112 research outputs found
The utility of curriculum-based measurement within a multitiered framework: establishing cut scores as predictors of student performance on the Alaska standards-based assessment
The purpose of this study was to explore the relationship between student performance on Reading Curriculum-based Measures (R-CBM) and student performance on the Alaska\u27s standards based assessment (SBA) administered to students in Studied School District (SSD) Grade 3 through Grade 5 students in the Studied School District as required by Alaska\u27s accountability system. The 2 research questions were: (a) To what extent, if at all, is there a relationship between student performance on the R-CBM tools administered in Grades 3, 4, and 5 in the fall, winter, and spring and student performance on the Alaska SBA administered in the spring of the same school year in the SSD? (b) To what extent, if at all, can cut scores be derived for each of the 3 R-CBM testing windows in the fall, winter, and spring that predict success on the Alaska SBA administered in the spring of the same school year in the SSD? The Study School District (SSD) served approximately 9,500 students, with 14% of students eligible for special education services. The enrollment was 81% Caucasian, 10% Alaska Native, 3% Hispanic, 3% multiethnic, and 4% as the total of American Indian, Asian, Black, and Native Hawaiian/Pacific Islander. The sample was 3rd (n = 472), 4th (n = 435), and 5th (n = 517) graders and consisted of all students with an Alaska SBA score and an R-CBM score for each of the 3 administrations of the R-CBM used in the 2009-2010 (FY10) and 2010-2011 (FY11) years. Pearson correlations were significant between R-CBM scores across 3rd, 4th, and 5th grades and the same grade Alaska SBA scores for FY10 data, r = .689 to r = .728, p \u3c .01. A test of the full model with R-CBM as predictor against a constant-only model was statistically reliable, p \u3c .001. The R-CBM reliably distinguished between passing and failing the Alaska SBA for students in Grades 3 through 5. Criterion validity of the cut scores was ascertained by applying scores to the FY11 data and yielded adequate levels of sensitivity from 49% to 88% while specificity levels ranged from 89% to 97%
Examining the impact of integrated and non-integrated parasport events on volunteer attitudes towards disability
Drought drove forest decline and dune building in eastern upper Michigan, USA, as the upper Great Lakes became closed basins
Current models of landscape response to Holocene climate change in midcontinent North America largely reconcile Earth orbital and atmospheric climate forcing with pollen-based forest histories on the east and eolian chronologies in Great Plains grasslands on the west. However, thousands of sand dunes spread across 12,000 km2 in eastern upper Michigan (EUM), more than 500 km east of the present forest-prairie ecotone, present a challenge to such models. We use 65 optically stimulated luminescence (OSL) ages on quartz sand deposited in silt caps (n = 8) and dunes (n = 57) to document eolian activity in EUM. Dune building was widespread ca. 10–8 ka, indicating a sharp, sustained decline in forest cover during that period. This decline was roughly coincident with hydrologic closure of the upper Great Lakes, but temporally inconsistent with most pollen-based models that imply canopy closure throughout the Holocene. Early Holocene forest openings are rarely recognized in pollen sums from EUM because faint signatures of non-arboreal pollen are largely obscured by abundant and highly mobile pine pollen. Early Holocene spikes in nonarboreal pollen are recorded in cores from small ponds, but suggest only a modest extent of forest openings. OSL dating of dune emplacement provides a direct, spatially explicit archive of greatly diminished forest cover during a very dry climate in eastern midcontinent North America ca. 10–8 ka
Evaluation of university library impact on students’ academic success
U radu se iznosi teorijski okvir vrednovanja knjižnica, a posebno se govori o mogućnostima istraživanja utjecaja zbirki i usluga sveučilišnih knjižnica na akademski uspjeh studenata. Ukazuje se na terminološke probleme vezane uz vrednovanje knjižnica, o važnosti vrednovanja za poslovanje knjižnica, o knjižničnoj statistici, a posebno o mjerenju utjecaja knjižničnih zbirki i usluga na korisnike. U Hrvatskoj se do sada nisu provodila istraživanja utjecaja sveučilišnih knjižnica na korisnike, a istraživanja vezanih uz utjecaj knjižnice na obrazovanje studenata jako je malo i u svijetu. Razlog tome je činjenica da je utjecaje relativno teško izmjeriti, no oni su veoma važni pokazatelji uspješnosti poslovanja određene akademske knjižnice.The paper gives a theoretical framework for library evaluation, and indicates possible effects the library collections and services might have on students’ academic achievement. The paper discusses terminological problems, the importance of evaluation for library performance, library statistics, and focuses on the measurement of impact of library collections and services on their users. So far, there has been no research in Croatia about the impact of university libraries on student academic achievement, and the studies that deal with this topic are rare even around the world. The reason for this lies in the fact that the outcomes are very difficult to measure, and are therefore avoided in measurements. However, they represent extremely important indicators of university library impact on students’ academic performance
Objective effect manifestation of pectus excavatum on load-stressed pulmonary function testing: a case report
Abstract Introduction Pectus excavatum is the most common congenital deformity of the anterior chest wall that, under certain conditions, may pose functional problems due to cardiopulmonary compromise and exercise intolerance. Case presentation We present the case of an otherwise physically-adept 21-year-old Chinese sportsman with idiopathic pectus excavatum, whose symptoms manifested only on bearing a loaded body vest and backpack during physical exercise. Corroborative objective evidence was obtained via load-stressed pulmonary function testing, which demonstrated restrictive lung function. Conclusion This report highlights the possible detrimental synergism of thoracic load stress and pectus excavatum on cardiopulmonary function. Thoracic load-stressed pulmonary function testing provides objective evidence in support of such a synergistic relationship.</p
The Vehicle, 1963, Vol. 5
Vol. 5
Table of Contents
Milepostspage 3
Rhyme Conceived At DawnDaun Alan Leggpage 4
NightRoss Kokospage 4
UncrownedOra Blanche T. Kingpage 4
SunfishingL.J.G.page 5
The Man Who Went To New YorkEric Crookspage 7
The DreamPauline B. Smithpage 18
Open WindowsDavid Helmpage 19
SalvationChristine McCollpage 19
The Chess GamePierre Hooverpage 20
CataclysmRaymond Kapraunpage 20
A Microscopic ViewKenneth L. Vadovskypage 21
See How Love ComesLiz Puckettpage 21
A Can Of Beer For AndyKenneth L. Vadovskypage 22
A MonsterDixie Lee Motleypage 28
InconstancyJanice Brookspage 29
DreamerDaun Alan Leggpage 29
The Third WishGlenda Vursellpage 30
The MiracleJanice Brookspage 32
What Lives Where Love Once Dwelt?Vernell Vyvialpage 33
The Most Unforgettable Person I Have Ever KnownJames Flingpage 34
Winter ThoughtsPauline B. Smithpage 35
A Winter NightPeggy Lambertpage 35
The Silver WhaleL.J.G.page 36
RaindropsDixie Lee Motleypage 40
Conflict Of Soul IJean Konzelmanpage 40
JudyChristine McCollpage 41
Sadness No. 3 (Vergessen)Sherry Sue Frypage 41
Lost GoldLarry Pricepage 42
EchoesCharles Cooleypage 48
TruthDaun Alan Leggpage 48
SunsetCarol Bennettpage 48
Cover designTom Windsor
Illustration for winning storyJoel E. Hendrickshttps://thekeep.eiu.edu/vehicle/1011/thumbnail.jp
The Vehicle, 1964, Vol. 6
Vol. 6
Table of Contents
Milepostspage 2
John Fitzgerald Kennedy Memorial Pagepage 4
Sadness No. 4 (Sorgen)Sherry S. Frypage 5
Christian BurialRoger J. Barrypage 7
The World of BeautyDavid Helmpage 9
The Song of the LarksDon Kapraunpage 10
ContrastKeith Haierpage 13
PanoramaDaun Alan Leggpage 13
A Child\u27s View of DeathCherie Brondellpage 14
RegretLiz Puckettpage 16
Brutal WarMary H. Soukuppage 17
aloneLiz Puckettpage 18
MadgeLinda Galeypage 19
Moon WatchingJoel E. Hendrickspage 20
AnalysisLiz Puckettpage 21
UniverseRick Talleypage 21
Anyone Can Be A LuniticRick Towsonpage 22
I, Too, Have A Rendezvous with DeathElaine Lancepage 23
The ReturnRobert D. Thomaspage 24
NamesLarry Gatespage 25
Eternal MomentsDavid Helmpage 25
The Last DaysPauline B. Smithpage 26
BeliefRichard J. Wiesepage 27
StormPauline B. Smithpage 28
ExplosionLiz Puckettpage 29
Autumn EveJoel E. Hendrickspage 29
The Girl On the White PonyLarry Gatespage 31
HoffnungTerry Michael Salempage 33
Stone WallsDaun Alan Leggpage 34
AdorationGail M. Barenfangerpage 37
MirageRoy L. Carlsonpage 38
Nature and NonsenseRick Talleypage 39
A Step Through A Looking GlassMarilyn Henrypage 40
Thoughts of a Summer PastPauline B Smithpage 42
Indiana GrassLarry Gatespage 43
RedondillaRoberta Matthewspage 44
Summer LoveDaun Alan Leggpage 45
To Youth Reaching For MaturityDavid Helmpage 45
Thanksgiving DayJoel E. Hendrickspage 46
Sadness No. 6 (Schatten)Sherry S. Frypage 48https://thekeep.eiu.edu/vehicle/1012/thumbnail.jp
Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal Depletion
Zn(II) and Cu(II) precipitate Abeta in vitro into insoluble aggregates that are dissolved by metal chelators. We now report evidence that these biometals also mediate the deposition of Abeta amyloid in Alzheimer's disease, since the solubilization of Abeta from post-mortem brain tissue was significantly increased by the presence of chelators, EGTA, N,N,N',N'-tetrakis(2-pyridyl-methyl) ethylene diamine, and bathocuproine. Efficient extraction of Abeta also required Mg(II) and Ca(II). The chelators were more effective in extracting Abeta from Alzheimer's disease brain tissue than age-matched controls, suggesting that metal ions differentiate the chemical architecture of amyloid in Alzheimer's disease. Agents that specifically chelate copper and zinc ions but preserve Mg(II) and Ca(II) may be of therapeutic value in Alzheimer's disease
Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials
Background
Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response.
Methods
We did hierarchical cluster analysis using five common symptoms associated with primary Sjögren's syndrome (pain, fatigue, dryness, anxiety, and depression), followed by multinomial logistic regression to identify subgroups in the UK Primary Sjögren's Syndrome Registry (UKPSSR). We assessed clinical and biological differences between these subgroups, including transcriptional differences in peripheral blood. Patients from two independent validation cohorts in Norway and France were used to confirm patient stratification. Data from two phase 3 clinical trials were similarly stratified to assess the differences between subgroups in treatment response to hydroxychloroquine and rituximab.
Findings
In the UKPSSR cohort (n=608), we identified four subgroups: Low symptom burden (LSB), high symptom burden (HSB), dryness dominant with fatigue (DDF), and pain dominant with fatigue (PDF). Significant differences in peripheral blood lymphocyte counts, anti-SSA and anti-SSB antibody positivity, as well as serum IgG, κ-free light chain, β2-microglobulin, and CXCL13 concentrations were observed between these subgroups, along with differentially expressed transcriptomic modules in peripheral blood. Similar findings were observed in the independent validation cohorts (n=396). Reanalysis of trial data stratifying patients into these subgroups suggested a treatment effect with hydroxychloroquine in the HSB subgroup and with rituximab in the DDF subgroup compared with placebo.
Interpretation
Stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments. Our data have important implications for clinical management, trial design, and therapeutic development. Similar stratification approaches might be useful for patients with other chronic immune-mediated diseases.
Funding
UK Medical Research Council, British Sjogren's Syndrome Association, French Ministry of Health, Arthritis Research UK, Foundation for Research in Rheumatology
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