were 1210 adults in the 1976 survey and 931 cases in 1977. The initial interview contained questions on respondent's health beliefs, e.g. items on health values; and the final interview contained new questions on knowledge or perspective concerning cancer. At each call-back, respondents who reported having a health problem were queried in detail about their illness. If they did not report an illness, respondents were asked their opinion about certain health matters using a brief schedule that contained an eleven-item health locus of control scale. Sense of health control scores were thus obtained for 1054 respondents. In both 1976 and 1977 interviews, respondents were asked to indicate, which, if any, of nine-preventive health behaviors they engaged in over the preceding two months

Population Policies, 1975

This survey, conducted by Leo G. Reeder and the UCLA Survey Research Center is a second-stage survey administered to respondents who previously participated in a similar survey in Fall of 1973. The principal investigator seeks information about the political and social attitudes of Los Angeles residents on various contemporary issues, such as Schools, Unemployment, Health Problems, Government Services, Civil Liberties and more. The codebook is featured in four parts, separating adult sample responses from teen sample responses